Peroxiredoxin 6, a novel player in the pathogenesis of diabetes

Diabetes

Volumn 63, Issue 10, 2014, Pages 3210-3220

  Pacifici, Francesca ^a   Arriga, Roberto ^a   Sorice, Gian Pio ^b,c   Capuani, Barbara ^a   Scioli, Maria Giovanna ^a   Pastore, Donatella ^a   Donadel, Giulia ^a   Bellia, Alfonso ^a   Caratelli, Sara ^a,d   Coppola, Andrea ^a   Ferrelli, Francesca ^a   Federici, Massimo ^a   Sconocchia, Giuseppe ^a,d   Tesauro, Manfredi ^a   Sbraccia, Paolo ^a   Della Morte, David ^a,e   Giaccari, Andrea ^b,f   Orlandi, Augusto ^a   Lauro, Davide ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c Sovrano Ordine Militare Cavalieri di Malta CAD Palmiro Togliatti   (Italy)

^d INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

^e IRCCS SAN RAFFAELE PISANA   (Italy)

^f IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; PEROXIDE; PEROXIREDOXIN 6; PEROXYNITRITE; PRDX6 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD GLUCOSE METER; CELL FRACTIONATION; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION SYSTEM; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HYPERGLYCEMIA; IMMUNOPRECIPITATION; INSULIN METABOLISM; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; KNOCKOUT MOUSE; MALE; METABOLIC PARAMETERS; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WESTERN BLOTTING; ANIMAL; FEMALE; GENETICS; GLUCOSE TOLERANCE TEST; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MICE, KNOCKOUT; OXIDATIVE STRESS; PEROXIREDOXIN VI;

EID: 84907494213     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0144     Document Type: Article

References (48)

1. Styskal J, Van Remmen H, Richardson A, Salmon AB. Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med 2012;52:46-58
2. Tiedge M, Lortz S, Munday R, Lenzen S. Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells. Diabetologia 1999;42: 849-855
3. Rains JL, Jain SK. Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 2011;50:567-575
4. Wood ZA, Schröder E, Robin Harris J, Poole LB. Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci 2003;28:32-40
5. Fisher AB. Peroxiredoxin 6: a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities. Antioxid Redox Signal 2011;15:831 -844
6. Wang X, Phelan SA, Forsman-Semb K, et al. Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J Biol Chem 2003;278:25179-25190
7. Fatma N, Singh P, Chhunchha B, et al. Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis. Am J Physiol Cell Physiol 2011;301 :C954-C967
8. Brinkmann C, Chung N, Schmidt U, et al. Training alters the skeletal muscle antioxidative capacity in non-insulin-dependent type 2 diabetic men. Scand J Med Sci Sports 2012;22:462-470
9. Liang H, Balas B, Tantiwong P, et al. Whole body overexpression of PGC-1 alpha has opposite effects on hepatic and muscle insulin sensitivity. Am J Physiol Endocrinol Metab 2009;296:E945-E954
10. Carter JD, Dula SB, Corbin KL, Wu R, Nunemaker CS. A practical guide to rodent islet isolation and assessment. Biol Proced Online 2009;11:3-31
11. Ferlosio A, Arcuri G, Doldo E, et al. Age-related increase of stem marker expression influences vascular smooth muscle cell properties. Atherosclerosis 2012;224:51-57
12. Kleiner DE, Brunt EM, Van Natta M, et al.; Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-1321
13. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25:402-408
14. Thiebaud D, Jacot E, DeFronzo RA, Maeder E, Jequier E, Felber JP. The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man. Diabetes 1982;31:957-963
15. Asano T, Fujishiro M, Kushiyama A, et al. Role of phosphatidylinositol 3-kinase activation on insulin action and its alteration in diabetic conditions. Biol Pharm Bull 2007;30:1610-1616
16. Ojuka EO, Goyaram V, Smith JA. The role of CaMKII in regulating GLUT4 expression in skeletal muscle. Am J Physiol Endocrinol Metab 2012;303:E322-E331
17. Ng Y, Ramm G, Lopez JA, James DE. Rapid activation of Akt2 is sufficient to stimulate GLUT4 translocation in 3T3-L1 adipocytes. Cell Metab 2008;7:348-356
18. Mooradian AD. Dyslipidemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab 2009;5:150-159
19. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444: 860-867
20. Ding Y, Yamada S, Wang KY, et al. Overexpression of peroxiredoxin 4 protects against high-dose streptozotocin-induced diabetes by suppressing oxidative stress and cytokines in transgenic mice. Antioxid Redox Signal 2010;13:1477-1490
21. Da Silva-Azevedo L, Jähne S, Hoffmann C, et al. Up-regulation of the peroxiredoxin-6 related metabolism of reactive oxygen species in skeletal muscle of mice lacking neuronal nitric oxide synthase. J Physiol 2009;587:655-668
22. Wang X, Vatamaniuk MZ, Roneker CA, et al. Knockouts of S0D1 and GPX1 exert different impacts on murine islet function and pancreatic integrity. Antioxid Redox Signal 2011;14:391-401
23. Dowman JK, Tomlinson JW, Newsome PN. Pathogenesis of non-alcoholic fatty liver disease. QJM 2010;103:71-83
24. Masuoka HC, Chalasani N. Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals. Ann N Y Acad Sci 2013;1281:106-122
25. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 2005;115:1111-1119
26. Kaneto H, Katakami N, Kawamori D, et al. Involvement of oxidative stress in the pathogenesis of diabetes. Antioxid Redox Signal 2007;9:355-366
27. Muscogiuri G, Salmon AB, Aguayo-Mazzucato C, et al. Genetic disruption of S0D1 gene causes glucose intolerance and impairs ß-cell function. Diabetes 2013;62:4201-4207
28. Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006;7:85-96
29. Cual P, Le Marchand-Brustel Y, Tanti JF. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 2005;87:99-109
30. Archuleta TL, Lemieux AM, Saengsirisuwan V, et al. Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: role of p38 MAPK. Free Radic Biol Med 2009;47:1486-1493
31. Bloch-Damti A, Bashan N. Proposed mechanisms for the induction of insulin resistance by oxidative stress. Antioxid Redox Signal 2005;7:1553-1567
32. Masharani UB, Maddux BA, Li X, et al. Insulin resistance in non-obese subjects is associated with activation of the JNK pathway and impaired insulin signaling in skeletal muscle. PLoS ONE 2011;6:e19878
33. Lei XG, Vatamaniuk MZ. Two tales of antioxidant enzymes on ß cells and diabetes. Antioxid Redox Signal 2011;14:489-503
34. Kobayashi H, Matsuda M, Fukuhara A, Komuro R, Shimomura I. Dysregulated glutathione metabolism links to impaired insulin action in adipocytes. Am J Physiol Endocrinol Metab 2009;296:E1326-E1334
35. Weir GC, Bonner-Weir S. Islet ß cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci 2013;1281:92-105
36. Arca M, Pigna G, Favoccia C. Mechanisms of diabetic dyslipidemia: relevance for atherogenesis. Gurr Vase Pharmacol 2012;10:684-686
37. Wang X, Phelan SA, Petros C, et al. Peroxiredoxin 6 deficiency and atherosclerosis susceptibility in mice: significance of genetic background for assessing atherosclerosis. Atherosclerosis 2004;177:61-70
38. Eismann T, Huber N, Shin T, et al. Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice. Am J Physiol Gastrointest Liver Physiol 2009;296:G266-G274
39. Nabeshima A, Yamada S, Guo X, et al. Peroxiredoxin 4 protects against nonalcoholic steatohepatitis and type 2 diabetes in a nongenetic mouse model. Antioxid Redox Signal 2013;19:1983-1998
40. Ibdah JA, Perlegas P, Zhao Y, et al. Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Gastroenterology 2005;128:1381-1390
41. Shi H, Yu HJ, Wang HY, et al. Topical administration of peroxiredoxin-6 on the cornea suppresses inflammation and neovascularization induced by ultraviolet radiation. Invest Ophthalmol Vis Sci 2012;53:8016-8028
42. Paula FM, Ferreira SM, Boschero AC, Souza KL. Modulation of the peroxiredoxin system by cytokines in insulin-producing RINm5F cells: down-regulation of PRDX6 increases susceptibility of beta cells to oxidative stress. Mol Cell Endocrinol 2013;374:56-64
43. Rhee SG, Woo HA. Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger H2O2, and protein chaperones. Antioxid Redox Signal 2011;15:781-794
44. El Eter E, Al Masri A, Habib S, et al. Novel links among peroxiredoxins, endothelial dysfunction, and severity of atherosclerosis in type 2 diabetic patients with peripheral atherosclerotic disease. Cell Stress Chaperones 2014;19:173 -181.
45. Brinkmann C, Blossfeld J, Pesch M, et al. Lipid-peroxidation and peroxiredoxin-overoxidation in the erythrocytes of non-insulin-dependent type 2 diabetic men during acute exercise. Eur J Appl Physiol 2012;112:2277-2287
46. Plum L, Wunderlich FT, Baudler S, Krone W, Brüning JC. Transgenic and knockout mice in diabetes research: novel insights into pathophysiology, limitations, and perspectives. Physiology (Bethesda) 2005;20:152-161
47. Marra F, Bertolani C. Adipokines in liver diseases. Hepatology 2009;50: 957-969
48. Seibold P, Hall P, Schoof N, et al. Polymorphisms in oxidative stress-related genes and mortality in breast cancer patients-potential differential effects by radiotherapy? Breast 2013;22:817-823