An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions

Tetrahedron

Volumn 71, Issue 37, 2015, Pages 6569-6579

  Nakano, Hayato ^a   Sugawara, Akihiro ^a   Hirose, Tomoyasu ^a   Gouda, Hiroaki ^b   Hirono, Shuichi ^a   Omura, Satoshi ^a   Sunazuka, Toshiaki ^a  

^a KITASATO UNIVERSITY   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Erythromycin A; Macrodiolides; Macrolactonization; Natural product inspired compounds; Stereochemical diversity

Indexed keywords

3 [(BENZYLOXY)METHOXYL] 6 [3,5 BIS[(BENZYLOXY)METHOXY] 6' [[(4 METHOXYBENZYL)OXY] 2',4' DIMETHYLHEPTANOYL]OXY] 5 [(TERT BUTYLDIMETHYLSILYL)OXY] 2,4 DIMETHYLHEPTANOIC ACID; 3 [(TERT BUTYLDIMETHYLSILYL)OXY] 4 (4 METHOXYBENZYL)OXY 2 METHYLPENTANAL; 3 [(TERT BUTYLDIMETHYLSILYL)OXY] N METHOXY 4 [(4 METHOXYBENZYL)OXY] N,2 DIMETHYLPENTAMIDE; 3,5 BIS[(BENZYLOXY)METHOXY] 6 (4 METHOXYBENZYL)OXY 2,4 DIMETHYLHEPTANOIC ACID; 4 BENZYL 3 [3' HYDROXY 4' [(4 METHOXYBENZYL)OXY] 2' METHYLPENTANOYL]OXAZOLIDIN 2 ONE; 4 BENZYL 3 [3' [(BENZYLOXY)METHOXY] 5' [(TERT BUTYLDIMETHYLSILYL)OXY] 6' HYDROXY 2',4' DIMETHYLHEPTANOYL]OXAZOLIDIN 2 ONE; 4 BENZYL 3 [3' [(BENZYLOXY)METHOXY] 5' [(TERT BUTYLDIMETHYLSILYL)OXY] 6' [(4 METHOXYBENZYL)OXY] 2',4' DIMETHYLHEPTANOYL]OXAZOLIDIN 2 ONE; 4 BENZYL 3 [3',5' BIS[(BENZYLOXY)METHOXY] 6' [(4 METHOXYBENZYL)OXY] 2',4' DIMETHYLHEPTANOYL]OXAZOLIDIN 2 ONE; 4 BENZYL 3 [3',5' DIHYDROXY 6' [(4 METHOXYBENZYL)OXY] 2',4' DIMETHYLHEPTANOYL]OXAZOLIDIN 2 ONE; 4 BENZYL 3 [5 [(TERT BUTYLDIMETHYLSILYL)OXY] 3 HYDROXY 6 (4 METHOXYBENZYLOXY) 2,4 DIMETHYLHEPTANOYL]OXAZOLIDIN 2 ONE; 4,11,13 TRIS[(BENZYLOXY)METHOXY] 13 HYDROXY 3,5,7,10,12,14 HEXAMETHYL 1,8 DIOXACYCLOTETRADECANE 2,9 DIONE; 4,11,13 TRIS[(BENZYLOXY)METHOXY] 6 [(TERT BUTYLDIMETHYLSILYL)OXY] 3,5,7,10,12,14 HEXAMETHYL 1,8 DIOXACYCLOTETRADECANE 2,9 DIONE; 7 (4" BENZYL 2" OXAZOLIDIN 3" YL) 5' [(BENZYLOXY)METHOXYL] 3' [(TERT BUTYLDIMETHYLSILYL)OXY] 4',6' DI METHYL 7' OXOHEPTAN 2' YL 3,5 BIS[(BENZYLOXY)METHOXY] 6 [(4 METHOXYBENZYL)OXY] 2,4 DIMETHYLHEPTANOATE; AGLYCONE; AMINOSUGAR; MACRODIOLIDE; MACROLIDE; PROTECTED MACRODIOLIDE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CONFORMATION; DIASTEREOISOMER; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; GLYCOSYLATION; MACROLACTONIZATION; MOLECULAR LIBRARY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STATIC ELECTRICITY; STEREOCHEMISTRY; STEREOISOMERISM;

EID: 84938738961     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2015.01.030     Document Type: Article

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