Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; Synthesis, structure-activity relationships and in vivo study

Journal of Antibiotics

Volumn 65, Issue 9, 2012, Pages 487-490

  Sugawara, Akihiro ^a   Sueki, Akito ^a   Hirose, Tomoyasu ^a   Shima, Hideaki ^a   Akagawa, Kiyoko S ^a   Mura, Satoshi ^a   Sunazuka, Toshiaki ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8,9 DIHYDRO 6,9 EPOXY 8,9 ANHYDROPSEUDOERYTHROMYCIN A DERIVATIVE; ANTIINFLAMMATORY AGENT; DE (3' N METHYL) 3' (4 CHLOROBENZYL) 8,9 DIHYDRO 6,9 EPOXY 8,9 ANHYDROPSEUDOERYTHROMYCIN A; DE (3' N,N DIMETHYLAMINO) 3' MORPHOLINO 8,9 DIHYDRO 6,9 EPOXY 8,9 ANHYDROPSEUDOERYTHROMYCIN A; EM 900; EM 901; EM 902; EM 903; EM 904; EM 905; EM 912; EM 914; EM 919; EM 920; EM 921; EM 922; EM 923; EM 924; EM 928; EM 929; EM 933; EM 940; EM 955; EM 956; EM 957; EM 958; EM 959; EM 960; EM 961; EM 962; EM 965; EM 966; ERYTHROMYCIN DERIVATIVE; IMMUNOMODULATING AGENT; PREDNISOLONE; SALAZOSULFAPYRIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL VIABILITY; CROHN DISEASE; CYTOTOXICITY; DRUG SYNTHESIS; ENTERITIS; HUMAN; HYDROGENATION; IMMUNOMODULATION; IN VIVO STUDY; MACROPHAGE; METHYLATION; MONOCYTIC LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; CROHN DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMMUNOLOGIC FACTORS; MACROLIDES; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84866930694     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2012.51     Document Type: Article

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