Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3373-3376

  Sugawara, Akihiro ^a   Sueki, Akito ^a   Hirose, Tomoyasu ^a   Nagai, Kenichiro ^a   Gouda, Hiroaki ^a   Hirono, Shuichi ^a   Shima, Hideaki ^a   Akagawa, Kiyoko S ^a   Õmura, Satoshi ^a   Sunazuka, Toshiaki ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

(8R,9S) 8,9 Dihydro 6,9 epoxy 8,9 anhydropseudoerythromycin A (EM900); 14 Membered non antibiotic macrolide; Anti inflammatory agent; Diffuse panbronchiolitis; Immunomodulatory agent

Indexed keywords

4'',13 O DIACETYL DIACETYL 8,9 DIHYDRO 6,9 EPOXY 8,9 ANHYDROPSEUDOERYTHROMYCIN A; 8,9 DIHYDRO 6,9 EPOXY 8,9 ANHYDROPSEUDOERYTHROMYCIN A; ACID; ANTIINFLAMMATORY AGENT; ERYTHROMYCIN; IMMUNOMODULATING AGENT; MACROLIDE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; NONHUMAN;

ANTI-INFLAMMATORY AGENTS; CELL DIFFERENTIATION; CELLS, CULTURED; DRUG DESIGN; ERYTHROMYCIN; HUMANS; IMMUNOLOGIC FACTORS; IMMUNOMODULATION; MACROLIDES; MACROPHAGES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

BACTERIA (MICROORGANISMS);

EID: 79956084563     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.004     Document Type: Article

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