Impact of stereochemistry on the biological activity of novel oleandomycin derivatives

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 7, 2012, Pages 2274-2281

  Bauer, Jurica ^a   Vine, Mark ^a   Čorić, Ilija ^a   Bosnar, Martina ^a   Pašalić, Ivanka ^a   Turkalj, Gordana ^a   Lazarevski, Gorjana ^a   Čulić, Ognjen ^a   Kragol, Goran ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Biological activity; Configuration determination; Inflammation; Macrolide

Indexed keywords

8 METHYL DIASTEREOMER; 8 METHYL ISOMER; 8 METHYLENE OLEANDOMYCIN; 9 HYDROXY 8 METHYLENE OLEANDOMYCIN; INTERLEUKIN 6; KETONE DERIVATIVE; LIPOPOLYSACCHARIDE; OLEANDOMYCIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; LUNG NEUTROPHILIA; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NEUTROPHILIA; NONHUMAN; SPLEEN CELL; STEREOCHEMISTRY;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; CELL LINE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; MICROBIAL SENSITIVITY TESTS; NEUTROPHILS; OLEANDOMYCIN; SPLEEN; STEREOISOMERISM;

EID: 84858281428     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.013     Document Type: Article

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