Cocaine-Mediated Autophagy in Astrocytes Involves Sigma 1 Receptor, PI3K, mTOR, Atg5/7, Beclin-1 and Induces Type II Programed Cell Death

Molecular Neurobiology

Volumn 53, Issue 7, 2016, Pages 4417-4430

  Cao, Lu ^a   Walker, Mary P ^a   Vaidya, Naveen K ^a   Fu, Mingui ^b   Kumar, Santosh ^c   Kumar, Anil ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Astrocytes; Autophagy; Cocaine; mTOR; siRNAs

Indexed keywords

AUTOPHAGY PROTEIN 5; AUTOPHAGY PROTEIN 7; BECLIN 1; BIOLOGICAL MARKER; CASPASE 3; COCAINE; LC3II PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; SIGMA 1 OPIATE RECEPTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; AUTOPHAGY RELATED PROTEIN; LIGHT CHAIN 3, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR; TARGET OF RAPAMYCIN KINASE;

ARTICLE; ASTROCYTE; AUTOPHAGY; CELL DEATH; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; TRANSMISSION ELECTRON MICROSCOPY; APOPTOSIS; BIOLOGICAL MODEL; CYTOLOGY; DRUG EFFECTS; METABOLISM; SIGNAL TRANSDUCTION; TIME FACTOR; ULTRASTRUCTURE;

APOPTOSIS; ASTROCYTES; AUTOPHAGY; AUTOPHAGY-RELATED PROTEINS; BECLIN-1; CASPASE 3; COCAINE; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTORS, SIGMA; SIGNAL TRANSDUCTION; TIME FACTORS; TOR SERINE-THREONINE KINASES;

EID: 84938703941     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9377-x     Document Type: Article

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