Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 32, 2013, Pages

  Rolland, Stéphane G ^a   Motori, Elisa ^a,b,g   Memar, Nadin ^a   Hench, Jürgen ^c   Frank, Stephan ^c   Winklhofer, Konstanze F ^a,d,e,f   Conradt, Barbara ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^e Germany 3 Munich Cluster for Systems Neurology   (Germany)

^f RUHR UNIVERSITY BOCHUM   (Germany)

^g MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

Author keywords

Cytochrome c oxidase deficiency neurodegeneration; Mitochondrial dynamics

Indexed keywords

ADENOSINE TRIPHOSPHATE; CAENORHABDITIS ELEGANS PROTEIN; CYTOCHROME C OXIDASE; DOUBLE STRANDED RNA; LEUCINE RICH PENTATRICOPEPTIDE REPEAT CONTAINING; MITOCHONDRIAL MORPHOLOGY ABNORMAL 1; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SCAFFOLD PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL FRACTIONATION; CELL FUNCTION; CELL STRUCTURE; CYTOPLASM; DOWN REGULATION; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; GENE INTERACTION; GENE SILENCING; GLYCOLYSIS; HUMAN; HUMAN CELL; LARVAL STAGE; LEIGH DISEASE; LOSS OF FUNCTION MUTATION; MAMMAL CELL; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL GENE; MITOCHONDRIAL HYPERFUSION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL TARGETING SIGNAL; MITOCHONDRION; MUSCLE CELL; NONHUMAN; OPERON; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY CHAIN; RNA INTERFERENCE; SEQUENCE HOMOLOGY; TRANSGENIC ANIMAL; WILD TYPE;

CYTOCHROME C OXIDASE DEFICIENCY NEURODEGENERATION; MITOCHONDRIAL DYNAMICS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOTTING, WESTERN; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL LINE; CELL LINE, TUMOR; DNA-BINDING PROTEINS; ELECTRON TRANSPORT COMPLEX IV; GREEN FLUORESCENT PROTEINS; GTP PHOSPHOHYDROLASES; HUMANS; LEIGH DISEASE; MEMBRANE PROTEINS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEOPLASM PROTEINS; RNA INTERFERENCE; TRANSCRIPTION FACTORS;

EID: 84881393265     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303872110     Document Type: Article

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