-
1
-
-
33749986298
-
Free radicals and antioxidants in normal physiological functions and human disease
-
CrossRef PubMed
-
Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T. D., Mazur, M. and Telser, J. (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39, 44-84 CrossRef PubMed
-
(2007)
Int. J. Biochem. Cell Biol.
, vol.39
, pp. 44-84
-
-
Valko, M.1
Leibfritz, D.2
Moncol, J.3
Cronin, M.T.D.4
Mazur, M.5
Telser, J.6
-
2
-
-
84902965305
-
Role of the Keap1-Nrf2 pathway in cancer
-
CrossRef PubMed
-
Leinonen, H.M., Kansanen, E., Pölönen, P., Heinäniemi, M. and Levonen, A.-L. (2014) Role of the Keap1-Nrf2 pathway in cancer. Adv. Cancer Res. 122, 281-320 CrossRef PubMed
-
(2014)
Adv. Cancer Res.
, vol.122
, pp. 281-320
-
-
Leinonen, H.M.1
Kansanen, E.2
Pölönen, P.3
Heinäniemi, M.4
Levonen, A.-L.5
-
3
-
-
74049120454
-
Nrf2: Friend or foe for chemoprevention?
-
CrossRef PubMed
-
Kensler, T.W. and Wakabayashi, N. (2010) Nrf2: friend or foe for chemoprevention? Carcinogenesis 31, 90-99 CrossRef PubMed
-
(2010)
Carcinogenesis
, vol.31
, pp. 90-99
-
-
Kensler, T.W.1
Wakabayashi, N.2
-
4
-
-
0035153227
-
High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
-
CrossRef PubMed
-
Enomoto, A., Itoh, K., Nagayoshi, E., Haruta, J., Kimura, T., O'Connor, T., Harada, T. and Yamamoto, M. (2001) High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol. Sci. 59, 169-177 CrossRef PubMed
-
(2001)
Toxicol. Sci.
, vol.59
, pp. 169-177
-
-
Enomoto, A.1
Itoh, K.2
Nagayoshi, E.3
Haruta, J.4
Kimura, T.5
O'Connor, T.6
Harada, T.7
Yamamoto, M.8
-
5
-
-
0035875447
-
Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
-
CrossRef PubMed
-
Aoki, Y., Sato, H., Nishimura, N., Takahashi, S., Itoh, K. and Yamamoto, M. (2001) Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol. Appl. Pharmacol. 173, 154-160 CrossRef PubMed
-
(2001)
Toxicol. Appl. Pharmacol.
, vol.173
, pp. 154-160
-
-
Aoki, Y.1
Sato, H.2
Nishimura, N.3
Takahashi, S.4
Itoh, K.5
Yamamoto, M.6
-
6
-
-
0037356451
-
Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice
-
CrossRef PubMed
-
Ramos-Gomez, M. (2003) Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis 24, 461-467 CrossRef PubMed
-
(2003)
Carcinogenesis
, vol.24
, pp. 461-467
-
-
Ramos-Gomez, M.1
-
7
-
-
33344456501
-
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
-
CrossRef PubMed
-
Padmanabhan, B., Tong, K.I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Kang, M.-I., Kobayashi, A., Yokoyama, S. and Yamamoto, M. (2006) Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol. Cell 21, 689-700 CrossRef PubMed
-
(2006)
Mol. Cell
, vol.21
, pp. 689-700
-
-
Padmanabhan, B.1
Tong, K.I.2
Ohta, T.3
Nakamura, Y.4
Scharlock, M.5
Ohtsuji, M.6
Kang, M.-I.7
Kobayashi, A.8
Yokoyama, S.9
Yamamoto, M.10
-
8
-
-
33750885385
-
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
-
CrossRef PubMed
-
Singh, A., Misra, V., Thimmulappa, R.K., Lee, H., Ames, S., Hoque, M.O., Herman, J.G., Baylin, S.B., Sidransky, D., Gabrielson, E. et al. (2006) Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med. 3, e420 CrossRef PubMed
-
(2006)
PLoS Med.
, vol.3
, pp. e420
-
-
Singh, A.1
Misra, V.2
Thimmulappa, R.K.3
Lee, H.4
Ames, S.5
Hoque, M.O.6
Herman, J.G.7
Baylin, S.B.8
Sidransky, D.9
Gabrielson, E.10
-
9
-
-
77953460849
-
Genetic analysis of cytoprotective functions supported by graded expression of Keap1
-
CrossRef PubMed
-
Taguchi, K., Maher, J.M., Suzuki, T., Kawatani, Y., Motohashi, H. and Yamamoto, M. (2010) Genetic analysis of cytoprotective functions supported by graded expression of Keap1. Mol. Cell. Biol. 30, 3016-3026 CrossRef PubMed
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 3016-3026
-
-
Taguchi, K.1
Maher, J.M.2
Suzuki, T.3
Kawatani, Y.4
Motohashi, H.5
Yamamoto, M.6
-
10
-
-
53049105119
-
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
-
CrossRef PubMed
-
Shibata, T., Kokubu, A., Gotoh, M., Ojima, H., Ohta, T., Yamamoto, M. and Hirohashi, S. (2008) Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology 135, 1358-1368, 1368.e1-1368.e4 CrossRef PubMed
-
(2008)
Gastroenterology
, vol.135
-
-
Shibata, T.1
Kokubu, A.2
Gotoh, M.3
Ojima, H.4
Ohta, T.5
Yamamoto, M.6
Hirohashi, S.7
-
11
-
-
79960958309
-
Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer
-
CrossRef PubMed
-
Konstantinopoulos, P.A., Spentzos, D., Fountzilas, E., Francoeur, N., Sanisetty, S., Grammatikos, A.P., Hecht, J.L. and Cannistra, S.A. (2011) Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer. Cancer Res. 71, 5081-5089 CrossRef PubMed
-
(2011)
Cancer Res.
, vol.71
, pp. 5081-5089
-
-
Konstantinopoulos, P.A.1
Spentzos, D.2
Fountzilas, E.3
Francoeur, N.4
Sanisetty, S.5
Grammatikos, A.P.6
Hecht, J.L.7
Cannistra, S.A.8
-
12
-
-
84862786878
-
Somatic mutations of the KEAP1 gene in common solid cancers
-
CrossRef PubMed
-
Yoo, N.J., Kim, H.R., Kim, Y.R., An, C.H. and Lee, S.H. (2012) Somatic mutations of the KEAP1 gene in common solid cancers. Histopathology 60, 943-952 CrossRef PubMed
-
(2012)
Histopathology
, vol.60
, pp. 943-952
-
-
Yoo, N.J.1
Kim, H.R.2
Kim, Y.R.3
An, C.H.4
Lee, S.H.5
-
13
-
-
40449107193
-
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
-
CrossRef PubMed
-
Ohta, T., Iijima, K., Miyamoto, M., Nakahara, I., Tanaka, H., Ohtsuji, M., Suzuki, T., Kobayashi, A., Yokota, J., Sakiyama, T. et al. (2008) Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth. Cancer Res. 68, 1303-1309 CrossRef PubMed
-
(2008)
Cancer Res.
, vol.68
, pp. 1303-1309
-
-
Ohta, T.1
Iijima, K.2
Miyamoto, M.3
Nakahara, I.4
Tanaka, H.5
Ohtsuji, M.6
Suzuki, T.7
Kobayashi, A.8
Yokota, J.9
Sakiyama, T.10
-
14
-
-
79952221884
-
Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo
-
CrossRef PubMed
-
Suzuki, T., Maher, J. and Yamamoto, M. (2011) Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo. Cancer Res. 71, 1700-1709 CrossRef PubMed
-
(2011)
Cancer Res.
, vol.71
, pp. 1700-1709
-
-
Suzuki, T.1
Maher, J.2
Yamamoto, M.3
-
15
-
-
51649130168
-
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
-
CrossRef PubMed
-
Shibata, T., Ohta, T., Tong, K.I., Kokubu, A., Odogawa, R., Tsuta, K., Asamura, H., Yamamoto, M. and Hirohashi, S. (2008) Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc. Natl. Acad. Sci. U.S.A. 105, 13568-13573 CrossRef PubMed
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 13568-13573
-
-
Shibata, T.1
Ohta, T.2
Tong, K.I.3
Kokubu, A.4
Odogawa, R.5
Tsuta, K.6
Asamura, H.7
Yamamoto, M.8
Hirohashi, S.9
-
16
-
-
80053439769
-
NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer
-
CrossRef PubMed
-
Shibata, T., Kokubu, A., Saito, S., Narisawa-Saito, M., Sasaki, H., Aoyagi, K., Yoshimatsu, Y., Tachimori, Y., Kushima, R., Kiyono, T. et al. (2011) NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer. Neoplasia 13, 864-873 CrossRef PubMed
-
(2011)
Neoplasia
, vol.13
, pp. 864-873
-
-
Shibata, T.1
Kokubu, A.2
Saito, S.3
Narisawa-Saito, M.4
Sasaki, H.5
Aoyagi, K.6
Yoshimatsu, Y.7
Tachimori, Y.8
Kushima, R.9
Kiyono, T.10
-
17
-
-
84885735554
-
Mutational landscape and significance across 12 major cancer types
-
CrossRef PubMed
-
Kandoth, C., McLellan, M.D., Vandin, F., Ye, K., Niu, B., Lu, C., Xie, M., Zhang, Q., McMichael, J.F., Wyczalkowski, M.A. et al. (2013) Mutational landscape and significance across 12 major cancer types. Nature 502, 333-339 CrossRef PubMed
-
(2013)
Nature
, vol.502
, pp. 333-339
-
-
Kandoth, C.1
McLellan, M.D.2
Vandin, F.3
Ye, K.4
Niu, B.5
Lu, C.6
Xie, M.7
Zhang, Q.8
McMichael, J.F.9
Wyczalkowski, M.A.10
-
18
-
-
84866894408
-
Comprehensive genomic characterization of squamous cell lung cancers
-
CrossRef PubMed
-
The Cancer Genome Atlas Network (2012) Comprehensive genomic characterization of squamous cell lung cancers. Nature 489, 519-525 CrossRef PubMed
-
(2012)
Nature
, vol.489
, pp. 519-525
-
-
The Cancer Genome Atlas Network1
-
19
-
-
84883269669
-
The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): Cellular functions and disease implications
-
CrossRef PubMed
-
Genschik, P., Sumara, I. and Lechner, E. (2013) The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications. EMBO J. 32, 2307-2320 CrossRef PubMed
-
(2013)
EMBO J.
, vol.32
, pp. 2307-2320
-
-
Genschik, P.1
Sumara, I.2
Lechner, E.3
-
20
-
-
84876005313
-
CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma
-
CrossRef PubMed
-
Ooi, A., Dykema, K., Ansari, A., Petillo, D., Snider, J., Kahnoski, R., Anema, J., Craig, D., Carpten, J., Teh, B.-T. et al. (2013) CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma. Cancer Res. 73, 2044-2051 CrossRef PubMed
-
(2013)
Cancer Res.
, vol.73
, pp. 2044-2051
-
-
Ooi, A.1
Dykema, K.2
Ansari, A.3
Petillo, D.4
Snider, J.5
Kahnoski, R.6
Anema, J.7
Craig, D.8
Carpten, J.9
Teh, B.-T.10
-
21
-
-
84904628667
-
Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer
-
PubMed
-
Martinez, V.D., Vucic, E.A., Thu, K.L., Pikor, L.A., Hubaux, R. and Lam, W.L. (2014) Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer. Biomed. Res. Int. 2014, 159459 PubMed
-
(2014)
Biomed. Res. Int.
, vol.2014
, pp. 159459
-
-
Martinez, V.D.1
Vucic, E.A.2
Thu, K.L.3
Pikor, L.A.4
Hubaux, R.5
Lam, W.L.6
-
22
-
-
84892833777
-
Discovery and saturation analysis of cancer genes across 21 tumour types
-
CrossRef PubMed
-
Lawrence, M.S., Stojanov, P., Mermel, C.H., Robinson, J.T., Garraway, L.A., Golub, T.R., Meyerson, M., Gabriel, S.B., Lander, E.S. and Getz, G. (2014) Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505, 495-501 CrossRef PubMed
-
(2014)
Nature
, vol.505
, pp. 495-501
-
-
Lawrence, M.S.1
Stojanov, P.2
Mermel, C.H.3
Robinson, J.T.4
Garraway, L.A.5
Golub, T.R.6
Meyerson, M.7
Gabriel, S.B.8
Lander, E.S.9
Getz, G.10
-
23
-
-
84897022815
-
Comprehensive molecular characterization of urothelial bladder carcinoma
-
CrossRef PubMed
-
The Cancer Genome Atlas Research Network (2014) Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 507, 315-322 CrossRef PubMed
-
(2014)
Nature
, vol.507
, pp. 315-322
-
-
The Cancer Genome Atlas Research Network1
-
24
-
-
84923197605
-
Comprehensive genomic characterization of head and neck squamous cell carcinomas
-
CrossRef PubMed
-
Lawrence, M.S., Sougnez, C., Lichtenstein, L., Cibulskis, K., Lander, E., Gabriel, S.B., Getz, G., Ally, A., Balasundaram, M., Birol, I. et al. (2015) Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 517, 576-582 CrossRef PubMed
-
(2015)
Nature
, vol.517
, pp. 576-582
-
-
Lawrence, M.S.1
Sougnez, C.2
Lichtenstein, L.3
Cibulskis, K.4
Lander, E.5
Gabriel, S.B.6
Getz, G.7
Ally, A.8
Balasundaram, M.9
Birol, I.10
-
25
-
-
84875490185
-
Cancer genome landscapes
-
CrossRef PubMed
-
Vogelstein, B., Papadopoulos, N., Velculescu, V.E., Zhou, S., Diaz, L.A. and Kinzler, K.W. (2013) Cancer genome landscapes. Science 339, 1546-1558 CrossRef PubMed
-
(2013)
Science
, vol.339
, pp. 1546-1558
-
-
Vogelstein, B.1
Papadopoulos, N.2
Velculescu, V.E.3
Zhou, S.4
Diaz, L.A.5
Kinzler, K.W.6
-
26
-
-
84899747138
-
Identification of genomic alterations in oesophageal squamous cell cancer
-
CrossRef PubMed
-
Song, Y., Li, L., Ou, Y., Gao, Z., Li, E., Li, X., Zhang, W., Wang, J., Xu, L., Zhou, Y. et al. (2014) Identification of genomic alterations in oesophageal squamous cell cancer. Nature 509, 91-95 CrossRef PubMed
-
(2014)
Nature
, vol.509
, pp. 91-95
-
-
Song, Y.1
Li, L.2
Ou, Y.3
Gao, Z.4
Li, E.5
Li, X.6
Zhang, W.7
Wang, J.8
Xu, L.9
Zhou, Y.10
-
27
-
-
84894231823
-
Landscape of genomic alterations in cervical carcinomas
-
CrossRef PubMed
-
Ojesina, A.I., Lichtenstein, L., Freeman, S.S., Pedamallu, C.S., Imaz-Rosshandler, I., Pugh, T.J., Cherniack, A.D., Ambrogio, L., Cibulskis, K., Bertelsen, B. et al. (2014) Landscape of genomic alterations in cervical carcinomas. Nature 506, 371-375 CrossRef PubMed
-
(2014)
Nature
, vol.506
, pp. 371-375
-
-
Ojesina, A.I.1
Lichtenstein, L.2
Freeman, S.S.3
Pedamallu, C.S.4
Imaz-Rosshandler, I.5
Pugh, T.J.6
Cherniack, A.D.7
Ambrogio, L.8
Cibulskis, K.9
Bertelsen, B.10
-
28
-
-
84908460595
-
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
-
CrossRef PubMed
-
Hoadley, K.A., Yau, C., Wolf, D.M., Cherniack, A.D., Tamborero, D., Ng, S., Leiserson, M.D. M., Niu, B., McLellan, M.D., Uzunangelov, V. et al. (2014) Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell 158, 929-944 CrossRef PubMed
-
(2014)
Cell
, vol.158
, pp. 929-944
-
-
Hoadley, K.A.1
Yau, C.2
Wolf, D.M.3
Cherniack, A.D.4
Tamborero, D.5
Ng, S.6
Leiserson, M.D.M.7
Niu, B.8
McLellan, M.D.9
Uzunangelov, V.10
-
29
-
-
45849133744
-
Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
-
CrossRef PubMed
-
Wang, R., An, J., Ji, F., Jiao, H., Sun, H. and Zhou, D. (2008) Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues. Biochem. Biophys. Res. Commun. 373, 151-154 CrossRef PubMed
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.373
, pp. 151-154
-
-
Wang, R.1
An, J.2
Ji, F.3
Jiao, H.4
Sun, H.5
Zhou, D.6
-
30
-
-
76649089973
-
Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth
-
CrossRef PubMed
-
Zhang, P., Singh, A., Yegnasubramanian, S., Esopi, D., Kombairaju, P., Bodas, M., Wu, H., Bova, S.G. and Biswal, S. (2010) Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth. Mol. Cancer Ther. 9, 336-346 CrossRef PubMed
-
(2010)
Mol. Cancer Ther.
, vol.9
, pp. 336-346
-
-
Zhang, P.1
Singh, A.2
Yegnasubramanian, S.3
Esopi, D.4
Kombairaju, P.5
Bodas, M.6
Wu, H.7
Bova, S.G.8
Biswal, S.9
-
31
-
-
84857997256
-
Methylation of the KEAP1 gene promoter region in human colorectal cancer
-
CrossRef PubMed
-
Hanada, N., Takahata, T., Zhou, Q., Ye, X., Sun, R., Itoh, J., Ishiguro, A., Kijima, H., Mimura, J., Itoh, K. et al. (2012) Methylation of the KEAP1 gene promoter region in human colorectal cancer. BMC Cancer 12, 66 CrossRef PubMed
-
(2012)
BMC Cancer
, vol.12
, pp. 66
-
-
Hanada, N.1
Takahata, T.2
Zhou, Q.3
Ye, X.4
Sun, R.5
Itoh, J.6
Ishiguro, A.7
Kijima, H.8
Mimura, J.9
Itoh, K.10
-
32
-
-
84901018671
-
Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: Involvement of TET-dependent DNA demethylation
-
CrossRef PubMed
-
Kang, K.A., Piao, M.J., Kim, K.C., Kang, H.K., Chang, W.Y., Park, I.C., Keum, Y.S., Surh, Y.J. and Hyun, J.W. (2014) Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation. Cell Death Dis. 5, e1183 CrossRef PubMed
-
(2014)
Cell Death Dis.
, vol.5
-
-
Kang, K.A.1
Piao, M.J.2
Kim, K.C.3
Kang, H.K.4
Chang, W.Y.5
Park, I.C.6
Keum, Y.S.7
Surh, Y.J.8
Hyun, J.W.9
-
33
-
-
81755171451
-
miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
-
CrossRef PubMed
-
Eades, G., Yang, M., Yao, Y., Zhang, Y. and Zhou, Q. (2011) miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells. J. Biol. Chem. 286, 40725-40733 CrossRef PubMed
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 40725-40733
-
-
Eades, G.1
Yang, M.2
Yao, Y.3
Zhang, Y.4
Zhou, Q.5
-
34
-
-
84883743438
-
miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells
-
CrossRef PubMed
-
Van Jaarsveld, M.T.M., Helleman, J., Boersma, A.W.M., van Kuijk, P.F., van Ijcken, W.F., Despierre, E., Vergote, I., Mathijssen, R.H. J., Berns, E.M.J.J., Verweij, J. et al. (2013) miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells. Oncogene 32, 4284-4293 CrossRef PubMed
-
(2013)
Oncogene
, vol.32
, pp. 4284-4293
-
-
Van Jaarsveld, M.T.M.1
Helleman, J.2
Boersma, A.W.M.3
Van Kuijk, P.F.4
Van Ijcken, W.F.5
Despierre, E.6
Vergote, I.7
Mathijssen, R.H.J.8
Berns, E.M.J.J.9
Verweij, J.10
-
35
-
-
84893143652
-
The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors
-
CrossRef PubMed
-
Yamamoto, S., Inoue, J., Kawano, T., Kozaki, K., Omura, K. and Inazawa, J. (2014) The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors. Mol. Cancer Res. 12, 58-68 CrossRef PubMed
-
(2014)
Mol. Cancer Res.
, vol.12
, pp. 58-68
-
-
Yamamoto, S.1
Inoue, J.2
Kawano, T.3
Kozaki, K.4
Omura, K.5
Inazawa, J.6
-
36
-
-
84865287281
-
Keap1 degradation by autophagy for the maintenance of redox homeostasis
-
CrossRef PubMed
-
Taguchi, K., Fujikawa, N., Komatsu, M., Ishii, T., Unno, M., Akaike, T., Motohashi, H. and Yamamoto, M. (2012) Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proc. Natl. Acad. Sci. U.S.A. 109, 13561-13566 CrossRef PubMed
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 13561-13566
-
-
Taguchi, K.1
Fujikawa, N.2
Komatsu, M.3
Ishii, T.4
Unno, M.5
Akaike, T.6
Motohashi, H.7
Yamamoto, M.8
-
37
-
-
77649265091
-
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
-
PubMed
-
Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y.-S., Ueno, I., Sakamoto, A., Tong, K.I. et al. (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat. Cell Biol. 12, 213-223 PubMed
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 213-223
-
-
Komatsu, M.1
Kurokawa, H.2
Waguri, S.3
Taguchi, K.4
Kobayashi, A.5
Ichimura, Y.6
Sou, Y.-S.7
Ueno, I.8
Sakamoto, A.9
Tong, K.I.10
-
38
-
-
77954599053
-
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
-
CrossRef PubMed
-
Jain, A., Lamark, T., Sjøttem, E., Larsen, K.B., Awuh, J.A., Øvervatn, A., McMahon, M., Hayes, J.D. and Johansen, T. (2010) p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J. Biol. Chem. 285, 22576-22591 CrossRef PubMed
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 22576-22591
-
-
Jain, A.1
Lamark, T.2
Sjøttem, E.3
Larsen, K.B.4
Awuh, J.A.5
Øvervatn, A.6
McMahon, M.7
Hayes, J.D.8
Johansen, T.9
-
39
-
-
84883830467
-
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy
-
CrossRef PubMed
-
Ichimura, Y., Waguri, S., Sou, Y.-S., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T. et al. (2013) Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol. Cell 51, 618-631 CrossRef PubMed
-
(2013)
Mol. Cell
, vol.51
, pp. 618-631
-
-
Ichimura, Y.1
Waguri, S.2
Sou, Y.-S.3
Kageyama, S.4
Hasegawa, J.5
Ishimura, R.6
Saito, T.7
Yang, Y.8
Kouno, T.9
Fukutomi, T.10
-
40
-
-
84861312722
-
PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function
-
CrossRef PubMed
-
Ma, J., Cai, H., Wu, T., Sobhian, B., Huo, Y., Alcivar, A., Mehta, M., Cheung, K.L., Ganesan, S., Kong, A.-N.T. et al. (2012) PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol. Cell. Biol. 32, 1506-1517 CrossRef PubMed
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 1506-1517
-
-
Ma, J.1
Cai, H.2
Wu, T.3
Sobhian, B.4
Huo, Y.5
Alcivar, A.6
Mehta, M.7
Cheung, K.L.8
Ganesan, S.9
Kong, A.-N.T.10
-
41
-
-
84876011848
-
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination
-
CrossRef PubMed
-
Hast, B.E., Goldfarb, D., Mulvaney, K.M., Hast, M.A., Siesser, P.F., Yan, F., Hayes, D.N. and Major, M.B. (2013) Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. Cancer Res. 73, 2199-2210 CrossRef PubMed
-
(2013)
Cancer Res.
, vol.73
, pp. 2199-2210
-
-
Hast, B.E.1
Goldfarb, D.2
Mulvaney, K.M.3
Hast, M.A.4
Siesser, P.F.5
Yan, F.6
Hayes, D.N.7
Major, M.B.8
-
42
-
-
84857493148
-
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein
-
CrossRef PubMed
-
Camp, N.D., James, R.G., Dawson, D.W., Yan, F., Davison, J.M., Houck, S.A., Tang, X., Zheng, N., Major, M.B. and Moon, R.T. (2012) Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. J. Biol. Chem. 287, 6539-6550 CrossRef PubMed
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 6539-6550
-
-
Camp, N.D.1
James, R.G.2
Dawson, D.W.3
Yan, F.4
Davison, J.M.5
Houck, S.A.6
Tang, X.7
Zheng, N.8
Major, M.B.9
Moon, R.T.10
-
43
-
-
67449128222
-
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
-
Chen, W., Sun, Z., Wang, X.-J., Jiang, T., Huang, Z., Fang, D. and Zhang, D.D. (2009) Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol. Cell 34, 663-673
-
(2009)
Mol. Cell
, vol.34
, pp. 663-673
-
-
Chen, W.1
Sun, Z.2
Wang, X.-J.3
Jiang, T.4
Huang, Z.5
Fang, D.6
Zhang, D.D.7
-
44
-
-
84884215156
-
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival
-
CrossRef PubMed
-
Gorrini, C., Baniasadi, P.S., Harris, I.S., Silvester, J., Inoue, S., Snow, B., Joshi, P. a, Wakeham, A., Molyneux, S.D., Martin, B. et al. (2013) BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. J. Exp. Med. 210, 1529-1544 CrossRef PubMed
-
(2013)
J. Exp. Med.
, vol.210
, pp. 1529-1544
-
-
Gorrini, C.1
Baniasadi, P.S.2
Harris, I.S.3
Silvester, J.4
Inoue, S.5
Snow, B.6
Joshi, P.A.7
Wakeham, A.8
Molyneux, S.D.9
Martin, B.10
-
45
-
-
80054772589
-
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma
-
CrossRef PubMed
-
Ooi, A., Wong, J.-C., Petillo, D., Roossien, D., Perrier-Trudova, V., Whitten, D., Min, B.W. H., Tan, M.-H., Zhang, Z., Yang, X.J. et al. (2011) An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell 20, 511-523 CrossRef PubMed
-
(2011)
Cancer Cell
, vol.20
, pp. 511-523
-
-
Ooi, A.1
Wong, J.-C.2
Petillo, D.3
Roossien, D.4
Perrier-Trudova, V.5
Whitten, D.6
Min, B.W.H.7
Tan, M.-H.8
Zhang, Z.9
Yang, X.J.10
-
46
-
-
80054767730
-
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: Roles for fumarate in KEAP1 succination and Nrf2 signaling
-
CrossRef PubMed
-
Adam, J., Hatipoglu, E., O'Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban, D., Nye, E., Stamp, G.W., Wolhuter, K. et al. (2011) Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell 20, 524-537 CrossRef PubMed
-
(2011)
Cancer Cell
, vol.20
, pp. 524-537
-
-
Adam, J.1
Hatipoglu, E.2
O'Flaherty, L.3
Ternette, N.4
Sahgal, N.5
Lockstone, H.6
Baban, D.7
Nye, E.8
Stamp, G.W.9
Wolhuter, K.10
-
47
-
-
79960060305
-
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
-
CrossRef PubMed
-
DeNicola, G.M., Karreth, F.A., Humpton, T.J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K.H., Yeo, C.J., Calhoun, E.S. et al. (2011) Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475, 106-109 CrossRef PubMed
-
(2011)
Nature
, vol.475
, pp. 106-109
-
-
DeNicola, G.M.1
Karreth, F.A.2
Humpton, T.J.3
Gopinathan, A.4
Wei, C.5
Frese, K.6
Mangal, D.7
Yu, K.H.8
Yeo, C.J.9
Calhoun, E.S.10
-
48
-
-
84863764614
-
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
-
CrossRef PubMed
-
Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M. and Motohashi, H. (2012) Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. Cancer Cell 22, 66-79 CrossRef PubMed
-
(2012)
Cancer Cell
, vol.22
, pp. 66-79
-
-
Mitsuishi, Y.1
Taguchi, K.2
Kawatani, Y.3
Shibata, T.4
Nukiwa, T.5
Aburatani, H.6
Yamamoto, M.7
Motohashi, H.8
-
49
-
-
84860708221
-
NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones
-
PubMed
-
Liao, H., Zhou, Q., Zhang, Z., Wang, Q., Sun, Y., Yi, X. and Feng, Y. (2012) NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones. Oncol. Rep. 27, 1918-1924 PubMed
-
(2012)
Oncol. Rep.
, vol.27
, pp. 1918-1924
-
-
Liao, H.1
Zhou, Q.2
Zhang, Z.3
Wang, Q.4
Sun, Y.5
Yi, X.6
Feng, Y.7
|