메뉴 건너뛰기




Volumn 43, Issue , 2015, Pages 645-649

Dysregulation of the Keap1-Nrf2 pathway in cancer

Author keywords

Cancer; Genome; Kelch like ECH associated protein 1 (Keap1); Nuclear factor E2 related factor 2 (Nrf2); Oxidative stress; The Cancer Genome Atlas (TCGA)

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2; KEAP1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

EID: 84938681490     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20150048     Document Type: Short Survey
Times cited : (71)

References (49)
  • 1
    • 33749986298 scopus 로고    scopus 로고
    • Free radicals and antioxidants in normal physiological functions and human disease
    • CrossRef PubMed
    • Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T. D., Mazur, M. and Telser, J. (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39, 44-84 CrossRef PubMed
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , pp. 44-84
    • Valko, M.1    Leibfritz, D.2    Moncol, J.3    Cronin, M.T.D.4    Mazur, M.5    Telser, J.6
  • 3
    • 74049120454 scopus 로고    scopus 로고
    • Nrf2: Friend or foe for chemoprevention?
    • CrossRef PubMed
    • Kensler, T.W. and Wakabayashi, N. (2010) Nrf2: friend or foe for chemoprevention? Carcinogenesis 31, 90-99 CrossRef PubMed
    • (2010) Carcinogenesis , vol.31 , pp. 90-99
    • Kensler, T.W.1    Wakabayashi, N.2
  • 4
    • 0035153227 scopus 로고    scopus 로고
    • High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
    • CrossRef PubMed
    • Enomoto, A., Itoh, K., Nagayoshi, E., Haruta, J., Kimura, T., O'Connor, T., Harada, T. and Yamamoto, M. (2001) High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol. Sci. 59, 169-177 CrossRef PubMed
    • (2001) Toxicol. Sci. , vol.59 , pp. 169-177
    • Enomoto, A.1    Itoh, K.2    Nagayoshi, E.3    Haruta, J.4    Kimura, T.5    O'Connor, T.6    Harada, T.7    Yamamoto, M.8
  • 5
    • 0035875447 scopus 로고    scopus 로고
    • Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
    • CrossRef PubMed
    • Aoki, Y., Sato, H., Nishimura, N., Takahashi, S., Itoh, K. and Yamamoto, M. (2001) Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol. Appl. Pharmacol. 173, 154-160 CrossRef PubMed
    • (2001) Toxicol. Appl. Pharmacol. , vol.173 , pp. 154-160
    • Aoki, Y.1    Sato, H.2    Nishimura, N.3    Takahashi, S.4    Itoh, K.5    Yamamoto, M.6
  • 6
    • 0037356451 scopus 로고    scopus 로고
    • Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice
    • CrossRef PubMed
    • Ramos-Gomez, M. (2003) Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis 24, 461-467 CrossRef PubMed
    • (2003) Carcinogenesis , vol.24 , pp. 461-467
    • Ramos-Gomez, M.1
  • 9
    • 77953460849 scopus 로고    scopus 로고
    • Genetic analysis of cytoprotective functions supported by graded expression of Keap1
    • CrossRef PubMed
    • Taguchi, K., Maher, J.M., Suzuki, T., Kawatani, Y., Motohashi, H. and Yamamoto, M. (2010) Genetic analysis of cytoprotective functions supported by graded expression of Keap1. Mol. Cell. Biol. 30, 3016-3026 CrossRef PubMed
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 3016-3026
    • Taguchi, K.1    Maher, J.M.2    Suzuki, T.3    Kawatani, Y.4    Motohashi, H.5    Yamamoto, M.6
  • 10
    • 53049105119 scopus 로고    scopus 로고
    • Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
    • CrossRef PubMed
    • Shibata, T., Kokubu, A., Gotoh, M., Ojima, H., Ohta, T., Yamamoto, M. and Hirohashi, S. (2008) Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology 135, 1358-1368, 1368.e1-1368.e4 CrossRef PubMed
    • (2008) Gastroenterology , vol.135
    • Shibata, T.1    Kokubu, A.2    Gotoh, M.3    Ojima, H.4    Ohta, T.5    Yamamoto, M.6    Hirohashi, S.7
  • 12
    • 84862786878 scopus 로고    scopus 로고
    • Somatic mutations of the KEAP1 gene in common solid cancers
    • CrossRef PubMed
    • Yoo, N.J., Kim, H.R., Kim, Y.R., An, C.H. and Lee, S.H. (2012) Somatic mutations of the KEAP1 gene in common solid cancers. Histopathology 60, 943-952 CrossRef PubMed
    • (2012) Histopathology , vol.60 , pp. 943-952
    • Yoo, N.J.1    Kim, H.R.2    Kim, Y.R.3    An, C.H.4    Lee, S.H.5
  • 14
    • 79952221884 scopus 로고    scopus 로고
    • Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo
    • CrossRef PubMed
    • Suzuki, T., Maher, J. and Yamamoto, M. (2011) Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo. Cancer Res. 71, 1700-1709 CrossRef PubMed
    • (2011) Cancer Res. , vol.71 , pp. 1700-1709
    • Suzuki, T.1    Maher, J.2    Yamamoto, M.3
  • 16
  • 18
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • CrossRef PubMed
    • The Cancer Genome Atlas Network (2012) Comprehensive genomic characterization of squamous cell lung cancers. Nature 489, 519-525 CrossRef PubMed
    • (2012) Nature , vol.489 , pp. 519-525
    • The Cancer Genome Atlas Network1
  • 19
    • 84883269669 scopus 로고    scopus 로고
    • The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): Cellular functions and disease implications
    • CrossRef PubMed
    • Genschik, P., Sumara, I. and Lechner, E. (2013) The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications. EMBO J. 32, 2307-2320 CrossRef PubMed
    • (2013) EMBO J. , vol.32 , pp. 2307-2320
    • Genschik, P.1    Sumara, I.2    Lechner, E.3
  • 20
    • 84876005313 scopus 로고    scopus 로고
    • CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma
    • CrossRef PubMed
    • Ooi, A., Dykema, K., Ansari, A., Petillo, D., Snider, J., Kahnoski, R., Anema, J., Craig, D., Carpten, J., Teh, B.-T. et al. (2013) CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma. Cancer Res. 73, 2044-2051 CrossRef PubMed
    • (2013) Cancer Res. , vol.73 , pp. 2044-2051
    • Ooi, A.1    Dykema, K.2    Ansari, A.3    Petillo, D.4    Snider, J.5    Kahnoski, R.6    Anema, J.7    Craig, D.8    Carpten, J.9    Teh, B.-T.10
  • 21
    • 84904628667 scopus 로고    scopus 로고
    • Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer
    • PubMed
    • Martinez, V.D., Vucic, E.A., Thu, K.L., Pikor, L.A., Hubaux, R. and Lam, W.L. (2014) Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer. Biomed. Res. Int. 2014, 159459 PubMed
    • (2014) Biomed. Res. Int. , vol.2014 , pp. 159459
    • Martinez, V.D.1    Vucic, E.A.2    Thu, K.L.3    Pikor, L.A.4    Hubaux, R.5    Lam, W.L.6
  • 23
    • 84897022815 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of urothelial bladder carcinoma
    • CrossRef PubMed
    • The Cancer Genome Atlas Research Network (2014) Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 507, 315-322 CrossRef PubMed
    • (2014) Nature , vol.507 , pp. 315-322
    • The Cancer Genome Atlas Research Network1
  • 26
    • 84899747138 scopus 로고    scopus 로고
    • Identification of genomic alterations in oesophageal squamous cell cancer
    • CrossRef PubMed
    • Song, Y., Li, L., Ou, Y., Gao, Z., Li, E., Li, X., Zhang, W., Wang, J., Xu, L., Zhou, Y. et al. (2014) Identification of genomic alterations in oesophageal squamous cell cancer. Nature 509, 91-95 CrossRef PubMed
    • (2014) Nature , vol.509 , pp. 91-95
    • Song, Y.1    Li, L.2    Ou, Y.3    Gao, Z.4    Li, E.5    Li, X.6    Zhang, W.7    Wang, J.8    Xu, L.9    Zhou, Y.10
  • 29
    • 45849133744 scopus 로고    scopus 로고
    • Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
    • CrossRef PubMed
    • Wang, R., An, J., Ji, F., Jiao, H., Sun, H. and Zhou, D. (2008) Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues. Biochem. Biophys. Res. Commun. 373, 151-154 CrossRef PubMed
    • (2008) Biochem. Biophys. Res. Commun. , vol.373 , pp. 151-154
    • Wang, R.1    An, J.2    Ji, F.3    Jiao, H.4    Sun, H.5    Zhou, D.6
  • 30
    • 76649089973 scopus 로고    scopus 로고
    • Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth
    • CrossRef PubMed
    • Zhang, P., Singh, A., Yegnasubramanian, S., Esopi, D., Kombairaju, P., Bodas, M., Wu, H., Bova, S.G. and Biswal, S. (2010) Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth. Mol. Cancer Ther. 9, 336-346 CrossRef PubMed
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 336-346
    • Zhang, P.1    Singh, A.2    Yegnasubramanian, S.3    Esopi, D.4    Kombairaju, P.5    Bodas, M.6    Wu, H.7    Bova, S.G.8    Biswal, S.9
  • 32
    • 84901018671 scopus 로고    scopus 로고
    • Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: Involvement of TET-dependent DNA demethylation
    • CrossRef PubMed
    • Kang, K.A., Piao, M.J., Kim, K.C., Kang, H.K., Chang, W.Y., Park, I.C., Keum, Y.S., Surh, Y.J. and Hyun, J.W. (2014) Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation. Cell Death Dis. 5, e1183 CrossRef PubMed
    • (2014) Cell Death Dis. , vol.5
    • Kang, K.A.1    Piao, M.J.2    Kim, K.C.3    Kang, H.K.4    Chang, W.Y.5    Park, I.C.6    Keum, Y.S.7    Surh, Y.J.8    Hyun, J.W.9
  • 33
    • 81755171451 scopus 로고    scopus 로고
    • miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
    • CrossRef PubMed
    • Eades, G., Yang, M., Yao, Y., Zhang, Y. and Zhou, Q. (2011) miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells. J. Biol. Chem. 286, 40725-40733 CrossRef PubMed
    • (2011) J. Biol. Chem. , vol.286 , pp. 40725-40733
    • Eades, G.1    Yang, M.2    Yao, Y.3    Zhang, Y.4    Zhou, Q.5
  • 35
    • 84893143652 scopus 로고    scopus 로고
    • The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors
    • CrossRef PubMed
    • Yamamoto, S., Inoue, J., Kawano, T., Kozaki, K., Omura, K. and Inazawa, J. (2014) The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors. Mol. Cancer Res. 12, 58-68 CrossRef PubMed
    • (2014) Mol. Cancer Res. , vol.12 , pp. 58-68
    • Yamamoto, S.1    Inoue, J.2    Kawano, T.3    Kozaki, K.4    Omura, K.5    Inazawa, J.6
  • 38
    • 77954599053 scopus 로고    scopus 로고
    • p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
    • CrossRef PubMed
    • Jain, A., Lamark, T., Sjøttem, E., Larsen, K.B., Awuh, J.A., Øvervatn, A., McMahon, M., Hayes, J.D. and Johansen, T. (2010) p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription. J. Biol. Chem. 285, 22576-22591 CrossRef PubMed
    • (2010) J. Biol. Chem. , vol.285 , pp. 22576-22591
    • Jain, A.1    Lamark, T.2    Sjøttem, E.3    Larsen, K.B.4    Awuh, J.A.5    Øvervatn, A.6    McMahon, M.7    Hayes, J.D.8    Johansen, T.9
  • 41
    • 84876011848 scopus 로고    scopus 로고
    • Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination
    • CrossRef PubMed
    • Hast, B.E., Goldfarb, D., Mulvaney, K.M., Hast, M.A., Siesser, P.F., Yan, F., Hayes, D.N. and Major, M.B. (2013) Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. Cancer Res. 73, 2199-2210 CrossRef PubMed
    • (2013) Cancer Res. , vol.73 , pp. 2199-2210
    • Hast, B.E.1    Goldfarb, D.2    Mulvaney, K.M.3    Hast, M.A.4    Siesser, P.F.5    Yan, F.6    Hayes, D.N.7    Major, M.B.8
  • 42
    • 84857493148 scopus 로고    scopus 로고
    • Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein
    • CrossRef PubMed
    • Camp, N.D., James, R.G., Dawson, D.W., Yan, F., Davison, J.M., Houck, S.A., Tang, X., Zheng, N., Major, M.B. and Moon, R.T. (2012) Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. J. Biol. Chem. 287, 6539-6550 CrossRef PubMed
    • (2012) J. Biol. Chem. , vol.287 , pp. 6539-6550
    • Camp, N.D.1    James, R.G.2    Dawson, D.W.3    Yan, F.4    Davison, J.M.5    Houck, S.A.6    Tang, X.7    Zheng, N.8    Major, M.B.9    Moon, R.T.10
  • 43
    • 67449128222 scopus 로고    scopus 로고
    • Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
    • Chen, W., Sun, Z., Wang, X.-J., Jiang, T., Huang, Z., Fang, D. and Zhang, D.D. (2009) Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol. Cell 34, 663-673
    • (2009) Mol. Cell , vol.34 , pp. 663-673
    • Chen, W.1    Sun, Z.2    Wang, X.-J.3    Jiang, T.4    Huang, Z.5    Fang, D.6    Zhang, D.D.7
  • 46
    • 80054767730 scopus 로고    scopus 로고
    • Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: Roles for fumarate in KEAP1 succination and Nrf2 signaling
    • CrossRef PubMed
    • Adam, J., Hatipoglu, E., O'Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban, D., Nye, E., Stamp, G.W., Wolhuter, K. et al. (2011) Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell 20, 524-537 CrossRef PubMed
    • (2011) Cancer Cell , vol.20 , pp. 524-537
    • Adam, J.1    Hatipoglu, E.2    O'Flaherty, L.3    Ternette, N.4    Sahgal, N.5    Lockstone, H.6    Baban, D.7    Nye, E.8    Stamp, G.W.9    Wolhuter, K.10
  • 49
    • 84860708221 scopus 로고    scopus 로고
    • NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones
    • PubMed
    • Liao, H., Zhou, Q., Zhang, Z., Wang, Q., Sun, Y., Yi, X. and Feng, Y. (2012) NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones. Oncol. Rep. 27, 1918-1924 PubMed
    • (2012) Oncol. Rep. , vol.27 , pp. 1918-1924
    • Liao, H.1    Zhou, Q.2    Zhang, Z.3    Wang, Q.4    Sun, Y.5    Yi, X.6    Feng, Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.