메뉴 건너뛰기




Volumn 2014, Issue , 2014, Pages

Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer

Author keywords

[No Author keywords available]

Indexed keywords

CULLIN; CULLIN 3; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MULTIPROTEIN COMPLEX; TRANSCRIPTION FACTOR NRF2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CARRIER PROTEIN; CUL3 PROTEIN, HUMAN; KEAP1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; RBX1 PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE; SIGNAL PEPTIDE; UBIQUITIN PROTEIN LIGASE;

EID: 84904628667     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/159459     Document Type: Article
Times cited : (27)

References (47)
  • 1
    • 27344460746 scopus 로고    scopus 로고
    • Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system
    • DOI 10.1186/1477-7827-3-43
    • Fujii J., Iuchi Y., Okada F., Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system. Reproductive Biology and Endocrinology 2005 3, article 43 10.1186/1477-7827-3-43 2-s2.0-27344460746 (Pubitemid 41522393)
    • (2005) Reproductive Biology and Endocrinology , vol.3 , pp. 43
    • Fujii, J.1    Iuchi, Y.2    Okada, F.3
  • 2
    • 0025309491 scopus 로고
    • Extracellular ATP-induced production of hydrogen peroxide in porcine thyroid cells
    • Nakamura Y., Ohtaki S., Extracellular ATP-induced production of hydrogen peroxide in porcine thyroid cells. Journal of Endocrinology 1990 126 2 283 287 10.1677/joe.0.1260283 2-s2.0-0025309491 (Pubitemid 20227155)
    • (1990) Journal of Endocrinology , vol.126 , Issue.2 , pp. 283-287
    • Nakamura, Y.1    Ohtaki, S.2
  • 4
    • 84864348569 scopus 로고    scopus 로고
    • NRF2 and cancer: The Good, the bad and the importance of context
    • 10.1038/nrc3278 2-s2.0-84864348569
    • Sporn M. B., Liby K. T., NRF2 and cancer: the Good, the bad and the importance of context. Nature Reviews Cancer 2012 12 8 564 571 10.1038/nrc3278 2-s2.0-84864348569
    • (2012) Nature Reviews Cancer , vol.12 , Issue.8 , pp. 564-571
    • Sporn, M.B.1    Liby, K.T.2
  • 5
    • 84878681301 scopus 로고    scopus 로고
    • The Keap1-Nrf2 system in cancers: Stress response and anabolic metabolism
    • article 200 10.3389/fonc.2012.00200
    • Mitsuishi Y., Motohashi H., Yamamoto M., The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism. Frontiers in Oncology 2012 2 article 200 10.3389/fonc.2012.00200
    • (2012) Frontiers in Oncology , vol.2
    • Mitsuishi, Y.1    Motohashi, H.2    Yamamoto, M.3
  • 6
    • 78751703950 scopus 로고    scopus 로고
    • Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
    • 10.1111/j.1365-2443.2010.01473.x 2-s2.0-78751703950
    • Taguchi K., Motohashi H., Yamamoto M., Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes to Cells 2011 16 2 123 140 10.1111/j.1365-2443.2010.01473.x 2-s2.0-78751703950
    • (2011) Genes to Cells , vol.16 , Issue.2 , pp. 123-140
    • Taguchi, K.1    Motohashi, H.2    Yamamoto, M.3
  • 7
    • 63549121490 scopus 로고    scopus 로고
    • NRF2 and KEAP1 mutations: Permanent activation of an adaptive response in cancer
    • 10.1016/j.tibs.2008.12.008 2-s2.0-63549121490
    • Hayes J. D., McMahon M., NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends in Biochemical Sciences 2009 34 4 176 188 10.1016/j.tibs.2008.12.008 2-s2.0-63549121490
    • (2009) Trends in Biochemical Sciences , vol.34 , Issue.4 , pp. 176-188
    • Hayes, J.D.1    McMahon, M.2
  • 8
    • 33344463325 scopus 로고    scopus 로고
    • Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
    • 10.1128/MCB.26.8.2887-2900.2006 2-s2.0-33344463325
    • Tong K. I., Katoh Y., Kusunoki H., Itoh K., Tanaka T., Yamamoto M., Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Molecular and Cellular Biology 2006 26 8 2887 2900 10.1128/MCB.26.8.2887-2900.2006 2-s2.0-33344463325
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.8 , pp. 2887-2900
    • Tong, K.I.1    Katoh, Y.2    Kusunoki, H.3    Itoh, K.4    Tanaka, T.5    Yamamoto, M.6
  • 9
    • 84893840509 scopus 로고    scopus 로고
    • Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1
    • 10.1128/MCB.01191-13
    • Fukutomi T., Takagi K., Mizushima T., Ohuchi N., Yamamoto M., Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1. Molecular and Cellular Biology 2014 34 5 832 846 10.1128/MCB.01191-13
    • (2014) Molecular and Cellular Biology , vol.34 , Issue.5 , pp. 832-846
    • Fukutomi, T.1    Takagi, K.2    Mizushima, T.3    Ohuchi, N.4    Yamamoto, M.5
  • 10
    • 84867034260 scopus 로고    scopus 로고
    • Role of Nrf2 in oxidative stress and toxicity
    • 10.1146/annurev-pharmtox-011112-140320 2-s2.0-84867034260
    • Ma Q., Role of Nrf2 in oxidative stress and toxicity. Annual Review of Pharmacology and Toxicology 2013 53 401 426 10.1146/annurev-pharmtox-011112- 140320 2-s2.0-84867034260
    • (2013) Annual Review of Pharmacology and Toxicology , vol.53 , pp. 401-426
    • Ma, Q.1
  • 12
    • 22544464124 scopus 로고    scopus 로고
    • Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
    • DOI 10.1073/pnas.0502402102
    • Eggler A. L., Liu G., Pezzuto J. M., Van Breemen R. B., Mesecar A. D., Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proceedings of the National Academy of Sciences of the United States of America 2005 102 29 10070 10075 10.1073/pnas.0502402102 2-s2.0-22544464124 (Pubitemid 41023327)
    • (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , Issue.29 , pp. 10070-10075
    • Eggler, A.L.1    Liu, G.2    Pezzuto, J.M.3    Van Breemen, R.B.4    Mesecar, A.D.5
  • 15
    • 84869087891 scopus 로고    scopus 로고
    • Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers
    • 10.1038/onc.2011.628 2-s2.0-84869087891
    • Yamadori T., Ishii Y., Homma S., Morishima Y., Kurishima K., Itoh K., Yamamoto M., Minami Y., Noguchi M., Hizawa N., Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers. Oncogene 2012 31 45 4768 4777 10.1038/onc.2011.628 2-s2.0-84869087891
    • (2012) Oncogene , vol.31 , Issue.45 , pp. 4768-4777
    • Yamadori, T.1    Ishii, Y.2    Homma, S.3    Morishima, Y.4    Kurishima, K.5    Itoh, K.6    Yamamoto, M.7    Minami, Y.8    Noguchi, M.9    Hizawa, N.10
  • 16
    • 84867041441 scopus 로고    scopus 로고
    • Molecular basis of electrophilic and oxidative defense: Promises and perils of Nrf2
    • 10.1124/pr.110.004333 2-s2.0-84867041441
    • Ma Q., He X., Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2. Pharmacological Reviews 2012 64 4 1055 1081 10.1124/pr.110.004333 2-s2.0-84867041441
    • (2012) Pharmacological Reviews , vol.64 , Issue.4 , pp. 1055-1081
    • Ma, Q.1    He, X.2
  • 17
    • 74049120454 scopus 로고    scopus 로고
    • Nrf2: Friend or foe for chemoprevention?
    • bgp231 10.1093/carcin/bgp231 2-s2.0-74049120454
    • Kensler T. W., Wakabayashi N., Nrf2: friend or foe for chemoprevention? Carcinogenesis 2009 31 1 90 99 bgp231 10.1093/carcin/bgp231 2-s2.0-74049120454
    • (2009) Carcinogenesis , vol.31 , Issue.1 , pp. 90-99
    • Kensler, T.W.1    Wakabayashi, N.2
  • 18
    • 84860708221 scopus 로고    scopus 로고
    • NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones
    • 10.3892/or.2012.1700 2-s2.0-84860708221
    • Liao H., Zhou Q., Zhang Z., Wang Q., Sun Y., Yi X., Feng Y., NRF2 is overexpressed in ovarian epithelial carcinoma and is regulated by gonadotrophin and sex-steroid hormones. Oncology Reports 2012 27 6 1918 1924 10.3892/or.2012.1700 2-s2.0-84860708221
    • (2012) Oncology Reports , vol.27 , Issue.6 , pp. 1918-1924
    • Liao, H.1    Zhou, Q.2    Zhang, Z.3    Wang, Q.4    Sun, Y.5    Yi, X.6    Feng, Y.7
  • 19
    • 76749106638 scopus 로고    scopus 로고
    • Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
    • 10.1002/path.2653 2-s2.0-76749106638
    • Kim Y. R., Oh J. E., Kim M. S., Kang M. R., Park S. W., Han J. Y., Eom H. S., Yoo N. J., Lee S. H., Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. Journal of Pathology 2010 220 4 446 451 10.1002/path.2653 2-s2.0-76749106638
    • (2010) Journal of Pathology , vol.220 , Issue.4 , pp. 446-451
    • Kim, Y.R.1    Oh, J.E.2    Kim, M.S.3    Kang, M.R.4    Park, S.W.5    Han, J.Y.6    Eom, H.S.7    Yoo, N.J.8    Lee, S.H.9
  • 21
    • 53049105119 scopus 로고    scopus 로고
    • Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
    • 10.1053/j.gastro.2008.06.082
    • Shibata T., Kokubu A., Gotoh M., Ojima H., Ohta T., Yamamoto M., Hirohashi S., Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology 2008 135 4 1358.e4 1368.e4 10.1053/j.gastro.2008.06.082
    • (2008) Gastroenterology , vol.135 , Issue.4
    • Shibata, T.1    Kokubu, A.2    Gotoh, M.3    Ojima, H.4    Ohta, T.5    Yamamoto, M.6    Hirohashi, S.7
  • 22
    • 34548577395 scopus 로고    scopus 로고
    • A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity
    • DOI 10.1016/j.bbrc.2007.08.051, PII S0006291X07017433
    • Nioi P., Nguyen T., A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity. Biochemical and Biophysical Research Communications 2007 362 4 816 821 10.1016/j.bbrc.2007.08.051 2-s2.0-34548577395 (Pubitemid 47390646)
    • (2007) Biochemical and Biophysical Research Communications , vol.362 , Issue.4 , pp. 816-821
    • Nioi, P.1    Nguyen, T.2
  • 24
    • 80052268120 scopus 로고    scopus 로고
    • Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF- B pathway activation in lung cancer
    • 10.1097/JTO.0b013e3182289479 2-s2.0-80052268120
    • Thu K. L., Pikor L. A., Chari R., Wilson I. M., MacAulay C. E., English J. C., Tsao M., Gazdar A. F., Lam S., Lam W. L., Lockwood W. W., Genetic disruption of KEAP1/CUL3 E3 ubiquitin ligase complex components is a key mechanism of NF- B pathway activation in lung cancer. Journal of Thoracic Oncology 2011 6 9 1521 1529 10.1097/JTO.0b013e3182289479 2-s2.0-80052268120
    • (2011) Journal of Thoracic Oncology , vol.6 , Issue.9 , pp. 1521-1529
    • Thu, K.L.1    Pikor, L.A.2    Chari, R.3    Wilson, I.M.4    Macaulay, C.E.5    English, J.C.6    Tsao, M.7    Gazdar, A.F.8    Lam, S.9    Lam, W.L.10    Lockwood, W.W.11
  • 25
    • 10044228504 scopus 로고    scopus 로고
    • Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
    • DOI 10.1128/MCB.24.24.10941-10953.2004
    • Zhang D. D., Lo S., Cross J. V., Templeton D. J., Hannink M., Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Molecular and Cellular Biology 2004 24 24 10941 10953 10.1128/MCB.24.24.10941-10953.2004 2-s2.0-10044228504 (Pubitemid 39603148)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.24 , pp. 10941-10953
    • Zhang, D.D.1    Lo, S.-C.2    Cross, J.V.3    Templeton, D.J.4    Hannink, M.5
  • 26
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • DOI 10.1128/MCB.24.16.7130-7139.2004
    • Kobayashi A., Kang M., Okawa H., Ohtsuji M., Zenke Y., Chiba T., Igarashi K., Yamamoto M., Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Molecular and Cellular Biology 2004 24 16 7130 7139 10.1128/MCB.24.16.7130-7139.2004 2-s2.0-3543008924 (Pubitemid 39014439)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.16 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.-I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5    Chiba, T.6    Igarashi, K.7    Yamamoto, M.8
  • 29
    • 80053189298 scopus 로고    scopus 로고
    • Predicting the functional impact of protein mutations: Application to cancer genomics
    • article e118 10.1093/nar/gkr407 2-s2.0-80053189298
    • Reva B., Antipin Y., Sander C., Predicting the functional impact of protein mutations: application to cancer genomics. Nucleic Acids Research 2011 39 17 article e118 10.1093/nar/gkr407 2-s2.0-80053189298
    • (2011) Nucleic Acids Research , vol.39 , Issue.17
    • Reva, B.1    Antipin, Y.2    Sander, C.3
  • 31
    • 84875740314 scopus 로고    scopus 로고
    • Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
    • 10.1126/scisignal.2004088
    • Gao J., Aksoy B. A., Dogrusoz U., Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Science Signaling 2013 6 269 l1 10.1126/scisignal.2004088
    • (2013) Science Signaling , vol.6 , Issue.269
    • Gao, J.1    Aksoy, B.A.2    Dogrusoz, U.3
  • 32
    • 79955166265 scopus 로고    scopus 로고
    • GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
    • 10.1186/gb-2011-12-4-r41 2-s2.0-79955166265
    • Mermel C. H., Schumacher S. E., Hill B., Meyerson M. L., Beroukhim R., Getz G., GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biology 2011 12 4, article R41 10.1186/gb-2011-12-4-r41 2-s2.0-79955166265
    • (2011) Genome Biology , vol.12 , Issue.4 ARTICLE R41
    • Mermel, C.H.1    Schumacher, S.E.2    Hill, B.3    Meyerson, M.L.4    Beroukhim, R.5    Getz, G.6
  • 35
    • 84874730539 scopus 로고    scopus 로고
    • AntiReactive oxygen species regulate FSH-induced expression of vascular endothelial growth factor via Nrf2 and HIF1a signaling in human epithelial ovarian cancer
    • 10.3892/or.2013.2278 2-s2.0-84874730539
    • Zhang Z., Wang Q., Ma J., Yi X., Zhu Y., Xi X., Feng Y., Jin Z., AntiReactive oxygen species regulate FSH-induced expression of vascular endothelial growth factor via Nrf2 and HIF1a signaling in human epithelial ovarian cancer. Oncology Reports 2013 29 4 1429 1434 10.3892/or.2013.2278 2-s2.0-84874730539
    • (2013) Oncology Reports , vol.29 , Issue.4 , pp. 1429-1434
    • Zhang, Z.1    Wang, Q.2    Ma, J.3    Yi, X.4    Zhu, Y.5    Xi, X.6    Feng, Y.7    Jin, Z.8
  • 36
    • 84885524071 scopus 로고    scopus 로고
    • Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer
    • 10.1186/1476-4598-12-124
    • Martinez V. D., Vucic E. A., Pikor L. A., Thu K. L., Hubaux R., Lam W. L., Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer. Molecular Cancer 2013 12 1, article 124 10.1186/1476-4598-12-124
    • (2013) Molecular Cancer , vol.12 , Issue.1 ARTICLE 124
    • Martinez, V.D.1    Vucic, E.A.2    Pikor, L.A.3    Thu, K.L.4    Hubaux, R.5    Lam, W.L.6
  • 37
    • 84928211509 scopus 로고    scopus 로고
    • Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms is associated with poor prognosis in head and neck cancer
    • 10.1002/hed.23663
    • Martinez V. D., Vucic E. A., Thu K. L., Pikor L. A., Lam S., Lam W. L., Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms is associated with poor prognosis in head and neck cancer. Head & Neck 2014 10.1002/hed.23663
    • (2014) Head & Neck
    • Martinez, V.D.1    Vucic, E.A.2    Thu, K.L.3    Pikor, L.A.4    Lam, S.5    Lam, W.L.6
  • 38
    • 66849099347 scopus 로고    scopus 로고
    • Minimal oxidative load: A prerequisite for thyroid cell function
    • 10.1677/JOE-08-0470 2-s2.0-66849099347
    • Poncin S., Colin I. M., Gérard A., Minimal oxidative load: a prerequisite for thyroid cell function. Journal of Endocrinology 2009 201 1 161 167 10.1677/JOE-08-0470 2-s2.0-66849099347
    • (2009) Journal of Endocrinology , vol.201 , Issue.1 , pp. 161-167
    • Poncin, S.1    Colin, I.M.2    Gérard, A.3
  • 39
    • 77749273658 scopus 로고    scopus 로고
    • Oxidative stress: A required condition for thyroid cell proliferation
    • 10.2353/ajpath.2010.090682 2-s2.0-77749273658
    • Poncin S., van Eeckoudt S., Humblet K., Colin I. M., Gérard A., Oxidative stress: a required condition for thyroid cell proliferation. The American Journal of Pathology 2010 176 3 1355 1363 10.2353/ajpath.2010.090682 2-s2.0-77749273658
    • (2010) The American Journal of Pathology , vol.176 , Issue.3 , pp. 1355-1363
    • Poncin, S.1    Van Eeckoudt, S.2    Humblet, K.3    Colin, I.M.4    Gérard, A.5
  • 40
    • 84876011848 scopus 로고    scopus 로고
    • Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination
    • 10.1158/0008-5472.CAN-12-4400 2-s2.0-84876011848
    • Hast B. E., Goldfarb D., Mulvaney K. M., Hast M. A., Siesser P. F., Yan F., Hayes D. N., Major M. B., Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. Cancer Research 2013 73 7 2199 2210 10.1158/0008-5472.CAN-12-4400 2-s2.0-84876011848
    • (2013) Cancer Research , vol.73 , Issue.7 , pp. 2199-2210
    • Hast, B.E.1    Goldfarb, D.2    Mulvaney, K.M.3    Hast, M.A.4    Siesser, P.F.5    Yan, F.6    Hayes, D.N.7    Major, M.B.8
  • 41
    • 0141750416 scopus 로고    scopus 로고
    • BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases
    • DOI 10.1016/S1097-2765(03)00341-1
    • Geyer R., Wee S., Anderson S., Yates J. III, Wolf D. A., BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Molecular Cell 2003 12 3 783 790 10.1016/S1097-2765(03)00341-1 2-s2.0-0141750416 (Pubitemid 37222497)
    • (2003) Molecular Cell , vol.12 , Issue.3 , pp. 783-790
    • Geyer, R.1    Wee, S.2    Anderson, S.3    Yates III, J.4    Wolf, D.A.5
  • 42
    • 84878260314 scopus 로고    scopus 로고
    • Mechanisms and function of substrate recruitment by F-box proteins
    • 10.1038/nrm3582 2-s2.0-84878260314
    • Skaar J. R., Pagan J. K., Pagano M., Mechanisms and function of substrate recruitment by F-box proteins. Nature Reviews Molecular Cell Biology 2013 14 6 369 381 10.1038/nrm3582 2-s2.0-84878260314
    • (2013) Nature Reviews Molecular Cell Biology , vol.14 , Issue.6 , pp. 369-381
    • Skaar, J.R.1    Pagan, J.K.2    Pagano, M.3
  • 43
    • 11244351579 scopus 로고    scopus 로고
    • Function and regulation of cullin-RING ubiquitin ligases
    • DOI 10.1038/nrm1547
    • Petroski M. D., Deshaies R. J., Function and regulation of cullin-RING ubiquitin ligases. Nature Reviews Molecular Cell Biology 2005 6 1 9 20 10.1038/nrm1547 2-s2.0-11244351579 (Pubitemid 40064895)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.1 , pp. 9-20
    • Petroski, M.D.1    Deshaies, R.J.2
  • 45
    • 84881476323 scopus 로고    scopus 로고
    • Nrf2 is controlled by two distinct β -TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
    • 10.1038/onc.2012.388 2-s2.0-84881476323
    • Chowdhry S., Zhang Y., McMahon M., Sutherland C., Cuadrado A., Hayes J. D., Nrf2 is controlled by two distinct β -TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene 2013 32 32 3765 3781 10.1038/onc.2012.388 2-s2.0-84881476323
    • (2013) Oncogene , vol.32 , Issue.32 , pp. 3765-3781
    • Chowdhry, S.1    Zhang, Y.2    McMahon, M.3    Sutherland, C.4    Cuadrado, A.5    Hayes, J.D.6
  • 47
    • 84873862912 scopus 로고    scopus 로고
    • Prognostically relevant gene signatures of high-grade serous ovarian carcinoma
    • 10.1172/JCI65833
    • Verhaak R. G., Tamayo P., Yang J. Y., Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. Journal of Clinical Investigation 2013 123 1 517 525 10.1172/JCI65833
    • (2013) Journal of Clinical Investigation , vol.123 , Issue.1 , pp. 517-525
    • Verhaak, R.G.1    Tamayo, P.2    Yang, J.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.