Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death

Oncogene

Volumn 34, Issue 31, 2015, Pages 4032-4043

  Schoeneberger, H ^a   Belz, K ^a   Schenk, B ^a   Fulda, S ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; BUTHIONINE SULFOXIMINE; CASPASE 8; GLUTATHIONE; LIPOCORTIN 5; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; TOLL LIKE RECEPTOR 3; TROLOX C; BIOMIMETIC MATERIAL; BV6 PEPTIDE; DIABLO PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; OLIGOPEPTIDE; SIGNAL PEPTIDE;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL DEATH; COMPARATIVE STUDY; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOPRECIPITATION; LEUKEMIA CELL; LIPID PEROXIDATION; LONG TERM SURVIVAL; MESENCHYMAL STROMA CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RNA INTERFERENCE; CELL CULTURE; CHILD; DRUG EFFECTS; DRUG POTENTIATION; JURKAT CELL LINE; METABOLISM; PATHOLOGY;

APOPTOSIS; BIOMIMETIC MATERIALS; BUTHIONINE SULFOXIMINE; CELLS, CULTURED; CHILD; DRUG SYNERGISM; GLUTATHIONE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; LIPID PEROXIDATION; MITOCHONDRIAL PROTEINS; OLIGOPEPTIDES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; REACTIVE OXYGEN SPECIES;

EID: 84938550543     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.338     Document Type: Article

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