메뉴 건너뛰기




Volumn 4, Issue 11, 2013, Pages

Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis

Author keywords

Apoptosis; DR5; Glioblastoma; IAP proteins; Smac

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; DEATH RECEPTOR 5; ETANERCEPT; FAS ASSOCIATED DEATH DOMAIN PROTEIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

EID: 84889560425     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.457     Document Type: Article
Times cited : (42)

References (33)
  • 1
    • 38349194472 scopus 로고    scopus 로고
    • Cell death in health and disease
    • Lockshin RA, Zakeri Z. Cell death in health and disease. J Cell Mol Med 2007; 11: 1214-1224
    • (2007) J Cell Mol Med , vol.11 , pp. 1214-1224
    • Lockshin, R.A.1    Zakeri, Z.2
  • 2
    • 58149296552 scopus 로고    scopus 로고
    • Tumor resistance to apoptosis
    • Fulda S. Tumor resistance to apoptosis. Int J Cancer 2009; 124: 511-515
    • (2009) Int J Cancer , vol.124 , pp. 511-515
    • Fulda, S.1
  • 3
    • 44749085513 scopus 로고    scopus 로고
    • Targeting the extrinsic apoptosis pathway in cancer
    • Ashkenazi A. Targeting the extrinsic apoptosis pathway in cancer. Cytokine Growth Factor Rev 2008; 19: 325-331
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 325-331
    • Ashkenazi, A.1
  • 4
    • 84870383878 scopus 로고    scopus 로고
    • Tumor necrosis factor
    • Chu WM. Tumor necrosis factor. Cancer Lett 2013; 328: 222-225
    • (2013) Cancer Lett , vol.328 , pp. 222-225
    • Chu, W.M.1
  • 5
    • 84856495152 scopus 로고    scopus 로고
    • Targeting IAP proteins for therapeutic intervention in cancer
    • Fulda S, Vucic D. Targeting IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov 2012; 11: 109-124
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 109-124
    • Fulda, S.1    Vucic, D.2
  • 6
    • 33749252583 scopus 로고    scopus 로고
    • Human inhibitor of apoptosis proteins: Why XIAP is the black sheep of the family
    • Eckelman BP, Salvesen GS, Scott FL. Human inhibitor of apoptosis proteins: Why XIAP is the black sheep of the family. EMBO Rep 2006; 7: 988-994
    • (2006) EMBO Rep , vol.7 , pp. 988-994
    • Eckelman, B.P.1    Salvesen, G.S.2    Scott, F.L.3
  • 7
    • 80051987703 scopus 로고    scopus 로고
    • Crosstalk in NF-kappaB signaling pathways
    • Oeckinghaus A, Hayden MS, Ghosh S. Crosstalk in NF-kappaB signaling pathways. Nat Immunol 2011; 12: 695-708
    • (2011) Nat Immunol , vol.12 , pp. 695-708
    • Oeckinghaus, A.1    Hayden, M.S.2    Ghosh, S.3
  • 8
    • 54049155149 scopus 로고    scopus 로고
    • C-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
    • Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, et al. c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. J Biol Chem 2008; 283: 24295-24299
    • (2008) J Biol Chem , vol.283 , pp. 24295-24299
    • Varfolomeev, E.1    Goncharov, T.2    Fedorova, A.V.3    Dynek, J.N.4    Zobel, K.5    Deshayes, K.6
  • 9
    • 44949240664 scopus 로고    scopus 로고
    • CIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
    • Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 2008; 30: 689-700
    • (2008) Mol Cell , vol.30 , pp. 689-700
    • Bertrand, M.J.1    Milutinovic, S.2    Dickson, K.M.3    Ho, W.C.4    Boudreault, A.5    Durkin, J.6
  • 10
    • 56349164232 scopus 로고    scopus 로고
    • Nonredundant and complementary functions of traf2 and traf3 in a ubiquitination cascade that activates nik-dependent alternative nf-kappab signaling
    • Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol 2008; 9: 1364-1370
    • (2008) Nat Immunol , vol.9 , pp. 1364-1370
    • Vallabhapurapu, S.1    Matsuzawa, A.2    Zhang, W.3    Tseng, P.H.4    Keats, J.J.5    Wang, H.6
  • 11
    • 56349164239 scopus 로고    scopus 로고
    • Noncanonical nf-kappab activation requires coordinated assembly of a regulatory complex of the adaptors ciap1, ciap2, traf2 and traf3 and the kinase nik
    • Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J, et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol 2008; 9: 1371-1378
    • (2008) Nat Immunol , vol.9 , pp. 1371-1378
    • Zarnegar, B.J.1    Wang, Y.2    Mahoney, D.J.3    Dempsey, P.W.4    Cheung, H.H.5    He, J.6
  • 12
    • 36048999753 scopus 로고    scopus 로고
    • IAP antagonists induce autoubiquitination of c-IAPs NF-kappaB activation, and TNFalphadependent apoptosis
    • Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalphadependent apoptosis. Cell 2007; 131: 669-681
    • (2007) Cell , vol.131 , pp. 669-681
    • Varfolomeev, E.1    Blankenship, J.W.2    Wayson, S.M.3    Fedorova, A.V.4    Kayagaki, N.5    Garg, P.6
  • 13
    • 36148954336 scopus 로고    scopus 로고
    • IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    • Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007; 131: 682-693
    • (2007) Cell , vol.131 , pp. 682-693
    • Vince, J.E.1    Wong, W.W.2    Khan, N.3    Feltham, R.4    Chau, D.5    Ahmed, A.U.6
  • 14
    • 43049152912 scopus 로고    scopus 로고
    • TNF-Alpha induces two distinct caspase-8 activation pathways
    • Wang L, Du F, Wang X. TNF-Alpha induces two distinct caspase-8 activation pathways. Cell 2008; 133: 693-703
    • (2008) Cell , vol.133 , pp. 693-703
    • Wang, L.1    Du, F.2    Wang, X.3
  • 15
    • 84863248798 scopus 로고    scopus 로고
    • LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFalpha expression and receptor tyrosine kinase signaling
    • Bai L, McEachern D, Yang CY, Lu J, Sun H, Wang S. LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFalpha expression and receptor tyrosine kinase signaling. Cancer Res 2012; 72: 1229-1238
    • (2012) Cancer Res , vol.72 , pp. 1229-1238
    • Bai, L.1    McEachern, D.2    Yang, C.Y.3    Lu, J.4    Sun, H.5    Wang, S.6
  • 16
    • 0035067368 scopus 로고    scopus 로고
    • Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB
    • Ravi R, Bedi GC, Engstrom LW, Zeng Q, Mookerjee B, Gelinas C, et al. Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB. Nat Cell Biol 2001; 3: 409-416
    • (2001) Nat Cell Biol , vol.3 , pp. 409-416
    • Ravi, R.1    Bedi, G.C.2    Engstrom, L.W.3    Zeng, Q.4    Mookerjee, B.5    Gelinas, C.6
  • 17
    • 20744433491 scopus 로고    scopus 로고
    • Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1
    • Shetty S, Graham BA, Brown JG, Hu X, Vegh-Yarema N, Harding G, et al. Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1. Mol Cell Biol 2005; 25: 5404-5416
    • (2005) Mol Cell Biol , vol.25 , pp. 5404-5416
    • Shetty, S.1    Graham, B.A.2    Brown, J.G.3    Hu, X.4    Vegh-Yarema, N.5    Harding, G.6
  • 18
    • 50949098870 scopus 로고    scopus 로고
    • Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: Involvement of NF-kappa B and reactive oxygen species-mediated p53 activation
    • Chen JJ, Chou CW, Chang YF, Chen CC. Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: Involvement of NF-kappa B and reactive oxygen species-mediated p53 activation. J Immunol 2008; 180: 8030-8039
    • (2008) J Immunol , vol.180 , pp. 8030-8039
    • Chen, J.J.1    Chou, C.W.2    Chang, Y.F.3    Chen, C.C.4
  • 19
    • 35948994157 scopus 로고    scopus 로고
    • Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
    • Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J, et al. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 2007; 12: 445-456
    • (2007) Cancer Cell , vol.12 , pp. 445-456
    • Petersen, S.L.1    Wang, L.2    Yalcin-Chin, A.3    Li, L.4    Peyton, M.5    Minna, J.6
  • 20
    • 69949106920 scopus 로고    scopus 로고
    • Epigenetic silencing of death receptor 4 mediates tumor necrosis factorrelated apoptosis-inducing ligand resistance in gliomas
    • Elias A, Siegelin MD, Steinmuller A, von Deimling A, Lass U, Korn B, et al. Epigenetic silencing of death receptor 4 mediates tumor necrosis factorrelated apoptosis-inducing ligand resistance in gliomas. Clin Cancer Res 2009; 15: 5457-5465
    • (2009) Clin Cancer Res , vol.15 , pp. 5457-5465
    • Elias, A.1    Siegelin, M.D.2    Steinmuller, A.3    Von Deimling, A.4    Lass, U.5    Korn, B.6
  • 21
    • 84877095096 scopus 로고    scopus 로고
    • Smac mimetic birinapant induces apoptosis and enhances trail potency in inflammatory breast cancer cells in an iap-dependent and tnf-Alpha-independent mechanism
    • Allensworth JL, Sauer SJ, Lyerly HK, Morse MA, Devi GR. Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-Alpha-independent mechanism. Breast Cancer Res Treat 2013; 137: 359-371
    • (2013) Breast Cancer Res Treat , vol.137 , pp. 359-371
    • Allensworth, J.L.1    Sauer, S.J.2    Lyerly, H.K.3    Morse, M.A.4    Devi, G.R.5
  • 22
    • 84874763808 scopus 로고    scopus 로고
    • Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1-And NF-kappaB-dependent manner
    • Wagner L, Marschall V, Karl S, Cristofanon S, Zobel K, Deshayes K, et al. Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1-And NF-kappaB-dependent manner. Oncogene 2013; 32: 988-997
    • (2013) Oncogene , vol.32 , pp. 988-997
    • Wagner, L.1    Marschall, V.2    Karl, S.3    Cristofanon, S.4    Zobel, K.5    Deshayes, K.6
  • 23
    • 84855440150 scopus 로고    scopus 로고
    • Requirement of nuclear factor kappaB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis
    • Stadel D, Cristofanon S, Abhari BA, Deshayes K, Zobel K, Vucic D, et al. Requirement of nuclear factor kappaB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis. Neoplasia 2011; 13: 1162-1170
    • (2011) Neoplasia , vol.13 , pp. 1162-1170
    • Stadel, D.1    Cristofanon, S.2    Abhari, B.A.3    Deshayes, K.4    Zobel, K.5    Vucic, D.6
  • 24
    • 80053933840 scopus 로고    scopus 로고
    • NF-{kappa}B is required for Smac mimetic-mediated sensitization of glioblastoma cells for {gamma}-irradiation-induced apoptosis
    • Berger R, Jennewein C, Marschall V, Karl S, Cristofanon S, Wagner L, et al. NF-{kappa}B is required for Smac mimetic-mediated sensitization of glioblastoma cells for {gamma}-irradiation-induced apoptosis. Mol Cancer Ther 2011; 10: 1867-1875
    • (2011) Mol Cancer Ther , vol.10 , pp. 1867-1875
    • Berger, R.1    Jennewein, C.2    Marschall, V.3    Karl, S.4    Cristofanon, S.5    Wagner, L.6
  • 25
    • 84880265865 scopus 로고    scopus 로고
    • RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/ FADD/caspase-8 cell death complex
    • Abhari BA, Cristofanon S, Kappler R, von Schweinitz D, Humphreys R, Fulda S. RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/ FADD/caspase-8 cell death complex. Oncogene 2013; 32: 3263-3273
    • (2013) Oncogene , vol.32 , pp. 3263-3273
    • Abhari, B.A.1    Cristofanon, S.2    Kappler, R.3    Von Schweinitz, D.4    Humphreys, R.5    Fulda, S.6
  • 26
    • 70749151909 scopus 로고    scopus 로고
    • A smac-mimetic sensitizes prostate cancer cells to trail-induced apoptosis via modulating both iaps and nf-kappab
    • Dai Y, Liu M, Tang W, Li Y, Lian J, Lawrence TS, et al. A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB. BMC Cancer 2009; 9: 392
    • (2009) BMC Cancer , vol.9 , pp. 392
    • Dai, Y.1    Liu, M.2    Tang, W.3    Li, Y.4    Lian, J.5    Lawrence, T.S.6
  • 27
    • 67649371458 scopus 로고    scopus 로고
    • IKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cells
    • Bai L, Chen W, Wang X, Tang H, Lin Y. IKKbeta-mediated nuclear factor-kappaB activation attenuates smac mimetic-induced apoptosis in cancer cells. Mol Cancer Ther 2009; 8: 1636-1645
    • (2009) Mol Cancer Ther , vol.8 , pp. 1636-1645
    • Bai, L.1    Chen, W.2    Wang, X.3    Tang, H.4    Lin, Y.5
  • 28
    • 84856213846 scopus 로고    scopus 로고
    • The diverse and complex roles of NF-kappaB subunits in cancer
    • Perkins ND. The diverse and complex roles of NF-kappaB subunits in cancer. Nat Rev Cancer 2012; 12: 121-132
    • (2012) Nat Rev Cancer , vol.12 , pp. 121-132
    • Perkins, N.D.1
  • 29
    • 77449136821 scopus 로고    scopus 로고
    • Identification of a novel pro-Apopotic function of NF-kappaB in the DNA damage response
    • Karl S, Pritschow Y, Volcic M, Hacker S, Baumann B, Wiesmuller L, et al. Identification of a novel pro-Apopotic function of NF-kappaB in the DNA damage response. J Cell Mol Med 2009; 13: 4239-4256
    • (2009) J Cell Mol Med , vol.13 , pp. 4239-4256
    • Karl, S.1    Pritschow, Y.2    Volcic, M.3    Hacker, S.4    Baumann, B.5    Wiesmuller, L.6
  • 30
    • 84858337114 scopus 로고    scopus 로고
    • Identification of a novel pro-Apoptotic role of NF-kappaB in the regulation of TRAIL-And CD95-mediated apoptosis of glioblastoma cells
    • Jennewein C, Karl S, Baumann B, Micheau O, Debatin KM, Fulda S. Identification of a novel pro-Apoptotic role of NF-kappaB in the regulation of TRAIL-And CD95-mediated apoptosis of glioblastoma cells. Oncogene 2012; 31: 1468-1474
    • (2012) Oncogene , vol.31 , pp. 1468-1474
    • Jennewein, C.1    Karl, S.2    Baumann, B.3    Micheau, O.4    Debatin, K.M.5    Fulda, S.6
  • 31
    • 84863726751 scopus 로고    scopus 로고
    • Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process
    • Gonzalez P, Mader I, Tchoghandjian A, Enzenmuller S, Cristofanon S, Basit F, et al. Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process. Cell Death Differ 2012; 19: 1337-1346
    • (2012) Cell Death Differ , vol.19 , pp. 1337-1346
    • Gonzalez, P.1    Mader, I.2    Tchoghandjian, A.3    Enzenmuller, S.4    Cristofanon, S.5    Basit, F.6
  • 32
    • 0030815250 scopus 로고    scopus 로고
    • Betulinic acid triggers CD95 (APO-1/Fas)-And p53-independent apoptosis via activation of caspases in neuroectodermal tumors
    • Fulda S, Friesen C, Los M, Scaffidi C, Mier W, Benedict M, et al. Betulinic acid triggers CD95 (APO-1/Fas)-And p53-independent apoptosis via activation of caspases in neuroectodermal tumors. Cancer Res 1997; 57: 4956-4964
    • (1997) Cancer Res , vol.57 , pp. 4956-4964
    • Fulda, S.1    Friesen, C.2    Los, M.3    Scaffidi, C.4    Mier, W.5    Benedict, M.6
  • 33
    • 33846222280 scopus 로고    scopus 로고
    • Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells
    • Vogler M, Durr K, Jovanovic M, Debatin KM, Fulda S. Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells. Oncogene 2007; 26: 248-257
    • (2007) Oncogene , vol.26 , pp. 248-257
    • Vogler, M.1    Durr, K.2    Jovanovic, M.3    Debatin, K.M.4    Fulda, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.