-
2
-
-
34547150024
-
Integrating molecular information into treatment of childhood acute lymphoblastic leukemia-a perspective from the BFM Study Group
-
Stanulla M, Cario G, Meissner B, Schrauder A, Moricke A, Riehm H et al. Integrating molecular information into treatment of childhood acute lymphoblastic leukemia-a perspective from the BFM Study Group. Blood Cells Mol Dis 2007; 39: 160-163.
-
(2007)
Blood Cells Mol Dis
, vol.39
, pp. 160-163
-
-
Stanulla, M.1
Cario, G.2
Meissner, B.3
Schrauder, A.4
Moricke, A.5
Riehm, H.6
-
3
-
-
58149296552
-
Tumor resistance to apoptosis
-
Fulda S. Tumor resistance to apoptosis. Int J Cancer 2009; 124: 511-515.
-
(2009)
Int J Cancer
, vol.124
, pp. 511-515
-
-
Fulda, S.1
-
4
-
-
65449161842
-
Therapeutic opportunities for counteracting apoptosis resistance in childhood leukaemia
-
Fulda S. Therapeutic opportunities for counteracting apoptosis resistance in childhood leukaemia. Br J Haematol 2009; 145: 441-454.
-
(2009)
Br J Haematol
, vol.145
, pp. 441-454
-
-
Fulda, S.1
-
5
-
-
33746886979
-
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
-
Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006; 25: 4798-4811.
-
(2006)
Oncogene
, vol.25
, pp. 4798-4811
-
-
Fulda, S.1
Debatin, K.M.2
-
6
-
-
44749085513
-
Targeting the extrinsic apoptosis pathway in cancer
-
Ashkenazi A. Targeting the extrinsic apoptosis pathway in cancer. Cytokine Growth Factor Rev 2008; 19: 325-331.
-
(2008)
Cytokine Growth Factor Rev
, vol.19
, pp. 325-331
-
-
Ashkenazi, A.1
-
7
-
-
33845977959
-
Mitochondrial membrane permeabilization in cell death
-
Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol Rev 2007; 87: 99-163.
-
(2007)
Physiol Rev
, vol.87
, pp. 99-163
-
-
Kroemer, G.1
Galluzzi, L.2
Brenner, C.3
-
8
-
-
54249123632
-
IAPtargeted therapies for cancer
-
LaCasse EC, Mahoney DJ, Cheung HH, Plenchette S, Baird S, Korneluk RG. IAPtargeted therapies for cancer. Oncogene 2008; 27: 6252-6275.
-
(2008)
Oncogene
, vol.27
, pp. 6252-6275
-
-
Lacasse, E.C.1
Mahoney, D.J.2
Cheung, H.H.3
Plenchette, S.4
Baird, S.5
Korneluk, R.G.6
-
9
-
-
33749252583
-
Human inhibitor of apoptosis proteins: Why XIAP is the black sheep of the family
-
Eckelman BP, Salvesen GS, Scott FL. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep 2006; 7: 988-994.
-
(2006)
EMBO Rep
, vol.7
, pp. 988-994
-
-
Eckelman, B.P.1
Salvesen, G.S.2
Scott, F.L.3
-
10
-
-
44949240664
-
CIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
-
Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 2008; 30: 689-700.
-
(2008)
Mol Cell
, vol.30
, pp. 689-700
-
-
Bertrand, M.J.1
Milutinovic, S.2
Dickson, K.M.3
Ho, W.C.4
Boudreault, A.5
Durkin, J.6
-
11
-
-
33847051539
-
RIP1, a kinase on the crossroads of a cell's decision to live or die
-
Festjens N, Vanden Berghe T, Cornelis S, Vandenabeele P. RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ 2007; 14: 400-410.
-
(2007)
Cell Death Differ
, vol.14
, pp. 400-410
-
-
Festjens, N.1
Vanden Berghe, T.2
Cornelis, S.3
Vandenabeele, P.4
-
12
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
-
Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 2007; 131: 669-681.
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
Fedorova, A.V.4
Kayagaki, N.5
Garg, P.6
-
13
-
-
36148954336
-
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
-
Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007; 131: 682-693.
-
(2007)
Cell
, vol.131
, pp. 682-693
-
-
Vince, J.E.1
Wong, W.W.2
Khan, N.3
Feltham, R.4
Chau, D.5
Ahmed, A.U.6
-
14
-
-
43049152912
-
TNF-alpha induces two distinct caspase-8 activation pathways
-
Wang L, Du F, Wang X. TNF-alpha induces two distinct caspase-8 activation pathways. Cell 2008; 133: 693-703.
-
(2008)
Cell
, vol.133
, pp. 693-703
-
-
Wang, L.1
Du, F.2
Wang, X.3
-
15
-
-
77955123282
-
XIAP expression is posttranscriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL
-
Hundsdoerfer P, Dietrich I, Schmelz K, Eckert C, Henze G. XIAP expression is posttranscriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL. Pediatr Blood Cancer 2010; 55: 260-266.
-
(2010)
Pediatr Blood Cancer
, vol.55
, pp. 260-266
-
-
Hundsdoerfer, P.1
Dietrich, I.2
Schmelz, K.3
Eckert, C.4
Henze, G.5
-
16
-
-
2542602637
-
Differences in the expression pattern of apoptosis-related molecules between childhood and adult de novo acute myeloid leukemia
-
Wuchter C, Richter S, Oltersdorf D, Karawajew L, Ludwig WD, Tamm I. Differences in the expression pattern of apoptosis-related molecules between childhood and adult de novo acute myeloid leukemia. Haematologica 2004; 89: 363-364.
-
(2004)
Haematologica
, vol.89
, pp. 363-364
-
-
Wuchter, C.1
Richter, S.2
Oltersdorf, D.3
Karawajew, L.4
Ludwig, W.D.5
Tamm, I.6
-
17
-
-
85042587668
-
Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance
-
Fakler M, Loeder S, Vogler M, Schneider K, Jeremias I, Debatin KM et al. Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance. Blood 2009; 113: 1710-1722.
-
(2009)
Blood
, vol.113
, pp. 1710-1722
-
-
Fakler, M.1
Loeder, S.2
Vogler, M.3
Schneider, K.4
Jeremias, I.5
Debatin, K.M.6
-
18
-
-
4143099131
-
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer
-
Oost TK, Sun C, Armstrong RC, Al-Assaad AS, Betz SF, Deckwerth TL et al. Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J Med Chem 2004; 47: 4417-4426.
-
(2004)
J Med Chem
, vol.47
, pp. 4417-4426
-
-
Oost, T.K.1
Sun, C.2
Armstrong, R.C.3
Al-Assaad, A.S.4
Betz, S.F.5
Deckwerth, T.L.6
-
19
-
-
80053939958
-
-
inventors 16.02
-
Chao B, Deckwerth TL, Furth PS, Linton SD, Spada AP, Ullman BR et al., inventors; Tetrapeptide Analogs, United States patent PCT/US2005/024700. 2006 16.02.
-
(2006)
Tetrapeptide Analogs United States Patent PCT/US2005/024700
-
-
Chao, B.1
Deckwerth, T.L.2
Furth, P.S.3
Linton, S.D.4
Spada, A.P.5
Ullman, B.R.6
-
20
-
-
0033970949
-
Functional CD95 ligand and CD95 deathinducing signaling complex in activation-induced cell death and doxorubicininduced apoptosis in leukemic T cells
-
Fulda S, Strauss G, Meyer E, Debatin KM. Functional CD95 ligand and CD95 deathinducing signaling complex in activation-induced cell death and doxorubicininduced apoptosis in leukemic T cells. Blood 2000; 95: 301-308.
-
(2000)
Blood
, vol.95
, pp. 301-308
-
-
Fulda, S.1
Strauss, G.2
Meyer, E.3
Debatin, K.M.4
-
21
-
-
33846222280
-
Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells
-
Vogler M, Durr K, Jovanovic M, Debatin KM, Fulda S. Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells. Oncogene 2007; 26: 248-257.
-
(2007)
Oncogene
, vol.26
, pp. 248-257
-
-
Vogler, M.1
Durr, K.2
Jovanovic, M.3
Debatin, K.M.4
Fulda, S.5
-
22
-
-
5044243796
-
A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release
-
Mohr A, Zwacka RM, Debatin KM, Stahnke K. A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release. Cell Death Differ 2004; 11: 1153-1154.
-
(2004)
Cell Death Differ
, vol.11
, pp. 1153-1154
-
-
Mohr, A.1
Zwacka, R.M.2
Debatin, K.M.3
Stahnke, K.4
-
23
-
-
0002658306
-
The median-effect principle and the combination index for quantitation of synergism and antagonism
-
Chou TC (ed) Academic Press: San Diego, USA
-
Chou TC. The median-effect principle and the combination index for quantitation of synergism and antagonism. In: Chou TC (ed). Synergism and antagonism in chemotherapy. Academic Press: San Diego, USA, 1991, pp 61-102.
-
(1991)
Synergism and Antagonism in Chemotherapy
, pp. 61-102
-
-
Chou, T.C.1
-
24
-
-
35948994157
-
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimeticinduced apoptosis
-
Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J et al. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimeticinduced apoptosis. Cancer Cell 2007; 12: 445-456.
-
(2007)
Cancer Cell
, vol.12
, pp. 445-456
-
-
Petersen, S.L.1
Wang, L.2
Yalcin-Chin, A.3
Li, L.4
Peyton, M.5
Minna, J.6
-
25
-
-
0029858348
-
RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis
-
Ting AT, Pimentel-Muinos FX, Seed B. RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1-initiated apoptosis. Embo J 1996; 15: 6189-6196.
-
(1996)
Embo J
, vol.15
, pp. 6189-6196
-
-
Ting, A.T.1
Pimentel-Muinos, F.X.2
Seed, B.3
-
26
-
-
33644840693
-
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
-
Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005; 1: 112-119.
-
(2005)
Nat Chem Biol
, vol.1
, pp. 112-119
-
-
Degterev, A.1
Huang, Z.2
Boyce, M.3
Li, Y.4
Jagtap, P.5
Mizushima, N.6
-
27
-
-
42249102086
-
Identification of RIP1 kinase as a specific cellular target of necrostatins
-
Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 2008; 4: 313-321.
-
(2008)
Nat Chem Biol
, vol.4
, pp. 313-321
-
-
Degterev, A.1
Hitomi, J.2
Germscheid, M.3
Ch'En, I.L.4
Korkina, O.5
Teng, X.6
-
28
-
-
77949889993
-
Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis
-
Loeder S, Drensek A, Jeremias I, Debatin KM, Fulda S. Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis. Int J Cancer 2010; 126: 2216-2228.
-
(2010)
Int J Cancer
, vol.126
, pp. 2216-2228
-
-
Loeder, S.1
Drensek, A.2
Jeremias, I.3
Debatin, K.M.4
Fulda, S.5
-
29
-
-
65549139431
-
Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma
-
Vogler M, Walczak H, Stadel D, Haas TL, Genze F, Jovanovic M et al. Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma. Cancer Res 2009; 69: 2425-2434.
-
(2009)
Cancer Res
, vol.69
, pp. 2425-2434
-
-
Vogler, M.1
Walczak, H.2
Stadel, D.3
Haas, T.L.4
Genze, F.5
Jovanovic, M.6
-
30
-
-
67650485853
-
Smallmolecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma
-
Vellanki SH, Grabrucker A, Liebau S, Proepper C, Eramo A, Braun V et al. Smallmolecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma. Neoplasia 2009; 11: 743-752.
-
(2009)
Neoplasia
, vol.11
, pp. 743-752
-
-
Vellanki, S.H.1
Grabrucker, A.2
Liebau, S.3
Proepper, C.4
Eramo, A.5
Braun, V.6
-
31
-
-
71549134615
-
A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia
-
Loeder S, Zenz T, Schnaiter A, Mertens D, Winkler D, Dohner H et al. A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia. Cancer Res 2009; 69: 8977-8986.
-
(2009)
Cancer Res
, vol.69
, pp. 8977-8986
-
-
Loeder, S.1
Zenz, T.2
Schnaiter, A.3
Mertens, D.4
Winkler, D.5
Dohner, H.6
-
32
-
-
62549108186
-
Inhibitor of apoptosis proteins in hematological malignancies
-
Fulda S. Inhibitor of apoptosis proteins in hematological malignancies. Leukemia 2009; 23: 467-476.
-
(2009)
Leukemia
, vol.23
, pp. 467-476
-
-
Fulda, S.1
|