메뉴 건너뛰기




Volumn 145, Issue 4, 2009, Pages 441-454

Therapeutic opportunities for counteracting apoptosis resistance in childhood leukaemia

Author keywords

Apoptosis; Bcl 2; Childhood leukaemia; Inhibitor of apoptosis proteins; Tumour necrosis factor related apoptosis inducing ligand

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ABT 263; AEG 35156; ANTILEUKEMIC AGENT; ANTINEOPLASTIC AGENT; ASPARAGINASE; DEATH RECEPTOR; FENRETINIDE; FLAVOPIRIDOL; GLUCOCORTICOID; HISTONE DEACETYLASE INHIBITOR; INHIBITOR OF APOPTOSIS PROTEIN; LY 2813008; OBATOCLAX; OBLIMERSEN; PREDNISONE; PROTEIN BCL 2; ROSCOVITINE; SORAFENIB; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 65449161842     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07603.x     Document Type: Review
Times cited : (16)

References (173)
  • 1
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • DOI 10.1038/sj.onc.1210220, PII 1210220
    • Adams, J.M. Cory, S. (2007) The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene, 26, 1324 1337. (Pubitemid 46328466)
    • (2007) Oncogene , vol.26 , Issue.9 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 3
    • 37549036729 scopus 로고    scopus 로고
    • Survivin, cancer networks and pathway-directed drug discovery
    • Altieri, D.C. (2008) Survivin, cancer networks and pathway-directed drug discovery. Nature Reviews Cancer, 8, 61 70.
    • (2008) Nature Reviews Cancer , vol.8 , pp. 61-70
    • Altieri, D.C.1
  • 5
    • 0347895102 scopus 로고    scopus 로고
    • Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ
    • DOI 10.1074/jbc.M207578200
    • Arnt, C.R., Chiorean, M.V., Heldebrant, M.P., Gores, G.J. Kaufmann, S.H. (2002) Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ. Journal of Biological Chemistry, 277, 44236 44243. (Pubitemid 36157856)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.46 , pp. 44236-44243
    • Arnt, C.R.1    Chiorean, M.V.2    Heldebrant, M.P.3    Gores, G.J.4    Kaufmann, S.H.5
  • 6
    • 44749085513 scopus 로고    scopus 로고
    • Targeting the extrinsic apoptosis pathway in cancer
    • Ashkenazi, A. (2008) Targeting the extrinsic apoptosis pathway in cancer. Cytokine and Growth Factor Reviews, 19, 325 331.
    • (2008) Cytokine and Growth Factor Reviews , vol.19 , pp. 325-331
    • Ashkenazi, A.1
  • 7
    • 45749098451 scopus 로고    scopus 로고
    • To kill a tumor cell: The potential of proapoptotic receptor agonists
    • Ashkenazi, A. Herbst, R.S. (2008) To kill a tumor cell: the potential of proapoptotic receptor agonists. Journal of Clinical Investigation, 118, 1979 1990.
    • (2008) Journal of Clinical Investigation , vol.118 , pp. 1979-1990
    • Ashkenazi, A.1    Herbst, R.S.2
  • 9
    • 49049086338 scopus 로고    scopus 로고
    • Ligand-based targeting of apoptosis in cancer: The potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL)
    • Ashkenazi, A., Holland, P. Eckhardt, S.G. (2008) Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL). Journal of Clinical Oncology, 26, 3621 3630.
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 3621-3630
    • Ashkenazi, A.1    Holland, P.2    Eckhardt, S.G.3
  • 10
    • 15244341393 scopus 로고    scopus 로고
    • Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor
    • DOI 10.1182/blood-2004-05-2023
    • Bachmann, P.S., Gorman, R., Mackenzie, K.L., Lutze-Mann, L. Lock, R.B. (2005) Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor. Blood, 105, 2519 2526. (Pubitemid 40387054)
    • (2005) Blood , vol.105 , Issue.6 , pp. 2519-2526
    • Bachmann, P.S.1    Gorman, R.2    MacKenzie, K.L.3    Lutze-Mann, L.4    Lock, R.B.5
  • 11
    • 0035912109 scopus 로고    scopus 로고
    • Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL
    • DOI 10.1038/sj.onc.1204318
    • Belka, C., Schmid, B., Marini, P., Durand, E., Rudner, J., Faltin, H., Bamberg, M., Schulze-Osthoff, K. Budach, W. (2001) Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL. Oncogene, 20, 2190 2196. (Pubitemid 32424014)
    • (2001) Oncogene , vol.20 , Issue.17 , pp. 2190-2196
    • Belka, C.1    Schmid, B.2    Marini, P.3    Durand, E.4    Rudner, J.5    Faltin, H.6    Bamberg, M.7    Schulze-Osthoff, K.8    Budach, W.9
  • 12
    • 0032525198 scopus 로고    scopus 로고
    • CD95 (APO-1/Fas) mutations in childhood T-lineage acute lymphoblastic leukemia
    • Beltinger, C., Kurz, E., Bohler, T., Schrappe, M., Ludwig, W.D. Debatin, K.M. (1998a) CD95 (APO-1/Fas) mutations in childhood T-lineage acute lymphoblastic leukemia. Blood, 91, 3943 3951. (Pubitemid 28225764)
    • (1998) Blood , vol.91 , Issue.10 , pp. 3943-3951
    • Beltinger, C.1    Kurz, E.2    Bohler, T.3    Schrappe, M.4    Ludwig, W.-D.5    Debatin, K.-M.6
  • 13
    • 0031813065 scopus 로고    scopus 로고
    • Mutation analysis of CD95 (APO-1/Fas) in childhood B-lineage acute lymphoblastic leukaemia
    • DOI 10.1046/j.1365-2141.1998.00827.x
    • Beltinger, C., Bohler, T., Karawajew, L., Ludwig, W.D., Schrappe, M. Debatin, K.M. (1998b) Mutation analysis of CD95 (APO-1/Fas) in childhood B-lineage acute lymphoblastic leukaemia. British Journal of Haematology, 102, 722 728. (Pubitemid 28387055)
    • (1998) British Journal of Haematology , vol.102 , Issue.3 , pp. 722-728
    • Beltinger, C.1    Bohler, T.2    Karawajew, L.3    Ludwig, W.-D.4    Schrappe, M.5    Debatin, K.-M.6
  • 14
    • 0032440288 scopus 로고    scopus 로고
    • Mechanisms and control of programmed cell death in invertebrates
    • Bergmann, A., Agapite, J. Steller, H. (1998) Mechanisms and control of programmed cell death in invertebrates. Oncogene, 17, 3215 3223. (Pubitemid 29043974)
    • (1998) Oncogene , vol.17 , Issue.25 , pp. 3215-3223
    • Bergmann, A.1    Agapite, J.2    Steller, H.3
  • 15
    • 1642512435 scopus 로고    scopus 로고
    • Role of PML and the PML-nuclear body in the control of programmed cell death
    • DOI 10.1038/sj.onc.1207106, Apoptosis - Part 2
    • Bernardi, R. Pandolfi, P.P. (2003) Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene, 22, 9048 9057. (Pubitemid 38121705)
    • (2003) Oncogene , vol.22 , Issue.REV. ISS. 8 , pp. 9048-9057
    • Bernardi, R.1    Pandolfi, P.P.2
  • 16
    • 0035854738 scopus 로고    scopus 로고
    • X-linked Inhibitor of Apoptosis Protein Functions as a Cofactor in Transforming Growth Factor-beta Signaling
    • DOI 10.1074/jbc.M100331200
    • Birkey Reffey, S., Wurthner, J.U., Parks, W.T., Roberts, A.B. Duckett, C.S. (2001) X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling. Journal of Biological Chemistry, 276, 26542 26549. (Pubitemid 37412876)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.28 , pp. 26542-26549
    • Reffey, S.B.1    Wurthner, J.U.2    Parks, W.T.3    Roberts, A.B.4    Duckett, C.S.5
  • 17
    • 0037817310 scopus 로고    scopus 로고
    • Therapeutic targeting of the survivin pathway in cancer: Initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis
    • Blanc-Brude, O.P., Mesri, M., Wall, N.R., Plescia, J., Dohi, T. Altieri, D.C. (2003) Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis. Clinical Cancer Research, 9, 2683 2692. (Pubitemid 36842114)
    • (2003) Clinical Cancer Research , vol.9 , Issue.7 , pp. 2683-2692
    • Blanc-Brude, O.P.1    Mesri, M.2    Wall, N.R.3    Plescia, J.4    Dohi, T.5    Altieri, D.C.6
  • 18
    • 0344309002 scopus 로고    scopus 로고
    • Mechanisms of caspase activation
    • DOI 10.1016/j.ceb.2003.10.009
    • Boatright, K.M. Salvesen, G.S. (2003) Mechanisms of caspase activation. Current Opinion in Cell Biology, 15, 725 731. (Pubitemid 37492933)
    • (2003) Current Opinion in Cell Biology , vol.15 , Issue.6 , pp. 725-731
    • Boatright, K.M.1    Salvesen, G.S.2
  • 19
    • 27744526342 scopus 로고    scopus 로고
    • A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells
    • DOI 10.1038/sj.onc.1208888, PII 1208888
    • Bockbrader, K.M., Tan, M. Sun, Y. (2005) A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL- and etoposide-induced apoptosis in breast cancer cells. Oncogene, 24, 7381 7388. (Pubitemid 41622242)
    • (2005) Oncogene , vol.24 , Issue.49 , pp. 7381-7388
    • Bockbrader, K.M.1    Tan, M.2    Sun, Y.3
  • 20
    • 0029929585 scopus 로고    scopus 로고
    • Expression of BCL-2 proto-oncogene in adult acute lymphoblastic leukemia
    • Campos, L., Sabido, O., Sebban, C., Charrin, C., Bertheas, M.F., Fiere, D. Guyotat, D. (1996) Expression of BCL-2 proto-oncogene in adult acute lymphoblastic leukemia. Leukemia, 10, 434 438. (Pubitemid 26128781)
    • (1996) Leukemia , vol.10 , Issue.3 , pp. 434-438
    • Campos, L.1    Sabido, O.2    Sebban, C.3    Charrin, C.4    Bertheas, M.-F.5    Fiere, D.6    Guyotat, D.7
  • 21
    • 0344394469 scopus 로고    scopus 로고
    • Caspase-independent cell death in AML: Caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis
    • DOI 10.1182/blood-2003-03-0960
    • Carter, B.Z., Kornblau, S.M., Tsao, T., Wang, R.Y., Schober, W.D., Milella, M., Sung, H.G., Reed, J.C. Andreeff, M. (2003a) Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis. Blood, 102, 4179 4186. (Pubitemid 37487005)
    • (2003) Blood , vol.102 , Issue.12 , pp. 4179-4186
    • Carter, B.Z.1    Kornblau, S.M.2    Tsao, T.3    Wang, R.-Y.4    Schober, W.D.5    Milella, M.6    Sung, H.-G.7    Reed, J.C.8    Andreeff, M.9
  • 24
    • 0035831021 scopus 로고    scopus 로고
    • Structural basis of caspase-7 inhibition by XIAP
    • PII S0092867401002720
    • Chai, J., Shiozaki, E., Srinivasula, S.M., Wu, Q., Datta, P., Alnemri, E.S. Shi, Y. (2001) Structural basis of caspase-7 inhibition by XIAP. Cell, 104, 769 780. (Pubitemid 32241026)
    • (2001) Cell , vol.104 , Issue.5 , pp. 769-780
    • Chai, J.1    Shiozaki, E.2    Srinivasula, S.M.3    Wu, Q.4    Dataa, P.5    Alnemri, E.S.6    Shi, Y.7
  • 27
    • 0027172909 scopus 로고
    • Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome
    • Chen, C.S., Sorensen, P.H., Domer, P.H., Reaman, G.H., Korsmeyer, S.J., Heerema, N.A., Hammond, G.D. Kersey, J.H. (1993) Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. Blood, 81, 2386 2393. (Pubitemid 23127075)
    • (1993) Blood , vol.81 , Issue.9 , pp. 2386-2393
    • Chen, C.-S.1    Sorensen, P.H.B.2    Domer, P.H.3    Reaman, G.H.4    Korsmeyer, S.J.5    Heerema, N.A.6    Hammond, G.D.7    Kersey, J.H.8
  • 28
    • 0035496921 scopus 로고    scopus 로고
    • Apo2L/TRAIL and Bcl-2-related proteins regulate type i interferon-induced apoptosis in multiple myeloma
    • Chen, Q., Gong, B., Mahmoud-Ahmed, A.S., Zhou, A., Hsi, E.D., Hussein, M. Almasan, A. (2001) Apo2L/TRAIL and Bcl-2-related proteins regulate type I interferon-induced apoptosis in multiple myeloma. Blood, 98, 2183 2192.
    • (2001) Blood , vol.98 , pp. 2183-2192
    • Chen, Q.1    Gong, B.2    Mahmoud-Ahmed, A.S.3    Zhou, A.4    Hsi, E.D.5    Hussein, M.6    Almasan, A.7
  • 29
    • 19944432123 scopus 로고    scopus 로고
    • Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    • DOI 10.1016/j.molcel.2004.12.030, PII S1097276505010403
    • Chen, L., Willis, S.N., Wei, A., Smith, B.J., Fletcher, J.I., Hinds, M.G., Colman, P.M., Day, C.L., Adams, J.M. Huang, D.C. (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Molecular Cell, 17, 393 403. (Pubitemid 40193310)
    • (2005) Molecular Cell , vol.17 , Issue.3 , pp. 393-403
    • Chen, L.1    Willis, S.N.2    Wei, A.3    Smith, B.J.4    Fletcher, J.I.5    Hinds, M.G.6    Colman, P.M.7    Day, C.L.8    Adams, J.M.9    Huang, D.C.S.10
  • 30
    • 33846674886 scopus 로고    scopus 로고
    • Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
    • DOI 10.1158/0008-5472.CAN-06-3964
    • Chen, S., Dai, Y., Harada, H., Dent, P. Grant, S. (2007) Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Research, 67, 782 791. (Pubitemid 46192219)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 782-791
    • Chen, S.1    Dai, Y.2    Harada, H.3    Dent, P.4    Grant, S.5
  • 31
    • 33846209478 scopus 로고    scopus 로고
    • Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia
    • DOI 10.1182/blood-2006-07-032557
    • Choi, J., Hwang, Y.K., Sung, K.W., Lee, S.H., Yoo, K.H., Jung, H.L., Koo, H.H., Kim, H.J., Kang, H.J., Shin, H.Y. Ahn, H.S. (2007) Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia. Blood, 109, 471 477. (Pubitemid 46105940)
    • (2007) Blood , vol.109 , Issue.2 , pp. 471-477
    • Choi, J.1    Yu, K.H.2    Ki, W.S.3    Soo, H.L.4    Keon, H.Y.5    Hye, L.J.6    Hong, H.K.7    Kim, H.-J.8    Hyong, J.K.9    Hee, Y.S.10    Hyo, S.A.11
  • 32
    • 0034533011 scopus 로고    scopus 로고
    • Expression of tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors and sensitivity to TRAIL-induced apoptosis in primary B-cell acute lymphoblastic leukaemia cells
    • DOI 10.1046/j.1365-2141.2000.02404.x
    • Clodi, K., Wimmer, D., Li, Y., Goodwin, R., Jaeger, U., Mann, G., Gadner, H. Younes, A. (2000) Expression of tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors and sensitivity to TRAIL-induced apoptosis in primary B-cell acute lymphoblastic leukaemia cells. British Journal of Haematology, 111, 580 586. (Pubitemid 32009356)
    • (2000) British Journal of Haematology , vol.111 , Issue.2 , pp. 580-586
    • Cappellini, M.D.1    Robbiolo, L.2    Bottasso, B.M.3    Coppola, R.4    Fiorelli, G.5    Mannucci, P.M.6
  • 34
    • 34248202709 scopus 로고    scopus 로고
    • Targeting multiple arms of the apoptotic regulatory machinery
    • DOI 10.1158/0008-5472.CAN-07-0082
    • Dai, Y. Grant, S. (2007) Targeting multiple arms of the apoptotic regulatory machinery. Cancer Research, 67, 2908 2911. (Pubitemid 46724822)
    • (2007) Cancer Research , vol.67 , Issue.7 , pp. 2908-2911
    • Dai, Y.1    Grant, S.2
  • 35
    • 0347601880 scopus 로고    scopus 로고
    • A decade of caspases
    • DOI 10.1038/sj.onc.1207107
    • Degterev, A., Boyce, M. Yuan, J. (2003) A decade of caspases. Oncogene, 22, 8543 8567. (Pubitemid 38028527)
    • (2003) Oncogene , vol.22 , Issue.REV. ISS. 7 , pp. 8543-8567
    • Degterev, A.1    Boyce, M.2    Yuan, J.3
  • 36
    • 33845994359 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
    • DOI 10.1172/JCI28281
    • Del Gaizo Moore, V., Brown, J.R., Certo, M., Love, T.M., Novina, C.D. Letai, A. (2007) Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. Journal of Clinical Investigation, 117, 112 121. (Pubitemid 46048458)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.1 , pp. 112-121
    • Moore, V.D.G.1    Brown, J.R.2    Certo, M.3    Love, T.M.4    Novina, C.D.5    Letai, A.6
  • 37
    • 41349123507 scopus 로고    scopus 로고
    • BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia
    • Del Gaizo Moore, V., Schlis, K.D., Sallan, S.E., Armstrong, S.A. Letai, A. (2008) BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. Blood, 111, 2300 2309.
    • (2008) Blood , vol.111 , pp. 2300-2309
    • Del Gaizo Moore, V.1    Schlis, K.D.2    Sallan, S.E.3    Armstrong, S.A.4    Letai, A.5
  • 39
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • Du, C., Fang, M., Li, Y., Li, L. Wang, X. (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell, 102, 33 42.
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3    Li, L.4    Wang, X.5
  • 40
    • 33749252583 scopus 로고    scopus 로고
    • Human inhibitor of apoptosis proteins: Why XIAP is the black sheep of the family
    • DOI 10.1038/sj.embor.7400795, PII 7400795
    • Eckelman, B.P., Salvesen, G.S. Scott, F.L. (2006) Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Reports, 7, 988 994. (Pubitemid 44480512)
    • (2006) EMBO Reports , vol.7 , Issue.10 , pp. 988-994
    • Eckelman, B.P.1    Salvesen, G.S.2    Scott, F.L.3
  • 41
    • 0038339094 scopus 로고    scopus 로고
    • TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB
    • DOI 10.1038/sj.onc.1206520
    • Ehrhardt, H., Fulda, S., Schmid, I., Hiscott, J., Debatin, K.M. Jeremias, I. (2003) TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene, 22, 3842 3852. (Pubitemid 36819657)
    • (2003) Oncogene , vol.22 , Issue.25 , pp. 3842-3852
    • Ehrhardt, H.1    Fulda, S.2    Schmid, I.3    Hiscott, J.4    Debatin, K.-M.5    Jeremias, I.6
  • 42
    • 28844472952 scopus 로고    scopus 로고
    • BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo
    • DOI 10.1182/blood-2005-04-1595
    • Erlacher, M., Michalak, E.M., Kelly, P.N., Labi, V., Niederegger, H., Coultas, L., Adams, J.M., Strasser, A. Villunger, A. (2005) BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood, 106, 4131 4138. (Pubitemid 41775918)
    • (2005) Blood , vol.106 , Issue.13 , pp. 4131-4138
    • Erlacher, M.1    Michalak, E.M.2    Kelly, P.N.3    Labi, V.4    Niederegger, H.5    Coultas, L.6    Adams, J.M.7    Strasser, A.8    Villunger, A.9
  • 43
    • 65449133136 scopus 로고    scopus 로고
    • Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance
    • doi
    • Fakler, M., Loder, S., Vogler, M., Schneider, K., Jeremias, I., Debatin, K.M. Fulda, S. 2008) Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance. Blood, doi
    • (2008) Blood
    • Fakler, M.1    Loder, S.2    Vogler, M.3    Schneider, K.4    Jeremias, I.5    Debatin, K.M.6    Fulda, S.7
  • 45
    • 33746886979 scopus 로고    scopus 로고
    • Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    • DOI 10.1038/sj.onc.1209608, PII 1209608
    • Fulda, S. Debatin, K.M. (2006) Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene, 25, 4798 4811. (Pubitemid 44187627)
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4798-4811
    • Fulda, S.1    Debatin, K.-M.2
  • 46
    • 0036341291 scopus 로고    scopus 로고
    • Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
    • Fulda, S., Wick, W., Weller, M. Debatin, K.M. (2002) Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nature Medicine, 8, 808 815.
    • (2002) Nature Medicine , vol.8 , pp. 808-815
    • Fulda, S.1    Wick, W.2    Weller, M.3    Debatin, K.M.4
  • 48
    • 33746895175 scopus 로고    scopus 로고
    • Mitochondria as therapeutic targets for cancer chemotherapy
    • DOI 10.1038/sj.onc.1209598, PII 1209598
    • Galluzzi, L., Larochette, N., Zamzami, N. Kroemer, G. (2006) Mitochondria as therapeutic targets for cancer chemotherapy. Oncogene, 25, 4812 4830. (Pubitemid 44192089)
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4812-4830
    • Galluzzi, L.1    Larochette, N.2    Zamzami, N.3    Kroemer, G.4
  • 49
    • 0032717188 scopus 로고    scopus 로고
    • TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells
    • Gazitt, Y. (1999) TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells. Leukemia, 13, 1817 1824. (Pubitemid 29535266)
    • (1999) Leukemia , vol.13 , Issue.11 , pp. 1817-1824
    • Gazitt, Y.1
  • 50
    • 24944458177 scopus 로고    scopus 로고
    • Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: Induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death
    • DOI 10.1111/j.1365-2141.2005.05656.x
    • Georgakis, G.V., Li, Y., Humphreys, R., Andreeff, M., O'Brien, S., Younes, M., Carbone, A., Albert, V. Younes, A. (2005) Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death. British Journal of Haematology, 130, 501 510. (Pubitemid 43899752)
    • (2005) British Journal of Haematology , vol.130 , Issue.4 , pp. 501-510
    • Georgakis, G.V.1    Li, Y.2    Humphreys, R.3    Andreeff, M.4    O'Brien, S.5    Younes, M.6    Carbone, A.7    Albert, V.8    Younes, A.9
  • 52
    • 11144358387 scopus 로고    scopus 로고
    • Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/ Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells
    • DOI 10.1158/0008-5472.CAN-03-2629
    • Guo, F., Sigua, C., Tao, J., Bali, P., George, P., Li, Y., Wittmann, S., Moscinski, L., Atadja, P. Bhalla, K. (2004) Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells. Cancer Research, 64, 2580 2589. (Pubitemid 38523916)
    • (2004) Cancer Research , vol.64 , Issue.7 , pp. 2580-2589
    • Guo, F.1    Sigua, C.2    Tao, J.3    Bali, P.4    George, P.5    Li, Y.6    Wittmann, S.7    Moscinski, L.8    Atadja, P.9    Bhalla, K.10
  • 53
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D. Weinberg, R.A. (2000) The hallmarks of cancer. Cell, 100, 57 70. (Pubitemid 30046295)
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 54
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner, M.O. (2000) The biochemistry of apoptosis. Nature, 407, 770 776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 56
    • 0034698053 scopus 로고    scopus 로고
    • Activation of NF-kappaB by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1
    • DOI 10.1074/jbc.M910346199
    • Hofer-Warbinek, R., Schmid, J.A., Stehlik, C., Binder, B.R., Lipp, J. de Martin, R. (2000) Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1. Journal of Biological Chemistry, 275, 22064 22068. (Pubitemid 30621784)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.29 , pp. 22064-22068
    • Hofer-Warbinek, R.1    Schmid, J.A.2    Stehlik, C.3    Binder, B.R.4    Lipp, J.5    De Martin, R.6
  • 57
    • 0033560819 scopus 로고    scopus 로고
    • Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia
    • Hogarth, L.A. Hall, A.G. (1999) Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia. Blood, 93, 2671 2678. (Pubitemid 29181200)
    • (1999) Blood , vol.93 , Issue.8 , pp. 2671-2678
    • Hogarth, L.A.1    Hall, A.G.2
  • 58
    • 30444446961 scopus 로고    scopus 로고
    • The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia
    • DOI 10.1182/blood-2005-07-2930
    • Holleman, A., den Boer, M.L., de Menezes, R.X., Cheok, M.H., Cheng, C., Kazemier, K.M., Janka-Schaub, G.E., Gobel, U., Graubner, U.B., Evans, W.E. Pieters, R. (2006) The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia. Blood, 107, 769 776. (Pubitemid 43076404)
    • (2006) Blood , vol.107 , Issue.2 , pp. 769-776
    • Holleman, A.1    Den Boer, M.L.2    De Menezes, R.X.3    Cheok, M.H.4    Cheng, C.5    Kazemier, K.M.6    Janka-Schaub, G.E.7    Gobel, U.8    Graubner, U.B.9    Evans, W.E.10    Pieters, R.11
  • 59
    • 0035831022 scopus 로고    scopus 로고
    • Structural basis of caspase inhibition by XIAP: Differential roles of the linker versus the BIR domain
    • Huang, Y., Park, Y.C., Rich, R.L., Segal, D., Myszka, D.G. Wu, H. (2001) Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell, 104, 781 790. (Pubitemid 32241027)
    • (2001) Cell , vol.104 , Issue.5 , pp. 781-790
    • Huang, Y.1    Park, Y.C.2    Rich, R.L.3    Segal, D.4    Myszka, D.G.5    Wu, H.6
  • 61
    • 34547126428 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) as cancer targets
    • Hunter, A.M., LaCasse, E.C. Korneluk, R.G. (2007) The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis, 12, 1543 1568.
    • (2007) Apoptosis , vol.12 , pp. 1543-1568
    • Hunter, A.M.1    Lacasse, E.C.2    Korneluk, R.G.3
  • 62
    • 12744261484 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies
    • Inoue, S., MacFarlane, M., Harper, N., Wheat, L.M., Dyer, M.J. Cohen, G.M. (2004) Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies. Cell Death and Differentiation, 11 (Suppl. 2 S193 S206.
    • (2004) Cell Death and Differentiation , vol.11 , Issue.SUPPL. 2
    • Inoue, S.1    MacFarlane, M.2    Harper, N.3    Wheat, L.M.4    Dyer, M.J.5    Cohen, G.M.6
  • 63
    • 33746144518 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase class i but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
    • DOI 10.1158/0008-5472.CAN-05-4563
    • Inoue, S., Mai, A., Dyer, M.J.S. Cohen, G.M. (2006) Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Research, 66, 6785 6792. (Pubitemid 44085638)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6785-6792
    • Inoue, S.1    Mai, A.2    Dyer, M.J.S.3    Cohen, G.M.4
  • 64
    • 42349095198 scopus 로고    scopus 로고
    • Downregulation of Mcl-1 potentiates HDACi-mediated apoptosis in leukemic cells
    • Inoue, S., Walewska, R., Dyer, M.J.S. Cohen, G.M. (2008) Downregulation of Mcl-1 potentiates HDACi-mediated apoptosis in leukemic cells. Leukemia, 22, 819 825.
    • (2008) Leukemia , vol.22 , pp. 819-825
    • Inoue, S.1    Walewska, R.2    Dyer, M.J.S.3    Cohen, G.M.4
  • 66
    • 0037169358 scopus 로고    scopus 로고
    • Apoptosis: A link between cancer genetics and chemotherapy
    • DOI 10.1016/S0092-8674(02)00625-6
    • Johnstone, R.W., Ruefli, A.A. Lowe, S.W. (2002) Apoptosis: a link between cancer genetics and chemotherapy. Cell, 108, 153 164. (Pubitemid 34161136)
    • (2002) Cell , vol.108 , Issue.2 , pp. 153-164
    • Johnstone, R.W.1    Ruefli, A.A.2    Lowe, S.W.3
  • 68
    • 34548814971 scopus 로고    scopus 로고
    • Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
    • DOI 10.1182/blood-2007-03-080325
    • Kang, M.H., Kang, Y.H., Szymanska, B., Wilczynska-Kalak, U., Sheard, M.A., Harned, T.M., Lock, R.B. Reynolds, C.P. (2007) Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo. Blood, 110, 2057 2066. (Pubitemid 47443923)
    • (2007) Blood , vol.110 , Issue.6 , pp. 2057-2066
    • Kang, M.H.1    Kang, H.K.2    Szymanska, B.3    Wilczynska-Kalak, U.4    Sheard, M.A.5    Harned, T.M.6    Lock, R.B.7    Reynolds, C.P.8
  • 69
    • 43149117910 scopus 로고    scopus 로고
    • Mechanism of synergy of N-(4-hydroxyphenyl) retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation
    • Kang, M.H., Wan, Z., Kang, Y.H., Sposto, R. Reynolds, C.P. (2008) Mechanism of synergy of N-(4-hydroxyphenyl) retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation. Journal of the National Cancer Institute, 100, 580 595.
    • (2008) Journal of the National Cancer Institute , vol.100 , pp. 580-595
    • Kang, M.H.1    Wan, Z.2    Kang, Y.H.3    Sposto, R.4    Reynolds, C.P.5
  • 72
    • 0035793557 scopus 로고    scopus 로고
    • Livin, a Novel Inhibitor of Apoptosis Protein Family Member
    • DOI 10.1074/jbc.M003670200
    • Kasof, G.M. Gomes, B.C. (2001) Livin, a novel inhibitor of apoptosis protein family member. Journal of Biological Chemistry, 276, 3238 3246. (Pubitemid 37411617)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.5 , pp. 3238-3246
    • Kasof, G.M.1    Gomes, B.C.2
  • 73
    • 34250770481 scopus 로고    scopus 로고
    • ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells
    • DOI 10.1038/sj.leu.2404719, PII 2404719
    • Kline, M.P., Rajkumar, S.V., Timm, M.M., Kimlinger, T.K., Haug, J.L., Lust, J.A., Greipp, P.R. Kumar, S. (2007) ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells. Leukemia, 21, 1549 1560. (Pubitemid 46965297)
    • (2007) Leukemia , vol.21 , Issue.7 , pp. 1549-1560
    • Kline, M.P.1    Rajkumar, S.V.2    Timm, M.M.3    Kimlinger, T.K.4    Haug, J.L.5    Lust, J.A.6    Greipp, P.R.7    Kumar, S.8
  • 76
    • 33845977959 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in cell death
    • DOI 10.1152/physrev.00013.2006
    • Kroemer, G., Galluzzi, L. Brenner, C. (2007) Mitochondrial membrane permeabilization in cell death. Physiological Reviews, 87, 99 163. (Pubitemid 46209992)
    • (2007) Physiological Reviews , vol.87 , Issue.1 , pp. 99-163
    • Kroemer, G.1    Galluzzi, L.2    Brenner, C.3
  • 81
    • 14044278251 scopus 로고    scopus 로고
    • Death receptor signaling
    • DOI 10.1242/jcs.01610
    • Lavrik, I., Golks, A. Krammer, P.H. (2005) Death receptor signaling. Journal of Cell Science, 118, 265 267. (Pubitemid 40277339)
    • (2005) Journal of Cell Science , vol.118 , Issue.2 , pp. 265-267
    • Lavrik, I.1    Golks, A.2    Krammer, P.H.3
  • 82
    • 0037273848 scopus 로고    scopus 로고
    • Apo2L/TRAIL and its death and decoy receptors
    • DOI 10.1038/sj.cdd.4401187
    • LeBlanc, H.N. Ashkenazi, A. (2003) Apo2L/TRAIL and its death and decoy receptors. Cell Death and Differentiation, 10, 66 75. (Pubitemid 36511833)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.1 , pp. 66-75
    • Leblanc, H.N.1    Ashkenazi, A.2
  • 83
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • DOI 10.1016/S1535-6108(02)00127-7
    • Letai, A., Bassik, M.C., Walensky, L.D., Sorcinelli, M.D., Weiler, S. Korsmeyer, S.J. (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell, 2, 183 192. (Pubitemid 41043974)
    • (2002) Cancer Cell , vol.2 , Issue.3 , pp. 183-192
    • Letai, A.1    Bassik, M.C.2    Walensky, L.D.3    Sorcinelli, M.D.4    Weiler, S.5    Korsmeyer, S.J.6
  • 84
    • 0035895597 scopus 로고    scopus 로고
    • XIAP induces cell-cycle arrest and activates nuclear factor-kappaB: New survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells
    • Levkau, B., Garton, K.J., Ferri, N., Kloke, K., Nofer, J.R., Baba, H.A., Raines, E.W. Breithardt, G. (2001) xIAP induces cell-cycle arrest and activates nuclear factor-kappaB: new survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells. Circulation Research, 88, 282 290. (Pubitemid 32173751)
    • (2001) Circulation Research , vol.88 , Issue.3 , pp. 282-290
    • Levkau, B.1    Garton, K.J.2    Ferri, N.3    Kloke, K.4    Nofer, J.-R.5    Baba, H.A.6    Raines, E.W.7    Breithardt, G.8
  • 85
    • 1542335506 scopus 로고    scopus 로고
    • Uncoupling of the Signaling and Caspase-inhibitory Properties of X-linked Inhibitor of Apoptosis
    • DOI 10.1074/jbc.M312891200
    • Lewis, J., Burstein, E., Reffey, S.B., Bratton, S.B., Roberts, A.B. Duckett, C.S. (2004) Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis. Journal of Biological Chemistry, 279, 9023 9029. (Pubitemid 38295965)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.10 , pp. 9023-9029
    • Lewis, J.1    Burstein, E.2    Reffey, S.B.3    Bratton, S.B.4    Roberts, A.B.5    Duckett, C.S.6
  • 86
    • 4444243683 scopus 로고    scopus 로고
    • A small molecule smac mimic potentiates TRAIL- and TNFalpha-mediated cell death
    • DOI 10.1126/science.1098231
    • Li, L., Thomas, R.M., Suzuki, H., De Brabander, J.K., Wang, X. Harran, P.G. (2004) A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science, 305, 1471 1474. (Pubitemid 39167668)
    • (2004) Science , vol.305 , Issue.5689 , pp. 1471-1474
    • Li, L.1    Thomas, R.M.2    Suzuki, H.3    De Brabander, J.K.4    Wang, X.5    Harran, P.G.6
  • 88
    • 34249996230 scopus 로고    scopus 로고
    • L inhibitor ABT-737
    • DOI 10.1038/sj.onc.1210166, PII 1210166
    • Lin, X., Morgan-Lappe, S., Huang, X., Li, L., Zakula, D.M., Vernetti, L.A., Fesik, S.W. Shen, Y. (2007) 'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737. Oncogene, 26, 3972 3979. (Pubitemid 46884293)
    • (2007) Oncogene , vol.26 , Issue.27 , pp. 3972-3979
    • Lin, X.1    Morgan-Lappe, S.2    Huang, X.3    Li, L.4    Zakula, D.M.5    Vernetti, L.A.6    Fesik, S.W.7    Shen, Y.8
  • 89
    • 0034899005 scopus 로고    scopus 로고
    • Additive effect of Apo2L/TRAIL and Adeno-p53 in the induction of apoptosis in myeloma cell lines
    • DOI 10.1016/S0301-472X(01)00677-4, PII S0301472X01006774
    • Liu, Q., El-Deiry, W.S. Gazitt, Y. (2001) Additive effect of Apo2L/TRAIL and Adeno-p53 in the induction of apoptosis in myeloma cell lines. Experimental Hematology, 29, 962 970. (Pubitemid 32725794)
    • (2001) Experimental Hematology , vol.29 , Issue.8 , pp. 962-970
    • Liu, Q.1    El-Deiry, W.S.2    Gazitt, Y.3
  • 91
    • 34249799878 scopus 로고    scopus 로고
    • XIAP Induces NF-kappaB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization
    • DOI 10.1016/j.molcel.2007.05.006, PII S1097276507002870
    • Lu, M., Lin, S.-C., Huang, Y., Kang, Y.J., Rich, R., Lo, Y.-C., Myszka, D., Han, J. Wu, H. (2007) XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Molecular Cell, 26, 689 702. (Pubitemid 46856243)
    • (2007) Molecular Cell , vol.26 , Issue.5 , pp. 689-702
    • Lu, M.1    Lin, S.-C.2    Huang, Y.3    Kang, Y.J.4    Rich, R.5    Lo, Y.-C.6    Myszka, D.7    Han, J.8    Wu, H.9
  • 94
    • 3242804413 scopus 로고    scopus 로고
    • Biology of chronic myelogenous leukemia - Signaling pathways of initiation and transformation
    • DOI 10.1016/j.hoc.2004.03.008, PII S0889858804000139
    • Melo, J.V. Deininger, M.W.N. (2004) Biology of chronic myelogenous leukemia - signaling pathways of initiation and transformation. Hematology - Oncology Clinics of North America, 18, 545 568. (Pubitemid 38969131)
    • (2004) Hematology/Oncology Clinics of North America , vol.18 , Issue.3 , pp. 545-568
    • Melo, J.V.1    Deininger, M.W.N.2
  • 96
    • 0035437171 scopus 로고    scopus 로고
    • TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic applications
    • Mitsiades, C.S., Treon, S.P., Mitsiades, N., Shima, Y., Richardson, P., Schlossman, R., Hideshima, T. Anderson, K.C. (2001) TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. Blood, 98, 795 804.
    • (2001) Blood , vol.98 , pp. 795-804
    • Mitsiades, C.S.1    Treon, S.P.2    Mitsiades, N.3    Shima, Y.4    Richardson, P.5    Schlossman, R.6    Hideshima, T.7    Anderson, K.C.8
  • 97
    • 0141954004 scopus 로고    scopus 로고
    • Caspase-mediated cleavage converts livin from an antiapoptotic to a proapoptotic factor: Implications for drug-resistant melanoma
    • Nachmias, B., Ashhab, Y., Bucholtz, V., Drize, O., Kadouri, L., Lotem, M., Peretz, T., Mandelboim, O. Ben-Yehuda, D. (2003) Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanoma. Cancer Research, 63, 6340 6349. (Pubitemid 37255182)
    • (2003) Cancer Research , vol.63 , Issue.19 , pp. 6340-6349
    • Nachmias, B.1    Ashhab, Y.2    Bucholtz, V.3    Drize, O.4    Kadouri, L.5    Lotem, M.6    Peretz, T.7    Mandelboim, O.8    Ben-Yehuda, D.9
  • 98
    • 4344666663 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
    • DOI 10.1038/sj.onc.1207830
    • Nakata, S., Yoshida, T., Horinaka, M., Shiraishi, T., Wakada, M. Sakai, T. (2004) Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells. Oncogene, 23, 6261 6271. (Pubitemid 39215296)
    • (2004) Oncogene , vol.23 , Issue.37 , pp. 6261-6271
    • Nakata, S.1    Yoshida, T.2    Horinaka, M.3    Shiraishi, T.4    Wakada, M.5    Sakai, T.6
  • 99
    • 33947166799 scopus 로고    scopus 로고
    • Expression of apoptosis regulators Bcl-2 and Bax in childhood acute lymphoblastic leukemia
    • DOI 10.1080/10245330600938125, PII 772840059
    • Narayan, S., Chandra, J., Sharma, M., Naithani, R. Sharma, S. (2007) Expression of apoptosis regulators Bcl-2 and Bax in childhood acute lymphoblastic leukemia. Hematology, 12, 39 43. (Pubitemid 46394868)
    • (2007) Hematology , vol.12 , Issue.1 , pp. 39-43
    • Narayan, S.1    Chandra, J.2    Sharma, M.3    Naithani, R.4    Sharma, S.5
  • 101
    • 34047217206 scopus 로고    scopus 로고
    • Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia
    • DOI 10.1200/JCO.2006.07.1191
    • O'Brien, S., Moore, J.O., Boyd, T.E., Larratt, L.M., Skotnicki, A., Koziner, B., Chanan-Khan, A.A., Seymour, J.F., Bociek, R.G., Pavletic, S. Rai, K.R. (2007) Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. Journal of Clinical Oncology, 25, 1114 1120. (Pubitemid 46596764)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.9 , pp. 1114-1120
    • O'Brien, S.1    Moore, J.O.2    Boyd, T.E.3    Larratt, L.M.4    Skotnicki, A.5    Koziner, B.6    Chanan-Khan, A.A.7    Seymour, J.F.8    Bociek, R.G.9    Pavletic, S.10    Rai, K.R.11
  • 102
    • 35348887715 scopus 로고    scopus 로고
    • Mechanisms of transcription factor deregulation in lymphoid cell transformation
    • DOI 10.1038/sj.onc.1210766, PII 1210766
    • O'Neil, J. Look, A.T. (2007) Mechanisms of transcription factor deregulation in lymphoid cell transformation. Oncogene, 26, 6838 6849. (Pubitemid 47585107)
    • (2007) Oncogene , vol.26 , Issue.47 , pp. 6838-6849
    • O'Neil, J.1    Look, A.T.2
  • 103
    • 3543092021 scopus 로고    scopus 로고
    • Pathways of apoptotic and non-apoptotic death in tumour cells
    • Okada, H. Mak, T.W. (2004) Pathways of apoptotic and non-apoptotic death in tumour cells. Nature Reviews Cancer, 4, 592 603. (Pubitemid 39025054)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.8 , pp. 592-603
    • Okada, H.1    Mak, T.W.2
  • 104
    • 0035195486 scopus 로고    scopus 로고
    • Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D
    • Olsson, A., Diaz, T., Aguilar-Santelises, M., Osterborg, A., Celsing, F., Jondal, M. Osorio, L.M. (2001) Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D. Leukemia, 15, 1868 1877. (Pubitemid 33114993)
    • (2001) Leukemia , vol.15 , Issue.12 , pp. 1868-1877
    • Olsson, A.1    Diaz, T.2    Aguilar-Santelises, M.3    Osterborg, A.4    Celsing, F.5    Jondal, M.6    Osorio, L.M.7
  • 108
    • 51649115498 scopus 로고    scopus 로고
    • BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells
    • Perez-Galan, P., Roue, G., Lopez-Guerra, M., Nguyen, M., Villamor, N., Montserrat, E., Shore, G.C., Campo, E. Colomer, D. (2008) BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells. Leukemia, 22, 1712 1720.
    • (2008) Leukemia , vol.22 , pp. 1712-1720
    • Perez-Galan, P.1    Roue, G.2    Lopez-Guerra, M.3    Nguyen, M.4    Villamor, N.5    Montserrat, E.6    Shore, G.C.7    Campo, E.8    Colomer, D.9
  • 109
    • 35948994157 scopus 로고    scopus 로고
    • Autocrine TNFalpha Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis
    • DOI 10.1016/j.ccr.2007.08.029, PII S1535610807002619
    • Petersen, S.L., Wang, L., Yalcin-Chin, A., Li, L., Peyton, M., Minna, J., Harran, P. Wang, X. (2007) Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell, 12, 445 456. (Pubitemid 350064365)
    • (2007) Cancer Cell , vol.12 , Issue.5 , pp. 445-456
    • Petersen, S.L.1    Wang, L.2    Yalcin-Chin, A.3    Li, L.4    Peyton, M.5    Minna, J.6    Harran, P.7    Wang, X.8
  • 110
    • 0037226583 scopus 로고    scopus 로고
    • Role of apical caspases and glucocorticoid-regulated genes in glucocorticoid-induced apoptosis of pre-B leukemic cells
    • Planey, S.L., Abrams, M.T., Robertson, N.M. Litwack, G. (2003) Role of apical caspases and glucocorticoid-regulated genes in glucocorticoid-induced apoptosis of pre-B leukemic cells. Cancer Research, 63, 172 178. (Pubitemid 36070437)
    • (2003) Cancer Research , vol.63 , Issue.1 , pp. 172-178
    • Planey, S.L.1    Abrams, M.T.2    Robertson, N.M.3    Litwack, G.4
  • 111
    • 85009895235 scopus 로고    scopus 로고
    • TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors
    • DOI 10.1038/sj/leu/2402338
    • Plasilova, M., Zivny, J., Jelinek, J., Neuwirtova, R., Cermak, J., Necas, E., Andera, L. Stopka, T. (2002) TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. Leukemia, 16, 67 73. (Pubitemid 34105601)
    • (2002) Leukemia , vol.16 , Issue.1 , pp. 67-73
    • Plasilova, M.1    Zivny, J.2    Jelinek, J.3    Neuwirtova, R.4    Cermak, J.5    Necas, E.6    Andera, L.7    Stopka, T.8
  • 112
    • 0033832590 scopus 로고    scopus 로고
    • Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo
    • Prokop, A., Wieder, T., Sturm, I., Essmann, F., Seeger, K., Wuchter, C., Ludwig, W.D., Henze, G., Dorken, B. Daniel, P.T. (2000) Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo. Leukemia, 14, 1606 1613.
    • (2000) Leukemia , vol.14 , pp. 1606-1613
    • Prokop, A.1    Wieder, T.2    Sturm, I.3    Essmann, F.4    Seeger, K.5    Wuchter, C.6    Ludwig, W.D.7    Henze, G.8    Dorken, B.9    Daniel, P.T.10
  • 114
    • 43549112759 scopus 로고    scopus 로고
    • Bcl-2-family proteins and hematologic malignancies: History and future prospects
    • Reed, J.C. (2008) Bcl-2-family proteins and hematologic malignancies: history and future prospects. Blood, 111, 3322 3330.
    • (2008) Blood , vol.111 , pp. 3322-3330
    • Reed, J.C.1
  • 115
    • 22144460556 scopus 로고    scopus 로고
    • Apoptosis-based therapies for hematologic malignancies
    • DOI 10.1182/blood-2004-07-2761
    • Reed, J.C. Pellecchia, M. (2005) Apoptosis-based therapies for hematologic malignancies. Blood, 106, 408 418. (Pubitemid 40981231)
    • (2005) Blood , vol.106 , Issue.2 , pp. 408-418
    • Reed, J.C.1    Pellecchia, M.2
  • 116
    • 34247345833 scopus 로고    scopus 로고
    • The apoptosome: Signalling platform of cell death
    • DOI 10.1038/nrm2153, PII NRM2153
    • Riedl, S.J. Salvesen, G.S. (2007) The apoptosome: signalling platform of cell death. Nature Reviews Molecular Cell Biology, 8, 405 413. (Pubitemid 46643237)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.5 , pp. 405-413
    • Riedl, S.J.1    Salvesen, G.S.2
  • 118
    • 35148900795 scopus 로고    scopus 로고
    • L down-regulation
    • DOI 10.1158/0008-5472.CAN-07-0598
    • Rosato, R.R., Almenara, J.A., Coe, S. Grant, S. (2007) The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation. Cancer Research, 67, 9490 9500. (Pubitemid 47535939)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 9490-9500
    • Rosato, R.R.1    Almenara, J.A.2    Coe, S.3    Grant, S.4
  • 119
    • 55249116841 scopus 로고    scopus 로고
    • Chromosomal translocations: Revisited yet again
    • Rowley, J.D. (2008) Chromosomal translocations: revisited yet again. Blood, 112, 2183 2189.
    • (2008) Blood , vol.112 , pp. 2183-2189
    • Rowley, J.D.1
  • 121
    • 0032847005 scopus 로고    scopus 로고
    • Bcl-2 family members in childhood acute lymphoblastic leukemia: Relationships with features at presentation, in vitro and in vivo drug response and long-term clinical outcome
    • Salomons, G.S., Smets, L.A., Verwijs-Janssen, M., Hart, A.A., Haarman, E.G., Kaspers, G.J., Wering, E.V., Der Does-Van Den Berg, A.V. Kamps, W.A. (1999) Bcl-2 family members in childhood acute lymphoblastic leukemia: relationships with features at presentation, in vitro and in vivo drug response and long-term clinical outcome. Leukemia, 13, 1574 1580. (Pubitemid 29465620)
    • (1999) Leukemia , vol.13 , Issue.10 , pp. 1574-1580
    • Salomons, G.S.1    Smets, L.A.2    Verwijs-Janssen, M.3    Hart, A.A.M.4    Haarman, E.G.5    Kaspers, G.J.L.6    Van Wering, E.R.7    Van Derdoes-Vanden Berg, A.8    Kamps, W.A.9
  • 122
    • 0036088471 scopus 로고    scopus 로고
    • IAP proteins: Blocking the road to death's door
    • DOI 10.1038/nrm830
    • Salvesen, G.S. Duckett, C.S. (2002) IAP proteins: blocking the road to death's door. Nature Reviews Molecular Cell Biology, 3, 401 410. (Pubitemid 34685698)
    • (2002) Nature Reviews Molecular Cell Biology , vol.3 , Issue.6 , pp. 401-410
    • Salvesen, G.S.1    Duckett, C.S.2
  • 125
    • 40749106485 scopus 로고    scopus 로고
    • Apoptosis in leukemia: From molecular pathways to targeted therapies
    • Schimmer, A.D. (2008) Apoptosis in leukemia: from molecular pathways to targeted therapies. Bailliere's Best Practice in Clinical Haematology, 21, 5 11.
    • (2008) Bailliere's Best Practice in Clinical Haematology , vol.21 , pp. 5-11
    • Schimmer, A.D.1
  • 129
    • 4344691959 scopus 로고    scopus 로고
    • Caspases, IAPs and Smac/DIABLO: Mechanisms from structural biology
    • DOI 10.1016/j.tibs.2004.07.003, PII S0968000404001744
    • Shiozaki, E.N. Shi, Y. (2004) Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology. Trends in Biochemical Sciences, 29, 486 494. (Pubitemid 39158872)
    • (2004) Trends in Biochemical Sciences , vol.29 , Issue.9 , pp. 486-494
    • Shiozaki, E.N.1    Shi, Y.2
  • 133
    • 0037663452 scopus 로고    scopus 로고
    • Direct interaction between Survivin and Smac/DIABLO is essential for the anti-apoptotic activity of Survivin during Taxol-induced apoptosis
    • DOI 10.1074/jbc.M300957200
    • Song, Z., Yao, X. Wu, M. (2003) Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. Journal of Biological Chemistry, 278, 23130 23140. (Pubitemid 36830379)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.25 , pp. 23130-23140
    • Song, Z.1    Yao, X.2    Wu, M.3
  • 136
    • 3843086358 scopus 로고    scopus 로고
    • Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site
    • DOI 10.1021/jm0499108
    • Sun, H., Nikolovska-Coleska, Z., Yang, C.Y., Xu, L., Tomita, Y., Krajewski, K., Roller, P.P. Wang, S. (2004b) Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site. Journal of Medicinal Chemistry, 47, 4147 4150. (Pubitemid 39045419)
    • (2004) Journal of Medicinal Chemistry , vol.47 , Issue.17 , pp. 4147-4150
    • Sun, H.1    Nikolovska-Coleska, Z.2    Yang, C.-Y.3    Xu, L.4    Tomita, Y.5    Krajewski, K.6    Roller, P.P.7    Wang, S.8
  • 137
    • 33845919012 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic
    • DOI 10.1021/jm061108d
    • Sun, H., Nikolovska-Coleska, Z., Lu, J., Qiu, S., Yang, C.Y., Gao, W., Meagher, J., Stuckey, J. Wang, S. (2006) Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic. Journal of Medicinal Chemistry, 49, 7916 7920. (Pubitemid 46033683)
    • (2006) Journal of Medicinal Chemistry , vol.49 , Issue.26 , pp. 7916-7920
    • Sun, H.1    Nikolovska-Coleska, Z.2    Lu, J.3    Qiu, S.4    Yang, C.-Y.5    Gao, W.6    Meagher, J.7    Stuckey, J.8    Wang, S.9
  • 138
    • 58549089682 scopus 로고    scopus 로고
    • Bcl-2 antisense oligonucleotide inhibits the proliferation of childhood leukemia/lymphoma cells of the B-cell lineage
    • Szegedi, I., Katona, K., Horvath, A., Molnar, A., Aradi, J. Kiss, C. (2008) Bcl-2 antisense oligonucleotide inhibits the proliferation of childhood leukemia/lymphoma cells of the B-cell lineage. Pathology Oncology Research, 14, 275 279.
    • (2008) Pathology Oncology Research , vol.14 , pp. 275-279
    • Szegedi, I.1    Katona, K.2    Horvath, A.3    Molnar, A.4    Aradi, J.5    Kiss, C.6
  • 140
    • 2542549018 scopus 로고    scopus 로고
    • High expression levels of X-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia
    • DOI 10.1158/1078-0432.CCR-03-0642
    • Tamm, I., Richter, S., Oltersdorf, D., Creutzig, U., Harbott, J., Scholz, F., Karawajew, L., Ludwig, W.-D. Wuchter, C. (2004) High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia. Clinical Cancer Research, 10, 3737 3744. (Pubitemid 38697607)
    • (2004) Clinical Cancer Research , vol.10 , Issue.11 , pp. 3737-3744
    • Tamm, I.1    Richter, S.2    Oltersdorf, D.3    Creutzig, U.4    Harbott, J.5    Scholz, F.6    Karawajew, L.7    Ludwig, W.-D.8    Wuchter, C.9
  • 141
    • 33745239599 scopus 로고    scopus 로고
    • Recent advances in targeting regulators of apoptosis in cancer cells for therapeutic gain
    • DOI 10.1517/13543784.15.6.669
    • Taylor, K., Micha, D., Ranson, M. Dive, C. (2006) Recent advances in targeting regulators of apoptosis in cancer cells for therapeutic gain. Expert Opinion on Investigational Drugs, 15, 669 690. (Pubitemid 43919302)
    • (2006) Expert Opinion on Investigational Drugs , vol.15 , Issue.6 , pp. 669-690
    • Taylor, K.1    Micha, D.2    Ranson, M.3    Dive, C.4
  • 142
    • 26044462215 scopus 로고    scopus 로고
    • Targeting Bcl-2 protein expression in solid tumors and hematologic malignancies with antisense oligonucleotides
    • Tolcher, A.W. (2005) Targeting Bcl-2 protein expression in solid tumors and hematologic malignancies with antisense oligonucleotides. Clinical Advances in Hematology and Oncology, 3, 635 642. (Pubitemid 41403805)
    • (2005) Clinical Advances in Hematology and Oncology , vol.3 , Issue.8
    • Tolcher, A.W.1
  • 143
    • 34248187996 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
    • DOI 10.1200/JCO.2006.08.8898
    • Tolcher, A.W., Mita, M., Meropol, N.J., von Mehren, M., Patnaik, A., Padavic, K., Hill, M., Mays, T., McCoy, T., Fox, N.L., Halpern, W., Corey, A. Cohen, R.B. (2007) Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. Journal of Clinical Oncology, 25, 1390 1395. (Pubitemid 46706887)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.11 , pp. 1390-1395
    • Tolcher, A.W.1    Mita, M.2    Meropol, N.J.3    Von Mehren, M.4    Patnaik, A.5    Padavic, K.6    Hill, M.7    Mays, T.8    McCoy, T.9    Fox, N.L.10    Halpern, W.11    Corey, A.12    Cohen, R.B.13
  • 146
    • 34447096461 scopus 로고    scopus 로고
    • HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway
    • DOI 10.1016/j.biocel.2007.03.009, PII S1357272507000866
    • Tsapis, M., Lieb, M., Manzo, F., Shankaranarayanan, P., Herbrecht, R., Lutz, P. Gronemeyer, H. (2007) HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway. International Journal of Biochemistry and Cell Biology, 39, 1500 1509. (Pubitemid 47031039)
    • (2007) International Journal of Biochemistry and Cell Biology , vol.39 , Issue.7-8 , pp. 1500-1509
    • Tsapis, M.1    Lieb, M.2    Manzo, F.3    Shankaranarayanan, P.4    Herbrecht, R.5    Lutz, P.6    Gronemeyer, H.7
  • 150
    • 17144377113 scopus 로고    scopus 로고
    • IAPs, RINGs and ubiquitylation
    • DOI 10.1038/nrm1621
    • Vaux, D.L. Silke, J. (2005) IAPs, RINGs and ubiquitylation. Nature Reviews Molecular Cell Biology, 6, 287 297. (Pubitemid 40516895)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.4 , pp. 287-297
    • Vaux, D.L.1    Silke, J.2
  • 153
    • 42149113415 scopus 로고    scopus 로고
    • A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells
    • Vogler, M., Dinsdale, D., Sun, X.M., Young, K.W., Butterworth, M., Nicotera, P., Dyer, M.J.S. Cohen, G.M. (2008) A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells. Cell Death and Differentiation, 15, 820 830.
    • (2008) Cell Death and Differentiation , vol.15 , pp. 820-830
    • Vogler, M.1    Dinsdale, D.2    Sun, X.M.3    Young, K.W.4    Butterworth, M.5    Nicotera, P.6    Dyer, M.J.S.7    Cohen, G.M.8
  • 154
    • 0034597630 scopus 로고    scopus 로고
    • ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas
    • Vucic, D., Stennicke, H.R., Pisabarro, M.T., Salvesen, G.S. Dixit, V.M. (2000) ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas. Current Biology, 10, 1359 1366.
    • (2000) Current Biology , vol.10 , pp. 1359-1366
    • Vucic, D.1    Stennicke, H.R.2    Pisabarro, M.T.3    Salvesen, G.S.4    Dixit, V.M.5
  • 157
    • 33747516350 scopus 로고    scopus 로고
    • In vivo expression of survivin and its splice variant survivin-2B: Impact on clinical outcome in acute myeloid leukemia
    • DOI 10.1002/ijc.21995
    • Wagner, M., Schmelz, K., Wuchter, C., Ludwig, W.D., Dorken, B. Tamm, I. (2006) In vivo expression of survivin and its splice variant survivin-2B: impact on clinical outcome in acute myeloid leukemia. International Journal of Cancer, 119, 1291 1297. (Pubitemid 44258802)
    • (2006) International Journal of Cancer , vol.119 , Issue.6 , pp. 1291-1297
    • Wagner, M.1    Schmelz, K.2    Wuchter, C.3    Ludwig, W.-D.4    Dorken, B.5    Tamm, I.6
  • 159
    • 0037592259 scopus 로고    scopus 로고
    • Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis
    • DOI 10.1074/jbc.M301843200
    • Wang, Z., Malone, M.H., He, H., McColl, K.S. Distelhorst, C.W. (2003) Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis. Journal of Biological Chemistry, 278, 23861 23867. (Pubitemid 36830212)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.26 , pp. 23861-23867
    • Wang, Z.1    Malone, M.H.2    He, H.3    McColl, K.S.4    Distelhorst, C.W.5
  • 161
    • 0034015672 scopus 로고    scopus 로고
    • Phase i clinical and pharmacokinetic study of Bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma
    • Waters, J.S., Webb, A., Cunningham, D., Clarke, P.A., Raynaud, F., di Stefano, F. Cotter, F.E. (2000) Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma. Journal of Clinical Oncology, 18, 1812 1823. (Pubitemid 30261918)
    • (2000) Journal of Clinical Oncology , vol.18 , Issue.9 , pp. 1812-1823
    • Waters, J.S.1    Webb, A.2    Cunningham, D.3    Clarke, P.A.4    Raynaud, F.5    Di Stefano, F.6    Cotter, F.E.7
  • 166
    • 0034551746 scopus 로고    scopus 로고
    • Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells
    • Wen, J., Ramadevi, N., Nguyen, D., Perkins, C., Worthington, E. Bhalla, K. (2000) Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L-induced apoptosis of human acute leukemia cells. Blood, 96, 3900 3906.
    • (2000) Blood , vol.96 , pp. 3900-3906
    • Wen, J.1    Ramadevi, N.2    Nguyen, D.3    Perkins, C.4    Worthington, E.5    Bhalla, K.6
  • 169
    • 0033886840 scopus 로고    scopus 로고
    • Constitutive expression levels of CD95 and Bcl-2 as well as CD95 function and spontaneous apoptosis in vitro do not predict the response to induction chemotherapy and relapse rate in childhood acute lymphoblastic leukaemia
    • DOI 10.1046/j.1365-2141.2000.02147.x
    • Wuchter, C., Karawajew, L., Ruppert, V., Schrappe, M., Harbott, J., Ratei, R., Dorken, B. Ludwig, W.D. (2000) Constitutive expression levels of CD95 and Bcl-2 as well as CD95 function and spontaneous apoptosis in vitro do not predict the response to induction chemotherapy and relapse rate in childhood acute lymphoblastic leukaemia. British Journal of Haematology, 110, 154 160. (Pubitemid 30625603)
    • (2000) British Journal of Haematology , vol.110 , Issue.1 , pp. 154-160
    • Wuchter, C.1    Karawajew, L.2    Ruppert, V.3    Schrappe, M.4    Harbott, J.5    Ratei, R.6    Dorken, B.7    Ludwig, W.-D.8
  • 170
    • 0142188706 scopus 로고    scopus 로고
    • Coexistence of High Levels of Apoptotic Signaling and Inhibitor of Apoptosis Proteins in Human Tumor Cells: Implication for Cancer Specific Therapy
    • Yang, L., Cao, Z., Yan, H. Wood, W.C. (2003) Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells: implication for cancer specific therapy. Cancer Research, 63, 6815 6824. (Pubitemid 37322964)
    • (2003) Cancer Research , vol.63 , Issue.20 , pp. 6815-6824
    • Yang, L.1    Cao, Z.2    Yan, H.3    Wood, W.C.4
  • 171
    • 33646390886 scopus 로고    scopus 로고
    • Results of a Phase 2 trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed/refractory non-Hodgkin's lymphoma (ETR1-HM01)
    • Younes, A., Vose, J.M. Zelenetz, A.D. (2005) Results of a Phase 2 trial of HGS-ETR1 (agonistic human monoclonal antibody to TRAIL receptor 1) in subjects with relapsed/refractory non-Hodgkin's lymphoma (ETR1-HM01). Blood Abstract, 106, 489.
    • (2005) Blood Abstract , vol.106
    • Younes, A.1    Vose, J.M.2    Zelenetz, A.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.