MEN1 Missense Mutations Impair Sensitization to Apoptosis Induced by Wild-Type Menin in Endocrine Pancreatic Tumor Cells

Gastroenterology

Volumn 135, Issue 5, 2008, Pages

  Bazzi, Wissam ^a,b   Renon, Maud ^a,b   Vercherat, Cécile ^a,b   Hamze, Zeinab ^a,b   Lacheretz Bernigaud, Annie ^a,b   Wang, Hayian ^c   Blanc, Martine ^a,b   Roche, Colette ^a,b   Calender, Alain ^b,d   Chayvialle, Jean Alain ^a,b   Scoazec, Jean Yves ^a,b   Cordier Bussat, Martine ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ LYON 1   (France)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; METHIONINE; PROTEIN P21; PROTEIN P53;

ACETYLATION; APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; GAMMA IRRADIATION; GENE AMPLIFICATION; MISSENSE MUTATION; MULTIPLE ENDOCRINE NEOPLASIA; NONHUMAN; PANCREAS ISLET CELL TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TUMOR CELL;

EID: 55449136054     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.07.031     Document Type: Article

References (27)

1. Marx S., Spiegel A.M., Skarulis M.C., et al. Multiple endocrine neoplasia type 1: clinical and genetic topics. Ann Intern Med 129 (1998) 484-494
2. Chandrasekharappa S.C., Guru S.C., Manickam P., et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276 (1997) 404-407
3. Lemmens I., Van de Ven W.J., Kas K., et al. Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. Hum Mol Genet 6 (1997) 1177-1183
4. Fromaget M., Vercherat C., Zhang C.X., et al. Functional characterization of a promoter region in the human MEN1 tumor suppressor gene. J Mol Biol 333 (2003) 87-102
5. Khodaei-O'Brien S., Zablewska B., Fromaget M., et al. Heterogeneity at the 5'-end of MEN1 transcripts. Biochem Biophys Res Commun 276 (2000) 508-514
6. Yang Y., and Hua X. In search of tumor suppressing functions of menin. Mol Cell Endocrinol 265-266 (2007) 34-41
7. Chandrasekharappa S.C., and Teh B.T. Functional studies of the MEN1 gene. J Intern Med 253 (2003) 606-615
8. Wautot V., Vercherat C., Lespinasse J., et al. Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein. Hum Mutat 20 (2002) 35-47
9. Yaguchi H., Ohkura N., Takahashi M., et al. Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway. Mol Cell Biol 24 (2004) 6569-6580
10. Agarwal S.K., Kester M.B., Debelenko L.V., et al. Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. Hum Mol Genet 6 (1997) 1169-1175
11. Wang H., and Iynedjian P.B. Modulation of glucose responsiveness of insulinoma beta-cells by graded over expression of glucokinase. Proc Natl Acad Sci U S A 94 (1997) 4372-4377
12. Asfari M., Janjic D., Meda P., et al. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130 (1992) 167-178
13. Gossen M., and Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A 89 (1992) 5547-5551
14. Wautot V., Khodaei S., Frapport L., et al. Expression analysis of endogenous menin, the product of the multiple endocrine neoplasia type 1 gene, in cell lines and human tissues. Int J Cancer 85 (2000) 877-881
15. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
16. Kohler M., Zaitsev S.V., Zaitseva I.I., et al. On-line monitoring of apoptosis in insulin-secreting cells. Diabetes 52 (2003) 2943-2950
17. Toledo F., and Wahl G.M. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 6 (2006) 909-923
18. Appella E., and Anderson C.W. Post-translational modifications and activation of p53 by genotoxic stresses. Eur J Biochem 268 (2001) 2764-2772
19. Sayo Y., Murao K., Imachi H., et al. The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cells. Endocrinology 143 (2002) 2437-2440
20. Stalberg P., Grimfjard P., Santesson M., et al. Transfection of the multiple endocrine neoplasia type 1 gene to a human endocrine pancreatic tumor cell line inhibits cell growth and affects expression of JunD, delta-like protein 1/preadipocyte factor-1, proliferating cell nuclear antigen, and QM/Jif-1. J Clin Endocrinol Metab 89 (2004) 2326-2337
21. Dilley W.G., Kalyanaraman S., Verma S., et al. Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome. Mol Cancer 4 (2005) 9
22. Farley S.M., Chen G., Guo S., et al. Menin localizes to chromatin through an ATR-CHK1 mediated pathway after UV-induced DNA damage. J Surg Res 133 (2006) 29-37
23. Jin S., Mao H., Schnepp R.W., et al. Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res 63 (2003) 4204-4210
24. Agarwal S.K., Guru S.C., Heppner C., et al. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 96 (1999) 143-152
25. Balogh K., Racz K., Patocs A., et al. Menin and its interacting proteins: elucidation of menin function. Trends Endocrinol Metab 17 (2006) 357-364
26. Shan L., Nakamura Y., Nakamura M., et al. Somatic mutations of multiple endocrine neoplasia type 1 gene in the sporadic endocrine tumors. Lab Invest 78 (1998) 471-475
27. Zabala M., Wang L., Hernandez-Alcoceba R., et al. Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors. Cancer Res 64 (2004) 2799-2804