Mechanism of Oxygen Activation in a Flavin-Dependent Monooxygenase: A Nearly Barrierless Formation of C4a-Hydroperoxyflavin via Proton-Coupled Electron Transfer

Journal of the American Chemical Society

Volumn 137, Issue 29, 2015, Pages 9363-9374

  Visitsatthawong, Surawit ^a   Chenprakhon, Pirom ^b   Chaiyen, Pimchai ^b   Surawatanawong, Panida ^a  

^a Mahidol University ^*  (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; COMPLEXATION; DENSITY FUNCTIONAL THEORY; ELECTRON TRANSITIONS; ENZYMES; OXYGEN;

ENTHALPY OF ACTIVATION; FLAVIN-DEPENDENT MONOOXYGENASE; INTER-SYSTEM CROSSINGS; OPTIMUM POSITION; OXYGEN ACTIVATIONS; POSITIVELY CHARGED; PROTON COUPLED ELECTRON TRANSFERS; TRANSIENT KINETICS;

HYDROGEN BONDS;

4 HYDROXYPHENYLACETATE 3 HYDROXYLASE; C4A HYDROPEROXYFLAVIN; OXYGEN; OXYGENASE; QUERCETIN; SEMIQUINONE; UNCLASSIFIED DRUG; C4A-HYDROPEROXYFLAVIN; HYDROGEN PEROXIDE; MIXED FUNCTION OXIDASE; PROTON; RIBOFLAVIN DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; DENSITY FUNCTIONAL THEORY; ELECTRON TRANSPORT; ENTHALPY; HYDROGEN BOND; KINETICS; PROTON TRANSPORT; RATE CONSTANT; SITE DIRECTED MUTAGENESIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; METABOLISM; QUANTUM THEORY; TEMPERATURE; THERMODYNAMICS;

CATALYTIC DOMAIN; ELECTRON TRANSPORT; ENZYME ACTIVATION; FLAVINS; HYDROGEN PEROXIDE; KINETICS; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; OXYGEN; PROTONS; QUANTUM THEORY; TEMPERATURE; THERMODYNAMICS;

EID: 84938412624     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b04328     Document Type: Article

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