Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement

Nature

Volumn 503, Issue 7477, 2013, Pages 552-556

  Teufel, Robin ^a   Miyanaga, Akimasa ^a   Michaudel, Quentin ^b   Stull, Frederick ^c   Louie, Gordon ^d   Noel, Joseph P ^d   Baran, Phil S ^b   Palfey, Bruce ^c,e   Moore, Bradley S ^a,f  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; CARBONYL DERIVATIVE; ENTEROCIN; FLAVIN N5 OXIDE; FLAVOENZYME ENCM; FLAVOPROTEIN; POLYKETIDE; POLYKETIDE SYNTHASE; QUERCETIN; UNCLASSIFIED DRUG;

BACTERIUM; BIOCHEMISTRY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; MOLECULAR ANALYSIS; OXIDATION; REDOX CONDITIONS; SUBSTRATE;

ARTICLE; BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; FAVORSKII REARRANGEMENT; ISOTOPE LABELING; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE DEHYDROGENATION; PRIORITY JOURNAL; STREPTOMYCES;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOCATALYSIS; BRIDGED COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; FLAVINS; FLAVOPROTEINS; ISOTOPE LABELING; MIXED FUNCTION OXYGENASES; MODELS, CHEMICAL; MODELS, MOLECULAR; OXIDATION-REDUCTION; POLYKETIDES; PROTEIN CONFORMATION; STREPTOMYCES; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 84888645117     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12643     Document Type: Article

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