Multiple pathways guide oxygen diffusion into flavoenzyme active sites

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 26, 2009, Pages 10603-10608

  Baron, Riccardo ^a   Riley, Conor ^a   Chenprakhon, Pirom ^b   Thotsaporn, Kittisak ^b   Winter, Remko T ^c   Alfieri, Andrea ^d   Forneris, Federico ^d   Van Berkel, Willem J H ^e   Chaiyen, Pimchai ^b   Fraaije, Marco W ^c   Mattevi, Andrea ^d   McCammon, J Andrew ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAHIDOL UNIVERSITY   (Thailand)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d UNIVERSITY OF PAVIA   (Italy)

^e WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Computational biochemistry; Enzymology; Flavin; Oxygen reactivity

Indexed keywords

CARBON; HYDROLASE; OXIDOREDUCTASE; OXYGEN; UNSPECIFIC MONOOXYGENASE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; MOLECULAR DYNAMICS; NONHUMAN; OXYGEN DIFFUSION; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ALCOHOL OXIDOREDUCTASES; CATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DIFFUSION; FLAVINS; FLAVOPROTEINS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES; OXYGEN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STREPTOMYCES COELICOLOR;

EID: 67649819680     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903809106     Document Type: Article

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