Oxygenases: Mechanisms and structural motifs for O2 activation

Current Opinion in Chemical Biology

Volumn 5, Issue 5, 2001, Pages 550-555

  Bugg, Timothy D H ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIOXYGENASE; HEME; IRON; OXYGEN; OXYGENASE; PTERIN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENZYME MECHANISM; ENZYME STRUCTURE; MODEL; PROTEIN MOTIF; REACTION ANALYSIS; REVIEW;

EID: 0035478824     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(00)00236-2     Document Type: Review

References (49)

1. Chemical models and mechanisms for oxygenases
2. Life as aerobes: Are there simple rules for activation of dioxygen by enzymes?
3. One electron at a time oxidations and enzymatic paradigms: From metallic to non-metallic redox centers
4. Activation of molecular oxygen by flavins and flavoproteins
5. The 2-His-1-carboxylate facial triad - An emerging structural motif in mononuclear non-heme iron (II) enzymes
6. Crystal structure and site-specific mutagenesis of pterin-bound human phenylalanine hydroxylase
7. On the catalytic mechanism of tryptophan hydroxylase
8. Phenylalanine hydroxylase from Chromobacterium violaceum. Uncoupled oxidation of tetrahydropterin and the role of iron in hydroxylation
9. An examination of the copper requirement of phenylalanine hydroxylase from Chromobacterium violaceum
10. Evidence for urate hydroperoxide as an intermediate in the urate oxidase reaction
11. Bacterial 2,4-dioxygenases: New members of the α/β hydrolase-fold superfamily of enzymes functionally related to serine hydrolases
12. Site-directed mutagenesis of potential catalytic residues in 1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase, and hypothesis on the catalytic mechanism of 2,4-dioxygenolytic ring cleavage
13. An incredibly fast apparent oxygen rebound rate constant for hydrocarbon hydroxylation by cytochrome P450 enzymes
14. Aliphatic hydroxylation by highly purified liver microsomal cytochrome P450. Evidence for a carbon radical intermediate
15. A non-synchronous concerted mechanism for cytochrome P450 catalyzed hydroxylation
16. Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: Switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4
17. Epoxidation of olefins by cytochrome P450: Evidence from site-directed mutagenesis for hydroperoxo-iron as an electrophilic oxidant
18. Cytochrome P450-catalyzed hydroxylation of mechanistic probes that distinguish between radicals and cations. Evidence for cationic but not for radical intermediates
19. Hypersensitive radical probes and the mechanisms of cytochrome P450-catalysed hydroxylation reactions
20. A model 'rebound' mechanism of hydroxylation by cytochrome P450: Stepwise and effectively concerted pathways, and their reactivity patterns
21. cam at atomic resolution
22. An archetypal extradiol-cleaving dioxygenase: The crystal structure of catechol 2,3-dioxygenase (metapyrochatechase) from Pseudomonas putida mt-2
23. Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading Pseudomonas
24. Crystal structure of an aromatic ring opening dioxygenase LigAB, a protocatechuate 4,5-dioxygenase, under aerobic conditions
25. Crystal structure of human homogentisate dioxygenase
26. Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
27. The 1.8 Å crystal structure of catechol 1,2-dioxygenase reveals a novel hydrophobic helical zipper as a subunit linker
28. Structure and assembly of protocatechuate 3,4-dioxygenase
29. 3+ ligand displacement in response to substrate binding
30. 4
31. A solvolytic C-C cleavage reaction of 6-acetoxy-cyclohexa-2,4-dienones: Mechanistic implications for the intradiol catechol dioxygenases
32. Cis-trans isomerisation of a cyclopropyl radical trap catalyzed by extradiol catechol dioxygenases: Evidence for a semiquinone intermediate
33. Mechanism of extradiol catechol dioxygenases: Evidence for a lactone intermediate in the 2,3-dihydroxyphenylpropionate 1,2-dioxygenase reaction
34. Elucidation of the catalytic mechanisms of the non-haem iron-dependent catechol dioxygenases: Synthesis of carba analogues for hydroperoxide reaction intermediates
35. Dioxygen activation by enzymes with mononuclear non-heme iron active sites
36. Synthesis, characterization, and reactivity of catecholato adducts of iron (III) triazaazamacrocyclic and tetraazaazamacrocyclic complexes. Chemical evidence of the role of the metal ion in the oxidative cleavage
37. III catecholate complexes: Tridentate facial versus meridional ligands
38. A bio-mimetic model reaction for the extradiol catechol dioxygenases
39. Extradiol oxidative cleavage of catechols by ferrous and ferric complexes of 1,4,9-triazacyclononane: Insight into the mechanism of the extradiol catechol dioxygenases
40. Structure of an aromatic ring-hydroxylating dioxygenase- naphthalene dioxygenase
41. Substrate binding site of naphthalene 1,2-dioxygenase: Functional implications of indole binding
42. Benzene-induced uncoupling of naphthalene dioxygenase and enzyme inactivation by production of hydrogen peroxide
43. 2 activation by the oxygenase component of naphthalene 1,2-dioxygenase
44. cis-Dihydroxylation of olefins by a non-heme iron catalyst: A functional model for the Rieske dioxygenases
45. Incorporation of oxygen-18 into benzene by Pseudomonas putida
46. The dioxygenase-catalysed formation of vicinal cis-diols
47. Biosynthesis of the vancomycin group of antibiotics: Involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine
48. Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics
49. Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: An enzyme involved in the tyrosine degradation pathway