Stabilization of C4a-hydroperoxyflavin in a two-component flavin-dependent monooxygenase is achieved through interactions at flavin N5 and C4a Atoms

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 28170-28180

  Thotsaporn, Kittisak ^a   Chenprakhon, Pirom ^a   Sucharitakul, Jeerus ^b   Mattevi, Andrea ^c   Chaiyen, Pimchai ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE MUTANTS; FLAVIN-DEPENDENT MONOOXYGENASE; HYDROXYL GROUPS; OXYGENASES; PH DEPENDENCE; SIDE-CHAINS; SINGLE MUTATION; TRANSIENT KINETICS; TWO-COMPONENT; WILD TYPES; WILD-TYPE ENZYMES;

CRYSTAL STRUCTURE; ENZYMES; OXYGEN; STABILIZATION;

RATE CONSTANTS;

4 HYDROXYPHENYLACETIC ACID 3 HYDROXYLASE; FLAVIN DEPENDENT MONOOXYGENASE; FLAVINE NUCLEOTIDE; HISTIDINE; HYDROGEN PEROXIDE; HYDROPEROXIDE DERIVATIVE; HYDROPEROXYFLAVIN; HYDROXYL GROUP; OXYGEN; SERINE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; ENZYME MECHANISM; ENZYME STRUCTURE; GENE MUTATION; OXIDATION; PH; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STABILITY; ULTRAVIOLET SPECTROSCOPY; WILD TYPE;

ACINETOBACTER BAUMANNII; AMINO ACID SUBSTITUTION; BINDING SITES; FLAVIN MONONUCLEOTIDE; FLAVINS; HYDROGEN PEROXIDE; KINETICS; MIXED FUNCTION OXYGENASES; MUTATION, MISSENSE; OXIDATION-REDUCTION;

EID: 80051480273     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.241836     Document Type: Article

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