-
1
-
-
79959740380
-
Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets
-
K.Aston-MourneyR.L.HullS.ZraikaJ.UdayasankarS.L.SubramanianS.E.Kahn (2011). Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets. Diabetologia54:1756-1765.
-
(2011)
Diabetologia
, vol.54
, pp. 1756-1765
-
-
Aston-Mourney, K.1
Hull, R.L.2
Zraika, S.3
Udayasankar, J.4
Subramanian, S.L.5
Kahn, S.E.6
-
3
-
-
0014142582
-
The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects
-
J.D.BagdadeE.L.BiermanD.PorteJr (1967). The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J Clin Invest46:1549-1557.
-
(1967)
J Clin Invest
, vol.46
, pp. 1549-1557
-
-
Bagdade, J.D.1
Bierman, E.L.2
Porte, D.3
-
5
-
-
77957670380
-
Contribution of postnatally formed small beta cell aggregates to functional beta cell mass in adult rat pancreas
-
M.ChintinneG.StangeB.DenysP.In ‘t VeldK.HellemansM.Pipeleers-MarichalZ.LingD.Pipeleers (2010). Contribution of postnatally formed small beta cell aggregates to functional beta cell mass in adult rat pancreas. Diabetologia53:2380-2388.
-
(2010)
Diabetologia
, vol.53
, pp. 2380-2388
-
-
Chintinne, M.1
Stange, G.2
Denys, B.3
In ‘t Veld, P.4
Hellemans, K.5
Pipeleers-Marichal, M.6
Ling, Z.7
Pipeleers, D.8
-
6
-
-
2342510386
-
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
-
Y.DorJ.BrownO.I.MartinezD.A.Melton (2004). Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature429:41-46.
-
(2004)
Nature
, vol.429
, pp. 41-46
-
-
Dor, Y.1
Brown, J.2
Martinez, O.I.3
Melton, D.A.4
-
7
-
-
0022475906
-
The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom
-
A.K.FoulisC.N.LiddleM.A.FarquharsonJ.A.RichmondR.S.Weir (1986). The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia29:267-274.
-
(1986)
Diabetologia
, vol.29
, pp. 267-274
-
-
Foulis, A.K.1
Liddle, C.N.2
Farquharson, M.A.3
Richmond, J.A.4
Weir, R.S.5
-
8
-
-
0033667824
-
Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15
-
C.E.GleasonM.GonzalezJ.S.HarmonR.P.Robertson (2000). Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15. Am J Physiol Endocrinol Metab279:E997-E1002.
-
(2000)
Am J Physiol Endocrinol Metab
, vol.279
, pp. E997-E1002
-
-
Gleason, C.E.1
Gonzalez, M.2
Harmon, J.S.3
Robertson, R.P.4
-
10
-
-
7944228597
-
Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine
-
P.A.Halban (2004). Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine. Nat Cell Biol6:1021-1025.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1021-1025
-
-
Halban, P.A.1
-
11
-
-
84859134790
-
Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance
-
H.J.HiddingaS.SakagashiraM.IshigameP.MaddeT.SankeK.NanjoY.C.KudvaJ.J.LeeJ.van DeursenN.L.Eberhardt (2012). Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance. J Diabetes Investig3:138-147.
-
(2012)
J Diabetes Investig
, vol.3
, pp. 138-147
-
-
Hiddinga, H.J.1
Sakagashira, S.2
Ishigame, M.3
Madde, P.4
Sanke, T.5
Nanjo, K.6
Kudva, Y.C.7
Lee, J.J.8
van Deursen, J.9
Eberhardt, N.L.10
-
12
-
-
8344271936
-
Cell lines derived from pancreatic islets
-
H.E.HohmeierC.B.Newgard (2004). Cell lines derived from pancreatic islets. Mol Cell Endocrinol228:121-128.
-
(2004)
Mol Cell Endocrinol
, vol.228
, pp. 121-128
-
-
Hohmeier, H.E.1
Newgard, C.B.2
-
13
-
-
0027451036
-
Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia
-
D.J.W.M.HöppenerDr. J. W. MJ.S.VerbeekE.J.P.de KoningC.OosterwijkK.L.van HulstH.J.Visser-VernooyF.M.A.HofhuisS.van GaalenM.J.H.BerendsW.H.L.HackengH.S.JanszJ.F.MorrisA.ClarkP.J.A.CapelC.J.M.Lips (1993). Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia. Diabetologia36:1258-1265.
-
(1993)
Diabetologia
, vol.36
, pp. 1258-1265
-
-
Höppener, D.J.W.M.1
Verbeek, J.S.2
de Koning, E.J.P.3
Oosterwijk, C.4
van Hulst, K.L.5
Visser-Vernooy, H.J.6
Hofhuis, F.M.A.7
van Gaalen, S.8
Berends, M.J.H.9
Hackeng, W.H.L.10
Jansz, H.S.11
Morris, J.F.12
Clark, A.13
Capel, P.J.A.14
Lips, C.J.M.15
-
15
-
-
79954543511
-
beta-cell loss and beta-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition
-
C.A.JurgensM.N.ToukatlyC.L.FlignerJ.UdayasankarS.L.SubramanianS.ZraikaK.Aston-MourneyD.B.CarrP.WestermarkG.T.WestermarkS.E.KahnR.L.Hull (2011). beta-cell loss and beta-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition. Am J Pathol178:2632-2640.
-
(2011)
Am J Pathol
, vol.178
, pp. 2632-2640
-
-
Jurgens, C.A.1
Toukatly, M.N.2
Fligner, C.L.3
Udayasankar, J.4
Subramanian, S.L.5
Zraika, S.6
Aston-Mourney, K.7
Carr, D.B.8
Westermark, P.9
Westermark, G.T.10
Kahn, S.E.11
Hull, R.L.12
-
16
-
-
0027375768
-
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function
-
S.E.KahnR.L.PrigeonD.K.McCullochE.J.BoykoR.N.BergmanM.W.SchwartzJ.L.NeifingW.K.WardJ.C.BeardJ.P.Palmer (1993). Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes42:1663-1672.
-
(1993)
Diabetes
, vol.42
, pp. 1663-1672
-
-
Kahn, S.E.1
Prigeon, R.L.2
McCulloch, D.K.3
Boyko, E.J.4
Bergman, R.N.5
Schwartz, M.W.6
Neifing, J.L.7
Ward, W.K.8
Beard, J.C.9
Palmer, J.P.10
-
20
-
-
2142728495
-
Amyloid fibril formation is progressive and correlates with beta-cell secretion in transgenic mouse isolated islets
-
D.L.MacArthurE.J.de KoningJ.S.VerbeekJ.F.MorrisA.Clark (1999). Amyloid fibril formation is progressive and correlates with beta-cell secretion in transgenic mouse isolated islets. Diabetologia42:1219-1227.
-
(1999)
Diabetologia
, vol.42
, pp. 1219-1227
-
-
MacArthur, D.L.1
de Koning, E.J.2
Verbeek, J.S.3
Morris, J.F.4
Clark, A.5
-
21
-
-
0001210612
-
Quantitative estimation of the pancreatic islet tissue in diabetic subjects
-
N.MacleanR.F.Ogilvie (1955). Quantitative estimation of the pancreatic islet tissue in diabetic subjects. Diabetes4:367-376.
-
(1955)
Diabetes
, vol.4
, pp. 367-376
-
-
Maclean, N.1
Ogilvie, R.F.2
-
23
-
-
0017065890
-
Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes
-
L.OrciD.BaetensC.RufenerM.AmherdtM.RavazzolaP.StuderF.Malaisse-LagaeR.Unger (1976). Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes. Proc Natl Acad Sci U S A73:1338-1342.
-
(1976)
Proc Natl Acad Sci U S A
, vol.73
, pp. 1338-1342
-
-
Orci, L.1
Baetens, D.2
Rufener, C.3
Amherdt, M.4
Ravazzola, M.5
Studer, P.6
Malaisse-Lagae, F.7
Unger, R.8
-
25
-
-
84856735212
-
cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets
-
S.L.SubramanianR.L.HullS.ZraikaK.Aston-MourneyJ.UdayasankarS.E.Kahn (2012). cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets. Diabetologia55:166-174.
-
(2012)
Diabetologia
, vol.55
, pp. 166-174
-
-
Subramanian, S.L.1
Hull, R.L.2
Zraika, S.3
Aston-Mourney, K.4
Udayasankar, J.5
Kahn, S.E.6
-
27
-
-
0035514444
-
Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells
-
F.WangR.L.HullJ.VidalM.CnopS.E.Kahn (2001). Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells. Diabetes50:2514-2520.
-
(2001)
Diabetes
, vol.50
, pp. 2514-2520
-
-
Wang, F.1
Hull, R.L.2
Vidal, J.3
Cnop, M.4
Kahn, S.E.5
-
28
-
-
0034570847
-
Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP
-
G.T.WestermarkS.Gebre-MedhinD.F.SteinerP.Westermark (2000). Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP. Mol Med6:998-1007.
-
(2000)
Mol Med
, vol.6
, pp. 998-1007
-
-
Westermark, G.T.1
Gebre-Medhin, S.2
Steiner, D.F.3
Westermark, P.4
-
30
-
-
77953296955
-
Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation
-
S.ZraikaK.Aston-MourneyP.MarekR.L.HullP.S.GreenJ.UdayasankarS.L.SubramanianD.P.RaleighS.E.Kahn (2010). Neprilysin impedes islet amyloid formation by inhibition of fibril formation rather than peptide degradation. J Biol Chem285:18177-18183.
-
(2010)
J Biol Chem
, vol.285
, pp. 18177-18183
-
-
Zraika, S.1
Aston-Mourney, K.2
Marek, P.3
Hull, R.L.4
Green, P.S.5
Udayasankar, J.6
Subramanian, S.L.7
Raleigh, D.P.8
Kahn, S.E.9
-
31
-
-
61449123871
-
Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis
-
S.ZraikaR.L.HullJ.UdayasankarK.Aston-MourneyS.L.SubramanianR.KisilevskyW.A.SzarekS.E.Kahn (2009). Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis. Diabetologia52:626-635.
-
(2009)
Diabetologia
, vol.52
, pp. 626-635
-
-
Zraika, S.1
Hull, R.L.2
Udayasankar, J.3
Aston-Mourney, K.4
Subramanian, S.L.5
Kisilevsky, R.6
Szarek, W.A.7
Kahn, S.E.8
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