Age-associated reduction of cell spreading induces mitochondrial DNA common deletion by oxidative stress in human skin dermal fibroblasts: Implication for human skin connective tissue aging

Journal of Biomedical Science

Volumn 22, Issue 1, 2015, Pages

  Quan, Chunji ^a   Cho, Moon Kyun ^b   Perry, Daniel ^c   Quan, Taihao ^c  

^a YANBIAN UNIVERSITY   (China)

^b Soonchunhyang University College of Medicine   (South Korea)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Cell shape; Human skin connective tissue aging; Mitochondrial common deletion; Reactive oxygen species

Indexed keywords

GENOMIC DNA; MITOCHONDRIAL DNA;

ACTIN FILAMENT; ADULT; AGED; AGING; ANTIOXIDANT ACTIVITY; ARTICLE; CELL SHAPE; CELL SPREADING; CONNECTIVE TISSUE; CONTROLLED STUDY; DERMIS; FROZEN SECTION; GENE DELETION; GENOME SIZE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MITOCHONDRIAL DNA COMMON DELETION; OXIDATIVE STRESS; PHOTOAGING; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN FIBROBLAST; CUTANEOUS PARAMETERS; FIBROBLAST; GENETICS; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AGING; DERMIS; DNA, MITOCHONDRIAL; FIBROBLASTS; HUMANS; MALE; MIDDLE AGED; OXIDATIVE STRESS; SEQUENCE DELETION; SKIN AGING;

EID: 84938333807     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-015-0167-6     Document Type: Article

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