Age-associated reduction of cellular spreading/mechanical force up-regulates matrix metalloproteinase-1 expression and collagen fibril fragmentation via c-Jun/AP-1 in human dermal fibroblasts

Aging Cell

Volumn 13, Issue 6, 2014, Pages 1028-1037

  Qin, Zhaoping ^a   Voorhees, John J ^a   Fisher, Gary J ^a   Quan, Taihao ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Aging; C Jun AP 1; Extracellular matrix microenvironment; Fibroblast; Mechanical force; MMP 1

Indexed keywords

INTERSTITIAL COLLAGENASE; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1; COLLAGEN; MMP1 PROTEIN, HUMAN; STRESS ACTIVATED PROTEIN KINASE;

ADULT; AGE; ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING SITE; BIOMECHANICS; CELL DAMAGE; CELL DISRUPTION; CELL SHAPE; CELL SIZE; CELL SPREADING; COLLAGEN FIBRIL; CONTROLLED STUDY; CUTANEOUS PARAMETERS; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MMP 1 GENE; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKIN FIBROBLAST; BIOSYNTHESIS; CELL CULTURE; CELL MOTION; CYTOLOGY; ENZYMOLOGY; FIBROBLAST; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKIN;

AGE FACTORS; BIOMECHANICAL PHENOMENA; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN; FIBROBLASTS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MATRIX METALLOPROTEINASE 1; SIGNAL TRANSDUCTION; SKIN; TRANSCRIPTION FACTOR AP-1;

EID: 84911985487     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12265     Document Type: Article

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