-
1
-
-
10044298236
-
Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism
-
Van Regenmortel MH. Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism. EMBO Rep. 2004;5:1016-20.
-
(2004)
EMBO Rep
, vol.5
, pp. 1016-1020
-
-
Regenmortel, M.H.1
-
2
-
-
77949479491
-
So what do we really mean when we say that systems biology is holistic?
-
Gatherer D. So what do we really mean when we say that systems biology is holistic? BMC Syst Biol. 2010;4:22.
-
(2010)
BMC Syst Biol
, vol.4
, pp. 22
-
-
Gatherer, D.1
-
3
-
-
77956838065
-
Advances in understanding cancer genomes through second-generation sequencing
-
Meyerson M, Gabriel S, Getz G. Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet. 2010;11:685-96.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 685-696
-
-
Meyerson, M.1
Gabriel, S.2
Getz, G.3
-
4
-
-
77951094805
-
Big science: the cancer genome challenge
-
Ledford H. Big science: the cancer genome challenge. Nature. 2010;464:972-4.
-
(2010)
Nature
, vol.464
, pp. 972-974
-
-
Ledford, H.1
-
6
-
-
82655184653
-
Personalized oncology through integrative high-throughput sequencing: a pilot study
-
Roychowdhury S, Iyer MK, Robinson DR, Lonigro RJ, Wu YM, Cao X, et al. Personalized oncology through integrative high-throughput sequencing: a pilot study. Sci Transl Med. 2011;3:111ra121.
-
(2011)
Sci Transl Med
, vol.3
, pp. 111-121
-
-
Roychowdhury, S.1
Iyer, M.K.2
Robinson, D.R.3
Lonigro, R.J.4
Wu, Y.M.5
Cao, X.6
-
7
-
-
84880452562
-
Genomics-driven oncology: framework for an emerging paradigm
-
Garraway LA. Genomics-driven oncology: framework for an emerging paradigm. J Clin Oncol. 2013;31:1806-14.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1806-1814
-
-
Garraway, L.A.1
-
8
-
-
79957523828
-
PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer
-
De Roock W, De Vriendt V, Normanno N, Ciardiello F, Tejpar SKRAS, BRAF. PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol. 2011;12:594-603.
-
(2011)
Lancet Oncol
, vol.12
, pp. 594-603
-
-
Roock, W.1
Vriendt, V.2
Normanno, N.3
Ciardiello, F.4
Tejpar, S.K.R.A.S.5
-
9
-
-
84878981521
-
Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: a systematic review with meta-analysis
-
Meng D, Yuan M, Li Z, Chen L, Yang J, Zhao X, et al. Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: a systematic review with meta-analysis. Lung Cancer. 2013;81:1-10.
-
(2013)
Lung Cancer
, vol.81
, pp. 1-10
-
-
Meng, D.1
Yuan, M.2
Li, Z.3
Chen, L.4
Yang, J.5
Zhao, X.6
-
10
-
-
84875758730
-
Lessons from the cancer genome
-
Garraway LA, Lander ES. Lessons from the cancer genome. Cell. 2013;153:17-37.
-
(2013)
Cell
, vol.153
, pp. 17-37
-
-
Garraway, L.A.1
Lander, E.S.2
-
11
-
-
84928248330
-
Personalized genomic analyses for cancer mutation discovery and interpretation
-
283ra253
-
Jones S, Anagnostou V, Lytle K, Parpart-Li S, Nesselbush M, Riley DR, et al. Personalized genomic analyses for cancer mutation discovery and interpretation. Sci Transl Med. 2015;7:283ra253.
-
(2015)
Sci Transl Med
, vol.7
-
-
Jones, S.1
Anagnostou, V.2
Lytle, K.3
Parpart-Li, S.4
Nesselbush, M.5
Riley, D.R.6
-
12
-
-
84893838300
-
Clinical application of amplicon-based next-generation sequencing in cancer
-
Chang F, Li MM. Clinical application of amplicon-based next-generation sequencing in cancer. Cancer Genet. 2013;206:413-19.
-
(2013)
Cancer Genet
, vol.206
, pp. 413-419
-
-
Chang, F.1
Li, M.M.2
-
13
-
-
84865833740
-
High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
-
Wagle N, Berger MF, Davis MJ, Blumenstiel B, DeFelice M, Pochanard P, et al. High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Cancer Discov. 2012;2:82-93.
-
(2012)
Cancer Discov
, vol.2
, pp. 82-93
-
-
Wagle, N.1
Berger, M.F.2
Davis, M.J.3
Blumenstiel, B.4
DeFelice, M.5
Pochanard, P.6
-
14
-
-
84964310688
-
Assessing copy number alterations in targeted, amplicon-based next-generation sequencing data
-
Grasso C, Butler T, Rhodes K, Quist M, Neff TL, Moore S, et al. Assessing copy number alterations in targeted, amplicon-based next-generation sequencing data. J Mol Diagn. 2015;17:53-63.
-
(2015)
J Mol Diagn
, vol.17
, pp. 53-63
-
-
Grasso, C.1
Butler, T.2
Rhodes, K.3
Quist, M.4
Neff, T.L.5
Moore, S.6
-
15
-
-
65249144557
-
Commonality but diversity in cancer gene fusions
-
Rabbitts TH. Commonality but diversity in cancer gene fusions. Cell. 2009;137:391-5.
-
(2009)
Cell
, vol.137
, pp. 391-395
-
-
Rabbitts, T.H.1
-
16
-
-
84871181092
-
Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions
-
Suehara Y, Arcila M, Wang L, Hasanovic A, Ang D, Ito T, et al. Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions. Clin Cancer Res. 2012;18:6599-608.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6599-6608
-
-
Suehara, Y.1
Arcila, M.2
Wang, L.3
Hasanovic, A.4
Ang, D.5
Ito, T.6
-
17
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366:883-92.
-
(2012)
N Engl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
Larkin, J.4
Endesfelder, D.5
Gronroos, E.6
-
18
-
-
84855185866
-
Correcting for cancer genome size and tumour cell content enables better estimation of copy number alterations from next-generation sequence data
-
Gusnanto A, Wood HM, Pawitan Y, Rabbitts P, Berri S. Correcting for cancer genome size and tumour cell content enables better estimation of copy number alterations from next-generation sequence data. Bioinformatics. 2012;28:40-7.
-
(2012)
Bioinformatics
, vol.28
, pp. 40-47
-
-
Gusnanto, A.1
Wood, H.M.2
Pawitan, Y.3
Rabbitts, P.4
Berri, S.5
-
19
-
-
84920507475
-
Sequence artifacts in DNA from formalin-fixed tissues: causes and strategies for minimization
-
Do H, Dobrovic A. Sequence artifacts in DNA from formalin-fixed tissues: causes and strategies for minimization. Clin Chem. 2015;61:64-71.
-
(2015)
Clin Chem
, vol.61
, pp. 64-71
-
-
Do, H.1
Dobrovic, A.2
-
20
-
-
0032755991
-
A high frequency of sequence alterations is due to formalin fixation of archival specimens
-
Williams C, Pontén F, Moberg C, Söderkvist P, Uhlén M, Pontén J, et al. A high frequency of sequence alterations is due to formalin fixation of archival specimens. Am J Pathol. 1999;155:1467-71.
-
(1999)
Am J Pathol
, vol.155
, pp. 1467-1471
-
-
Williams, C.1
Pontén, F.2
Moberg, C.3
Söderkvist, P.4
Uhlén, M.5
Pontén, J.6
-
21
-
-
84871790986
-
Rebooting cancer tissue handling in the sequencing era: toward routine use of frozen tumor tissue
-
Goetz L, Bethel K, Topol EJ. Rebooting cancer tissue handling in the sequencing era: toward routine use of frozen tumor tissue. JAMA. 2013;309:37-8.
-
(2013)
JAMA
, vol.309
, pp. 37-38
-
-
Goetz, L.1
Bethel, K.2
Topol, E.J.3
-
22
-
-
84902148239
-
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine
-
Van Allen EM, Wagle N, Stojanov P, Perrin DL, Cibulskis K, Marlow S, et al. Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. Nat Med. 2014;20:682-8.
-
(2014)
Nat Med
, vol.20
, pp. 682-688
-
-
Allen, E.M.1
Wagle, N.2
Stojanov, P.3
Perrin, D.L.4
Cibulskis, K.5
Marlow, S.6
-
23
-
-
84902313616
-
Next-generation sequencing of RNA and DNA isolated from paired fresh-frozen and formalin-fixed paraffin-embedded samples of human cancer and normal tissue
-
Hedegaard J, Thorsen K, Lund MK, Hein A-M K, Hamilton-Dutoit SJ, Vang S, et al. Next-generation sequencing of RNA and DNA isolated from paired fresh-frozen and formalin-fixed paraffin-embedded samples of human cancer and normal tissue. PLoS One. 2014;9, e98187.
-
(2014)
PLoS One
, vol.9
-
-
Hedegaard, J.1
Thorsen, K.2
Lund, M.K.3
Hein A-M, K.4
Hamilton-Dutoit, S.J.5
Vang, S.6
-
24
-
-
84899934660
-
Genome-wide DNA methylation analysis of formalin-fixed paraffin embedded colorectal cancer tissue
-
Dumenil TD, Wockner LF, Bettington M, McKeone DM, Klein K, Bowdler LM, et al. Genome-wide DNA methylation analysis of formalin-fixed paraffin embedded colorectal cancer tissue. Genes Chromosomes Cancer. 2014;53:537-48.
-
(2014)
Genes Chromosomes Cancer
, vol.53
, pp. 537-548
-
-
Dumenil, T.D.1
Wockner, L.F.2
Bettington, M.3
McKeone, D.M.4
Klein, K.5
Bowdler, L.M.6
-
25
-
-
84925300542
-
Biology, detection, and clinical implications of circulating tumor cells
-
Joosse SA, Gorges TM, Pantel K. Biology, detection, and clinical implications of circulating tumor cells. EMBO Mol Med. 2015;7:1-11.
-
(2015)
EMBO Mol Med
, vol.7
, pp. 1-11
-
-
Joosse, S.A.1
Gorges, T.M.2
Pantel, K.3
-
26
-
-
84900333051
-
Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer
-
Lohr JG, Adalsteinsson VA, Cibulskis K, Choudhury AD, Rosenberg M, Cruz-Gordillo P, et al. Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer. Nat Biotechnol. 2014;32:479-84.
-
(2014)
Nat Biotechnol
, vol.32
, pp. 479-484
-
-
Lohr, J.G.1
Adalsteinsson, V.A.2
Cibulskis, K.3
Choudhury, A.D.4
Rosenberg, M.5
Cruz-Gordillo, P.6
-
27
-
-
84898542288
-
Liquid biopsies: genotyping circulating tumor DNA
-
Diaz LA, Bardelli A. Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol. 2014;32:579-86.
-
(2014)
J Clin Oncol
, vol.32
, pp. 579-586
-
-
Diaz, L.A.1
Bardelli, A.2
-
28
-
-
84875520648
-
Analysis of circulating tumor DNA to monitor metastatic breast cancer
-
Dawson SJ, Tsui DWY, Murtaza M, Biggs H, Rueda OM, Chin S-F, et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med. 2013;368:1199-209.
-
(2013)
N Engl J Med
, vol.368
, pp. 1199-1209
-
-
Dawson, S.J.1
Tsui, D.W.Y.2
Murtaza, M.3
Biggs, H.4
Rueda, O.M.5
Chin, S.-F.6
-
29
-
-
84903218109
-
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
-
Newman AM, Bratman SV, To J, Wynne JF, Eclov NCW, Modlin LA, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med. 2014;20:548-54.
-
(2014)
Nat Med
, vol.20
, pp. 548-554
-
-
Newman, A.M.1
Bratman, S.V.2
To, J.3
Wynne, J.F.4
Eclov, N.C.W.5
Modlin, L.A.6
-
31
-
-
84920550975
-
A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
-
SEQC/MAQC-III Consortium. A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nat Biotechnol. 2014;32:903-14.
-
(2014)
Nat Biotechnol
, vol.32
, pp. 903-914
-
-
-
32
-
-
84899129255
-
Tumor heterogeneity in the clinic: is it a real problem?
-
Janku F. Tumor heterogeneity in the clinic: is it a real problem? Ther Adv Med Oncol. 2014;6:43-51.
-
(2014)
Ther Adv Med Oncol
, vol.6
, pp. 43-51
-
-
Janku, F.1
-
33
-
-
84908551274
-
Characterizing regions in the human genome unmappable by next-generation-sequencing at the read length of 1000 bases
-
Li W, Freudenberg J. Characterizing regions in the human genome unmappable by next-generation-sequencing at the read length of 1000 bases. Comput Biol Chem. 2014;53:108-17.
-
(2014)
Comput Biol Chem
, vol.53
, pp. 108-117
-
-
Li, W.1
Freudenberg, J.2
-
34
-
-
84880467544
-
Clinical analysis and interpretation of cancer genome data
-
Van Allen EM, Wagle N, Levy MA. Clinical analysis and interpretation of cancer genome data. J Clin Oncol. 2013;31:1825-33.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1825-1833
-
-
Allen, E.M.1
Wagle, N.2
Levy, M.A.3
-
35
-
-
84893744718
-
The estimation of tumor cell percentage for molecular testing by pathologists is not accurate
-
Smits AJJ, Kummer JA, de Bruin PC, Bol M, van den Tweel JG, Seldenrijk KA, et al. The estimation of tumor cell percentage for molecular testing by pathologists is not accurate. Mod Pathol. 2014;27:168-74.
-
(2014)
Mod Pathol
, vol.27
, pp. 168-174
-
-
Smits, A.J.J.1
Kummer, J.A.2
Bruin, P.C.3
Bol, M.4
Tweel, J.G.5
Seldenrijk, K.A.6
-
36
-
-
84866728909
-
Chromothripsis and cancer: causes and consequences of chromosome shattering
-
Forment JV, Kaidi A, Jackson SP. Chromothripsis and cancer: causes and consequences of chromosome shattering. Nat Rev Cancer. 2012;12:663-70.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 663-670
-
-
Forment, J.V.1
Kaidi, A.2
Jackson, S.P.3
-
37
-
-
85019196479
-
-
PHIAL. http://www.broadinstitute.org/cancer/cga/phial .
-
-
-
-
38
-
-
75549087826
-
COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer
-
Forbes SA, Tang G, Bindal N, Bamford S, Dawson E, Cole C, et al. COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer. Nucleic Acids Res. 2010;38:D652-7.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. D652-D657
-
-
Forbes, S.A.1
Tang, G.2
Bindal, N.3
Bamford, S.4
Dawson, E.5
Cole, C.6
-
39
-
-
85019249222
-
-
COSMIC. http://cancer.sanger.ac.uk/cosmic/ .
-
-
-
-
40
-
-
84866002291
-
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
-
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012;2:401-4.
-
(2012)
Cancer Discov
, vol.2
, pp. 401-404
-
-
Cerami, E.1
Gao, J.2
Dogrusoz, U.3
Gross, B.E.4
Sumer, S.O.5
Aksoy, B.A.6
-
41
-
-
84938205099
-
-
cBioPortal
-
cBioPortal. http://www.cbioportal.org/ .
-
-
-
-
42
-
-
84938209813
-
A decision support framework for genomically informed investigational cancer therapy
-
Meric-Bernstam F, Johnson A, Holla V, Bailey AM, Brusco L, Chen K, et al. A decision support framework for genomically informed investigational cancer therapy. J Natl Cancer Inst. 2015;107:djv098. doi:10.1093/jnci/djv098.
-
(2015)
J Natl Cancer Inst
, vol.107
-
-
Meric-Bernstam, F.1
Johnson, A.2
Holla, V.3
Bailey, A.M.4
Brusco, L.5
Chen, K.6
-
44
-
-
84877097462
-
DNA-mutation inventory to refine and enhance cancer treatment (DIRECT): a catalog of clinically relevant cancer mutations to enable genome-directed anticancer therapy
-
Yeh P, Chen H, Andrews J, Naser R, Pao W, Horn L. DNA-mutation inventory to refine and enhance cancer treatment (DIRECT): a catalog of clinically relevant cancer mutations to enable genome-directed anticancer therapy. Clin Cancer Res. 2013;19:1894-901.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1894-1901
-
-
Yeh, P.1
Chen, H.2
Andrews, J.3
Naser, R.4
Pao, W.5
Horn, L.6
-
46
-
-
85019234040
-
-
TARGET. https://www.broadinstitute.org/cancer/cga/target .
-
-
-
-
47
-
-
84880535720
-
ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing
-
Green RC, Berg JS, Grody WW, Kalia SS, Korf BR, Martin CL, et al. ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genet Med. 2013;15:565-74.
-
(2013)
Genet Med
, vol.15
, pp. 565-574
-
-
Green, R.C.1
Berg, J.S.2
Grody, W.W.3
Kalia, S.S.4
Korf, B.R.5
Martin, C.L.6
-
48
-
-
84905815773
-
Clinical tumor sequencing: an incidental casualty of the American College of Medical Genetics and Genomics recommendations for reporting of incidental findings
-
Parsons DW, Roy A, Plon SE, Roychowdhury S, Chinnaiyan AM. Clinical tumor sequencing: an incidental casualty of the American College of Medical Genetics and Genomics recommendations for reporting of incidental findings. J Clin Oncol. 2014;32:2203-5.
-
(2014)
J Clin Oncol
, vol.32
, pp. 2203-2205
-
-
Parsons, D.W.1
Roy, A.2
Plon, S.E.3
Roychowdhury, S.4
Chinnaiyan, A.M.5
-
49
-
-
84930225081
-
Integrative clinical genomics of advanced prostate cancer
-
Robinson D, Van Allen EM, Wu Y-M, Schultz N, Lonigro RJ, Mosquera J-M, et al. Integrative clinical genomics of advanced prostate cancer. Cell. 2015;161:1215-28.
-
(2015)
Cell
, vol.161
, pp. 1215-1228
-
-
Robinson, D.1
Allen, E.M.2
Wu, Y.-M.3
Schultz, N.4
Lonigro, R.J.5
Mosquera, J.-M.6
-
50
-
-
84896732099
-
Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma
-
Honeyman JN, Simon EM, Robine N, Chiaroni-Clarke R, Darcy DG, Lim IIP, et al. Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma. Science. 2014;343:1010-14.
-
(2014)
Science
, vol.343
, pp. 1010-1014
-
-
Honeyman, J.N.1
Simon, E.M.2
Robine, N.3
Chiaroni-Clarke, R.4
Darcy, D.G.5
Lim, I.I.P.6
-
51
-
-
84883680951
-
Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
-
Douillard JY, Oliner KS, Siena S, Tabernero J, Burkes R, Barugel M, et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 2013;369:1023-34.
-
(2013)
N Engl J Med
, vol.369
, pp. 1023-1034
-
-
Douillard, J.Y.1
Oliner, K.S.2
Siena, S.3
Tabernero, J.4
Burkes, R.5
Barugel, M.6
-
52
-
-
84928739294
-
AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer
-
Jänne PA, Yang JC-H, Kim D-W, Planchard D, Ohe Y, Ramalingam SS, et al. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N Engl J Med. 2015;372:1689-99.
-
(2015)
N Engl J Med
, vol.372
, pp. 1689-1699
-
-
Jänne, P.A.1
Yang, J.-H.2
Kim, D.-W.3
Planchard, D.4
Ohe, Y.5
Ramalingam, S.S.6
-
53
-
-
84892775264
-
Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA
-
Nathanson DA, Gini B, Mottahedeh J, Visnyei K, Koga T, Gomez G, et al. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science. 2014;343:72-6.
-
(2014)
Science
, vol.343
, pp. 72-76
-
-
Nathanson, D.A.1
Gini, B.2
Mottahedeh, J.3
Visnyei, K.4
Koga, T.5
Gomez, G.6
-
54
-
-
84905850596
-
National Cancer Institute's Precision Medicine Initiatives for the new National Clinical Trials Network
-
Abrams J, Conley B, Mooney M, Zwiebel J, Chen A, Welch JJ, et al. National Cancer Institute's Precision Medicine Initiatives for the new National Clinical Trials Network. Am Soc Clin Oncol Educ Book. 2014;34:71-6.
-
(2014)
Am Soc Clin Oncol Educ Book
, vol.34
, pp. 71-76
-
-
Abrams, J.1
Conley, B.2
Mooney, M.3
Zwiebel, J.4
Chen, A.5
Welch, J.J.6
-
55
-
-
84927154472
-
Basket trials and the evolution of clinical trial design in an era of genomic medicine
-
Redig AJ, Jänne PA. Basket trials and the evolution of clinical trial design in an era of genomic medicine. J Clin Oncol. 2015;33:975-7.
-
(2015)
J Clin Oncol
, vol.33
, pp. 975-977
-
-
Redig, A.J.1
Jänne, P.A.2
-
56
-
-
11844293427
-
P53 and prognosis: new insights and further complexity
-
Vousden KH, Prives C. P53 and prognosis: new insights and further complexity. Cell. 2005;120:7-10.
-
(2005)
Cell
, vol.120
, pp. 7-10
-
-
Vousden, K.H.1
Prives, C.2
-
57
-
-
84858600403
-
Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases
-
Gelsi-Boyer V, Brecqueville M, Devillier R, Murati A, Mozziconacci M-J, Birnbaum D. Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases. J Hematol Oncol. 2012;5:12.
-
(2012)
J Hematol Oncol
, vol.5
, pp. 12
-
-
Gelsi-Boyer, V.1
Brecqueville, M.2
Devillier, R.3
Murati, A.4
Mozziconacci, M.-J.5
Birnbaum, D.6
-
58
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Williams Parsons D, Jin G, McLendon R, Ahmed Rasheed B, Yuan W, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360:765-73.
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Williams Parsons, D.2
Jin, G.3
McLendon, R.4
Ahmed Rasheed, B.5
Yuan, W.6
-
59
-
-
84908279899
-
DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies
-
Im AP, Sehgal AR, Carroll MP, Smith BD, Tefferi A, Johnson DE, et al. DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies. Leukemia. 2014;28:1774-83.
-
(2014)
Leukemia
, vol.28
, pp. 1774-1783
-
-
Im, A.P.1
Sehgal, A.R.2
Carroll, M.P.3
Smith, B.D.4
Tefferi, A.5
Johnson, D.E.6
-
60
-
-
84877620952
-
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
-
Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013;340:622-6.
-
(2013)
Science
, vol.340
, pp. 622-626
-
-
Wang, F.1
Travins, J.2
DeLaBarre, B.3
Penard-Lacronique, V.4
Schalm, S.5
Hansen, E.6
-
61
-
-
84905366894
-
Acquired resistance to TKIs in solid tumours: learning from lung cancer
-
Camidge DR, Pao W, Sequist LV. Acquired resistance to TKIs in solid tumours: learning from lung cancer. Nat Rev Clin Oncol. 2014;11:473-81.
-
(2014)
Nat Rev Clin Oncol
, vol.11
, pp. 473-481
-
-
Camidge, D.R.1
Pao, W.2
Sequist, L.V.3
-
62
-
-
0042964835
-
p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study
-
Ahrendt SA, Hu Y, Buta M, McDermott MP, Benoit N, Yang SC, et al. p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study. J Natl Cancer Inst. 2003;95:961-70.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 961-970
-
-
Ahrendt, S.A.1
Hu, Y.2
Buta, M.3
McDermott, M.P.4
Benoit, N.5
Yang, S.C.6
-
63
-
-
84928746232
-
Rociletinib in EGFR-mutated non-small-cell lung cancer
-
Sequist LV, Soria J-C, Goldman JW, Wakelee HA, Gadgeel SM, Varga A, et al. Rociletinib in EGFR-mutated non-small-cell lung cancer. N Engl J Med. 2015;372:1700-9.
-
(2015)
N Engl J Med
, vol.372
, pp. 1700-1709
-
-
Sequist, L.V.1
Soria, J.-C.2
Goldman, J.W.3
Wakelee, H.A.4
Gadgeel, S.M.5
Varga, A.6
-
64
-
-
84930755018
-
Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M
-
Thress KS, Paweletz CP, Felip E, Cho BC, Stetson D, Dougherty B, et al. Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M. Nat Med. 2015;21:560-2.
-
(2015)
Nat Med
, vol.21
, pp. 560-562
-
-
Thress, K.S.1
Paweletz, C.P.2
Felip, E.3
Cho, B.C.4
Stetson, D.5
Dougherty, B.6
-
65
-
-
84938196408
-
The allelic context of the C797S mutation acquired upon treatment with third generation EGFR inhibitors impacts sensitivity to subsequent treatment strategies
-
Niederst MJ, Hu H, Mulvey HE, Lockerman EL, Garcia AR, Piotrowska Z, et al. The allelic context of the C797S mutation acquired upon treatment with third generation EGFR inhibitors impacts sensitivity to subsequent treatment strategies. Clin Cancer Res. 2015. doi:10.1158/1078-0432.CCR-15-0560.
-
(2015)
Clin Cancer Res
-
-
Niederst, M.J.1
Hu, H.2
Mulvey, H.E.3
Lockerman, E.L.4
Garcia, A.R.5
Piotrowska, Z.6
-
66
-
-
77955976922
-
The grand challenge to decipher the cancer proteome
-
Hanash S, Taguchi A. The grand challenge to decipher the cancer proteome. Nat Rev Cancer. 2010;10:652-60.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 652-660
-
-
Hanash, S.1
Taguchi, A.2
-
67
-
-
84908460595
-
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
-
Hoadley KA, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S, et al. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell. 2014;158:929-44.
-
(2014)
Cell
, vol.158
, pp. 929-944
-
-
Hoadley, K.A.1
Yau, C.2
Wolf, D.M.3
Cherniack, A.D.4
Tamborero, D.5
Ng, S.6
-
68
-
-
84925031191
-
Methods of integrating data to uncover genotype-phenotype interactions
-
Ritchie MD, Holzinger ER, Li R, Pendergrass SA, Kim D. Methods of integrating data to uncover genotype-phenotype interactions. Nat Rev Genet. 2015;16:85-97.
-
(2015)
Nat Rev Genet
, vol.16
, pp. 85-97
-
-
Ritchie, M.D.1
Holzinger, E.R.2
Li, R.3
Pendergrass, S.A.4
Kim, D.5
-
69
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med. 2015;372:2521-32.
-
(2015)
N Engl J Med
, vol.372
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
Arance, A.4
Grob, J.J.5
Mortier, L.6
-
70
-
-
84928770388
-
Neoantigens in cancer immunotherapy
-
Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science. 2015;348:69-74.
-
(2015)
Science
, vol.348
, pp. 69-74
-
-
Schumacher, T.N.1
Schreiber, R.D.2
-
72
-
-
84920956731
-
Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
-
Yadav M, Jhunjhunwala S, Phung WT, Lupardus P, Tanguay J, Bumbaca S, et al. Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. Nature. 2014;515:572-6.
-
(2014)
Nature
, vol.515
, pp. 572-576
-
-
Yadav, M.1
Jhunjhunwala, S.2
Phung, W.T.3
Lupardus, P.4
Tanguay, J.5
Bumbaca, S.6
-
73
-
-
84938202468
-
-
IntOGen
-
IntOGen. https://www.intogen.org/ .
-
-
-
-
74
-
-
85019177990
-
-
CIViC. https://civic.genome.wustl.edu/#/home .
-
-
-
-
75
-
-
85019237230
-
-
DGIdb. http://www.dgidb.org/ .
-
-
-
|