Sequence artifacts in DNA from formalin-fixed tissues: Causes and strategies for minimization

Clinical Chemistry

Volumn 61, Issue 1, 2015, Pages 64-71

  Do, Hongdo ^a,b,c   Dobrovic, Alexander ^a,b,c  

^a AUSTIN HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c LA TROBE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; DNA; DNA GLYCOSYLTRANSFERASE; FORMALDEHYDE; PARAFFIN; THYMINE; URACIL;

AMPLICON; ARTIFACT; DEAMINATION; DNA CROSS LINKING; DNA DAMAGE; DNA FRAGMENTATION; DNA MODIFICATION; DNA SEQUENCE; DNA TEMPLATE; FORMALIN FIXED PARAFFIN EMBEDDED TISSUE; GENE MUTATION; GENETIC VARIABILITY; HEAT TREATMENT; HUMAN; IN VITRO STUDY; REVIEW; TISSUES; VALIDATION PROCESS; GENETICS; LABORATORY DIAGNOSIS; NEOPLASM; REPRODUCIBILITY; TISSUE FIXATION;

ARTIFACTS; DNA; DNA DAMAGE; FALSE NEGATIVE REACTIONS; FALSE POSITIVE REACTIONS; FORMALDEHYDE; HUMANS; NEOPLASMS; PARAFFIN EMBEDDING; REPRODUCIBILITY OF RESULTS; SEQUENCE ANALYSIS, DNA; TEMPLATES, GENETIC; TISSUE FIXATION;

EID: 84920507475     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2014.223040     Document Type: Review

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