Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage

Journal of Molecular Medicine

Volumn 93, Issue 8, 2015, Pages 905-916

  Brandstetter, Carolina ^a   Mohr, Lena K M ^a   Latz, Eicke ^a,b,c,d   Holz, Frank G ^a   Krohne, Tim U ^a  

^a UNIVERSITY OF BONN   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Age related macular degeneration; Interleukin 1 ; Lipid peroxidation; Lysosomal membrane permeabilization; Retinal pigment epithelium

Indexed keywords

CATHEPSIN B; CATHEPSIN L; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOFUSCIN; LYSOSOME ENZYME; CARRIER PROTEIN; NLRP3 PROTEIN, HUMAN;

ARTICLE; BLUE LIGHT; CELL DEATH; HUMAN; HUMAN CELL; IRRADIATION; LYSOSOME MEMBRANE; MEMBRANE PERMEABILITY; PHOTOTOXICITY; RETINA PIGMENT CELL; CELL CULTURE; IMMUNOLOGY; LIGHT; LYSOSOME; MACULAR DEGENERATION; PATHOLOGY; RADIATION RESPONSE; RETINAL PIGMENT EPITHELIUM;

CARRIER PROTEINS; CASPASE 1; CELLS, CULTURED; HUMANS; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; LIGHT; LIPOFUSCIN; LYSOSOMES; MACULAR DEGENERATION; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; RETINAL PIGMENT EPITHELIUM;

EID: 84937973081     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-015-1275-1     Document Type: Article

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