메뉴 건너뛰기




Volumn 8, Issue 7, 2015, Pages 647-656

Challenges in understanding psychiatric disorders and developing therapeutics: A role for zebrafish

Author keywords

Animal models; Autism; Chemical screens; Co morbidities; Psychiatric disorders; Schizophrenia; Zebrafish

Indexed keywords

ARTICLE; CYTOPLASM; GENETIC CONSERVATION; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; HIGH THROUGHPUT SCREENING; HUMAN; INVERTEBRATE; MENTAL DISEASE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; ZEBRA FISH; ANIMAL; CAENORHABDITIS ELEGANS; CELL CULTURE TECHNIQUE; DISEASE MODEL; DROSOPHILA MELANOGASTER; EVOLUTION; GENETICS; MENTAL DISORDERS; MOUSE; PHENOTYPE; PHYSIOLOGY; TRANSGENIC ANIMAL; TRANSLATIONAL RESEARCH;

EID: 84937936413     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.019620     Document Type: Article
Times cited : (36)

References (127)
  • 1
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
    • Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U. and Zoghbi, H. Y. (1999). Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet. 23, 185-188.
    • (1999) Nat. Genet. , vol.23 , pp. 185-188
    • Amir, R.E.1    Van Den Veyver, I.B.2    Wan, M.3    Tran, C.Q.4    Francke, U.5    Zoghbi, H.Y.6
  • 2
    • 33747173376 scopus 로고    scopus 로고
    • Mutagenesis strategies in zebrafish for identifying genes involved in development and disease
    • Amsterdam, A. and Hopkins, N. (2006). Mutagenesis strategies in zebrafish for identifying genes involved in development and disease. Trends Genet. 22, 473-478.
    • (2006) Trends Genet. , vol.22 , pp. 473-478
    • Amsterdam, A.1    Hopkins, N.2
  • 3
    • 50049097537 scopus 로고    scopus 로고
    • Targeted gene expression by the Gal4-UAS system in zebrafish
    • Asakawa, K. and Kawakami, K. (2008). Targeted gene expression by the Gal4-UAS system in zebrafish. Dev. Growth Differ. 50, 391-399.
    • (2008) Dev. Growth Differ. , vol.50 , pp. 391-399
    • Asakawa, K.1    Kawakami, K.2
  • 5
    • 13844314605 scopus 로고    scopus 로고
    • Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression
    • Baraban, S. C., Taylor, M. R., Castro, P. A. and Baier, H. (2005). Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. Neuroscience 131, 759-768.
    • (2005) Neuroscience , vol.131 , pp. 759-768
    • Baraban, S.C.1    Taylor, M.R.2    Castro, P.A.3    Baier, H.4
  • 6
    • 77956204265 scopus 로고    scopus 로고
    • Synaptic activity and activity-dependent competition regulates axon arbor maturation, growth arrest, and territory in the retinotectal projection
    • Ben Fredj, N., Hammond, S., Otsuna, H., Chien, C.-B., Burrone, J. and Meyer, M. P. (2010). Synaptic activity and activity-dependent competition regulates axon arbor maturation, growth arrest, and territory in the retinotectal projection. J. Neurosci. 30, 10939-10951.
    • (2010) J. Neurosci. , vol.30 , pp. 10939-10951
    • Ben Fredj, N.1    Hammond, S.2    Otsuna, H.3    Chien, C.-B.4    Burrone, J.5    Meyer, M.P.6
  • 8
    • 84870002860 scopus 로고    scopus 로고
    • Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes
    • Blaker-Lee, A., Gupta, S., McCammon, J. M., De Rienzo, G. and Sive, H. (2012). Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. Dis. Model. Mech. 5, 834-851.
    • (2012) Dis. Model. Mech. , vol.5 , pp. 834-851
    • Blaker-Lee, A.1    Gupta, S.2    McCammon, J.M.3    De Rienzo, G.4    Sive, H.5
  • 9
    • 79960141266 scopus 로고    scopus 로고
    • Zebrafish behavioural assays of translational relevance for the study of psychiatric disease
    • Brennan, C. H. (2011). Zebrafish behavioural assays of translational relevance for the study of psychiatric disease. Rev. Neurosci. 22, 37-48.
    • (2011) Rev. Neurosci. , vol.22 , pp. 37-48
    • Brennan, C.H.1
  • 12
    • 83955161768 scopus 로고    scopus 로고
    • Maturation of shoaling behavior is accompanied by changes in the dopaminergic and serotoninergic systems in zebrafish
    • Buske, C. and Gerlai, R. (2012). Maturation of shoaling behavior is accompanied by changes in the dopaminergic and serotoninergic systems in zebrafish. Dev. Psychobiol. 54, 28-35.
    • (2012) Dev. Psychobiol. , vol.54 , pp. 28-35
    • Buske, C.1    Gerlai, R.2
  • 13
    • 75349088719 scopus 로고    scopus 로고
    • Genetic causes of syndromic and non-syndromic autism
    • Caglayan, A. O. (2010). Genetic causes of syndromic and non-syndromic autism. Dev. Med. Child Neurol. 52, 130-138.
    • (2010) Dev. Med. Child Neurol. , vol.52 , pp. 130-138
    • Caglayan, A.O.1
  • 14
    • 82555168325 scopus 로고    scopus 로고
    • Visualizing digestive organ morphology and function using differential fatty acid metabolism in live zebrafish
    • Carten, J. D., Bradford, M. K. and Farber, S. A. (2011). Visualizing digestive organ morphology and function using differential fatty acid metabolism in live zebrafish. Dev. Biol. 360, 276-285.
    • (2011) Dev. Biol. , vol.360 , pp. 276-285
    • Carten, J.D.1    Bradford, M.K.2    Farber, S.A.3
  • 16
    • 84876296688 scopus 로고    scopus 로고
    • Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis
    • Cross-Disorder Group of the Psychiatric Genomics Consortium and Genetic Risk Outcome of Psychosis Consortium. (2013). Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381, 1371-1379.
    • (2013) Lancet , vol.381 , pp. 1371-1379
  • 17
    • 0034639940 scopus 로고    scopus 로고
    • A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes
    • Culetto, E. and Sattelle, D. B. (2000). A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes. Hum. Mol. Genet. 9, 869-877.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 869-877
    • Culetto, E.1    Sattelle, D.B.2
  • 19
    • 84866386128 scopus 로고    scopus 로고
    • Efficient shRNA-mediated inhibition of gene expression in zebrafish
    • De Rienzo, G., Gutzman, J. H. and Sive, H. (2012). Efficient shRNA-mediated inhibition of gene expression in zebrafish. Zebrafish 9, 97-107.
    • (2012) Zebrafish , vol.9 , pp. 97-107
    • De Rienzo, G.1    Gutzman, J.H.2    Sive, H.3
  • 22
    • 84867336303 scopus 로고    scopus 로고
    • The role of sleep problems and circadian clock genes in childhood psychiatric disorders
    • Dueck, A., Thome, J. and Haessler, F. (2012). The role of sleep problems and circadian clock genes in childhood psychiatric disorders. J. Neural Transm. 119, 1097-1104.
    • (2012) J. Neural Transm. , vol.119 , pp. 1097-1104
    • Dueck, A.1    Thome, J.2    Haessler, F.3
  • 23
    • 79959918859 scopus 로고    scopus 로고
    • Mouse chimeras as a system to investigate development, cell and tissue function, disease mechanisms and organ regeneration
    • Eckardt, S., McLaughlin, K. J. and Willenbring, H. (2011). Mouse chimeras as a system to investigate development, cell and tissue function, disease mechanisms and organ regeneration. Cell Cycle 10, 2091-2099.
    • (2011) Cell Cycle , vol.10 , pp. 2091-2099
    • Eckardt, S.1    McLaughlin, K.J.2    Willenbring, H.3
  • 24
    • 49949086671 scopus 로고    scopus 로고
    • Controlling morpholino experiments: Don't stop making antisense
    • Eisen, J. S. and Smith, J. C. (2008). Controlling morpholino experiments: don'tstop making antisense. Development 135, 1735-1743.
    • (2008) Development , vol.135 , pp. 1735-1743
    • Eisen, J.S.1    Smith, J.C.2
  • 25
    • 84875849816 scopus 로고    scopus 로고
    • Control of a specific motor program by a small brain area in zebrafish
    • Fajardo, O., Zhu, P. and Friedrich, R. W. (2013). Control of a specific motor program by a small brain area in zebrafish. Front. Neural Circuits 7, 67.
    • (2013) Front. Neural Circuits , vol.7 , pp. 67
    • Fajardo, O.1    Zhu, P.2    Friedrich, R.W.3
  • 26
    • 79954578629 scopus 로고    scopus 로고
    • The role of fragile X mental retardation protein in major mental disorders
    • Fatemi, S. H. and Folsom, T. D. (2011). The role of fragile X mental retardation protein in major mental disorders. Neuropharmacology 60, 1221-1226.
    • (2011) Neuropharmacology , vol.60 , pp. 1221-1226
    • Fatemi, S.H.1    Folsom, T.D.2
  • 27
    • 49549101116 scopus 로고    scopus 로고
    • Zebrafish as a new animal model for movement disorders
    • Flinn, L., Bretaud, S., Lo, C., Ingham, P. W. and Bandmann, O. (2008). Zebrafish as a new animal model for movement disorders. J. Neurochem. 106, 1991-1997.
    • (2008) J. Neurochem. , vol.106 , pp. 1991-1997
    • Flinn, L.1    Bretaud, S.2    Lo, C.3    Ingham, P.W.4    Bandmann, O.5
  • 28
    • 84860300717 scopus 로고    scopus 로고
    • In silico drug screen in mouse liver identifies candidate calorie restriction mimetics
    • Fortney, K., Morgen, E. K., Kotlyar, M. and Jurisica, I. (2012). In silico drug screen in mouse liver identifies candidate calorie restriction mimetics. Rejuvenation Res. 15, 148-152.
    • (2012) Rejuvenation Res. , vol.15 , pp. 148-152
    • Fortney, K.1    Morgen, E.K.2    Kotlyar, M.3    Jurisica, I.4
  • 29
    • 77950598371 scopus 로고    scopus 로고
    • Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action
    • Freyberg, Z., Ferrando, S. J. and Javitch, J. A. (2010). Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action. Am. J. Psychiatry 167, 388-396.
    • (2010) Am. J. Psychiatry , vol.167 , pp. 388-396
    • Freyberg, Z.1    Ferrando, S.J.2    Javitch, J.A.3
  • 31
    • 79953885122 scopus 로고    scopus 로고
    • Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models
    • Goessling, W., Allen, R. S., Guan, X., Jin, P., Uchida, N., Dovey, M., Harris, J. M., Metzger, M. E., Bonifacino, A. C., Stroncek, D. et al. (2011). Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell 8, 445-458.
    • (2011) Cell Stem Cell , vol.8 , pp. 445-458
    • Goessling, W.1    Allen, R.S.2    Guan, X.3    Jin, P.4    Uchida, N.5    Dovey, M.6    Harris, J.M.7    Metzger, M.E.8    Bonifacino, A.C.9    Stroncek, D.10
  • 33
    • 0038823525 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatry: Etymology and strategic intentions
    • Gottesman, I. I. and Gould, T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 160, 636-645.
    • (2003) Am. J. Psychiatry , vol.160 , pp. 636-645
    • Gottesman, I.I.1    Gould, T.D.2
  • 34
    • 84863434758 scopus 로고    scopus 로고
    • Synaptopathies: Diseases of the synaptome
    • Grant, S. G. N. (2012). Synaptopathies: diseases of the synaptome. Curr. Opin. Neurobiol. 22, 522-529.
    • (2012) Curr. Opin. Neurobiol. , vol.22 , pp. 522-529
    • Grant, S.G.N.1
  • 35
    • 84901608878 scopus 로고    scopus 로고
    • Large-scale genomics unveils the genetic architecture of psychiatric disorders
    • Gratten, J., Wray, N. R., Keller, M. C. and Visscher, P. M. (2014). Large-scale genomics unveils the genetic architecture of psychiatric disorders. Nat. Neurosci. 17, 782-790.
    • (2014) Nat. Neurosci. , vol.17 , pp. 782-790
    • Gratten, J.1    Wray, N.R.2    Keller, M.C.3    Visscher, P.M.4
  • 37
    • 84872316775 scopus 로고    scopus 로고
    • In vitro study methodologies to investigate genetic aspects and effects of drugs used in attention-deficit hyperactivity disorder
    • Grünblatt, E., Bartl, J., Marinova, Z. and Walitza, S. (2013). In vitro study methodologies to investigate genetic aspects and effects of drugs used in attention-deficit hyperactivity disorder. J. Neural Transm. 120, 131-139.
    • (2013) J. Neural Transm. , vol.120 , pp. 131-139
    • Grünblatt, E.1    Bartl, J.2    Marinova, Z.3    Walitza, S.4
  • 38
    • 84881416732 scopus 로고    scopus 로고
    • Immunity, inflammation, and bipolar disorder: Diagnostic and therapeutic implications
    • Hamdani, N., Doukhan, R., Kurtlucan, O., Tamouza, R. and Leboyer, M. (2013). Immunity, inflammation, and bipolar disorder: diagnostic and therapeutic implications. Curr. Psychiatry Rep. 15, 387.
    • (2013) Curr. Psychiatry Rep. , vol.15 , pp. 387
    • Hamdani, N.1    Doukhan, R.2    Kurtlucan, O.3    Tamouza, R.4    Leboyer, M.5
  • 39
    • 84875185145 scopus 로고    scopus 로고
    • Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice
    • Han, X., Chen, M., Wang, F., Windrem, M., Wang, S., Shanz, S., Xu, Q., Oberheim, N. A., Bekar, L., Betstadt, S. et al. (2013). Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell 12, 342-353.
    • (2013) Cell Stem Cell , vol.12 , pp. 342-353
    • Han, X.1    Chen, M.2    Wang, F.3    Windrem, M.4    Wang, S.5    Shanz, S.6    Xu, Q.7    Oberheim, N.A.8    Bekar, L.9    Betstadt, S.10
  • 40
    • 84884132973 scopus 로고    scopus 로고
    • Selective small molecule targeting betacatenin function discovered by in vivo chemical genetic screen
    • Hao, J., Ao, A., Zhou, L., Murphy, C. K., Frist, A. Y., Keel, J. J., Thorne, C. A., Kim, K., Lee, E. and Hong, C. C. (2013). Selective small molecule targeting betacatenin function discovered by in vivo chemical genetic screen. Cell Rep. 4, 898-904.
    • (2013) Cell Rep. , vol.4 , pp. 898-904
    • Hao, J.1    Ao, A.2    Zhou, L.3    Murphy, C.K.4    Frist, A.Y.5    Keel, J.J.6    Thorne, C.A.7    Kim, K.8    Lee, E.9    Hong, C.C.10
  • 41
    • 84860249365 scopus 로고    scopus 로고
    • Development and evolution of cerebellar neural circuits
    • Hashimoto, M. and Hibi, M. (2012). Development and evolution of cerebellar neural circuits. Dev. Growth Differ. 54, 373-389.
    • (2012) Dev. Growth Differ. , vol.54 , pp. 373-389
    • Hashimoto, M.1    Hibi, M.2
  • 42
    • 84892670711 scopus 로고    scopus 로고
    • Genome editing using artificial sitespecific nucleases in zebrafish
    • Hisano, Y., Ota, S. and Kawahara, A. (2013). Genome editing using artificial sitespecific nucleases in zebrafish. Dev. Growth Differ. 56, 26-33.
    • (2013) Dev. Growth Differ. , vol.56 , pp. 26-33
    • Hisano, Y.1    Ota, S.2    Kawahara, A.3
  • 44
    • 84867439307 scopus 로고    scopus 로고
    • Revolution stalled
    • Hyman, S. E. (2012). Revolution stalled. Sci. Transl. Med. 4, 155cm111.
    • (2012) Sci. Transl. Med. , vol.4 , pp. 155cm111
    • Hyman, S.E.1
  • 45
    • 84890454893 scopus 로고    scopus 로고
    • Revitalizing psychiatric therapeutics
    • Hyman, S. E. (2014). Revitalizing psychiatric therapeutics. Neuropsychopharmacology 39, 220-229.
    • (2014) Neuropsychopharmacology , vol.39 , pp. 220-229
    • Hyman, S.E.1
  • 47
    • 84882788354 scopus 로고    scopus 로고
    • Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system
    • Jao, L.-E., Wente, S. R. and Chen, W. (2013). Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc. Natl. Acad. Sci. USA 110, 13904-13909.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 13904-13909
    • Jao, L.-E.1    Wente, S.R.2    Chen, W.3
  • 48
    • 84874939434 scopus 로고    scopus 로고
    • Do psychiatric comorbidities have a negative impact on the course and treatment of seizure disorders?
    • Kanner, A. M. (2013). Do psychiatric comorbidities have a negative impact on the course and treatment of seizure disorders? Curr. Opin. Neurol. 26, 208-213.
    • (2013) Curr. Opin. Neurol. , vol.26 , pp. 208-213
    • Kanner, A.M.1
  • 50
    • 84884671572 scopus 로고    scopus 로고
    • What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn
    • Kendler, K. S. (2013). What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn. Mol. Psychiatry 18, 1058-1066.
    • (2013) Mol. Psychiatry , vol.18 , pp. 1058-1066
    • Kendler, K.S.1
  • 51
    • 20344385026 scopus 로고    scopus 로고
    • Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication
    • Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R. and Walters, E. E. (2005a). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 62, 593-602.
    • (2005) Arch. Gen. Psychiatry , vol.62 , pp. 593-602
    • Kessler, R.C.1    Berglund, P.2    Demler, O.3    Jin, R.4    Merikangas, K.R.5    Walters, E.E.6
  • 52
    • 20344374645 scopus 로고    scopus 로고
    • Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    • Kessler, R. C., Chiu, W. T., Demler, O. and Walters, E. E. (2005b). Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 62, 617-627.
    • (2005) Arch. Gen. Psychiatry , vol.62 , pp. 617-627
    • Kessler, R.C.1    Chiu, W.T.2    Demler, O.3    Walters, E.E.4
  • 55
    • 84884826911 scopus 로고    scopus 로고
    • The next-generation sequencing revolution and its impact on genomics
    • Koboldt, D. C., Steinberg, K. M., Larson, D. E., Wilson, R. K. and Mardis, E. R. (2013). The next-generation sequencing revolution and its impact on genomics. Cell 155, 27-38.
    • (2013) Cell , vol.155 , pp. 27-38
    • Koboldt, D.C.1    Steinberg, K.M.2    Larson, D.E.3    Wilson, R.K.4    Mardis, E.R.5
  • 59
    • 84904396621 scopus 로고    scopus 로고
    • Organogenesis in a dish: Modeling development and disease using organoid technologies
    • Lancaster, M. A. and Knoblich, J. A. (2014). Organogenesis in a dish: modeling development and disease using organoid technologies. Science 345, 1247125.
    • (2014) Science , vol.345 , pp. 1247125
    • Lancaster, M.A.1    Knoblich, J.A.2
  • 61
    • 0000501074 scopus 로고
    • Classification of cell populations on the basis of their proliferative behavior
    • Leblond, C. P. (1964). Classification of cell populations on the basis of their proliferative behavior. Natl. Cancer Inst. Monogr. 14, 119-150.
    • (1964) Natl. Cancer Inst. Monogr. , vol.14 , pp. 119-150
    • Leblond, C.P.1
  • 62
    • 84907515426 scopus 로고    scopus 로고
    • In vitro organogenesis from pluripotent stem cells
    • Li, Y., Xu, C. and Ma, T. (2014). In vitro organogenesis from pluripotent stem cells. Organogenesis 10, 159-163.
    • (2014) Organogenesis , vol.10 , pp. 159-163
    • Li, Y.1    Xu, C.2    Ma, T.3
  • 63
    • 34247186766 scopus 로고    scopus 로고
    • Animal models of human disease: Zebrafish swim into view
    • Lieschke, G. J. and Currie, P. D. (2007). Animal models of human disease: zebrafish swim into view. Nat. Rev. Genet. 8, 353-367.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 353-367
    • Lieschke, G.J.1    Currie, P.D.2
  • 65
    • 84885131712 scopus 로고    scopus 로고
    • Assessing social engagement in heterogeneous groups of zebrafish: A new paradigm for autism-like behavioral responses
    • Maaswinkel, H., Zhu, L. and Weng, W. (2013). Assessing social engagement in heterogeneous groups of zebrafish: a new paradigm for autism-like behavioral responses. PLoS ONE 8, e75955.
    • (2013) PLoS ONE , vol.8
    • Maaswinkel, H.1    Zhu, L.2    Weng, W.3
  • 66
    • 84858434210 scopus 로고    scopus 로고
    • CNVs: Harbingers of a rare variant revolution in psychiatric genetics
    • Malhotra, D. and Sebat, J. (2012). CNVs: harbingers of a rare variant revolution in psychiatric genetics. Cell 148, 1223-1241.
    • (2012) Cell , vol.148 , pp. 1223-1241
    • Malhotra, D.1    Sebat, J.2
  • 67
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto, M. C. N., Carromeu, C., Acab, A., Yu, D., Yeo, G. W., Mu, Y., Chen, G., Gage, F. H. and Muotri, A. R. (2010). A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143, 527-539.
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.N.1    Carromeu, C.2    Acab, A.3    Yu, D.4    Yeo, G.W.5    Mu, Y.6    Chen, G.7    Gage, F.H.8    Muotri, A.R.9
  • 70
    • 84899816726 scopus 로고    scopus 로고
    • Gastrointestinal symptoms in autism spectrum disorder: A meta-analysis
    • McElhanon, B. O., McCracken, C., Karpen, S. and Sharp, W. G. (2014). Gastrointestinal symptoms in autism spectrum disorder: a meta-analysis. Pediatrics 133, 872-883.
    • (2014) Pediatrics , vol.133 , pp. 872-883
    • McElhanon, B.O.1    McCracken, C.2    Karpen, S.3    Sharp, W.G.4
  • 71
    • 85047698267 scopus 로고    scopus 로고
    • Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment
    • McEvoy, J. P., Lieberman, J. A., Stroup, T. S., Davis, S. M., Meltzer, H. Y., Rosenheck, R. A., Swartz, M. S., Perkins, D. O., Keefe, R. S. E., Davis, C. E. et al. (2006). Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. Am. J. Psychiatry 163, 600-610.
    • (2006) Am. J. Psychiatry , vol.163 , pp. 600-610
    • McEvoy, J.P.1    Lieberman, J.A.2    Stroup, T.S.3    Davis, S.M.4    Meltzer, H.Y.5    Rosenheck, R.A.6    Swartz, M.S.7    Perkins, D.O.8    Keefe, R.S.E.9    Davis, C.E.10
  • 72
    • 84873669503 scopus 로고    scopus 로고
    • Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells
    • McLaren, D., Gorba, T., Marguerie de Rotrou, A., Pillai, G., Chappell, C., Stacey, A., Lingard, S., Falk, A., Smith, A., Koch, P. et al. (2013). Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells. J. Biomol. Screen. 18, 258-268.
    • (2013) J. Biomol. Screen. , vol.18 , pp. 258-268
    • McLaren, D.1    Gorba, T.2    Marguerie De Rotrou, A.3    Pillai, G.4    Chappell, C.5    Stacey, A.6    Lingard, S.7    Falk, A.8    Smith, A.9    Koch, P.10
  • 73
    • 33645457013 scopus 로고    scopus 로고
    • Evidence from in vivo imaging that synaptogenesis guides the growth and branching of axonal arbors by two distinct mechanisms
    • Meyer, M. P. and Smith, S. J. (2006). Evidence from in vivo imaging that synaptogenesis guides the growth and branching of axonal arbors by two distinct mechanisms. J. Neurosci. 26, 3604-3614.
    • (2006) J. Neurosci. , vol.26 , pp. 3604-3614
    • Meyer, M.P.1    Smith, S.J.2
  • 76
    • 33748346840 scopus 로고    scopus 로고
    • Medical co-morbidity risk factors and barriers to care for people with schizophrenia
    • Muir-Cochrane, E. (2006). Medical co-morbidity risk factors and barriers to care for people with schizophrenia. J. Psychiatr. Mental Health Nurs. 13, 447-452.
    • (2006) J. Psychiatr. Mental Health Nurs. , vol.13 , pp. 447-452
    • Muir-Cochrane, E.1
  • 77
    • 0033780376 scopus 로고    scopus 로고
    • Effective targeted gene 'knockdown' in zebrafish
    • Nasevicius, A. and Ekker, S. C. (2000). Effective targeted gene 'knockdown' in zebrafish. Nat. Genet. 26, 216-220.
    • (2000) Nat. Genet. , vol.26 , pp. 216-220
    • Nasevicius, A.1    Ekker, S.C.2
  • 79
    • 77957273984 scopus 로고    scopus 로고
    • Animal models of neuropsychiatric disorders
    • Nestler, E. J. and Hyman, S. E. (2010). Animal models of neuropsychiatric disorders. Nat. Neurosci. 13, 1161-1169.
    • (2010) Nat. Neurosci. , vol.13 , pp. 1161-1169
    • Nestler, E.J.1    Hyman, S.E.2
  • 80
    • 84874854034 scopus 로고    scopus 로고
    • Behavioral and synaptic circuit features in a zebrafish model of fragile X syndrome
    • Ng, M.-C., Yang, Y.-L. and Lu, K.-T. (2013). Behavioral and synaptic circuit features in a zebrafish model of fragile X syndrome. PLoS ONE 8, e51456.
    • (2013) PLoS ONE , vol.8
    • Ng, M.-C.1    Yang, Y.-L.2    Lu, K.-T.3
  • 81
    • 84876068346 scopus 로고    scopus 로고
    • Toward developmental models of psychiatric disorders in zebrafish
    • Norton, W. H. (2013). Toward developmental models of psychiatric disorders in zebrafish. Front. Neural Circuits 7, 79.
    • (2013) Front. Neural Circuits , vol.7 , pp. 79
    • Norton, W.H.1
  • 82
    • 84885581328 scopus 로고    scopus 로고
    • Towards translational rodent models of depression
    • O'Leary, O. F. and Cryan, J. F. (2013). Towards translational rodent models of depression. Cell Tissue Res. 354, 141-153.
    • (2013) Cell Tissue Res. , vol.354 , pp. 141-153
    • O'Leary, O.F.1    Cryan, J.F.2
  • 83
    • 77955844066 scopus 로고    scopus 로고
    • The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases
    • Panula, P., Chen, Y.-C., Priyadarshini, M., Kudo, H., Semenova, S., Sundvik, M. and Sallinen, V. (2010). The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases. Neurobiol. Dis. 40, 46-57.
    • (2010) Neurobiol. Dis. , vol.40 , pp. 46-57
    • Panula, P.1    Chen, Y.-C.2    Priyadarshini, M.3    Kudo, H.4    Semenova, S.5    Sundvik, M.6    Sallinen, V.7
  • 84
    • 70449407836 scopus 로고    scopus 로고
    • Risk factors for development of depression and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids
    • Pariante, C. M. (2009). Risk factors for development of depression and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids. Ann. N. Y. Acad. Sci. 1179, 144-152.
    • (2009) Ann. N. Y. Acad. Sci. , vol.1179 , pp. 144-152
    • Pariante, C.M.1
  • 86
    • 84899982894 scopus 로고    scopus 로고
    • Drug discovery through stem cell-based organoid models
    • Ranga, A., Gjorevski, N. and Lutolf, M. P. (2014). Drug discovery through stem cell-based organoid models. Adv. Drug Deliv. Rev. 69-70C, 19-28.
    • (2014) Adv. Drug Deliv. Rev. , vol.69-70 C , pp. 19-28
    • Ranga, A.1    Gjorevski, N.2    Lutolf, M.P.3
  • 88
    • 0034837386 scopus 로고    scopus 로고
    • A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster
    • Reiter, L. T., Potocki, L., Chien, S., Gribskov, M. and Bier, E. (2001). A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res. 11, 1114-1125.
    • (2001) Genome Res. , vol.11 , pp. 1114-1125
    • Reiter, L.T.1    Potocki, L.2    Chien, S.3    Gribskov, M.4    Bier, E.5
  • 89
    • 84855870166 scopus 로고    scopus 로고
    • A model 450 million years in the making: Zebrafish and vertebrate immunity
    • Renshaw, S. A. and Trede, N. S. (2012). A model 450 million years in the making: zebrafish and vertebrate immunity. Dis. Model. Mech. 5, 38-47.
    • (2012) Dis. Model. Mech. , vol.5 , pp. 38-47
    • Renshaw, S.A.1    Trede, N.S.2
  • 92
    • 79952690820 scopus 로고    scopus 로고
    • Annual research review: Transgenic mouse models of childhood-onset psychiatric disorders
    • Robertson, H. R. and Feng, G. (2011). Annual research review: transgenic mouse models of childhood-onset psychiatric disorders. J. Child Psychol. Psychiatry 52, 442-475.
    • (2011) J. Child Psychol. Psychiatry , vol.52 , pp. 442-475
    • Robertson, H.R.1    Feng, G.2
  • 97
    • 84874762077 scopus 로고    scopus 로고
    • A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target
    • Saur, T., DeMarco, S. E., Ortiz, A., Sliwoski, G. R., Hao, L., Wang, X., Cohen, B. M. and Buttner, E. A. (2013). A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target. PLoS Genet. 9, e1003313.
    • (2013) PLoS Genet. , vol.9
    • Saur, T.1    DeMarco, S.E.2    Ortiz, A.3    Sliwoski, G.R.4    Hao, L.5    Wang, X.6    Cohen, B.M.7    Buttner, E.A.8
  • 98
    • 77952612537 scopus 로고    scopus 로고
    • Optogenetic localization and genetic perturbation of saccade-generating neurons in zebrafish
    • Schoonheim, P. J., Arrenberg, A. B., Del Bene, F. and Baier, H. (2010). Optogenetic localization and genetic perturbation of saccade-generating neurons in zebrafish. J. Neurosci. 30, 7111-7120.
    • (2010) J. Neurosci. , vol.30 , pp. 7111-7120
    • Schoonheim, P.J.1    Arrenberg, A.B.2    Del Bene, F.3    Baier, H.4
  • 99
    • 84885767134 scopus 로고    scopus 로고
    • Next-generation sequencing in schizophrenia and other neuropsychiatric disorders
    • Schreiber, M., Dorschner, M. and Tsuang, D. (2013). Next-generation sequencing in schizophrenia and other neuropsychiatric disorders. Am. J. Med. Genet. B Neuropsychiatr. Genet. 162B, 671-678.
    • (2013) Am. J. Med. Genet. B Neuropsychiatr. Genet. , vol.162 B , pp. 671-678
    • Schreiber, M.1    Dorschner, M.2    Tsuang, D.3
  • 101
    • 79955625425 scopus 로고    scopus 로고
    • Development of the zebrafish enteric nervous system
    • Shepherd, I. and Eisen, J. (2011). Development of the zebrafish enteric nervous system. Methods Cell Biol. 101, 143-160.
    • (2011) Methods Cell Biol. , vol.101 , pp. 143-160
    • Shepherd, I.1    Eisen, J.2
  • 102
    • 84862778046 scopus 로고    scopus 로고
    • Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
    • Shi, Y., Kirwan, P., Smith, J., Robinson, H. P. and Livesey, F. J. (2012). Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses. Nat. Neurosci. 15, 477-486.
    • (2012) Nat. Neurosci. , vol.15 , pp. 477-486
    • Shi, Y.1    Kirwan, P.2    Smith, J.3    Robinson, H.P.4    Livesey, F.J.5
  • 103
    • 84881115440 scopus 로고    scopus 로고
    • Aromatic L-amino acid decarboxylase (AADC) is crucial for brain development and motor functions
    • Shih, D.-F., Hsiao, C.-D., Min, M.-Y., Lai, W.-S., Yang, C.-W., Lee, W.-T. and Lee, S.-J. (2013). Aromatic L-amino acid decarboxylase (AADC) is crucial for brain development and motor functions. PLoS ONE 8, e71741.
    • (2013) PLoS ONE , vol.8
    • Shih, D.-F.1    Hsiao, C.-D.2    Min, M.-Y.3    Lai, W.-S.4    Yang, C.-W.5    Lee, W.-T.6    Lee, S.-J.7
  • 105
    • 79952352259 scopus 로고    scopus 로고
    • 'Model' or 'tool'? New definitions for translational research
    • Sive, H. (2011). 'Model' or 'tool'? New definitions for translational research. Dis. Model. Mech. 4, 137-138.
    • (2011) Dis. Model. Mech. , vol.4 , pp. 137-138
    • Sive, H.1
  • 110
    • 84867887824 scopus 로고    scopus 로고
    • Current perspectives of the signaling pathways directing neural crest induction
    • Stuhlmiller, T. J. and García-Castro, M. I. (2012). Current perspectives of the signaling pathways directing neural crest induction. Cell. Mol. Life Sci. 69, 3715-3737.
    • (2012) Cell. Mol. Life Sci. , vol.69 , pp. 3715-3737
    • Stuhlmiller, T.J.1    García-Castro, M.I.2
  • 116
    • 84855974464 scopus 로고    scopus 로고
    • The roles of neurotrophic factor and Wnt signaling in depression
    • Voleti, B. and Duman, R. S. (2012). The roles of neurotrophic factor and Wnt signaling in depression. Clin. Pharmacol. Ther. 91, 333-338.
    • (2012) Clin. Pharmacol. Ther. , vol.91 , pp. 333-338
    • Voleti, B.1    Duman, R.S.2
  • 118
    • 84864147096 scopus 로고    scopus 로고
    • A chemical screening system for glucocorticoid stress hormone signaling in an intact vertebrate
    • Weger, B. D., Weger, M., Nusser, M., Brenner-Weiss, G. and Dickmeis, T. (2012). A chemical screening system for glucocorticoid stress hormone signaling in an intact vertebrate. ACS Chem. Biol. 7, 1178-1183.
    • (2012) ACS Chem. Biol. , vol.7 , pp. 1178-1183
    • Weger, B.D.1    Weger, M.2    Nusser, M.3    Brenner-Weiss, G.4    Dickmeis, T.5
  • 119
    • 84901347920 scopus 로고    scopus 로고
    • The apoptotic perspective of autism
    • Wei, H., Alberts, I. and Li, X. (2014). The apoptotic perspective of autism. Int. J. Dev. Neurosci. 36, 13-18.
    • (2014) Int. J. Dev. Neurosci. , vol.36 , pp. 13-18
    • Wei, H.1    Alberts, I.2    Li, X.3
  • 120
    • 66349117984 scopus 로고    scopus 로고
    • Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and Xenopus
    • Wheeler, G. N. and Brändli, A. W. (2009). Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus. Dev. Dyn. 238, 1287-1308.
    • (2009) Dev. Dyn. , vol.238 , pp. 1287-1308
    • Wheeler, G.N.1    Brändli, A.W.2
  • 122
    • 84883183722 scopus 로고    scopus 로고
    • Zebrafish cancer: The state of the art and the path forward
    • White, R., Rose, K. and Zon, L. (2013). Zebrafish cancer: the state of the art and the path forward. Nat. Rev. Cancer 13, 624-636.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 624-636
    • White, R.1    Rose, K.2    Zon, L.3
  • 124
    • 77949400306 scopus 로고    scopus 로고
    • Secondary neurogenesis and telencephalic organization in zebrafish and mice: A brief review
    • Wullimann, M. F. (2009). Secondary neurogenesis and telencephalic organization in zebrafish and mice: a brief review. Integr. Zool. 4, 123-133.
    • (2009) Integr. Zool. , vol.4 , pp. 123-133
    • Wullimann, M.F.1
  • 125
    • 70349295632 scopus 로고    scopus 로고
    • Optogenetic dissection of a behavioural module in the vertebrate spinal cord
    • Wyart, C., Del Bene, F., Warp, E., Scott, E. K., Trauner, D., Baier, H. and Isacoff, E. Y. (2009). Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature 461, 407-410.
    • (2009) Nature , vol.461 , pp. 407-410
    • Wyart, C.1    Del Bene, F.2    Warp, E.3    Scott, E.K.4    Trauner, D.5    Baier, H.6    Isacoff, E.Y.7
  • 126
    • 24344457816 scopus 로고    scopus 로고
    • Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
    • Yan, Q. J., Rammal, M., Tranfaglia, M. and Bauchwitz, R. P. (2005). Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP. Neuropharmacology 49, 1053-1066.
    • (2005) Neuropharmacology , vol.49 , pp. 1053-1066
    • Yan, Q.J.1    Rammal, M.2    Tranfaglia, M.3    Bauchwitz, R.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.