Developing zebrafish models of autism spectrum disorder (ASD)

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 50, Issue , 2014, Pages 27-36

  Stewart, Adam Michael ^a,b   Nguyen, Michael ^c   Wong, Keith ^d   Poudel, Manoj K ^a   Kalueff, Allan V ^a  

^a The International Zebrafish Neuroscience Research Consortium (ZNRC)   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c University of Virginia   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autism spectrum disorder; Behavioral tests; Social deficits; Translational research; Zebrafish

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL; ISOTOCIN; NEUROLIGIN; OXYTOCIN; RESERPINE; RISPERIDONE;

AGGRESSION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; AUTISM; BRAIN FUNCTION; COGNITION; CONTROLLED STUDY; LOSS OF FUNCTION MUTATION; MOLECULAR MECHANICS; NEUROSCIENCE; NONHUMAN; OBSESSION; PATHOGENESIS; REVIEW; SOCIAL BEHAVIOR; ANIMAL; BRAIN; CHEMICALLY INDUCED; DISEASE MODEL; GENETICS; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; ZEBRA FISH;

ANIMALS; BRAIN; CHILD DEVELOPMENT DISORDERS, PERVASIVE; DISEASE MODELS, ANIMAL; HUMANS; SOCIAL BEHAVIOR; ZEBRAFISH;

EID: 84891048820     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2013.11.014     Document Type: Review

References (132)

1. Abaid N., Bartolini T., Macri S., Porfiri M. Zebrafish responds differentially to a robotic fish of varying aspect ratio, tail beat frequency, noise, and color. Behav Brain Res 2012, 233:545-553.
2. Al-Imari L., Gerlai R. Sight of conspecifics as reward in associative learning in zebrafish (Danio rerio). Behav Brain Res 2008, 189:216-219.
3. Bartz J.A., McInnes L.A. CD38 regulates oxytocin secretion and complex social behavior. BioEssays News Rev Mol Cell and Dev Biol 2007, 29:837-841.
4. Benvenuto A., Battan B., Porfirio M.C., Curatolo P. Pharmacotherapy of autism spectrum disorders. Brain Dev 2013, 35:119-127.
5. Bernardet M., Crusio W.E. Fmr1 KO mice as a possible model of autistic features. Sci World J 2006, 6:1164-1176.
6. Bisong S., Brown R., Osim E. Comparative effects of Rauwolfia vomitoria and chlorpromazine on social behaviour and pain. N Am J Med Sci 2011, 3:48-54.
7. Bisong S.A., Brown R., Osim E.E. Comparative effects of Rauwolfia vomitoria and chlorpromazine on locomotor behaviour and anxiety in mice. J Ethnopharmacol 2010, 132:334-339.
8. Blaker-Lee A., Gupta S., McCammon J.M., De Rienzo G., Sive H. Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. Dis Model Mech 2012, 5:834-851.
9. Boccuto L., Lauri M., Sarasua S.M., Skinner C.D., Buccella D., Dwivedi A., et al. Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders. Eur J Human Genet EJHG 2013, 21:310-316.
10. Bozdagi O., Sakurai T., Papapetrou D., Wang X., Dickstein D.L., Takahashi N., et al. Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism 2010, 1:15.
11. Braida D., Donzelli A., Martucci R., Capurro V., Busnelli M., Chini B., et al. Neurohypophyseal hormones manipulation modulate social and anxiety-related behavior in zebrafish. Psychopharmacology (Berl) 2012, 220:319-330.
12. Brodkin E.S. BALB/c mice: low sociability and other phenotypes that may be relevant to autism. Behav Brain Res 2007, 176:53-65.
13. Burket J.A., Cannon W.R., Jacome L.F., Deutsch S.I. MK-801, a noncompetitive NMDA receptor antagonist, elicits circling behavior in the genetically inbred Balb/c mouse strain. Brain Res Bull 2010, 83:337-339.
14. Cachat J., Kyzar E.J., Collins C., Gaikwad S., Green J., Roth A., et al. Unique and potent effects of acute ibogaine on zebrafish: the developing utility of novel aquatic models for hallucinogenic drug research. Behav Brain Res 2013, 236:258-269.
15. Capurro V. New pharmacological tools for autism research: oxytocin receptor mutant mice and zebrafish as neurobehavioral models [Doctoral dissertation] 2010, University of Milan, Milan.
16. Carneiro A.M., Cook E.H., Murphy D.L., Blakely R.D. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest 2008, 118:1544-1552.
17. Carter C.S. Sex differences in oxytocin and vasopressin: implications for autism spectrum disorders?. Behav Brain Res 2007, 176:170-186.
18. Carter C.S., Grippo A.J., Pournajafi-Nazarloo H., Ruscio M.G., Porges S.W. Oxytocin, vasopressin and sociality. Prog Brain Res 2008, 170:331-336.
19. Carter M.D., Shah C.R., Muller C.L., Crawley J.N., Carneiro A.M., Veenstra-VanderWeele J. Absence of preference for social novelty and increased grooming in integrin beta3 knockout mice: initial studies and future directions. Autism Res Off J Int Soc Autism Res 2011, 4:57-67.
20. Chadman K.K. Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism. Pharmacol Biochem Behav 2011, 97:586-594.
21. Corbett R., Camacho F., Woods A.T., Kerman L.L., Fishkin R.J., Brooks K., et al. Antipsychotic agents antagonize non-competitive N-methyl-d-aspartate antagonist-induced behaviors. Psychopharmacology 1995, 120:67-74.
22. Crawley J.N. Translational animal models of autism and neurodevelopmental disorders. Dialogues Clin Neurosci 2012, 14:293.
23. Ebstein R.P., Knafo A., Mankuta D., Chew S.H., Lai P.S. The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm Behav 2012, 61:359-379.
24. Edvardson S., Ashikov A., Jalas C., Sturiale L., Shaag A., Fedick A., et al. Mutations in SLC35A3 cause autism spectrum disorder, epilepsy and arthrogryposis. J Med Genet 2013, 50(11):733-739.
25. Egan R.J., Bergner C.L., Hart P.C., Cachat J.M., Canavello P.R., Elegante M.F., et al. Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish. Behav Brain Res 2009, 205:38-44.
26. Egashira N., Tanoue A., Matsuda T., Koushi E., Harada S., Takano Y., et al. Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice. Behav Brain Res 2007, 178:123-127.
27. El-Kordi A., Winkler D., Hammerschmidt K., Kastner A., Krueger D., Ronnenberg A., et al. Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism. Behav Brain Res 2012, 251:41-49.
28. Elsen G.E., Choi L.Y., Prince V.E., Ho R.K. The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration. Dev Biol 2009, 335:78-92.
29. Evans B. How autism became autism: the radical transformation of a central concept of child development in Britain. Hist Hum Sci 2013, 26:3-31.
30. Fairless A.H., Katz J.M., Vijayvargiya N., Dow H.C., Kreibich A.S., Berrettini W.H., et al. Development of home cage social behaviors in BALB/cJ vs. C57BL/6J mice. Behav Brain Res 2013, 237:338-347.
31. Farmer C., Thurm A., Grant P. Pharmacotherapy for the core symptoms in autistic disorder: current status of the research. Drugs 2013, 73:303-314.
32. Gaikwad S., Stewart A., Hart P., Wong K., Piet V., Cachat J., et al. Acute stress disrupts performance of zebrafish in the cued and spatial memory tests: the utility of fish models to study stress-memory interplay. Behav Proc 2011, 87:224-230.
33. Gao X.M., Elmer G.I., Adams-Huet B., Tamminga C.A. Social memory in mice: disruption with an NMDA antagonist and attenuation with antipsychotic drugs. Pharmacol Biochem Behav 2009, 92:236-242.
34. Gauthier J., Champagne N., Lafreniere R.G., Xiong L., Spiegelman D., Brustein E., et al. De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia. Proc Natl Acad Sci U S A 2010, 107:7863-7868.
35. Gerlai R. High-throughput behavioral screens: the first step towards finding genes involved in vertebrate brain function using zebrafish. Molecules 2010, 15:2609-2622.
36. Gerlai R. Zebrafish antipredatory responses: a future for translational research?. Behav Brain Res 2010, 207:223-231.
37. Gerlai R. A small fish with a big future: zebrafish in behavioral neuroscience. Rev Neurosci 2011, 22:3-4.
38. Gerlai R., Fernandes Y., Pereira T. Zebrafish (Danio rerio) responds to the animated image of a predator: towards the development of an automated aversive task. Behav Brain Res 2009, 201:318-324.
39. Geschwind D.H. Autism: many genes, common pathways?. Cell 2008, 135:391-395.
40. Gilby K.L. A new rat model for vulnerability to epilepsy and autism spectrum disorders. Epilepsia 2008, 49(Suppl. 8):108-110.
41. Golzio C., Willer J., Talkowski M.E., Oh E.C., Taniguchi Y., Jacquemont S., et al. KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant. Nature 2012, 485:363-367.
42. Goodson J.L., Bass A.H. Forebrain peptides modulate sexually polymorphic vocal circuitry. Nature 2000, 403:769-772.
43. Greco B., Manago F., Tucci V., Kao H.T., Valtorta F., Benfenati F. Autism-related behavioral abnormalities in synapsin knockout mice. Behav Brain Res 2013, 251:65-74.
44. Green J., Collins C., Kyzar E.J., Pham M., Roth A., Gaikwad S., et al. Automated high-throughput neurophenotyping of zebrafish social behavior. J Neurosci Methods 2012, 210:266-271.
45. Hanks A.N., Dlugolenski K., Hughes Z.A., Seymour P.A., Majchrzak M.J. Pharmacological disruption of mouse social approach behavior: relevance to negative symptoms of schizophrenia. Behav Brain Res 2013, 252:405-414.
46. Harony H., Wagner S. The contribution of oxytocin and vasopressin to mammalian social behavior: potential role in autism spectrum disorder. Neurosignals 2010, 18:82-97.
47. Higashida H., Yokoyama S., Kikuchi M., Munesue T. CD38 and its role in oxytocin secretion and social behavior. Horm Behav 2012, 61:351-358.
48. Higashida H., Yokoyama S., Munesue T., Kikuchi M., Minabe Y., Lopatina O. CD38 gene knockout juvenile mice: a model of oxytocin signal defects in autism. Biol Pharm Bull 2011, 34:1369-1372.
49. Hortopan G.A., Dinday M.T., Baraban S.C. Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish. J Neurosci Off J Soc Neurosci 2010, 30:13718-13728.
50. Insel T.R., O'Brien D.J., Leckman J.F. Oxytocin, vasopressin, and autism: is there a connection?. Biol Psychiatry 1999, 45:145-157.
51. Jacob S., Brune C.W., Carter C.S., Leventhal B.L., Lord C., Cook E.H. Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. Neurosci Lett 2007, 417:6-9.
52. Jacome L.F., Burket J.A., Herndon A.L., Cannon W.R., Deutsch S.I. d-Serine improves dimensions of the sociability deficit of the genetically-inbred Balb/c mouse strain. Brain Res Bull 2011, 84:12-16.
53. Jamain S., Radyushkin K., Hammerschmidt K., Granon S., Boretius S., Varoqueaux F., et al. Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc Natl Acad Sci 2008, 105:1710-1715.
54. Kalueff A.V., Gebhardt M., Stewart A.M., Cachat J.M., Brimmer M., Chawla J.S., et al. Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond. Zebrafish 2013, 10:70-86.
55. Kalueff A.V., Olivier J.D., Nonkes L.J., Homberg J.R. Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes. Neurosci Biobehav Rev 2010, 34:373-386.
56. Kalueff A.V., Ren-Patterson R.F., LaPorte J.L., Murphy D.L. Domain interplay concept in animal models of neuropsychiatric disorders: a new strategy for high-throughput neurophenotyping research. Behav Brain Res 2008, 188:243-249.
57. Kalueff A.V., Wheaton M., Murphy D.L. What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression. Behav Brain Res 2007, 179:1-18.
58. Kalueff A.V., Stewart A.M. Gerlai R 2014, Zebrafish as an emerging model for studying complex brain disorders, Trends Pharmacol Sci, [in press].
59. Kas M.J., Glennon J.C., Buitelaar J., Ey E., Biemans B., Crawley J., et al. Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: current status and future perspectives. Psychopharmacology 2013, [in press].
60. Kawicka A., Regulska-Ilow B. How nutritional status, diet and dietary supplements can affect autism. A review. Rocz. Panstw. Zakl. Hig. 2013, 64:1-12.
61. Kéïta L., Mottron L., Dawson M., Bertone A. Atypical lateral connectivity: a neural basis for altered visuospatial processing in autism. Biol Psychiatry 2011, 70:806-811.
62. Kesli R., Gokcen C., Bulug U., Terzi Y. Investigation of the relation between anaerobic bacteria genus clostridium and late-onset autism etiology in children. J Immunoassay Immunochem 2014, 35:101-109.
63. Kujala T., Lepistö T., Näätänen R. The neural basis of aberrant speech and audition in autism spectrum disorders. Neurosci Biobehav Rev 2013, 37:697-704.
64. Kumsta R., Heinrichs M. Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system. Curr Opin Neurobiol 2013, 23:11-16.
65. Kyzar E.J., Collins C., Gaikwad S., Green J., Roth A., Monnig L., et al. Effects of hallucinogenic agents mescaline and phencyclidine on zebrafish behavior and physiology. Prog Neuropsychopharmacol Biol Psychiatry 2012, 37:194-202.
66. Kyzar E.J., Pham M., Roth A., Cachat J., Green J., Gaikwad S., et al. Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: the utility of behavior-recognition tools to characterize mutant mouse phenotypes. Brain Res Bull 2012, 89:168-176.
67. LaSalle J.M. Epigenomic strategies at the interface of genetic and environmental risk factors for autism. J Hum Genet 2013, 58:396-401.
68. Lee S.H., Kim H.R., Han R.X., Oqani R.K., Jin D.I. Cardiovascular risk assessment of atypical antipsychotic drugs in a zebrafish model. J Appl Toxicol JAT 2013, 33:466-470.
69. Lim M.M., Bielsky I.F., Young L.J. Neuropeptides and the social brain: potential rodent models of autism. Int J Dev Neurosci 2005, 23:235-243.
70. Lopes da Fonseca T., Correia A., Hasselaar W., van der Linde H.C., Willemsen R., Outeiro T.F. The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival. Brain Res Bull 2013, 90:118-126.
71. Luca R.M., Gerlai R. Animated bird silhouette above the tank: acute alcohol diminishes fear responses in zebrafish. Behav Brain Res 2012, 229:194-201.
72. Maaswinkel H., Zhu L., Weng W. Assessing social engagement in heterogeneous groups of zebrafish: a new paradigm for autism-like behavioral responses. PloS One 2013, 8:e75955.
73. Matson J.L., Kozlowski A.M., Matson M.M. Speech deficits in persons with autism: etiology and symptom presentation. Res Autism Spectr Disord 2012, 6:573-577.
74. Mayes S.D., Calhoun S.L., Murray M.J., Ahuja M., Smith L.A. Anxiety, depression, and irritability in children with autism relative to other neuropsychiatric disorders and typical development. Res Autism Spectr Disord 2011, 5:474-485.
75. McFarlane H.G., Kusek G.K., Yang M., Phoenix J.L., Bolivar V.J., Crawley J.N. Autism-like behavioral phenotypes in BTBR T+tf/J mice. Genes Brain Behav 2008, 7:152-163.
76. McTighe S.M., Neal S.J., Lin Q., Hughes Z.A., Smith D.G. The BTBR mouse model of autism spectrum disorders has learning and attentional impairments and alterations in acetylcholine and kynurenic acid in prefrontal cortex. PloS One 2013, 8:e62189.
77. Meyza K.Z., Defensor E.B., Jensen A.L., Corley M.J., Pearson B.L., Pobbe R.L., et al. The BTBR T(+)tf/J mouse model for autism spectrum disorders-in search of biomarkers. Behav Brain Res 2012, 251:25-34.
78. Miller N., Gerlai R. Automated tracking of zebrafish shoals and the analysis of shoaling behavior. T Zebrafish Protoc Neurobehav Res 2012, 217-230.
79. Miller N., Gerlai R. From schooling to shoaling: patterns of collective motion in zebrafish (Danio rerio). PLoS One 2012, 7:e48865.
80. Miller N.Y., Gerlai R. Shoaling in zebrafish: what we don't know. Rev Neurosci 2011, 22:17-25.
81. Modi M.E., Young L.J. The oxytocin system in drug discovery for autism: animal models and novel therapeutic strategies. Horm Behav 2012, 61:340-350.
82. Moy S.S., Nadler J.J., Young N.B., Nonneman R.J., Segall S.K., Andrade G.M., et al. Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res 2008, 191:118-129.
83. Myers S.M. The status of pharmacotherapy for autism spectrum disorders. Expert Opin Pharmacother 2007, 8:1579-1603.
84. Neumann I.D., Landgraf R. Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. Trends Neurosci 2012, 35:649-659.
85. Norton W.H. Toward developmental models of psychiatric disorders in zebrafish. Front Neural Circ 2013, 7:79.
86. Oksenberg N., Stevison L., Wall J.D., Ahituv N. Function and regulation of AUTS2, a gene implicated in autism and human evolution. PLoS Genet 2013, 9:e1003221.
87. Oliveira R.F. Mind the fish: zebrafish as a model in cognitive social neuroscience. Front Neural Circ 2013, 7:131.
88. Oliveira R.F., Silva J.F., Simoes J.M. Fighting zebrafish: characterization of aggressive behavior and winner-loser effects. Zebrafish 2011, 8:73-81.
89. Pampanos A., Volaki K., Kanavakis E., Papandreou O., Youroukos S., Thomaidis L., et al. A substitution involving the NLGN4 gene associated with autistic behavior in the Greek population. Genet Test Mol Biomark 2009, 13:611-615.
90. Parker M.O., Gaviria J., Haigh A., Millington M.E., Brown V.J., Combe F.J., et al. Discrimination reversal and attentional sets in zebrafish (Danio rerio). Behav Brain Res 2012, 232:264-268.
91. Parker M.O., Ife D., Ma J., Pancholi M., Smeraldi F., Straw C., et al. Development and automation of a test of impulse control in zebrafish. Front Syst Neurosci 2013, 7:65.
92. Parker M.O., Millington M.E., Combe F.J., Brennan C.H. Development and implementation of a three-choice serial reaction time task for zebrafish (Danio rerio). Behav Brain Res 2012, 227:73-80.
93. Pather S., Gerlai R. Shuttle box learning in zebrafish (Danio rerio). Behav Brain Res 2009, 196:323-327.
94. Pietropaolo S., Guilleminot A., Martin B., D'Amato F.R., Crusio W.E. Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice. PloS One 2011, 6:e17073.
95. Pippal J.B., Cheung C.M., Yao Y.Z., Brennan F.E., Fuller P.J. Characterization of the zebrafish (Danio rerio) mineralocorticoid receptor. Mol Cell Endocrinol 2011, 332:58-66.
96. Pobbe R.L.H., Defensor E.B., Pearson B.L., Bolivar V.J., Blanchard D.C., Blanchard R.J. General and social anxiety in the BTBR T+tf/J mouse strain. Behav Brain Res 2011, 216:446-451.
97. Pobbe R.L.H., Pearson B.L., Blanchard D.C., Blanchard R.J. Oxytocin receptor and Mecp2308/Y knockout mice exhibit altered expression of autism-related social behaviors. Physiol Behav 2012, 107:641-648.
98. Polverino G., Abaid N., Kopman V., Macri S., Porfiri M. Zebrafish response to robotic fish: preference experiments on isolated individuals and small shoals. Bioinspiration Biomimetics 2012, 7:036019.
99. Prieto M., Gutierrez H., Arevalo R., Chiaramoni N., Alonso SdV Effect of risperidone and fluoxetine on the movement and neurochemical changes of zebrafish. Open J Med Chem 2012, 2:129-138.
100. Qiao H., Noda Y., Kamei H., Nagai T., Furukawa H., Miura H., et al. Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment. Neuroreport 2001, 12:11-15.
101. Reynolds S., Urruela M., Devine D.P. Effects of environmental enrichment on repetitive behaviors in the BTBR T+tf/J mouse model of autism. Autism Res Off J Int Soc Autism Res 2013, 6(5):337-343.
102. Richendrfer H., Pelkowski S.D., Colwill R.M., Creton R. Developmental sub-chronic exposure to chlorpyrifos reduces anxiety-related behavior in zebrafish larvae. Neurotoxicol Teratol 2012, 34:458-465.
103. Riehl R., Kyzar E., Allain A., Green J., Hook M., Monnig L., et al. Behavioral and physiological effects of acute ketamine exposure in adult zebrafish. Neurotoxicol Teratol 2011, 33:658-667.
104. Roy M., Ohlmeier M.D., Osterhagen L., Prox-Vagedes V., Dillo W. Asperger syndrome: a frequent comorbidity in first diagnosed adult ADHD patients?. Psychiatr Danub 2013, 25:133-141.
105. Ryan B.C., Young N.B., Crawley J.N., Bodfish J.W., Moy S.S. Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain. Behav Brain Res 2010, 208:178-188.
106. Scattoni M.L., Martire A., Cartocci G., Ferrante A., Ricceri L. Reduced social interaction, behavioural flexibility and BDNF signalling in the BTBR T+tf/J strain, a mouse model of autism. Behav Brain Res 2012, 251:35-40.
107. Schneider H. Measuring agonistic behavior in zebrafish. Neuromethods 2011, 51:125-134.
108. Schwartzer J.J., Careaga M., Onore C.E., Rushakoff J.A., Berman R.F., Ashwood P. Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice. Transl Psychiatry 2013, 3:e240.
109. Silverman J.L., Oliver C.F., Karras M.N., Gastrell P.T., Crawley J.N. AMPAKINE enhancement of social interaction in the BTBR mouse model of autism. Neuropharmacology 2013, 64:268-282.
110. Silverman J.L., Smith D.G., Rizzo S.J., Karras M.N., Turner S.M., Tolu S.S., et al. Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism. Sci Transl Med 2012, 4:131ra51.
111. Spence R., Gerlach G., Lawrence C., Smith C. The behaviour and ecology of the zebrafish, Danio rerio. Biol Rev 2008, 83:13-34.
112. Sprenger L., Buhler E., Poustka L., Bach C., Heinzel-Gutenbrunner M., Kamp-Becker I., et al. Impact of ADHD symptoms on autism spectrum disorder symptom severity. Res Dev Disabil 2013, 34:3545-3552.
113. Stewart A., Kadri F., DiLeo J., Chung K., Cachat J., Goodspeed J., et al. The developing utility of zebrafish in modeling neurobehavioral disorders. Int J Comp Psychol 2010, 23:104-121.
114. Stewart A.M., Cachat J., Green J., Gaikwad S., Kyzar E., Roth A., et al. Constructing the habituome for phenotype-driven zebrafish research. Behav Brain Res 2013, 236:110-117.
115. Stewart A.M., Desmond D., Kyzar E., Gaikwad S., Roth A., Riehl R., et al. Perspectives of zebrafish models of epilepsy: what, how and where next?. Brain Res Bull 2012, 87:135-143.
116. Stewart A.M., Kalueff A.V. The developing utility of zebrafish models for cognitive enhancers research. Curr Neuropharmacol 2012, 10:263-271.
117. Striepens N., Kendrick K.M., Maier W., Hurlemann R. Prosocial effects of oxytocin and clinical evidence for its therapeutic potential. Front Neuroendocrinol 2011, 32:426-450.
118. Suen M.F., Chan W.S., Hung K.W., Chen Y.F., Mo Z.X., Yung K.K. Assessments of the effects of nicotine and ketamine using tyrosine hydroxylase-green fluorescent protein transgenic zebrafish as biosensors. Biosens Bioelectron 2013, 42:177-185.
119. Teng B.L., Nonneman R.J., Agster K.L., Nikolova V.D., Davis T.T., Riddick N.V., et al. Prosocial effects of oxytocin in two mouse models of autism spectrum disorders. Neuropharmacology 2013, 72:187-196.
120. Thirtamara Rajamani K., Doherty-Lyons S., Bolden C., Willis D., Hoffman C., Zelikoff J., et al. Prenatal and early-life exposure to high-level diesel exhaust particles leads to increased locomotor activity and repetitive behaviors in mice. Autism Res Off J Int Soc Autism Res 2013, 6:248-257.
121. Thompson R.R., Walton J.C. Peptide effects on social behavior: effects of vasotocin and isotocin on social approach behavior in male goldfish (Carassius auratus). Behav Neurosci 2004, 118:620-626.
122. Tropepe V., Sive H.L. Can zebrafish be used as a model to study the neurodevelopmental causes of autism?. Genes Brain Behav 2003, 2:268-281.
123. Tuchman R. Autism and social cognition in epilepsy: implications for comprehensive epilepsy care. Curr Opin Neurol 2013, 26:214-218.
124. Veenstra-VanderWeele J., Muller C.L., Iwamoto H., Sauer J.E., Owens W.A., Shah C.R., et al. Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proc Natl Acad Sci U S A 2012, 109:5469-5474.
125. Warnick J.E., LaPorte J.L., Kalueff A.V. Domain interplay in mice and men: new possibilities for the "natural kinds" theory of emotion. New Ideas Psychol 2011, 29:49-56.
126. Wing J., O'Connor N., Lotter V. Autistic conditions in early childhood: a survey in Middlesex. Br Med J 1967, 3:389.
127. Wong K., Elegante M., Bartels B., Elkhayat S., Tien D., Roy S., et al. Analyzing habituation responses to novelty in zebrafish (Danio rerio). Behav Brain Res 2010, 208:450-457.
128. Wong K., Stewart A., Gilder T., Wu N., Frank K., Gaikwad S., et al. Modeling seizure-related behavioral and endocrine phenotypes in adult zebrafish. Brain Res 2010, 1348:209-215.
129. Wright D., Rimmer L.B., Pritchard V.L., Krause J., Butlin R.K. Inter and intra-population variation in shoaling and boldness in the zebrafish (Danio rerio). Naturwissenschaften 2003, 90:374-377.
130. Wright D., Nakamichi R., Krause J., Butlin R.K. QTL analysis of behavioral and morphological differentiation between wild and laboratory zebrafish (Danio rerio). Behav Genet 2006, 36:271-284.
131. Wright G.J., Washbourne P. Neurexins, neuroligins and LRRTMs: synaptic adhesion getting fishy. J Neurochem 2011, 117:765-778.
132. Yang M., Perry K., Weber M.D., Katz A.M., Crawley J.N. Social peers rescue autism-relevant sociability deficits in adolescent mice. Autism Res Off J Int Soc Autism Res 2011, 4:17-27.