Icariside II promotes osteogenic differentiation of bone marrow stromal cells in beagle canine

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 5, 2015, Pages 4367-4377

  Luo, Guangming ^a   Gu, Feifei ^a   Zhang, Yingdi ^a   Liu, Tianlin ^a   Guo, Pengnv ^a   Huang, Yuanliang ^a  

^a TONGJI UNIVERSITY   (China)

Author keywords

ALP; Bone marrow stromal cells (BMSCs); Icariside II; Osteogenic differentiation

Indexed keywords

BAOHUOSIDE I; FLAVONOID;

ANIMAL; BONE DEVELOPMENT; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DOG; DRUG EFFECTS; FLOW CYTOMETRY; MESENCHYMAL STROMA CELL;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; DOGS; FLAVONOIDS; FLOW CYTOMETRY; MESENCHYMAL STROMAL CELLS; OSTEOGENESIS;

EID: 84937870261     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Bianco P, Riminucci M, Gronthos S, Robey PG. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cell 2001; 19: 180-92.
2. Deng W, Obrocka M, Fischer I, Prockop DJ. In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP. Biochem Biophys Res Commun 2001; 282: 148-52.
3. Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neuro Res 2000; 61: 364-70.
4. Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y, Tajima N, Yamada H, Sawada H, Ishikawa H, Mimura T, Kitada M, Suzuki Y, Ide C. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J ClinInvest 2004; 113: 1701-10.
5. Banfi A, Muraglia A, Dozin B, Mastrogiacomo M, Cancedda R, Quarto R. Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: implications for their use in cell therapy. Exp Hematol 2000; 28: 707-15.
6. Colter DC, Class R, DiGirolamo CM, Prockop DJ. Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci 2000; 97: 3213-8.
7. Koc ON and Lazarus HM. Mesenchymal stem cells: heading into the clinic. Bone Marrow Transplant 2001; 27: 235-9.
8. Huang KC. The pharmacology of Chinese herbs. CRC press; 2011.
9. Meng FH, Li YB, Xiong ZL, Jiang ZM, Li FM. Osteoblastic proliferative activity of Epimedium brevicornum Maxim. Phytomedicine 2005; 12: 189-93.
10. Li L, Peng L, Miao J, Qiu Y, Zhou Y, Gao X, Xu Y, Shi Z, Shao D, Ma Z. Icariin induces the Expression of Toll-like Receptor 9 in Ana-1 Murine Macrophages. Phytother Res 2011; 25: 1732-5.
11. Liang Q, Wei G, Chen J, Wang Y, Huang H. Variation of Medicinal Components in a Unique Geographical Accession of Horny Goat Weed Epimedium sagittatum Maxim. (Berberidaceae). Molecules 2012; 17: 13345-56.
12. Liu ZQ, Luo XY, Sun YX, Wu W, Liu CM, Liu ZQ, Liu SY. The antioxidative effect of icariin in human erythrocytes against free-radical-induced haemolysis. J Pharm Pharmacol 2004; 56: 1557-62.
13. Makarova MN, Pozharitskaya ON, Shikov AN, Tesakova SV, Makarov VG, Tikhonov VP. Effect of lipid-based suspension of Epimedium koreanum Nakai extract on sexual behavior in rats. J Ethnopharmacol 2007; 114: 412-6.
14. Zhao J, Ohba S, Shinkai M, Chung UI, Nagamune T. Icariin induces osteogenic differentiation in vitro in a BMP-and Runx2-dependent manner. BiochemBiophy Res Commun 2008; 369: 444-8.
15. Liang W, Lin M, Li X, Li C, Gao B, Gan H, Yang Z, Lin X, Liao L, Yang M. Icariin promotes bone formation via the BMP-2/Smad4 signal transduction pathway in the hFOB 1.19 human osteoblastic cell line. Int J Mol Med 2012; 30: 889-95.
16. Zhao J, Ohba S, Komiyama Y, Shinkai M, Chung UI, Nagamune T. Icariin: a potential osteoinductive compound for bone tissue engineering. Tissue Eng Part A 2009; 16: 233-43.
17. Li D, Yuan T, Zhang X, Xiao Y, Wang R, Fan Y, Zhang X. Icariin: a potential promoting compound for cartilage tissue engineering. Osteoarthritis Cartilage 2012; 20: 1647-56.
18. Fan JJ, Cao LG, Wu T, Wang DX, Jin D, Jiang S, Zhang ZY, Bi L, Pei GX. The dose-effect of icariin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cells. Molecules 2011; 16: 10123-33.
19. Liu M, Liu H, Lu X, Li C, Xiong Z, Li F. Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese com pound formulation) by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 860: 113-20.
20. Choi HJ, Eun JS, Kim DK, Li RH, Shin TY, Park H, Cho NP, Soh Y. Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1a in human osteosarcoma cells. Eur J Pharmacol 2008; 579: 58-65.
21. Kang SH, Jeong SJ, Kim SH, Kim JH, Jung JH, Koh W, Kim JH, Kim DK, Chen CY, Kim SH. Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling. PLoS One 2012; 7: e28706.
22. Meng F. Osteoblastic proliferation stimulating activity of Epimedium koreanum. Nakai extracts and its flavonol glycosides. Pharmaceutical Biology 2005; 43: 92-95.
23. Huang J, Yuan L, Wang X, Zhang TL, Wang K. Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro. Life Sci 2007; 81: 832-40.
24. Trzeciakiewicz A, Habauzit V and Horcajada MN. When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols. Nutr Res Rev 2009; 22: 68-81.
25. Wang CG. LC determination of icariside II in rat plasma and tissues: application to a tissue distribution study. Chromatographia 2011; 74: 251-258.
26. Sun XJ, Xia LG, Chou LL, Zhong W, Zhang XL, Wang SY, Zhao J, Jiang XQ, Zhang ZY. Maxillary sinus floor elevation using a tissue engineered bone complex with BMP-2 gene modified bMSCs and a novel porous ceramic scaffold in rabbits. Arch Oral Biol 2010; 55: 195-202.
27. Kim SH, Ahn KS, Jeong SJ, Kwon TR, Jung JH, Yun SM, Han I, Lee SG, Kim DK, Kang M, Chen CY, Lee JW, Kim SH. Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells. Eur J Pharmacol 2011; 654: 10-6.
28. Xia Q, Xu D, Huang Z, Liu J, Wang X, Wang X, Liu S. Preparation of icariside II from icariin by enzymatic hydrolysis method. Fitoterapia 2010; 81: 437-42.
29. Lee KS, Lee HJ, Ahn KS, Kim SH, Nam D, Kim DK, Choi DY, Ahn KS, Lu J, Kim SH. Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells. Cancer Lett 2009; 280: 93-100.
30. 2 in vitro. Pharmacoll Res 2005; 52: 174-82.
31. Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, Chopp M. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 2001; 32: 1005-11.
32. Sanchez-Ramos J, Song S, Cardozo-Pelaez F, Hazzi C, Stedeford T, Willing A, Freeman TB, Saporta S, Janssen W, Patel N, Cooper DR, Sanberg PR. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000; 164: 247-56.
33. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002; 105: 93-8.
34. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop DJ, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006; 8: 315-7.
35. Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL. Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol 1998; 176: 57-66.
36. Dissanayaka WL, Zhu X, Zhang C, Jin L. Characterization of dental pulp stem cells isolated from canine premolars. J Endod 2011; 37: 1074-80.
37. Sugiura F, Kitoh H and Ishiguro N. Osteogenic potential of rat mesenchymal stem cells after several passages. Biochem Biophys Res Commun 2004; 316: 233-9.
38. Agata H, Asahina I, Watanabe N, Ishii Y, Kubo N, Ohshima S, Yamazaki M, Tojo A, Kagami H. Characteristic change and loss of in vivo osteogenic abilities of human bone marrow stromal cells during passage. Tissue Eng Part A 2010; 16: 663-73.
39. Yao D, Xie XH, Wang XL, Wan C, Lee YW, Chen SH, Pei DQ, Wang YX, Li G, Qin L. Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis-an in vitro efficacy study. PLoS One 2012; 7: e41264.
40. Wang XF and Wang J. Icaritin suppresses the proliferation of human osteosarcoma cells in vitro by increasing apoptosis and decreasing MMP expression. Acta Pharmacologica Sinica 2014; 35: 531-9.
41. Payushina O, Domaratskaya E and Starostin V. Mesenchymal stem cells: sources, phenotype, and differentiation potential. Biology Bulletin 2006; 33: 2-18.
42. Spencer ND, Chun R, Vidal MA, Gimble JM, Lopez MJ. In vitro expansion and differentiation of fresh and revitalized adult canine bone marrow-derived and adipose tissue-derived stromal cells. Vet J 2012; 191: 231-9.
43. Hessle L, Johnson KA, Anderson HC, Narisawa S, Sali A, Goding JW, Terkeltaub R, Millan JL. Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci 2002; 99: 9445-9.
44. Anderson HC, Sipe JB, Hessle L, Dhanyamraju R, Atti E, Camacho NP, Millán JL. Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice. Am J Pathol 2004; 164: 841-7.
45. Wagner EF and Karsenty G. Genetic control of skeletal development. Current Opin Gene Dev 2001; 11: 527-32.