Mesenchymal stem cells: Sources, phenotype, and differentiation potential

Biology Bulletin

Volumn 33, Issue 1, 2006, Pages 2-18

  Payushina, O V ^a   Domaratskaya, E I ^a   Starostin, V I ^a  

^a KOL TSOV INSTITUTE OF DEVELOPMENTAL BIOLOGY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33644920964     PISSN: 10623590     EISSN: None     Source Type: Journal    
DOI: 10.1134/S106235900601002X     Document Type: Review

References (161)

1. Abedin, M., Tintut, Y., and Demer, L.L., Mesenchymal Stem Cells and the Artery Wall, Circ. Res., 2004, vol. 95, no. 7, pp. 671-676.
2. Ahdjoudj, S., Kaabeche, K., Holy, X., Fromigue, O., Modrowski, D., Zerath, E., and Marie, P.J., Transforming Growth Factor-Beta Inhibits CCAAT/Enhancer-Binding Protein Expression and PPAR Gamma Activity in Unloaded Bone Marrow Stromal Cells, Exp. Cell Res., 2005, vol. 303, no. 1, pp. 138-147.
3. Altman, G.H., Horan, R.L., Martin, I., Farhadi, J., Stark, P.R., Volloch, V., Richmond, J.C., Vunjak-Novakovic, G., and Kaplan, D.L., Cell Differentiation by Mechanical Stress, FASEB J., 2002, vol. 16, no. 2, pp. 270-272.
4. Aoki, S., Toda, S., Ando, T., and Sugihara, H., Bone Marrow Stromal Cells, Preadipocytes, and Dermal Fibroblasts Promote Epidermal Regeneration in Their Distinctive Fashions, Mol. Biol. Cell, 2004, vol. 15, pp. 4647-4657.
5. Aoyama, K., Oritani, K., Yokota, T., Ishikawa, J., Nishiura, T., Miyake, K., Kanakura, Y., Tomiyama, Y., Kincade, P.W., and Matsuzawa, Y., Stromal Cell CD9 Regulates Differentiation of Hematopoietic Stem/Progenitor Cells, Blood, 1999, vol. 93, no. 8, pp. 2586-2594.
6. Atmani, H., Chappard, D., and Basle, M.F., Proliferation and Differentiation of Osteoblasts and Adipocytes in Rat Bone Marrow Stromal Cell Cultures: Effects of Dexamethasone and Calcitriol, J. Cell Biochem., 2003, vol. 89, no. 2, pp. 364-372.
7. Awad, H.A., Butler, D.L., Boivin, G.P., Smith, F.N., Malaviya, P., Huibregtse, B., and Caplan, A.I., Autologous Mesenchymal Stem Cells-Mediated Repair of Tendon, Tissue Eng., 1999, vol. 5, no. 3, pp. 267-277.
8. Baksh, D., Davies, J.E., and Zandstra, P.W., Adult Human Bone Marrow-Derived Mesenchymal Progenitor Cells Are Capable of Adhesion-Independent Survival and Expansion, Exp. Hematol., 2003, vol. 31, no. 8, pp. 723-732.
9. Ball, S.G., Shuttleworth, A.C., and Kielty, C.M., Direct Cell Contact Influences Bone Marrow Mesenchymal Stem Cells Fate, Int. J. Biochem. Cell. Biol., 2004, vol. 36, no. 4, pp. 714-727.
10. Barry, F., Boynton, R., Murphy, M., Haynesworth, S., and Zaia, J., The SH-3 and SH-4 Antibodies Recognize Distinct Epitopes on CD73 from Human Mesenchymal Stem Cells, Biochem. Biophys. Res. Commun., 2001, vol. 289, no. 2, pp. 519-524.
11. Barry, F.P., Boynton, R.E., Haynesworth, S., Murphy, J.M., and Zaia, J., The Monoclonal Antibody SH-2, Raised against Human Mesenchymal Stem Cells, Recognizes an Epitope on Endoglin (CD105), Biochem. Biophys. Res. Commun., 1999, vol. 265, no. 1, pp. 134-139.
12. Baxter, M.A., Wynn, R.F., Jowitt, S.N., Wraith, J.E., Fairbairn, L.J., and Bellantuono, I., Study of Telomere Length Reveals Rapid Aging of Human Marrow Stromal Cells Following in Vitro Expansion, Stem Cells, 2004, vol. 22, no. 5, pp. 675-682.
13. Bellows, C.G., Aubin, J.E., Heersche, J.N., and Antosz, M.E., Mineralized Bone Nodules Formed in Vitro from Enzymatically Released Rat Calvaria Cell Populations, Calcif. Tissue Int., 1986, vol. 38, no. 3, pp. 143-154.
14. Benavente, C.A., Sierralta, W.D., Conget, P.A., and Minguell, J.J., Subcellular Distribution and Mitogenic Effect of Basic Fibroblast Growth Factor in Mesenchymal Uncommitted Stem Cells, Growth Factors, 2003, vol. 21, no. 2, pp. 87-94.
15. Bennett, J.H., Joyner, C.J., Triffitt, J.T., and Owen, M.E., Adipocytic Cells Cultured from Marrow Have Osteogenic Potential, J. Cell Sci., 1991, vol. 99, pp. 131-139.
16. Bianco, P., Riminucci, M., Gronthos, S., and Robey, P.G., Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications, Stem Cells, 2001, vol. 19, no. 3, pp. 180-192.
17. Bosnakovski, D., Mizuno, M., Kim, G., Takagi, S., Okumura, M., and Fujinaga, T., Isolation and Multilineage Differentiation of Bovine Bone Marrow Mesenchymal Stem Cells, Cell Tissue Res., 2005, vol. 319, no. 2, pp. 243-253.
18. Bruder, S.P., Jaiswal, N., and Haynesworth, S.E., Growth Kinetics, Self-Renewal, and the Osteogenic Potential of Purified Human Mesenchymal Stem Cells during Extensive Subcultivation and Following Cryopreservation, J. Cell. Biochem., 1997, vol. 64, no. 2, pp. 278-294.
19. Bruder, S.P., Ricalton, N.S., Boynton, R.E., Connolly, T.J., Jaiswal, N., Zaia, J., and Barry, F.P., Mesenchymal Stem Cell Surface Antigen SB-10 Corresponds to Activated Leucocyte Cell Adhesion Molecule and Is Involved in Osteogenic Differentiation, J. Bone Miner. Res., 1998, vol. 13, no. 4, pp. 655-663.
20. Campioni, D., Lanza, F., Moretti, S., Dominici, M., Punturieri, M., Pauli, S., Hofmann, T., Horwitz, E., and Castoldi, G.L., Functional and Immunophenotypic Characteristics of Isolated CD105(+) and Fibroblasl(+) Stromal Cells from AML: Implications for Their Plasticity along Endolhelial Lineage, Cytotherapy, 2003, vol. 5, no. 1, pp. 66-79.
21. Caplan, A.I., Mesenchymal Stem Cells, J. Orthop. Res., 1991, vol. 9, no. 5, pp. 641-650.
22. Charbord, P., Oostendorp, R., Pang, W., Herault, O., Noel, F., Tsuji, T., Dzierzak, E., and Peault, B., Comparative Study of Stromal Cell Lines Derived from Embryonic, Fetal and Postnatal Mouse Blood-Forming Tissues, Exp. Hematol., 2002, vol. 30, no. 10, pp. 1202-1210.
23. Chaudhary, L.R., Hofmeister, A.M., and Hruska, K.A., Differential Growth Factor Control of Bone Formation Through Osteoprogenitor Differentiation, Bone, 2004, vol. 34, no. 3, pp. 402-411.
24. Chen, J.-L., Hunt, P., McElvain, M., Black, T., Kaufman, S., and Choi, E.S., H. Osteoblast Precursor Cells Are Found in CD34+ Cells from Human Bone Marrow, Stem Cells, 1997, vol. 15, pp. 368-377.
25. Chunmeng, S. and Tiamin, C., Effects of Plastic-Adherent Dermal Multipotent Cells on Peripheral Blood Leukocytes and CFU-GM in Rats, Transplant. Proc., 2004, vol. 36, no. 5, pp. 1578-1581.
26. Colter, D.C., Class, R., DiGirolamo, C.M., and Prockop, D.J., Rapid Expansion of Recycling Stem Cells in Cultures of Plastic-Adherent Cells from Human Bone Marrow, Proc. Nat. Acad. Sci. USA, 2000, vol. 97, no. 7, pp. 3213-3218.
27. Conget, P.A. and Minguell, J.J., Phenotypical and Functional Properties of Human Bone Marrow Mesenchymal Progenitor Cells, J. Cell Physiol., 1999, vol. 181, no. 1, pp. 67-73.
28. Cui, Q., Wang, G.J., and Balian, G., Pluripotential Marrow Cells Produce Adipocytes When Transplanted into Steroid-Treated Mice, Connect. Tissue Res., 2000, vol. 41, no. 1, pp. 45-56.
29. D'Ippolito, G., Diabira, S., Howard, G.A., Menei, P., Roos, B.A., and Schiller, P.C., Marrow-Derived Adult Multi-lineage (MIAMI) Cells, A Unique Population of Postnatal Young and Old Human Cells with Extensive Expansion and Differentiation Potential, J. Cell Sci., 2004, vol. 117, no. 14, pp. 2971-2981.
30. De Ugarte, D.A., Alfonso, Z., Zuk, P.A., Elbarbary, A., Zhu, M., Ashjian, P., Benhaim, P., Hedrick, M.H., and Fraser, J.K., Differential Expression of Stem Cell Mobilization-Associated Molecules on Multilineage Cells from Adipose Tissue and Bone Marrow, Immunol. Lett., 2003, vol. 89, nos. 2-3, pp. 267-270.
31. De la Fuente, R., Abad, J.L., Garcia-Castro, J., Fernandez-Miguel, G., Petriz, J., Rubio, D., Vicario-Abejon, C., Guillen, P., Gonzalez, M.A., and Bernad, A., Dedifferentiated Adult Articular Chondrocytes: A Population of Human Multipotent Primitive Cells, Exp. Cell Res., 2004, vol. 297, no. 2, pp. 313-328.
32. Deng, W., Han, Q., Liao, L., Li, C., Ge, W., Zhao, Z., You, S., Deng, H., Murad, F., and Zhao, R.C., Engrafted Bone Marrow-Derived Flk-1(+) Mesenchymal Stem Cells Regenerate Skin Tissue, Tissue Eng., 2005, vol. 11, nos. 1-2, pp. 110-119.
33. Denker, A.E., Nicoll, S.B., and Tuan, R.S., Induction and Characterization of Chondrogenesis in Multipotential Mesenchymal Cells: Abstr. 5th Int. Conf. Mol. Biol. And Pathol. Matrix, Philadelphia: Pa, June 19-22, 1994.
34. Dennis, J.E. and Charbord, P., Origin and Differentiation of Human and Murine Stroma, Stem Cells, 2002, vol. 20, pp. 205-214.
35. Domaratskaya, E.I., Bueverova, E.I., Payushina, O.V., and Starostin, V.I., Alkylating Damage by Dipin of Hematopoietic and Stromal Cells of the Bone Marrow, Izv. Akad. Nauk, Ser. Biol., 2005, no. 3, pp. 267-272.
36. Dominici, M., Pritchard, C., Garlits, J.E., Hoffmann, T.J., Persons, D.A., and Horwitz, E.M., Hematopoietic Cells and Osteoblasts Are Derived from a Common Marrow Progenitor after Bone Marrow Transplantation, Proc. Nat. Acad. Sci. USA, 2004, vol. 101, no. 32, pp. 11761-11766.
37. Dorheim, M.A., Sullivan, M., Dandapani, V., Wu, X., Hudson, J., Segarini, P.R., Rosen, D.M., Aulthouse, A.L., and Gimble, J.M., Osteoblastic Gene Expression during Adipo genesis in Hematopoietic Supporting Murine Bone Marrow Stromal Cells, J. Cell Physiol., 1993, vol. 154, no. 2, pp. 317-328.
38. Fang, L.J., Fu, X.B., Sun, T.Z., Li, J.F., Cheng, B., Yang, Y.H., and Wang, Y.X., An Experimental Study on the Differentiation of Bone Marrow Mesenchymal Stem Cells into Vascular Endothelial Cells, Zhonghua Shao Shang Za Zhi, 2003, vol. 19, no. 1, pp. 22-24.
39. Fickert, S., Fiedler, J., and Brenner, R.E., Identification, Quantification and Isolation of Mesenchymal Progenitor Cells from Osteoarthritic Synovium by Fluorescence Automated Cell Sorting, Osteoarthritis Cartilage, 2003, vol. 11, no. 11, pp. 790-800.
40. Fink, T., Abildtrup, L., Fogd, K., Abdallah, B.M., Kassem, M., Ebbesen, P., and Zachar, V., Induction of Adipocytes-like Phenotype in Human Mesenchymal Stem Cells by Hypoxia, Stem Cells, 2004, vol. 22, pp. 1346-1355.
41. Friedenstein, A.J., Chailakhyan, R.K., and Gerasimov, U.V., Bone Marrow Osteogenic Stem Cells: in Vitro Cultivation and Transplantation in Diffusion Chambers, Cell Tissue Kinet., 1987, vol. 20, no. 3, pp. 263-272.
42. Friedenstein, A.J., Gorskaya, J.F., and Kulagina, N.N., Fibroblast Precursors in Normal and Irradiated Mouse Hematopoietic Organs, Exp. Hematol., 1976, vol. 4, no. 5, pp. 267-274.
43. Friedenstein, A.J., Ivanov-Smolenski, A.A., Chailakjan, R.K., Gorskaya, U.F., Kuralesova, A.I., Latzinik, N.W., and Gerasimov, U.W., Origin of Bone Marrow Stromal Mechanocytes in Radiochimeras and Heterotopic Transplants, Exp. Hematol., 1978, vol. 6, no. 5, pp. 440-444.
44. Ghilzon, R., McCulloch, C.A., and Zohar, R., Stromal Mesenchymal Progenitor Cells, Leuk. Lymphoma, 1999, vol. 32, nos. 3-4, pp. 211-221.
45. Gimble, J.M., Morgan, C., Kelly, K., Wu, X., Dandapani, V., Wang, C.S., and Rosen, V., Bone Morphogenetic Proteins Inhibit Adipocyte Differentiation by Bone Marrow Stromal Cells, J. Cell. Biochem., 1995, vol. 58, no. 3, pp. 393-402.
46. Gimble, J.M., Wanker, F., Wang, C.S., Bass, H., Wu, X., Kelly, K., Yancoupoulos, G.D., and Hill, M.R., Regulation of Bone Marrow Stromal Cell Differentiation by Cytokines Whose Receptors Share the Gp130 Protein, J. Cell. Biochem., 1994, vol. 543, no. 1, pp. 122-133.
47. Greenberger, J.S., Corticosteroid-Dependent Differentiation of Human Marrow Preadipocytes in Vitro, Cell. Dev. Biol., 1979, vol. 15, no. 10, pp. 823-828.
48. Grigoriadis, A.E., Heersche, J.N., and Aubin, J.E., Differentiation of Muscle, Fat, Cartilage, and Bone from Progenitor Cells Present in a Bone-Derived Clonal Cell Population: Effects of Dexamethasone, J. Cell Biol., 1988, vol. 106, no. 6, pp. 2139-2151.
49. Gronthos, S., Graves, S.E., Ohta, S., and Simmons, P.J., The STRO-1+ Fraction of Adult Human Bone Marrow Contains the Osteogenic Precursors, Blood, 1994, vol. 84, no. 12, pp. 4164-4173.
50. Gronthos, S., Zannettino, A.C.W., Hay, S.J., Shi, S., Graves, S., Kortesidis, A., and Simmons, P.J., Molecular and Cellular Characterization of Highly Purified Stromal Stem Cells Derived from Human Bone Marrow, J. Cell Sci., 2003, vol. 116, pp. 1827-1835.
51. Kanada, K., Dennis, J.E., and Caplan, A.I., Stimulatory Effects of Basic Fibroblast Growth Factor and Bone Morphogenetic Protein-2 on Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells, J. Bone Mineral Res., 1997, vol. 12, no. 10, pp. 1606-1614.
52. Hermann, A., Gastl, R., Liebau, S., Popa, O., Fiedler, J., Boehm, B.O., Maisel, M., Lerche, H., Schwarz, J., Brenner, R., and Storch, A., Efficient Generation of Neural Stem Cell-Like Cells from Adult Human Bone Marrow Stromal Cells, J. Cell Sci., 2004, vol. 117, pp. 4411-4422.
53. Horwitz, E.M., Prockop, D.J., Fitzpatrick, L.A., Koo, W.W., Gordon, P.L., Neel, M., Sussman, M., Orchard, P., Marx, J.C., Pyeritz, R.E., and Brenner, M.K., Transplantability and Therapeutic Effects of Bone Marrow-Derived Mesenchymal Cells in Children with Osteogenesis Imperfecta, Nat. Med., 1999, vol. 5, no. 3, pp. 309-313.
54. Hou, Z., Nguyen, Q., Frenkel, B., Nilsson, S.K., Milne, M., van Wijnen, A.J., Stein, J.L., Quesenberry, P., Lian, J.B., and Stein, G.S., Osteoblast-Specific Gene Expression after Transplantation of Marrow Cells : Implications for Skeletal Gene Therapy, Proc. Nat. Acad. Sci. USA, 1999, vol. 96, no. 13, pp. 7294-7299.
55. Hu, Y., Liao, L., Wang, Q., Ma, L., Ma, G., Jiang, X., and Zhao, R.C., Isolation and Identification of Mesenchymal Stem Cells from Human Fetal Pancreas, J. Lab. Clin. Med., 2003, vol. 141, no. 5, pp. 342-349.
56. Hung, S.-C., Chen, N.-J., Hsieh, S.-L., Li, H., Ma, H.-L., and Lo, W.-H., Isolation and Characterization of Size-Sieved Stem Cells from Human Bone Marrow, Stem Cells, 2002, vol. 20, pp. 249-258.
57. Huss, R., Hong, D.S., McSweeney, P.A., Hoy, C.A., and Deeg, H.J., Differentiation of Canine Bone Marrow Cells with Hemopoietic Characteristics from an Adherent Stromal Cell Precursor, Proc. Nat. Acad. Sci. USA, 1995, vol. 92, no. 3, pp. 748-752.
58. - Hematopoietic and Mesenchymal Stem Cells from Various Sources, Stem Cells, 2000, vol. 18, no. 1, pp. 1-9.
59. In't Anker, P.S., Noort, W.A., and Scherjon, S.A., Kleijburgvan der Keur C., Kruisselbrink A.B., van Bezooijen, R.L., Beekhuizen, W., Willemze, R., Kanhai, H.H., and Fibbe, W.E., Mesenchymal Stem Cells in Human Second-Trimester Bone Marrow, Liver, Lung and Spleen Exhibit a Similar Immunophenotype but a Heterogeneous Multilineage Differentiation Potential, Haematological J., 2003, vol. 88, no. 8, pp. 845-852.
60. In't Anker, P.S., Scherjon, S.A., Kleijburg-van der Keur, C., de Groot-Swings, G.M., Claas, F.H., Fibbe, W.E., and Kanhai, H.H., Isolation of Mesenchymal Stem Cells of Fetal or Maternal Origin from Human Placenta, Stem Cells, 2004, vol. 22, no. 7, pp. 1338-1345.
61. Jaiswal, N., Haynesworth, S.E., Caplan, A.I., and Bruder, S.P., Osteogenic Differentiation of Purified, Culture-Expanded Human Mesenchymal Stem Cells in Vitro, J. Cell. Biochem., 1997, vol. 64, no. 2, pp. 295-312.
62. Jaiswal, R.K., Jaiswal, N., Bruder, S.P., Mbalaviele, G., Marshak, D.R., and Pittenger, M.F., Adult Human Mesenchymal Stem Cells Differentiation to the Osteogenic or Adipogenic Lineage Is Regulated by Mitogen-Activated Protein Kinase, J. Biol. Chem., 2000, vol. 275, no. 13, pp. 9645-9652.
63. Janderova, L., McNeil, N., Murrell, A.N., Mynatt, R.L., and Smith, S.R., Human Mesenchymal Stem Cells as an in Vitro Model for Human Adipogenesis, Obesity Res., 2003, vol. 11, no. 1, pp. 65-73.
64. Javason, E.H., Colter, D.C., Schwarz, E.J., and Prockop, D.J., Rat Marrow Stromal Cells Are More Sensitive to Plating Density and Expand More Rapidly from Single-Cell-Derived Colonies than Human Marrow Stromal Cells, Stem Cells, 2001, vol. 19, pp. 219-225.
65. Jiang, Y., Jahagirdar, B.N., Reinhardt, R.L., Schwartz, R.E., Keene, C.D., Ortiz-Gonzalea, X.R., Reyes, M., Lenvik, T., Lund, T., Blackstad, M., Du, J., Aldrich, S., Lisberg, A., Low, W.C., Largaespada, D.A., and Verfaillie, C.M., Pluripotency of Mesenchymal Stem Cells Derived from Adult Marrow, Nature, 2002a, vol. 418, pp. 41-49.
66. Jiang, Y., Vaessen, B., Lenvik, T., Blackstad, M., Reyes, M., and Verfaillie, C.M., Multipotent Progenitor Cells Can Be Isolated from Postnatal Murine Bone Marrow, Muscle, and Brain, Exp. Hematol., 2002b, vol. 30, no. 8, pp. 896-904.
67. Jo, D.-Y., Rafii, S., Hamada, T., and Moore, M.A.S., Chemotaxix of Primitive Hematopoietic Cells in Response to Stromal Cell-Derived Factor-1, J. Clin. Invest., 2000, vol. 105, pp. 101-111.
68. Johnstone, B., Hering, T.M., Caplan, A.I., Goldberg, V.M., and Yoo, J.U., In Vitro Chondrogenesis of Bone Marrow-Derived Mesenchymal Progenitor Cells, Exp. Cell Res., 1998, vol. 238, no. 1, pp. 265-272.
69. Kadiyala, S., Young, R.G., Thiede, M.A., and Bruder, S.P., Culture Expanded Canine Mesenchymal Stem Cells Possess Osteochondrogenic Potential in Vivo and in Vitro, Cell Transplant., 1997, vol. 6, no. 2, pp. 125-134.
70. Kadowaki, A., Tsukazaki, T., Hirata, K., Shibata, Y., Okubo, Y., Bessho, K., Komori, T., Yoshida, N., and Yamaguchi, A., Isolation and Characterization of a Mesenchymal Cell Line that Differentiates into Osteoblasts in Response to BMP-2 from Calvariae of GFP Transgenic Mice, Bone, 2004, vol. 34, no. 6, pp. 993-1003.
71. Kha, H.T., Basseri, B., Shouhed, D., Richardson, J., Tetradis, S., Hahn, T.J., and Parhami, F., Oxysterols Regulate Differentiation of Mesenchymal Stem Cells: Pro-Bone and Anti-Fat, J. Bone Miner. Res., 2004, vol. 19, no. 5, pp. 830-840.
72. Kii, I., Amizuka, N., Shimomura, J., Saga, Y., and Kudo, A., Cell-Cell Interaction Mediated by Cadherin-11 Directly Regulates the Differentiation of Mesenchymal Cells into the Cells of the Osteo-Lineage and the Chondro-Lineage, J. Bone Miner. Res., 2004, vol. 19, no. 11, pp. 1840-1849.
73. Kim, J.W., Kim, S.Y., Park, S.Y., Kim, Y.M., Lee, M.H., and Ryu, H.M., Mesenchymal Progenitor Cells in the Human Umbilical Cord, Ann. Hematol., 2004, vol. 83, no. 12, pp. 733-738.
74. Klees, R.F., Salasznyk, R.M., Kingsley, K., Williams, W.A., Boskey, A., and Plopper, G.E., Laminin-5 Induces Osteogenic Gene Expression in Human Mesenchymal Stem Cells through an ERK-Dependent Pathway, Mol. Biol. Cell, 2005, vol. 16, no. 2, pp. 881-890.
75. Koc, O.N., Peters, C., Aubourg, P., Raghavan, S., Dyhouse, S., DeGasperi, R., Kolodny, E.H., Yoseph, Y.B., Gerson, S.L., Lazarus, H.M., Caplan, A.I., Watkins, P.A., and Krivit, W., Bone Marrow-Derived Mesenchymal Stem Cells Remain Host-Derived Despite Successful Hematopoietic Engraftment after Allogenic Transplantation in Patients with Lysosomal and Peroxisomal Storage Diseases, Exp. Hematol., 1999, vol. 27, no. 11, pp. 1675-1681.
76. Kramer, P.R., Nares, S., Kramer, S.F., Grogan, D., and Kaiser, M., Mesenchymal Stem Cells Acquire Characteristics of Cells in the Periodontal Ligament in Vitro, J. Dent. Res., 2004, vol. 83, no. 1, pp. 27-34.
77. Kruglyakov, P.V., Sokolova, I.B., Amineva, Kh.K., Nekrasova, N.N., Viide, S.V., Cherednichenko, N.N., Zaritskii, A.Yu., Semernin, E.N., Kislyakova, T.V., and Polyntsev, D.G., Mesenchymal Stem Cell Transplantation for Myocardial Repair of Rat Experimental Heart Failure, Tsitologiya, 2004a, vol. 46, no. 12, pp. 1043-1054.
78. Kruglyakov, P.V., Sokolova, I.B., Nekrasova, N.N., Viide, S.V., Zaritskii, A.Yu., Kislyakova, T.V., and Polyntsev, D.G., Bone Tissue Repair Mediated by Stem Cells, Tsitologiya, 2004b, vol. 46, no. 10, pp. 920-921.
79. Kurozumi, K., Nakamura, K., Tamiya, T., Kawano, Y., Ishii, K., Kobune, M., Hirai, S., Uchida, H., Sasaki, K., Ito, Y., Kato, K., Honmou, O., Houkin, K., Date, I., and Hamada, H., Mesenchymal Stem Cells that Produce Neurotrophic Factors Reduce Ischemic Damage in the Rat Middle Cerebral Artery Occlusion Model, Mol. Ther, 2005, vol. 11, no. 1, pp. 96-104.
80. Kuznetsov, S.A., Mankani, M.H., and Robey, P.G., Effect of Serum on Human Bone Marrow Stromal Cells: Ex Vivo Expansion and in Vivo Bone Formation, Transplantation, 2000, vol. 70, no. 12, pp. 1780-1787.
81. Lataillade, J.J., Clay, D., Dupuy, C., Rigal, S., Jasmin, C., and Bourin, P., Le Bousse-Kerdiles M.C. Chemokine SDF-1 Enhances Circulating CD34(+) Cell Proliferation in Synergy with Cytokines: Possible Role in Progenitor Survival, Blood, 2000, vol. 95, no. 3, pp. 756-768.
82. Lazarus, H.M., Haynesworth, S.E., Gerson, S.L., and Caplan, A.I., Human Bone Marrow-Derived Mesenchymal (Stromal) Progenitor Cells (MPCs) Cannot Be Recovered from Peripheral Blood Progenitor Cell Collections, J. Hematother, 1997, vol. 6, no. 5, pp. 447-455.
83. Le Blanc, K., Immunomodulatory Effects of Fetal and Adult Mesenchymal Stem Cells, Cytotherapy, 2003, vol. 5, no. 6, pp. 485-489.
84. Lee, O.K., Kuo, T.K., Chen, W.M., Lee, K.D., Hsieh, S.L., and Chen, T.H., Isolation of Multipotent Mesenchymal Stem Cells from Umbilical Cord Blood, Blood, 2004, vol. 103, no. 5, pp. 1669-1675.
85. Lin, J.R., Guo, K.Y., Li, J.Q., and Yan, D.A., In Vitro Culture of Human Bone Marrow Mesenchymal Stem Cell Clones and Induced Differentiation into Neuron-Like Cells, Di Yi Jun Yi Da Xue Xue Bao, 2003, vol. 23, no. 3, p. 264.
86. Lou, S., Gu, P., Chen, F., He, C., Wang, M., and Lu, C., The Effect of Bone Marrow Stromal Cells on Neuronal Differentiation of Mesencephalic Neural Stem Cells in Spargue-Dawley Rats, Brain Res., 2003, vol. 968, no. 1, pp. 114-121.
87. Luo, Q., Kang, Q., Si, W., Jiang, W., Park, J.K., Peng, Y., Li, X., Luu, H.H., Luo, J., Montag, A.G., Haydon, R.C., and He, T.C., Connective Tissue Growth Factor (CTGF) Is Regulated by Wnt and Bone Morphogenetic Proteins Signaling in Osteoblasts Differentiation of Mesenchymal Stem Cells, J. Biol. Chem., 2004, vol. 279, no. 53, pp. 55958-55968.
88. Mackay, A.M., Beck, S.C., Murphy, J.M., Barry, F.P., Chichester, C.P., and Pittenger, M.F., Chondrogenic Differentiation of Cultured Human Mesenchymal Stem Cells from Marrow, Tissue Eng., 1998, vol. 4, no. 4, pp. 415-428.
89. Maeda, S., Nobukuni, T., Shimo-Onoda, K., Hayashi, K., Yone, K., Komiya, S., and Inoue, I., Sortilin Is Upregulated during Osteoblastic Differentiation of Mesenchymal Stem Cells and Promotes Extracellular Matrix Mineralization, J. Cell Physiol., 2002, vol. 193, pp. 73-79.
90. Majumdar, M.K., Thiede, M.A., Mosca, J.D., Moorman, M., and Gerson, S.L., Phenotypic and Functional Comparison of Cultures of Marrow-Derived Mesenchymal Stem Cells (MSCs) and Stromal Cells, J. Cell Physiol., 1998, vol. 176, no. 1, pp. 57-66.
91. Majumdar, M.K., Keane-Moore, M., Buyander, D., Hardy, W.B., Moorman, M.A., McIntosh, K.R., and Mosca, J.D., Characterization and Functionality of Cell Surface Molecules on Human Mesenchymal Stem Cells, J. Biomed. Sci, 2003, vol. 10, no. 2, pp. 228-241.
92. MacKenzie, T.C. and Flake, A.W., Human Mesenchymal Stem Cells: Insights from a Surrogate in vivo Assay System, Cells Tissues Organs, 2002, vol. 171, no. 1, pp. 90-95.
93. Martin, D.R., Cox, N.R., Hathcock, T.L., Niemeyer, G.P., and Baker, H.J., Isolation and Characterization of Multipotential Mesenchymal Stem Cells from Feline Bone Marrow, Exp. Hematol., 2002, vol. 30, no. 8, pp. 879-886.
94. Massague, J. and Wotton, D., Transcriptional Control by the TGF-/Smad Signaling System, EMBO J., 2000, vol. 19, no. 8, pp. 1745-1754.
95. Minguell, J.J., Martinez, J., and Walter, T., Effect of Hydrocortisone on the Growth of Human Bone Marrow Fibroblasts, Br. J. Haematol., 1982, vol. 52, no. 2, pp. 307-310.
96. Minguell, J.J., Conget, P., and Erices, A., Biology and Clinical Utilization of Mesenchymal Progenitor Cells, Brazilian J. Med. Biol. Res., 2000, vol. 33, pp. 881-887.
97. Morigi, M., Imberti, B., Zoja, C., Corna, D., Tomasoni, S., Abbate, M., Rottoli, D., Angioletti, S., Benigni, A., Perico, N., Alison, M., and Remuzzi, G., Mesenchymal Stem Cells Are Renotropic, Helping to Repair the Kidney and Improve Function in Acute Renal Failure, J. Am. Soc. Nephrol., 2004, vol. 15, no. 7, pp. 1794-1804.
98. Muraglia, A., Cancedda, R., and Quarto, R., Clonal Mesenchymal Progenitors from Human Bone Marrow Differentiate in Vitro According to a Hierarchical Model, J. Cell Sci., 2000, vol. 113, pp. 1161-1166.
99. Nathan, S., Das De S., Thambyah A., Fen C., Goh J., Lee E.H. Cell-Based Therapy in the Repair of Osteochondral Defects: A Novel Use for Adipose Tissue, Tissue Eng., 2003, vol. 9, no. 4, pp. 733-744.
100. Noth, U., Osyczka, A.M., Tuli, R., Hickok, N.J., Danielson, K.G., and Tuan, R.S., Multilineage Mesenchymal Differentiation Potential of Human Trabecular Bone-Derived Cells, J. Orthop. Res., 2002, vol. 20, no. 5, pp. 1060-1069.
101. Owen, M., Marrow Stromal Stem Cells, J. Cell Sci., 1988, no. Suppl. 10, pp. 63-76.
102. Owen, M.E., Cave, J., and Joyner, C.J., Clonal Analysis in Vitro of Osteogenic Differentiation of Marrow CFU-F, J. Cell Sci., 1987, vol. 87, pp. 731-738.
103. Payushina, O.V., Bueverova, E.I., Satdykova, G.P., Starostin, V.I., Domaratskaya, E.I., and Khrushchov, N.G., Comparative Investigation of Mesenchymal Stem Cells Isolated from the Bone Marrow and Embryonic Liver of Mouse and Rat, Izv. Akad. Nauk, Ser. Biol., 2004, no. 6, pp. 659-664.
104. Peister, A., Mellad, J.A., Larson, B.L., Hall, B.M., Gibson, L.F., and Prockop, D.J., Adult Stem Cells from Bone Marrow (MSCs) Isolated from Different Strains of Inbred Mice Vary in Surface Epitopes, Rates of Proliferation, and Differentiation Potential, Blood, 2004, vol. 103, no. 5, pp. 1662-1668.
105. Pereira, R.F., O'Hara, M.D., Laptev, A.V., Halford, K.W., Pollard, M.D., Class, R., Simon, D., Livezey, K., and Prockop, D.J., Marrow Stromal Cell as a Source of Progenitor Cells for Nonhematopoietic Tissues in Transgenic Mice with a Phenotype of Osteogenesis Imperfecta, Proc. Nat. Acad. Sci. USA, 1998, vol. 95, no. 3, pp. 1142-1147.
106. Phinney, D.G., Kopen, G., Isaacson, R.L., and Prockop, D.J., Plastic Adherent Stromal Cells from the Bone Marrow of Commonly Used Strains of Inbred Mice: Variations in Yield, Growth, and Differentiation, J. Cell Biochem., 1999, vol. 72, no. 4, pp. 570-585.
107. Pittenger, M. and Marshak, D.R., Mesenchymal Stem Cells of Human Adult Bone Marrow, Stem Cell Biol., 2001, pp. 349-373.
108. Poliard, A., Nifuji, A., Lamblin, D., Plee, E., Forest, C., and Kellermann, O., Controlled Conversion of an Immortalized Mesodermal Progenitor Cell towards Osteogenic, Chondrogenic, or Adipogenic Pathways, J. Cell Biol., 1995, vol. 130, no. 6, pp. 1461-1472.
109. Prockop, D.J., Gregory, C.A., and Specs, L., One Strategy for Cell and Gene Therapy: Harnessing the Power of Adult Stem Cells to Repair Tissues, Proc. Nat. Acad. Sci. USA, 2003, vol. 100, no. Suppl. 1, pp. 11917-11923.
110. Quarto, R., Campanile, G., Cancedda, R., and Dozin, B., Modulation of Commitment, Proliferation, and Differentiation of Chondrogenic Cells in Defined Culture Medium, Endocrinol., 1997, vol. 138, no. 11, pp. 4966-4976.
111. Quito, F.L., Beh, J., Bashayan, O., Basilico, C., and Basch, R.S., Effects of Fibroblast Growth Factor-4 (K-FGF) on Long-Term Cultures of Human Bone Marrow Cells, Blood, 1996, vol. 87, no. 4, pp. 1282-1291.
112. Raff, M., Adult Stem Cell Plasticity: Fact or Artifact, Annu. Rev. Cell Dev. Biol., 2003, vol. 19, pp. 1-22.
113. Rasmusson, I., Ringden, O., and Sundberg, B., Le Blanc K. Mesenchymal Stem Cells Inhibit Lymphocyte Proliferation by Mitogens and Alloantigens by Different Mechanisms, Exp. Cell Res., 2005, vol. 305, no. 1, pp. 33-41.
114. Rhodes, N.P., Srivastava, J.K., Smith, R.F., and Longinotti, C., Heterogeneity in Proliferative Potential of Ovine Mesenchymal Stem Cell Colonies, J. Mater. Sci. Mater. Med., 2004, vol. 15, no. 4, pp. 397-402.
115. Rios, M. and Williams, D.A., Systematic Analysis of the Ability of Stromal Cell Lines Derived from Different Murine Adult Tissues to Support Maintenance of Hematopoietic Stem Cells, Exp. Hematol., 1990, vol. 18, no. 6, p. 568.
116. Rodriguez Mdel, C., Bernad, A., and Aracil, M., Interleukin-6 Deficiency Affects Bone Marrow Stromal Precursors, Resulting in Defective Hematopoietic Support, Blood, 2004, vol. 103, no. 9, pp. 3349-3354.
117. Salasznyk, R.M., Williams, W.A., Boskey, A., Batorsky, A., and Plopper, G.E., Adhesion to Vitronectin and Collagen I Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells, J. Biomed. Biotechnol., 2004, no. 1, pp. 24-34.
118. Sato, Y., Araki, H., Kato, J., Nakamura, K., Kawano, Y., Kobune, M., Sato, T., Miyanishi, K., Takayama, T., Takahashi, M., Takimoto, R., Iyama, S., Matsunaga, T., Ohtani, S., Matsuura, A., Hamada, H., and Niitsu, Y., Human Mesenchymal Stem Cells Xenografted Directly to Rat Liver Differentiated into Human Hepatocytes without Fusion, Blood, 2005, vol. 106, no. 2, pp. 756-763.
119. Schercroun, N. and Delloye, C., Bone-Like Nodules Formed by Human Bone Marrow Stromal Cells: Comparative Study and Characterization, Bone, 2003, vol. 32, no. 3, pp. 252-260.
120. Scutt, A. and Bertram, P., Bone Marrow Cells Are Targets for the Anabolic Actions of Prostaglandin E2 on Bone: Induction of a Transition from Nonadherent to Adherent Osteoblasts Precursors, J. Bone Miner. Res., 1995, vol. 10, no. 3, pp. 474-487.
121. Sekiya, I., Larson, B.L., Smith, J.R., Pochampally, R., Ciu, J.-G., and Prockop, D.J., Expansion of Human Adult Stem Cells from Bone Marrow Stroma: Conditions That Maximize the Yields of Early Progenitors and Evaluate Their Quality, Stem Cells, 2002a, vol. 20, pp. 530-541.
122. Sekiya, I., Vuoristo, J.T., Larson, B.L., and Prockop, D.J., In Vitro Cartilage Formation by Human Adult Stem Cells from Bone Marrow Stroma Defines the Sequence of Cellular and Molecular Events during Chondrogenesis, Proc. Nat. Acad. Sci. USA, 2002b, vol. 99, no. 7, pp. 4397-4402.
123. Seshi, B., Kumar, S., and Sellers, D., Human Bone Marrow Stromal Cell: Coexpression of Markers Specific for Multiple Mesenchymal Cell Lineages, Blood Cells, Molecules, and Diseases, 2000, vol. 26, no. 3, pp. 234-246.
124. Shake, J.G., Gruber, P.J., Baumgartner, W.A., Senechal, G., Meyers, J., Redmond, J.M., Pittenger, M.F., and Martin, B.J., Mesenchymal Stem Cell Implantation in a Swine Myocardial Infarct Model: Engraftment and Functional Effects, Ann. Thorac. Surg., 2002, vol. 73, no. 6, pp. 1919-1925.
125. Shi, X.M., Blair, H.C., Yang, X., McDonald, J.M., and Cao, X., Tandem Repeat of C/EBP Binding Sites Mediates PPAR Gamma2 Gene Transcription in Glucocorticoid-Induced Adipocytes Differentiation, J. Cell. Biochem., 2000, vol. 76, no. 3, pp. 518-527.
126. Silva, G.V., Litovsky, S., Assad, J.A., Sousa, A.L., Martin, B.J., Vela, D., Coulter, S.C., Lin, J., Ober, J., Vaughn, W.K., Branco, R.V., Oliveira, E.M., He, R., Geng, Y.J., Willerson, J.T., and Perin, E.C., Mesenchymal Stem Cells Differentiate into An Endothelial Phenotype, Enchance Vascular Density, and Improve Heart Function in a Canine Chronic Ischemia Model, Circulation, 2005, vol. 111, no. 2, pp. 150-156.
127. Silva, W.A., Covas, D.T., Panepucci, R.A., ProtoSiqueira, R., Siufi, J.L.C., Zanette, D.L., Santos, A.R.D., and Zago, M.A., The Profile of Gene Expression of Human Marrow Mesenchymal Stem Cells, Stem Cells, 2003, vol. 21, pp. 661-669.
128. Sohara, Y., Shimada, H., Minkin, C., Erdreich-Epstein, A., Nolta, J.A., and De Clerck, Y.A., Bone Marrow Mesenchymal Stem Cells Provide An Alternative Pathway of Osteoclast Activation and Bone Destruction by Cancer Cells, Cancer Res., 2005, vol. 65, no. 4, pp. 1129-1135.
129. Solrush, M., Formation of Cartilage Tissue in Vitro, J. Cell. Biochem., 1991, vol. 45, no. 3, pp. 258-260.
130. Starostin, V.I., Organ, Tissue, and Cell Mechanisms Controlling Hematopoiesis, in Stvolovye kletki krovi. Itogi nauki i tekhniki. Morfologiya cheloveka i zhivotnykh (Blood Stem Cells. Results of Science and Technology. Human and Animal Morphology), Moscow: VINITI, 1988, pp. 87-150.
131. Starostin, V.I. and Domaratskaya, E.I., Chondro- and Osteogenesis in Ectopic Transplants of Embryonic Mouse Liver, Ontogenez, 2001, vol. 32, no. 2, pp. 114-117.
132. Starostin, V.I. and Sludskaya, A.I., Differentiation of Hematopoietic and Stromal Elements of Extramedullary Bone Marrow Transplants in Irradiated Recipients, Ontogenez, 1974, vol. 5, no. 5, pp. 518-520.
133. Tang, Q.Q., Otto, T.C., and Lane, M.D., Commitment of C3H10T1/2 Pluripotent Stem Cells to the Adipocytes Lineage, Proc. Nat. Acad. Sci. USA, 2004, vol. 101, no. 26, pp. 9607-9611.
134. Tavassoli, M. and Hardy, C.L., Molecular Basis of Homing of Intravenously Transplanted Stem Cells to the Marrow, Blood, 1990, vol. 76, no. 6, pp. 1059-1070.
135. Taylor, S.M. and Jones, P.A., Multiple New Phenotypes Induced in 10T1/2 and 3T3 Cells Treated with 5-Azacytidine, Cell, 1979, vol. 17, no. 4, pp. 771-779.
136. Tomita, S., Nakatani, T., Fukuhara, S., Morisaki, T., Yutani, C., and Kitamura, S., Bone Marrow Stromal Cells Contract Synchronously with Cardiomyocytes in a Coculture System, Jpn. J. Thorac. Cardiovasc. Surg., 2002, vol. 50, pp. 321-324.
137. Tondreau, T., Lagneaux, L., Dejeneffe, M., Massy, M., Mortier, C., Delforge, A., and Bron, D., Bone Marrow-Derived Mesenchymal Stem Cells Already Express Specific Neural Proteins Before Any Differentiation, Differentiation, 2004, vol. 72, no. 7, pp. 319-326.
138. Torii, I., Morikawa, S., Nakano, A., and Morikawa, K., Establishment of a Human Preadipose Cell Line, HPB-AML-I: Refractory to PPAR-Mediated Adipogenic Stimulation, J. Cell Physiol., 2003, vol. 197, no. 1, pp. 42-52.
139. Tremain, N., Korkko, J., Ibberson, D., Kopen, G.C., Di Girolamo, C., and Phinney, D.G., Micro SAGE Analysis of 2.353 Expressed Genes in a Single Cell-Derived Colony of Undifferentiated Human Mesenchymal Stem Cells Reveals MRNAs of Multiple Cell Lineages, Stem Cells, 2001, vol. 19, pp. 408-418.
140. Tropel, P., Noel, D., Platet, N., Legrand, P., Benabid, A.L., and Berger, F., Isolation and Characterization of Mesenchymal Stem Cells from Adult Mouse Bone Marrow, Exp. Cell Res., 2004, vol. 295, no. 2, pp. 395-406.
141. Tsutsumi, S., Shimazu, A., Miyazaki, K., Pan, H., Koike, C., Yoshida, E., Takagishi, K., and Kato, Y., Retention of Multi-lineage Differentiation Potential of Mesenchymal Cells during Proliferation in Response to FGF, Biochem. Biophys. Res. Commun., 2001, vol. 288, no. 2, pp. 413-419.
142. Tuan, R.S., Boland, G., and Tuli, R., Adult Mesenchymal Stem Cells and Cell-Based Tissue Engineering, Arthritis Research and Therapy, 2002, vol. 5, no. 1, pp. 32-45.
143. Tuli, R., Seghatoleslami, M.R., Tuli, S., Howard, M.S., Danielson, K.G., and Tuan, R.S., P38 MAP Kinase Regulation of AP-2 Binding in TGF-Beta1-Stimulated Chondrogenesis of Human Trabecular Bone-Derived Cells, Ann. N. Y. Acad. Sci., 2002, vol. 961, pp. 172-177.
144. Van den Heuvel, R.L., Versele, S.R.M., Schoeters, G.E.R., and Vanderborght, O.L.J., Stromal Stem Cells (CFU-F) in Yolk Sac, Liver, Spleen and Bone Marrow of Pre- and Postnatal Mice, Br. J. Haematol., 1987, vol. 66, no. 1, pp. 15-20.
145. Wagers, A.J. and Weissman, I.L., Plasticity of Adult Stem Cells, Cell, 2004, vol. 116, pp. 639-648.
146. Wakitani, S., Saito, T., and Caplan, A.I., Myogenic Cells Derived from Rat Bone Marrow Mesenchymal Stem Cells Exposed to 5-Azacytidine, Muscle Nerve, 1995, vol. 18, no. 12, pp. 1417-1426.
147. Wallace, S.R., Oken, M.M., Lunetta, K.L., Panoskaltsis-Mortari, A., and
148. Walsh, S., Jordan, G.R., Jefferiss, C., Stewart, K., and Beresford, J.N., High Concentrations of Dexamethasone Suppress the Proliferation but Not the Differentiation Or Futher Maturation of Human Osteoblasts Precursors in Vitro: Relevance to Glucocorticoid-Induced Osteoporosis, Rheumatol., 2001, vol. 40, pp. 74-83.
149. Wang, J.S., Shum-Tim, D., Galipeau, J., Chedrawy, E., Eliopoulos, N., and Chiu, R.C., Marrow Stromal Cells for Cellular Cardiomyoplasty: Feasibility and Potential Clinical Advantages, J. Thorac. Cardiovasc. Surg., 2000, vol. 120, no. 5, pp. 999-1005.
150. Wang, P.P., Wang, J.H., Yan, Z.P., Hu, M.Y., Lau, G.K., Fan, S.T., and Luk, J.M., Expression of Hepatocyte-Like Phenotypes in Bone Marrow Stromal Cells after HGF Induction, Biochem. Biophys. Res. Commun., 2004, vol. 320, no. 3, pp. 712-716.
151. Wang, Q.-R., Yan, Z.-J., and Wolf, N.S., Dissecting the Hematopoietic Microenvironment. VI. The Effects of Several Growth Factors on the in Vitro Growth of Murine Bone Marrow CFU-F, Exp. Hematol., 1990, vol. 18, no. 4, pp. 341-347.
152. Warejcka, D.J., Harvey, R., Taylor, B.J., Young, H.E., and Lucas, P.A., A Population of Cells Isolated from Rat Heart Capable of Differentiating into Several Mesodermal Phenotypes, J. Surg. Res., 1996, vol. 62, no. 2, pp. 233-242.
153. Wieczorek, G., Steinhoff, C., Schulz, R., Scheller, M., Vingron, M., Ropers, H.H., and Nuber, U.A., Gene Expression Profile of Mouse Bone Marrow Stromal Cells Determined by cDNA Microarray Analysis, Cell Tissue Res., 2003, vol. 311, no. 2, pp. 227-237.
154. Wislet-Gendebien, S., Hans, G., Leprince, P., Rigo, J.M., Moonen, G., and Rogister, B., Plasticity of Cultured Mesenchymal Stem Cells: Switch from Nestin-Positive to Excitable Neuron-Like Phenotype, Stem Cells, 2005, vol. 23, no. 3, pp. 392-402.
155. Worster, A.A., Brower-Toland, B.D., Fortier, L.A., Bent, S.J., Williams, J., and Nixon, A.J., Chondrocytic Differentiation of Mesenchymal Stem Cells Sequentially Exposed to Transforming Growth Factor-Betal in Monolayer and Insulin-Like Growth Factor-1 in a Three-Dimensional Matrix, J. Orthop. Res., 2001, vol. 19, no. 4, pp. 738-749.
156. Xu, W., Zhang, X., Qian, H., Zhu, W., Sun, X., Hu, J., Zhou, H., and Chen, Y., Mesenchymal Stem Cells from Adult Human Bone Marrow Differentiate into a Cardiomyocyte Phenotype in Vitro, Exp. Biol. Med., 2004, vol. 229, no. 7, pp. 623-631.
157. Yamada, M., Suzu, S., Tanaka-Douzono, M., Wakimoto, N., Hatake, K., Hayasawa, M., and Motoyoshi, K., Effect of Cytokines on the Proliferation/ Differentiation of Stroma-Initiating Cells, J. Cell Physiol., 2000, vol. 184, no. 3, pp. 351-355.
158. Zavarzin, A.A., Nomenclature of Cell Forms of the Fibropblast Lineage in the Context of Revised Theory of Mesenchymal Reserve, in Izbr. tr. (Selected Works), Leningrad: Akad. Nauk SSSR, 1953, pp. 219-232.
159. Zhou, S., Eid, K., and Glowacki, J., Cooperation between TGF-Beta and Wnt Pathways during Chondrocyte and Adipocyte Differentiation of Human Marrow Stromal Cells, J. Bone Miner. Res., 2004, vol. 19, no. 3, pp. 463-470.
160. Zhou, Z., Jiang, E.L., Wang, M., Liu, Q.G., Zhai, W., Huang, Y., Wang, H.H., and Han, M.Z., Comparative Study on Various Subpopulations in Mesenchymal Stem Cells of Adult Bone Marrow, Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2005, vol. 13, no. 1, pp. 54-58.
161. Zvaifler, N.J., Marinova-Mutafchieva, L., Adams, G., Edwards, C.J., Moss, J., Burger, J.A., and Maini, R.N., Mesenchymal Precursor Cells in the Blood of Normal Individuals, Arthritis Res., 2000, vol. 2, no. 6, pp. 477-488.