Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy

Experimental Hematology

Volumn 28, Issue 6, 2000, Pages 707-715

  Banfi, Andrea ^a,b,c   Muraglia, Anita ^a   Dozin, Beatrice ^a,b   Mastrogiacomo, Maddalena ^a,c   Cancedda, Ranieri ^a,b,c   Quarto, Rodolfo ^a,b  

^a CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

Adipogenesis; Bone marrow stromal cells; Cell therapy; Chondrogenesis; Osteogenesis

Indexed keywords

ADOLESCENT; ADOPTIVE IMMUNOTHERAPY; ADULT; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CHILD; CHONDROGENESIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; PRODUCTIVITY; STROMA CELL;

ADULT; ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL AGING; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL DIFFERENTIATION; CELLS, CULTURED; CLONE CELLS; FIBROBLAST GROWTH FACTOR 2; GENE THERAPY; HUMANS; MICE; MICE, NUDE; OSTEOGENESIS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STROMAL CELLS; TRANSPLANTATION, HETEROLOGOUS; TRANSPLANTATION, HETEROTOPIC;

EID: 0034047440     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(00)00160-0     Document Type: Article

References (32)

1. Bentley S.A. Bone marrow connective tissue and the haemopoietic microenvironment. Br J Haematol. 50:1982;1.
2. Dexter T.M. Stromal cell associated haemopoiesis. J Cell Physiol Suppl. 1:1982;87.
3. Friedenstein A.J. Osteogenic stem cells in the bone marrow. Bone Miner Res. 7:1990;243.
4. Beresford J. Osteogenic stem cells and the stromal system of bone and marrow. Clin Orthop Rel Res. 240:1989;270.
5. Caplan A.I. Mesenchymal stem cell. J Orthop Res. 9:1991;641.
6. Brockbank K.G., de Jong J.P., Piersma A.H., Voerman J.S. Hemopoiesis on purified bone-marrow-derived reticular fibroblast in vitro. Exp Hematol. 14:1986;386.
7. Friedenstein A.J., Chailakhyan R.K., Latsinik N.V., Panasyuk A.F., Keiliss-Borok IV Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation. 17:1974;331.
8. Tavassoli M., Friedenstein A. Hemopoietic stromal microenvironment. Am J Hematol. 15:1983;195.
9. Owen M. Marrow stromal stem cells. J Cell Sci. 10:1988;63.
10. Beresford J.N., Bennett J.H., Devlin C., Leboy P.S., Owen M.E. Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci. 102:1992;341.
11. Johnstone B., Hering T.M., Caplan A.I., Goldberg V.M., Yoo J.U. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res. 238:1998;265.
12. Cherington V., Chiang G.G., McGrath C.A.et al. Retroviral vector-modified bone marrow stromal cells secrete biologically active factor IX in vitro and transiently deliver therapeutic levels of human factor IX to the plasma of dogs after reinfusion. Hum Gene Ther. 9:1998;1397.
13. Galotto M., Berisso G., Delfino L.et al. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp Hematol. 27:1999;1460.
14. Barbot C., Rice A., Vanes I., Mahon F.X., Jazwiec B., Reiffers J. Quality and functional capacity of the bone marrow microenvironment of autologous blood stem cell transplantation (ABSCT) recipients. Nouv Rev Fr Hematol. 36:1994;325.
15. Carlo-Stella C., Tabilio A., Regazzi E.et al. Effect of chemotherapy for acute myelogenous leukemia on hematopoietic and fibroblast marrow progenitors. Bone Marrow Transplant. 20:1997;465.
16. del Canizo C., Lopez N., Caballero D.et al. Haematopoietic damage persists 1 year after autologous peripheral blood stem cell transplantaion. Bone Marrow Transplant. 23:1999;901.
17. Domenech J., Gihana E., Dayan A.et al. Haemopoiesis of transplanted patients with autologous marrows assessed by long-term marrow culture. Br J Haematol. 88:1994;488.
18. Domenech J., Roingeard F., Herault O.et al. Changes in the functional capacity of marrow stromal cells after autologous bone marrow transplantation. Leuk Lymphoma. 29:1998;533.
19. Radford J.A., Testa N.G., Crowther D. The long-term effects of MVPP chemotherapy for Hodgkin's disease on bone marrow function. Br J Cancer. 62:1990;127.
20. Rice A., Reiffers J., Bernard P.et al. Incomplete stroma formation after allogeneic marrow or autologous blood stem cell transplantation. Nouv Rev Fr Hematol. 34:1992;167.
21. Testa N.G., Hendry J.H., Molineux G. Long-term bone marrow damage in experimental systems and in patients after radiation or chemotherapy. Anticancer Res. 5:1985;101.
22. Koc O.N., Gerson S.L., Cooper B.W.et al. Rapid hematopoietic recovery after coinfusion of autologous culture-expanded human mesenchymal stem cells (hMSCs) and PBPCs in breast cancer patients receiving high-dose chemotherapy. Blood. 92:1998;274a. (abstr).
23. Onyia J.E., Clapp D.W., Long H., Hock J.M. Osteoprogenitor cells as targets for ex vivo gene transfer. J Bone Miner Res. 13:1998;20.
24. Hou Z., Nguyen Q., Frenkel B.et al. Osteoblast-specific gene expression after transplantation of marrow cells. implications for skeletal gene therapy Proc Natl Acad Sci U S A. 96:1999;7294.
25. Pereira R.F., O'Hara M.D., Laptev A.V.et al. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci U S A. 95:1998;1142.
26. Horwitz E.M., Prockop D.J., Fitzpatrick L.A.et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med. 5:1999;309.
27. Martin I., Muraglia A., Campanile G., Cancedda R., Quarto R. Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology. 138:1997;4456.
28. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156.
29. Hicok K.C., Thomas T., Gori F., Rickard D.J., Spelsberg T.C., Riggs B.L. Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma. J Bone Miner Res. 13:1998;205.
30. Rickard D.J., Kassem M., Hefferan T.E., Sarkar G., Spelsberg T.C., Riggs B.L. Isolation and characterization of osteoblast precursor cells from human bone marrow. J Bone Miner Res. 11:1996;312.
31. Morrison S.J., Shah N.M., Anderson D.J. Regulatory mechanisms in stem cell biology. Cell. 88:1997;287.
32. Bruder S.P., Jaiswal N., Haynesworth S.E. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem. 64:1997;278.