Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1α in human osteosarcoma cells

European Journal of Pharmacology

Volumn 579, Issue 1-3, 2008, Pages 58-65

  Choi, Hwa Jung ^a   Eun, Jae Soon ^b   Kim, Dae Keun ^b   Li, Ri Hua ^b   Shin, Tae Yong ^b   Park, Hyunsung ^c   Cho, Nam Pyo ^d   Soh, Yunjo ^a  

^a Chonbuk National University   (South Korea)

^b Woosuk University   (South Korea)

^c University of Seoul   (South Korea)

^d Chonbuk National University   (South Korea)

Author keywords

Angiogenesis; Epimedium koreanum; HIF 1 ; HOS; Hypoxia; Icariside; Invasion; Metastasis; VEGF; VHL

Indexed keywords

ANTIOXIDANT; ENOLASE; EPIMEDIUM EXTRACT; FRUCTOSE BISPHOSPHATE ALDOLASE; GLYCOSIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ICARISIDE II; UNCLASSIFIED DRUG; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

ANGIOGENESIS; ARTICLE; CELL MIGRATION; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENDOTHELIUM CELL; EPIMEDIUM; EPIMEDIUM KOREANUM; GENE OVEREXPRESSION; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; HYPOXIA; METASTASIS; OSTEOSARCOMA; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; UMBILICAL VEIN;

ADRENOMEDULLIN; BONE NEOPLASMS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EPIMEDIUM; FLAVONOIDS; FRUCTOSE-BISPHOSPHATE ALDOLASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MATRIX METALLOPROTEINASE 2; OSTEOSARCOMA; PHOSPHOPYRUVATE HYDRATASE; RECEPTORS, CELL SURFACE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 37549017760     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.10.010     Document Type: Article

References (31)

1. Baek J.H., Mahon P.C., Oh J., Kelly B., Krishnamachary B., Pearson M., Chan D.A., Giaccia A.J., and Semenza G.L. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Mol. Cell 17 (2005) 503-512
2. Bogenrieder T., and Herlyn M. Axis of evil: molecular mechanisms of cancer metastasis. Oncogene 22 (2003) 6524-6536
3. Choi K.O., Lee T., Lee N., Kim J.H., Yang E.G., Yoon J.M., Kim J.H., Lee T.G., and Park H. Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger. Mol. Pharmacol. 68 (2005) 1803-1809
4. Dou J., Liu Z., and Liu S. Structure identification of a prenylflavonol glycoside from Epimedium koreanum by electrospray ionization tandem mass spectrometry. Anal. Sci. 22 (2006) 449-452
5. Fernandez-Sauze S., Delfino C., Mabrouk K., Dussert C., Chinot O., Martin P.M., Grisoli F., Ouafik L., and Boudouresque F. Effects of adrenomedullin on endothelial cells in the multistep process of angiogenesis: involvement of CRLR/RAMP2 and CRLR/RAMP3 receptors. Int. J. Cancer 108 (2004) 797-804
6. Flamme I., Krieg M., and Plate K.H. Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha. Am. J. Pathol. 153 (1998) 25-29
7. Frede S., Freitag P., Otto T., Heilmaier C., and Fandrey J. The proinflammatory cytokine interleukin 1beta and hypoxia cooperatively induce the expression of adrenomedullin in ovarian carcinoma cells through hypoxia inducible factor 1 activation. Cancer Res. 65 (2005) 4690-4697
8. Gerald D., Berra E., Frapart Y.M., Chan D.A., Giaccia A.J., Mansuy D., Pouyssegur J., Yaniv M., and Mechta-Grigoriou F. JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell 118 (2004) 781-794
9. Graeber T.G., Osmanian C., Jacks T., Housman D.E., Koch C.J., Lowe S.W., and Giaccia A.J. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379 (1996) 88-91
10. Graham C.H., Forsdike J., Fitzgerald C.J., and Macdonald-Goodfellow S. Hypoxia-mediated stimulation of carcinoma cell invasiveness via upregulation of urokinase receptor expression. Int. J. Cancer 80 (1999) 617-623
11. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 126 (1982) 131-138
12. Hollander A.P., Corke K.P., Freemont A.J., and Lewis C.E. Expression of hypoxia-inducible factor 1alpha by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed joint. Arthritis Rheum. 44 (2001) 1540-1544
13. Iorizzi M., Lanzotti V., De Marino S., Zollo F., Blanco-Molina M., Macho A., and Munoz E. New glycosides from Capsicum annuum L. var. acuminatum. Isolation, structure determination, and biological activity. J. Agric. Food Chem. 49 (2001) 2022-2029
14. Ke Q., and Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol. Pharmacol. 70 (2006) 1469-1480
15. Kwon Y.W., Kwon K.S., Moon H.E., Park J.A., Choi K.S., Kim Y.S., Jang H.S., Oh C.K., Lee Y.M., Kwon Y.G., Lee Y.S., and Kim K.W. Insulin-like growth factor-II regulates the expression of vascular endothelial growth factor by the human keratinocyte cell line HaCaT. J. Invest. Dermatol. 123 (2004) 152-158
16. Li W.K., Zhang R.Y., and Xiao P.G. Flavonoids from Epimedium wanshanense. Phytochemistry 43 (1996) 527-530
17. Marx J. Cell biology. How cells endure low oxygen. Science 303 (2004) 1454-1456
18. Mylonis I., Chachami G., Samiotaki M., Panayotou G., Paraskeva E., Kalousi A., Georgatsou E., Bonanou S., and Simos G. Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor 1a. J. Biol. Chem. 281 (2006) 33095-33106
19. Park J.W., Chun Y.S., and Kim M.S. Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools. J. Pharmacol. Sci. 94 (2004) 221-232
20. Semenza G.L. HIF-1 and human disease: one highly involved factor. Genes Dev. 14 (2000) 1983-1991
21. Semenza G.L., Roth P.H., Fang H.M., and Wang G.L. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269 (1994) 23757-23763
22. Soh Y., Jeong K.S., Lee I.J., Bae M.A., Kim Y.C., and Song B.J. Selective activation of the c-Jun N-terminal protein kinase pathway during 4-hydroxynonenal-induced apoptosis of PC12 cells. Mol. Pharmacol. 58 (2000) 535-541
23. Soh Y., Shin M.H., Lee J.S., Jang J.H., Kim O.H., Kang H., and Surh Y.J. Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline. Mutat. Res. 544 (2003) 129-142
24. Soh Y., Song B.J., Jeng J., and Kallarakal A.T. Critical role of arg433 in rat transketolase activity as probed by site-directed mutagenesis. Biochem. J. 333 (1998) 367-372
25. Ullah M.S., Davies A.J., and Halestrap A.P. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J. Biol. Chem. 281 (2006) 9030-9037
26. Vaupel P. The role of hypoxia-induced factors in tumor progression. Oncologist 9 (2004) 10-17
27. Wang J., Shen Y., He H., Kang W., and Hao X. Norsesquiterpenoid and sesquiterpenoid glycosides from Evodia austrosinensis. Planta Med. 71 (2005) 96-98
28. Wang R.F., Xie W.D., Zhang Z., Xing D.M., Ding Y., Wang W., Ma C., and Du L.J. Bioactive compounds from the seeds of Punica granatum (pomegranate). J. Nat. Prod. 67 (2004) 2096-2098
29. Zhang Y.W., Morita I., Shao G., Yao X.S., and Murota S. Screening of anti-hypoxia/reoxygenation agents by an in vitro model. Part 1: Natural inhibitors for protein tyrosine kinase activated by hypoxia/reoxygenation in cultured human umbilical vein endothelial cells. Planta Med. 66 (2000) 114-118
30. Zhang Z., ElSohly H.N., Li X.C., Khan S.I., Broedel Jr. S.E., Raulli R.E., Cihlar R.L., Burandt C., and Walker L.A. Phenolic compounds from Nymphaea odorata. J. Nat. Prod. 66 (2003) 548-550
31. Zhong H., De Marzo A.M., Laughner E., Lim M., Hilton D.A., Zagzag D., Buechler P., Isaacs W.B., Semenza G.L., and Simons J.W. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 59 (1999) 5830-5835