An analysis approach to identify specific functional sites in orthologous proteins using sequence and structural information: Application to neuroserpin reveals regions that differentially regulate inhibitory activity

Proteins: Structure, Function and Bioinformatics

Volumn 83, Issue 1, 2015, Pages 135-152

  Lee, Tet Woo ^a   Yang, Annie Shu Ping ^a   Brittain, Thomas ^a   Birch, Nigel P ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Amino acid conservation score; Antithrombin; Consensus residues; Evolutionary conservation; Multiple sequence alignment; Protease inhibition; Serpin superfamily; Site directed mutagenesis; Specifically conserved sites; Tissue plasminogen activator

Indexed keywords

ANTITHROMBIN; HEPARIN COFACTOR; MUTANT PROTEIN; NEUROSERPIN; TISSUE PLASMINOGEN ACTIVATOR; NEUROPEPTIDE; PROTEIN BINDING; SERINE PROTEINASE INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; ASSOCIATION RATE CONSTANT; BINDING SITE; COMPLEX FORMATION; CONSERVATION GENETICS; CONTROLLED STUDY; COVALENT BOND; DISSOCIATION; FUNCTIONAL PROTEOMICS; GEL ELECTROPHORESIS; HUMAN; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN FUNCTIONAL SITE; PROTEIN STRUCTURE; PROTEIN TARGETING; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MUTAGENESIS; MUTATION; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROCEDURES; RAT; SEQUENCE HOMOLOGY;

ANIMALS; ANTITHROMBINS; CONSERVED SEQUENCE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS; MUTANT PROTEINS; MUTATION; NEUROPEPTIDES; PROTEIN BINDING; RATS; SEQUENCE ANALYSIS, PROTEIN; SEQUENCE HOMOLOGY, AMINO ACID; SERPINS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84937557898     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24711     Document Type: Article

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