Antithrombin III phenylalanines 122 and 121 contribute to its high affinity for heparin and its conformational activation

Journal of Biological Chemistry

Volumn 278, Issue 18, 2003, Pages 15941-15950

  Jairajpuri, Mohamad Aman ^a   Lu, Aiqin ^a   Desai, Umesh ^b   Olson, Steven T ^c   Bjork, Ingemar ^d   Bock, Susan C ^a,e  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^e UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CHEMICAL ACTIVATION; CHEMICAL BONDS; CONFORMATIONS; DISSOCIATION; ENZYME KINETICS; FREE ENERGY; HYDROPHOBICITY;

HEPARIN;

ENZYME INHIBITION;

ANTITHROMBIN; ANTITHROMBIN III; GUANIDINE; HEPARIN; PENTASACCHARIDE; PHENYL GROUP; PHENYLALANINE; BLOOD CLOTTING FACTOR 10A; THROMBIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DISSOCIATION CONSTANT; ENERGY; EQUILIBRIUM CONSTANT; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; CHEMISTRY; HUMAN; KINETICS; METABOLISM; OSMOLARITY;

ANTITHROMBIN III; FACTOR XA; HEPARIN; HUMANS; KINETICS; OSMOLAR CONCENTRATION; PROTEIN CONFORMATION; THROMBIN;

EID: 0037507303     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212319200     Document Type: Article

References (36)

1. Olson, S., and Shore, J. (1981) J. Biol. Chem. 256, 11065-11072
2. Olson, S. T., Bjork, I., Sheffer, R., Craig, P. A., Shore, J. D., and Choay, J. (1992) J. Biol. Chem. 267, 12528-12538
3. Koide, T., Odani, S., Takahashi, K., Ono, T., and Sakuragawa, N. (1984) Proc. Natl. Acad. Sci. U. S. A. 81, 289-293
4. Peterson, C., Noyes, C., Pecon, J., Church, F., and Blackburn, M. (1987) J. Biol. Chem. 262, 8061-8065
5. Gandrille, S., Aiach, M., Lane, D., Vidaud, D., Molho-Sabatier, P., Caso, R., Moerloose, P. D., Fiessinger, J., and Clauser, E. (1990) J. Biol. Chem. 265, 18997-19001
6. Kridel, S., Chan, W., and Knauer, D. (1996) J. Biol. Chem. 271, 20935-20941
7. Kridel, S., and Knauer, D. (1997) J. Biol. Chem. 272, 7656-7660
8. Ersdal-Badju, E., Lu, A., Zuo, Y., Picard, V., and Bock, S. (1997) J. Biol. Chem. 272, 19393-19400
9. Arocas, V., Bock, S., Olson, S., and Bjork, I. (1999) Biochemistry 38, 10196-10204
10. Desai, U., Swanson, R., Bock, S., Bjork, I., and Olson, S. (2000) J. Biol. Chem. 275, 18967-18984
11. Arocas, V., Bock, S., Raja, S., Olson, S., and Bjork, I. (2001) J. Biol. Chem. 276, 43809-43817
12. Schedin-Weiss, S., Desai, U., Bock, S., Gettins, P., Olson, S., and Bjork, I. (2002) Biochemistry 41, 4779-4788
13. Jin, L., Abrahams, J., Skinner, R., Petitou, M., Pike, R., and Carrell, R. (1997) Proc. Natl. Acad. Sci., U. S. A. 94, 14683-14688
14. Belzar, K., Zhou, A., Carrell, R., Gettins, P., and Huntington, J. (2002) J. Biol. Chem. 277, 8551-8558
15. vanBoeckel, C., Grootenhuis, P., and Visser, A. (1996) Nat. Struct. Biol. 1, 423-425
16. Huntington, J., Olson, S., Fan, B., and Gettins, P. (1996) Biochemistry 35, 8495-8503
17. Olson, S., and Bjork, I. (1991) J. Biol. Chem. 266, 6353-6364
18. Hileman, R., Jennings, R., and Linhardt, R. (1998) Biochemistry 37, 15231-15237
19. Turk, B., Brieditis, I., Bock, S., Olson, S., and Bjork, I. (1997) Biochemistry 36, 6682-6691
20. Backovic, M., and Gettins, P. (2002) J. Proteome Res. 1, 367-373
21. Jordan, R. (1983) Arch. Biochem. Biophys. 227, 587-595
22. Jairajpuri, M., Lu, A., and Bock, S. (2002) J. Biol. Chem. 277, 24460-24465
23. Ersdal-Badju, E., Lu, A., Peng, X., Picard, V., Zendehrouh, P., Turk, B., Björk, I., Olson, S., and Bock, S. (1995) Biochem. J. 310, 323-330
24. Picard, V., and Bock, S. (1996) in Methods in Molecular Biology: PCR Protocols (White, B. A., ed) pp. 183-186, Humana Press, Totowa, NJ
25. Nordenman, B., Nystrom, C., and Bjork, I. (1977) Eur. J. Biochem. 18, 195-203
26. Olson, S., Bjork, I., and Shore, J. (1993) Methods Enzymol. 222, 525-560
27. Olson, S., Srinivasan, K., Bjork, I., and Shore, J. (1981) J. Biol. Chem. 256, 11073-11079
28. Olson, S., and Shore, J. (1982) J. Biol. Chem. 257, 14891-14895
29. Picard, V., Ersdal-Badju, E., and Bock, S. (1995) Biochemistry 34, 8433-8440
30. Meagher, J. L., Beechem, J. M., Olson, S. T., and Gettins, P. G. W. (1998) J. Biol. Chem. 273, 23283-23289
31. Arocas, V., Turk, B., Bock, S., Olson, S., and Bjork, I. (2000) Biochemistry 39, 8512-8518
32. Olson, S. (1985) J. Biol. Chem. 260, 10153-10160
33. Olson, S., Bjork, I., and Bock, S. (2002) Trends Cardiovasc. Med. 12, 198-205
34. Skinner, R., Abrahams, J., Whisstock, J., Lesk, A., Carrell, R., and Wardell, M. (1997) J. Mol. Biol. 266, 601-609
35. Okijama, K., Abe, H., Maeda, S., Motomura, M., Tsujihata, M., Nagataki, S., Okabe, H., and Takatsuki, K. (1993) Blood 81, 1300-1305
36. Chowdhury, V., Mille, B., Olds, R., Lane, D., Watton, J., Barrowcliffe, T., Pabinger, I., Woodcock, B., and Thein, S. (1995) Br. J. Haematol. 89, 602-609