Neuroserpin, an axonally secreted serine protease inhibitor

EMBO Journal

Volumn 15, Issue 12, 1996, Pages 2944-2953

  Osterwalder, T ^a   Contartese, J ^a   Stoeckli, E T ^a,b   Kuhn, T B ^a,c   Sonderegger, P ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Axonally secreted; Neuron specific; Neuroserpin; Serine protease inhibitor; Synapse formation

Indexed keywords

GLYCOPROTEIN; NEUROSERPIN; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CHICK EMBRYO; CONTROLLED STUDY; DNA SEQUENCE; DNA STRUCTURE; EMBRYO; IN SITU HYBRIDIZATION; MOLECULAR CLONING; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NERVE FIBER; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN PURIFICATION; PROTEIN SECRETION; SPINAL GANGLION; VENTRAL ROOT;

EID: 0029977875     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00657.x     Document Type: Article

References (67)

1. Baird,J.L. and Raper,J.A. (1995) A serine proteinase involved in contact mediated repulsion of retinal growth cones by DRG neuntes. J. Neurosci., 15, 6605-6618.
2. Baker,J.B., Low,D.A., Simmer,R.L. and Cunningham,D.D. (1980) Protease-nexin: a cellular component that links thrombin and plasminogen activator and mediates their binding to cells. Cell, 21, 37-45.
3. Blackburn,M.N., Smith,R.L., Carson,J. and Sibley,C.C. (1984) The heparin-binding site of antithrombin III. Identification of a critical tryptophan in the amino acid sequence. J. Biol. Chem., 259, 939-941.
4. Blinder,M.A. and Tollefsen,D.M. (1990) Site-directed mutagenesis of arginine 103 and lysine 185 in the proposed glycosaminoglycan-binding site of heparin cofactor II. J. Biol. Chem., 265, 286-291.
5. Campenot,R.B. (1977) Local control of neurite development by nerve growth factor. Proc. Natl Acad. Sci. USA, 74, 4516-4519.
6. Campenot,R.B. (1979) Independent control of the local environment of somas and neuntes. Methods Enzymol., 58, 302-307.
7. Chomczynski,P. and Sacchi,N. (1987) Single-step method of RNA isolation by acidic guanidinium thiocyanale-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
8. Connold,A.L. and Vrhova,G. (1994) Neuromuscular contacts of expanded motor units in rat soleus muscles are rescued by leupeptin. Neuroscience, 63, 327-338.
9. Constantine-Paton,M., Cline,H.T. and Debski,E. (1990) Patterned activity, synaptic convergence and the NMDA receptor in developing visual pathways. Annu. Rev. Neurosci., 13, 129-154.
10. Dent,M.A.R., Sumi,Y., Morris,R.J. and Seeley,P.J. (1993) Urokinase-type plasminogen activator expression by neurons and oligodendrocytes during process outgrowth in developing rat brain. Eur. J. Neurosci., 5, 633-647.
11. Deschepper,C.F., Bigornia,V., Berens,M.E. and Lapointe,M.C. (1991) Production of thrombin and antithrombin III by brain and astroglial cell cultures. Brain Res. Mol. Brain Res., 11, 355-358.
12. Evans,D.L., Christey,P.B. and Carrell,R.W. (1993) The heparin binding site and activation of protease nexin 1. In Festoff,B.W. (ed.), Serine Proteasea and Their Serpin Inhibitors in the Nervous System. Plenum Press, New York, pp. 69-78.
13. Friedman,K.D., Rosen,N.L., Newman,P.J. and Montgomery,R.R. (1988) Enzymatic amplification of specific cDNA inserts from λgt11 libraries. Nucleic Acids Res., 16, 8718.
14. Gettins,P. (1989) Absence of large-scale conformational change upon limited proteolysis of ovalbumin, the protolypic serpin. J. Biol. Chem., 264, 3781-3785.
15. Gettins,P., Patston,P.A. and Schapira,M. (199.3) The role of conformational change in serpin structure and function. BioEssays, 15, 461-467.
16. Gloor,S., Odink,K., Guenther,J., Nick,H. and Monard,D. (1986) A gliaderived neurite promoting factor with protease inhibitory activity belongs to the protease nexins. Cell, 47, 687-693.
17. Goodman,C.S. and Shatz,C.J. (1993) Developmental mechanisms that generate precise patterns of neuronal connectivity. Cell, 72/Neuron, 10 (suppl.), 77-98.
18. Guenther,J., Nick,H. and Monard,D. (1985) A glia-derived neurite promoting factor with protease inhibitory activity. EMBO J., 4, 1963-1966.
19. Hamburger,V. and Hamilton,H.L. (1951) A series of normal stages in the development of the chick embryo. J. Morphol., 88, 49-92.
20. Han,J.H., Stratowa,C. and Rutter,W.J. (1987) Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning. Biochemistry, 26, 1617-1625.
21. Hantai,D., Rao,J.S., Kahler,C. and Festoff,B.W. (1989) Decrease in plasminogen activator correlates with synapse elimination during neonatal development of mouse skeletal muscle. Proc. Natl Acad. Sci. USA, 86, 362-366.
22. Hopkins,P.C.R., Carell,R.W. and Stone,S.R. (1993) Effects of mutations in the hinge region of serpins. Biochemistry, 32, 7650-7657.
23. Huber,R. and Carell,R.W. (1989) Implications of the three-dimensional structure of α1-antitrypsin for structure and function of serpins. Biochemistry. 28, 8951-8966.
24. Kawasaki,H. and Suzuki,K. (1990) Separation of peptides dissolved in a sodium dodecyl sulfate solution by reversed-phase liquid chromatography: removal of sodium dodecyl sulfate from peptides using an ion exchange precolumn. Anal. Biochem., 186, 264-268.
25. Kozak,M. (1987) An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res., 15, 8125-8148.
26. Krystosek,A. and Seeds,N.W. (1981a) Plasminogen activator release at the neuronal growth cone. Science, 213, 1532-1534.
27. Krystosek,A. and Seeds,N.W. (1981b) Plasminogen activator secretion by granule neurons in cultures of developing cerebellum. Proc. Natl Acad. Sci. USA, 78, ? 7810-7814.
28. Kuenzel,W.J. and Masson,M. (1988) A Stereotaxic Atlas of the Brain of the Chick (Gallus domesticus). The John Hopkins University Press, Baltimore, MD, p. 142.
29. Laeumli,U.K. (1970) Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature, 227, 680-685.
30. LaVail,J.H. and Cowan,W.M. (1971) The development of the chick optic tectum. II. Autoradiographic studies. Brain Res., 28, 421-441.
31. Lawrence,D.A., Strandberg,L., Ericson,J. and Ny,T. (1990) Structure-function studies of the SERPIN plasminogen activator inhibitor type 1. J. Biol. Chem., 265, 20293-20301.
32. Liu,Y., Fields,D.R., Festoff,B.W. and Nelson,P.G. (1994) Proteolytic activity of thrombin is required for electrical activity-dependent synapse reduction. Proc. Natl Acad. Sci. USA, 91, 10300-10304.
33. Meier,R., Spreyer,P, Ortmann,R., Harel,A. and Monard,D. (1989) Induction of glia-derived nexin after lesion of a peripheral nerve. Nature, 342, 548-550.
34. Meiri,N., Masos,T., Rosenblum,K., Miskin,R. and Dudai,Y. (1994) Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning. Proc. Natl Acad. Sci. USA, 91, 3196-3200.
35. Mey,J. and Thanos,S. (1992) Development of the visual system of the chick - a review. J. Hirnforschung, 33, 673-702.
36. Needleman,S.B. and Wunsch,C.D. (1970) A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol., 48, 443-453.
37. Nick,H., Hofsteenge,J., Shaw,E., Rovelli,G. and Monard,D. (1990) Functional sites of glia-derived nexin (GDN): Importance of the site reacting with the protease. Biochemistry, 29, 2417-2421.
38. Oakley,B.R., Kirsch,D.R. and Morris,N.R. (1980) A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels. Anal. Biochem., 105, 361-363.
39. O'Farrell,P.H. (1975) High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem., 250, 4007-4021.
40. Oppenheim,R.W., Schneiderman,A., Shimizu,I. and Yaginuma,H. (1988) Onset and development of mtersegmental projections in the chick embryo spinal cord. J. Comp. Neurol., 275, 159-180.
41. Qian,Z., Gilbert,M.E., Colicos,M.A., Kandel,E.R. and Kuhl,D. (1993) Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation. Nature, 361, 453-457.
42. Rao,J.S., Chen,M. and Festoff,B.W. (1993) Plasminogen activator inhibitor 1, the primary regulator of fibrinolysis, in normal human cerebrospinal fluid. J. Neurosci. Res., 34, 340-345.
43. Rayford,A., Rao,J.S. and Festoff,B.W. (1992) Characterization of the serpin, alpha 1-antichymotrypsin, in normal human cerebrospinal fluid. J. Neurochem., 58, 88-94.
44. Ruegg,M.A., Stoeckli,E.T., Kuhn,T.B., Heller,M., Zuellig,R. and Sonderegger,P. (1989) Purification of axonin-1, a protein that is secreted from axons during neurogenesis. EMBO J., 8, 55-63.
45. Sambrook,J., Fritsch,E.F. and Maniatis,T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
46. Sanger,R. Nicklen,S. and Coulson,A.R. (1977) DNA sequencing with chain-terminating inhibitors. Prof. Nail Acad. Sci. USA, 74, 5463-5467.
47. Schaeren-Wiemers,N. and Gerfin-Moser,A. (1993) A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry. 100, 431-440.
48. Schapira,M. and Patston,P.A. (1991) Serine protease inhibitors (Serpins). TCM, 1, 146-151.
49. Schechter,I. and Berger,A. (1967) On the size of the active site in proteases. Biochem. Biophys, Res. Commun., 27, 157-162.
50. Schulze,A.J., Huber,R., Bode,W. and Engh,R.A. (1994) Structural aspects of serpin inhibition. FEBS Lett., 344, 117-124.
51. Sheets,M.D., Ogg,S.C. and Wickens,M.P. (1990) Point mutations in AAUAAA and the poly(A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro. Nucleic Acids Res., 18, 5799-5805.
52. Sherman,P.M., Lawrence,D.A., Yang,A.Y., Vandenberg,E.T., Paielli,D., Olson,S.T., Shore,J.D. and Ginsburg.D. (1992) Saturation mutagenesis of the plasminogen activator inhibitor-1 reactive center. J. Biol. Chem., 267, 7588-7595.
53. Sonderegger,P., Fishman,M.C., Bokoum,M., Bauer,H.C. and Nelson,P.G. (1983) Axonal proteins of presynaptic neurons during synaptogenesis. Science, 221, 1294-1297.
54. Sonderegger,P., Fishman,M.C., Bokoum,M., Bauer,M., Neale,H.C. and Nelson,P.G. (1984) A few axonal proteins distinguish ventral spinal cord neurons from dorsal root ganglion neurons. J. Cell Biol., 98, 364-368.
55. Sonderegger,P., Lemkin,P.F., Lipkin,L.E. and Nelson,P.G. (1985) Differential modulation of the expression of axonal proteins by nonneuronal cells of the peripheral and central nervous system. EMBO J., 4, 1395-1401.
56. Stein,P.E., Leslie,A.G.W. Finch,J.T., Turnell,W.G., McLaughlin,P.J. and Carell,R.W. (1990) Crystal structure of ovalbumin as a model for the reactive center of serpins. Nature, 347, 99-102.
57. Stoeckli,E.T., Lemkin,P.F., Kuhn,T.B., Ruegg,M.A., Heller,M. and Sonderegger,P. (1989) Identification of proteins secreted from axons of dorsal-root-ganglia neurons. Eur. J. Biochem., 180, 249-258.
58. Stoeckli,E.T. and Landmesser,L.T. (1995) Axonin-1, Nr-CAM and NgCAM play different roles in the in vivo guidance of chick commissural neurons. Neuron, 14, 1165-1179.
59. Stone,S.R., Brown-Luedi,M.L., Rovelli,G., Guidolin,A., McGlynn,E. and Monard,D. (1994) Localization of the heparin-binding site of gliaderived nexin/protease nexin 1 by site-directed mutagenesis. Biochemistry, 33, 7731-7735.
60. Sumi,Y., Dent,M.A.R., Owen,D.E., Seeley,P.J. and Morris,R.J. (1992) The expression of tissue and urokinase-type plasminogen activators in neural development suggest different modes of proteolylic involvement in neuronal growth. Development, 116, 625-637.
61. Sweadner,K.J. (1981) Environmentally regulated expression of soluble extracellular proteins of sympathetic neurons. J. Biol. Chem., 256, 4063-4070.
62. Switzer,R.C.,III, Merril,C.R. and Shifrin,S. (1979) A highly sensitive silver stain for detecting proteins and peptides in polyacrylamide gels. Anal. Biochem., 98, 231-237.
63. Udin,S.B. and Fawcett,J.W. (1988) Formation of topographic maps. Annu. Rev. Neurosci., 11, 289-327.
64. von Heijne,G. (1983) Patterns of amino acids near signal-sequence cleavage sites. Eur. J. Biochem., 133, 17-21.
65. Wessel,D. and Fluegge,U.I. (1984) A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal. Biochem., 138, 141-143
66. Wright,H.T., Qian,H.X. and Huber,R. (1990) Crystal structure of plakalbumin, a proteolytically nicked form of ovalbumin. J. Mol. Biol., 213, 513-528.
67. Zuellig,R.A. et al. (1992) The axonally secreted cell adhesion molecule, axonin-1; Primary structure, immunoglobulin-like and fibronectintype-III-like domains and glycosyl-phosphatidylinositol anchorage. Eur. J. Biochem., 204, 453-463.