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Volumn , Issue , 2015, Pages 1-9

The Angiotensin AT2 Receptor: From Enigma to Therapeutic Target

Author keywords

Angiotensin AT2 receptor; AT2R features; AT2R functions; AT2R research history; Neuroprotection; Renin angiotensin system

Indexed keywords


EID: 84937541326     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-801364-9.00001-8     Document Type: Chapter
Times cited : (7)

References (99)
  • 1
    • 0033513419 scopus 로고    scopus 로고
    • The angiotensin type 2 receptor: variations on an enigmatic theme
    • Unger T. The angiotensin type 2 receptor: variations on an enigmatic theme. J Hypertens 1999, 17:1775-1786.
    • (1999) J Hypertens , vol.17 , pp. 1775-1786
    • Unger, T.1
  • 2
    • 0033031543 scopus 로고    scopus 로고
    • Recent progress in angiotensin II type 2 receptor research in the cardiovascular system
    • Horiuchi M., Akishita M., Dzau V.J. Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. Hypertension 1999, 33:613-621.
    • (1999) Hypertension , vol.33 , pp. 613-621
    • Horiuchi, M.1    Akishita, M.2    Dzau, V.J.3
  • 4
    • 0024421343 scopus 로고
    • Preliminary biochemical characterization of two angiotensin II receptor subtypes
    • Whitebread S., Mele M., Kamber B., de Gasparo M. Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun 1989, 163:284-291.
    • (1989) Biochem Biophys Res Commun , vol.163 , pp. 284-291
    • Whitebread, S.1    Mele, M.2    Kamber, B.3    de Gasparo, M.4
  • 5
    • 0033824138 scopus 로고    scopus 로고
    • International union of pharmacology. XXIII. The angiotensin II receptors
    • De Gasparo M., Catt K.J., Inagami T., Wright J.W., Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 2000, 52:415-472.
    • (2000) Pharmacol Rev , vol.52 , pp. 415-472
    • De Gasparo, M.1    Catt, K.J.2    Inagami, T.3    Wright, J.W.4    Unger, T.5
  • 6
    • 0027362063 scopus 로고
    • Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors
    • Mukoyama M., Nakajima M., Horiuchi M., Sasamura H., Pratt R.E., Dzau V.J. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. J Biol Chem 1993, 268:24539-24542.
    • (1993) J Biol Chem , vol.268 , pp. 24539-24542
    • Mukoyama, M.1    Nakajima, M.2    Horiuchi, M.3    Sasamura, H.4    Pratt, R.E.5    Dzau, V.J.6
  • 8
    • 0027443482 scopus 로고
    • Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition
    • Kambayashi Y., Bardhan S., Takahashi K., Tsuzuki S., Inui H., Hamakubo T., et al. Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J Biol Chem 1993, 268:24543-24546.
    • (1993) J Biol Chem , vol.268 , pp. 24543-24546
    • Kambayashi, Y.1    Bardhan, S.2    Takahashi, K.3    Tsuzuki, S.4    Inui, H.5    Hamakubo, T.6
  • 9
    • 0028334119 scopus 로고
    • Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor
    • Tsuzuki S., Ichiki T., Nakakubo H., Kitami Y., Guo D.F., Shirai H., et al. Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor. Biochem Biophys Res Commun 1994, 200:1449-1454.
    • (1994) Biochem Biophys Res Commun , vol.200 , pp. 1449-1454
    • Tsuzuki, S.1    Ichiki, T.2    Nakakubo, H.3    Kitami, Y.4    Guo, D.F.5    Shirai, H.6
  • 10
    • 0028008738 scopus 로고
    • Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor
    • Ichiki T., Herold C.L., Kambayashi Y., Bardhan S., Inagami T. Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor. Biochim Biophys Acta 1994, 1189:247-250.
    • (1994) Biochim Biophys Acta , vol.1189 , pp. 247-250
    • Ichiki, T.1    Herold, C.L.2    Kambayashi, Y.3    Bardhan, S.4    Inagami, T.5
  • 11
    • 0028148285 scopus 로고
    • Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung
    • Koike G., Horiuchi M., Yamada T., Szpirer C., Jacob H.J., Dzau V.J. Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. Biochem Biophys Res Commun 1994, 203:1842-1850.
    • (1994) Biochem Biophys Res Commun , vol.203 , pp. 1842-1850
    • Koike, G.1    Horiuchi, M.2    Yamada, T.3    Szpirer, C.4    Jacob, H.J.5    Dzau, V.J.6
  • 12
    • 0030891355 scopus 로고    scopus 로고
    • Genomic organization and polymorphism of human angiotensin II type receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome
    • Katsuya T., Horiuchi M., Minami S., Koike G., Santoro N.F., Hsueh A.J., et al. Genomic organization and polymorphism of human angiotensin II type receptor: no evidence for its gene mutation in two families of human premature ovarian failure syndrome. Mol Cell Endocrinol 1997, 127(2):221-228.
    • (1997) Mol Cell Endocrinol , vol.127 , Issue.2 , pp. 221-228
    • Katsuya, T.1    Horiuchi, M.2    Minami, S.3    Koike, G.4    Santoro, N.F.5    Hsueh, A.J.6
  • 13
    • 0028885773 scopus 로고
    • Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice
    • Hein L., Barsh G.S., Pratt R.E., Dzau V.J., Kobilka B.K. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature 1995, 377:744-747.
    • (1995) Nature , vol.377 , pp. 744-747
    • Hein, L.1    Barsh, G.S.2    Pratt, R.E.3    Dzau, V.J.4    Kobilka, B.K.5
  • 14
    • 0028858478 scopus 로고
    • Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
    • Ichiki T., Labosky P.A., Shiota C., Okuyama S., Imagawa Y., Fogo A., et al. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature 1995, 377:748-750.
    • (1995) Nature , vol.377 , pp. 748-750
    • Ichiki, T.1    Labosky, P.A.2    Shiota, C.3    Okuyama, S.4    Imagawa, Y.5    Fogo, A.6
  • 15
    • 0026630420 scopus 로고
    • Effect of early onset angiotensin converting enzyme inhibition on myocardial capillaries
    • Unger T., Mattfeldt T., Lamberty V., Bock P., Mall G., Linz W., et al. Effect of early onset angiotensin converting enzyme inhibition on myocardial capillaries. Hypertension 1992, 20:478-482.
    • (1992) Hypertension , vol.20 , pp. 478-482
    • Unger, T.1    Mattfeldt, T.2    Lamberty, V.3    Bock, P.4    Mall, G.5    Linz, W.6
  • 16
  • 17
    • 0026612134 scopus 로고
    • The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase
    • Bottari S.P., King I.N., Reichlin S., Dahlstroem I., Lydon N., de Gasparo M. The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase. Biochem Biophys Res Commun 1992, 183:206-211.
    • (1992) Biochem Biophys Res Commun , vol.183 , pp. 206-211
    • Bottari, S.P.1    King, I.N.2    Reichlin, S.3    Dahlstroem, I.4    Lydon, N.5    de Gasparo, M.6
  • 18
    • 0018374317 scopus 로고
    • Effects of angiotensin II and angiotensin II antagonist saralasin on cell growth and renin in 3T3 and SV3T3 cells
    • Schelling P., Ganten D., Speck G., Fischer H. Effects of angiotensin II and angiotensin II antagonist saralasin on cell growth and renin in 3T3 and SV3T3 cells. J Cell Physiol 1979, 98:503-513.
    • (1979) J Cell Physiol , vol.98 , pp. 503-513
    • Schelling, P.1    Ganten, D.2    Speck, G.3    Fischer, H.4
  • 19
    • 0028804906 scopus 로고
    • The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer
    • Nakajima M., Hutchinson H.G., Fujinaga M., Hayashida W., Morishita R., Zhang L., et al. The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci U S A 1995, 92:10663-10667.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 10663-10667
    • Nakajima, M.1    Hutchinson, H.G.2    Fujinaga, M.3    Hayashida, W.4    Morishita, R.5    Zhang, L.6
  • 20
    • 0028876654 scopus 로고
    • The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells
    • Stoll M., Steckelings U.M., Paul M., Bottari S.P., Metzger R., Unger T. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 1995, 95:651-657.
    • (1995) J Clin Invest , vol.95 , pp. 651-657
    • Stoll, M.1    Steckelings, U.M.2    Paul, M.3    Bottari, S.P.4    Metzger, R.5    Unger, T.6
  • 21
    • 0029123864 scopus 로고
    • The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and 2
    • Horiuchi M., Koike G., Yamada T., Mukoyama M., Nakajima M., Dzau V.J. The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and 2. J Biol Chem 1995, 270:20225-20230.
    • (1995) J Biol Chem , vol.270 , pp. 20225-20230
    • Horiuchi, M.1    Koike, G.2    Yamada, T.3    Mukoyama, M.4    Nakajima, M.5    Dzau, V.J.6
  • 22
    • 84862322861 scopus 로고    scopus 로고
    • Regulation of angiotensin II receptors beyond the classical pathway
    • Horiuchi M., Iwanami J., Mogi M. Regulation of angiotensin II receptors beyond the classical pathway. Clin Sci Lond Eng 1979 2012, 123:193-203.
    • (2012) Clin Sci Lond Eng 1979 , vol.123 , pp. 193-203
    • Horiuchi, M.1    Iwanami, J.2    Mogi, M.3
  • 23
    • 0031800990 scopus 로고    scopus 로고
    • Receptors and their classification: focus on angiotensin II and the AT2 receptor
    • Csikós T., Chung O., Unger T. Receptors and their classification: focus on angiotensin II and the AT2 receptor. J Hum Hypertens 1998, 12:311-318.
    • (1998) J Hum Hypertens , vol.12 , pp. 311-318
    • Csikós, T.1    Chung, O.2    Unger, T.3
  • 24
    • 0042738775 scopus 로고    scopus 로고
    • Angiotensin II AT2 receptor subtype: an uprising frontier in cardiovascular disease?
    • Volpe M., Musumeci B., De Paolis P., Savoia C., Morganti A. Angiotensin II AT2 receptor subtype: an uprising frontier in cardiovascular disease?. J Hypertens 2003, 21:1429-1443.
    • (2003) J Hypertens , vol.21 , pp. 1429-1443
    • Volpe, M.1    Musumeci, B.2    De Paolis, P.3    Savoia, C.4    Morganti, A.5
  • 25
    • 12344269204 scopus 로고    scopus 로고
    • Angiotensin II AT2 receptor localization in cardiovascular tissues by its antibody developed in AT2 gene-deleted mice
    • Utsunomiya H., Nakamura M., Kakudo K., Inagami T., Tamura M. Angiotensin II AT2 receptor localization in cardiovascular tissues by its antibody developed in AT2 gene-deleted mice. Regul Pept 2005, 126:155-161.
    • (2005) Regul Pept , vol.126 , pp. 155-161
    • Utsunomiya, H.1    Nakamura, M.2    Kakudo, K.3    Inagami, T.4    Tamura, M.5
  • 26
    • 22544448655 scopus 로고    scopus 로고
    • The AT2 receptor-a matter of love and hate
    • Steckelings U.M., Kaschina E., Unger T. The AT2 receptor-a matter of love and hate. Peptides 2005, 26:1401-1409.
    • (2005) Peptides , vol.26 , pp. 1401-1409
    • Steckelings, U.M.1    Kaschina, E.2    Unger, T.3
  • 27
    • 84873035303 scopus 로고    scopus 로고
    • AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function
    • Padia S.H., Carey R.M. AT2 receptors: beneficial counter-regulatory role in cardiovascular and renal function. Pflüg Arch Eur J Physiol 2013, 465:99-110.
    • (2013) Pflüg Arch Eur J Physiol , vol.465 , pp. 99-110
    • Padia, S.H.1    Carey, R.M.2
  • 28
    • 0029814392 scopus 로고    scopus 로고
    • Intracellular third loop domain of angiotensin II type-2 receptor: role in mediating signal transduction and cellular function
    • Hayashida W., Horiuchi M., Dzau V.J. Intracellular third loop domain of angiotensin II type-2 receptor: role in mediating signal transduction and cellular function. J Biol Chem 1996, 271:21985-21992.
    • (1996) J Biol Chem , vol.271 , pp. 21985-21992
    • Hayashida, W.1    Horiuchi, M.2    Dzau, V.J.3
  • 29
    • 0027976098 scopus 로고
    • Angiotensin II type 2 receptor stimulation of neuronal K+ currents involves an inhibitory GTP binding protein
    • Kang J., Posner P., Sumners C. Angiotensin II type 2 receptor stimulation of neuronal K+ currents involves an inhibitory GTP binding protein. Am J Physiol 1994, 267:C1389-C1397.
    • (1994) Am J Physiol , vol.267 , pp. C1389-C1397
    • Kang, J.1    Posner, P.2    Sumners, C.3
  • 30
    • 0029666262 scopus 로고    scopus 로고
    • The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus
    • Zhang J., Pratt R.E. The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus. J Biol Chem 1996, 271:15026-15033.
    • (1996) J Biol Chem , vol.271 , pp. 15026-15033
    • Zhang, J.1    Pratt, R.E.2
  • 31
    • 77749310836 scopus 로고    scopus 로고
    • Adapter proteins and promoter regulation of the angiotensin AT2 receptor-implications for cardiac pathophysiology
    • Funke-Kaiser H., Reinemund J., Steckelings U.M., Unger T. Adapter proteins and promoter regulation of the angiotensin AT2 receptor-implications for cardiac pathophysiology. J Renin-Angiotensin-Aldosterone Syst 2010, 11:7-17.
    • (2010) J Renin-Angiotensin-Aldosterone Syst , vol.11 , pp. 7-17
    • Funke-Kaiser, H.1    Reinemund, J.2    Steckelings, U.M.3    Unger, T.4
  • 32
    • 0029033329 scopus 로고
    • Characterization of rat type 2 angiotensin II receptor stably expressed in 293 cells
    • Mukoyama M., Horiuchi M., Nakajima M., Pratt R.E., Dzau V.J. Characterization of rat type 2 angiotensin II receptor stably expressed in 293 cells. Mol Cell Endocrinol 1995, 112:61-68.
    • (1995) Mol Cell Endocrinol , vol.112 , pp. 61-68
    • Mukoyama, M.1    Horiuchi, M.2    Nakajima, M.3    Pratt, R.E.4    Dzau, V.J.5
  • 33
    • 0031446688 scopus 로고    scopus 로고
    • Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: evidence for selective sorting of receptor and ligand
    • Hein L., Meinel L., Pratt R.E., Dzau V.J., Kobilka B.K. Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: evidence for selective sorting of receptor and ligand. Mol Endocrinol 1997, 11:1266-1277.
    • (1997) Mol Endocrinol , vol.11 , pp. 1266-1277
    • Hein, L.1    Meinel, L.2    Pratt, R.E.3    Dzau, V.J.4    Kobilka, B.K.5
  • 35
    • 24044447872 scopus 로고    scopus 로고
    • Constitutively active homo-oligomeric angiotensin II type 2 receptor induces cell signaling independent of receptor conformation and ligand stimulation
    • Miura S.-I., Karnik S.S., Saku K. Constitutively active homo-oligomeric angiotensin II type 2 receptor induces cell signaling independent of receptor conformation and ligand stimulation. J Biol Chem 2005, 280:18237-18244.
    • (2005) J Biol Chem , vol.280 , pp. 18237-18244
    • Miura, S.-I.1    Karnik, S.S.2    Saku, K.3
  • 36
    • 0035955732 scopus 로고    scopus 로고
    • The angiotensin II AT2 receptor is an AT1 receptor antagonist
    • AbdAlla S., Lother H., Abdel-tawab A.M., Quitterer U. The angiotensin II AT2 receptor is an AT1 receptor antagonist. J Biol Chem 2001, 276:39721-39726.
    • (2001) J Biol Chem , vol.276 , pp. 39721-39726
    • AbdAlla, S.1    Lother, H.2    Abdel-tawab, A.M.3    Quitterer, U.4
  • 37
    • 33748160210 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization
    • Abadir P.M., Periasamy A., Carey R.M., Siragy H.M. Angiotensin II type 2 receptor-bradykinin B2 receptor functional heterodimerization. Hypertension 2006, 48:316-322.
    • (2006) Hypertension , vol.48 , pp. 316-322
    • Abadir, P.M.1    Periasamy, A.2    Carey, R.M.3    Siragy, H.M.4
  • 39
    • 0037125793 scopus 로고    scopus 로고
    • Gbeta gamma-independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1
    • Feng Y.-H., Sun Y., Douglas J.G. Gbeta gamma-independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1. Proc Natl Acad Sci U S A 2002, 99:12049-12054.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12049-12054
    • Feng, Y.-H.1    Sun, Y.2    Douglas, J.G.3
  • 40
    • 3142773716 scopus 로고    scopus 로고
    • Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP
    • Nouet S., Amzallag N., Li J.-M., Louis S., Seitz I., Cui T.-X., et al. Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. J Biol Chem 2004, 279:28989-28997.
    • (2004) J Biol Chem , vol.279 , pp. 28989-28997
    • Nouet, S.1    Amzallag, N.2    Li, J.-M.3    Louis, S.4    Seitz, I.5    Cui, T.-X.6
  • 42
    • 78049316308 scopus 로고    scopus 로고
    • An ATIPical family of angiotensin II AT2 receptor-interacting proteins
    • Rodrigues-Ferreira S., Nahmias C. An ATIPical family of angiotensin II AT2 receptor-interacting proteins. Trends Endocrinol Metab 2010, 21:684-690.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 684-690
    • Rodrigues-Ferreira, S.1    Nahmias, C.2
  • 43
    • 10744230356 scopus 로고    scopus 로고
    • A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy
    • Senbonmatsu T., Saito T., Landon E.J., Watanabe O., Price E., Roberts R.L., et al. A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. EMBO J 2003, 22:6471-6482.
    • (2003) EMBO J , vol.22 , pp. 6471-6482
    • Senbonmatsu, T.1    Saito, T.2    Landon, E.J.3    Watanabe, O.4    Price, E.5    Roberts, R.L.6
  • 44
    • 33845608395 scopus 로고    scopus 로고
    • A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein
    • Schefe J.H., Menk M., Reinemund J., Effertz K., Hobbs R.M., Pandolfi P.P., et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res 2006, 99:1355-1366.
    • (2006) Circ Res , vol.99 , pp. 1355-1366
    • Schefe, J.H.1    Menk, M.2    Reinemund, J.3    Effertz, K.4    Hobbs, R.M.5    Pandolfi, P.P.6
  • 45
    • 0033617108 scopus 로고    scopus 로고
    • Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk
    • Horiuchi M., Hayashida W., Akishita M., Tamura K., Daviet L., Lehtonen J.Y., et al. Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk. Circ Res 1999, 84:876-882.
    • (1999) Circ Res , vol.84 , pp. 876-882
    • Horiuchi, M.1    Hayashida, W.2    Akishita, M.3    Tamura, K.4    Daviet, L.5    Lehtonen, J.Y.6
  • 46
    • 0034707501 scopus 로고    scopus 로고
    • Inflammation influences vascular remodeling through AT2 receptor expression and signaling
    • Akishita M., Horiuchi M., Yamada H., Zhang L., Shirakami G., Tamura K., et al. Inflammation influences vascular remodeling through AT2 receptor expression and signaling. Physiol Genomics 2000, 2(1):13-20.
    • (2000) Physiol Genomics , vol.2 , Issue.1 , pp. 13-20
    • Akishita, M.1    Horiuchi, M.2    Yamada, H.3    Zhang, L.4    Shirakami, G.5    Tamura, K.6
  • 47
    • 77950472601 scopus 로고    scopus 로고
    • Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappa B
    • Rompe F., Artuc M., Hallberg A., Alterman M., Ströder K., Thöne-Reineke C., et al. Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappa B. Hypertension 2010, 55:924-931.
    • (2010) Hypertension , vol.55 , pp. 924-931
    • Rompe, F.1    Artuc, M.2    Hallberg, A.3    Alterman, M.4    Ströder, K.5    Thöne-Reineke, C.6
  • 48
    • 0032588252 scopus 로고    scopus 로고
    • AT2 receptor and vascular smooth muscle cell differentiation in vascular development
    • Yamada H., Akishita M., Ito M., Tamura K., Daviet L., Lehtonen J.Y., et al. AT2 receptor and vascular smooth muscle cell differentiation in vascular development. Hypertension 1999, 33(6):1414-1419.
    • (1999) Hypertension , vol.33 , Issue.6 , pp. 1414-1419
    • Yamada, H.1    Akishita, M.2    Ito, M.3    Tamura, K.4    Daviet, L.5    Lehtonen, J.Y.6
  • 49
    • 0030667099 scopus 로고    scopus 로고
    • Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism
    • Ohkubo N., Matsubara H., Nozawa Y., Mori Y., Murasawa S., Kijima K., et al. Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism. Circulation 1997, 96(11):3954-3962.
    • (1997) Circulation , vol.96 , Issue.11 , pp. 3954-3962
    • Ohkubo, N.1    Matsubara, H.2    Nozawa, Y.3    Mori, Y.4    Murasawa, S.5    Kijima, K.6
  • 50
    • 0032541392 scopus 로고    scopus 로고
    • The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult rats
    • Lucius R., Gallinat S., Rosenstiel P., Herdegen T., Sievers J., Unger T. The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult rats. J Exp Med 1998, 188(4):661-670.
    • (1998) J Exp Med , vol.188 , Issue.4 , pp. 661-670
    • Lucius, R.1    Gallinat, S.2    Rosenstiel, P.3    Herdegen, T.4    Sievers, J.5    Unger, T.6
  • 51
    • 0642273041 scopus 로고    scopus 로고
    • Angiotensin II accelerates functional recovery in the rat sciatic nerve in vivo: role of the AT2 receptor and the transcription factor NF-kappaB
    • Epub 2003 Sep 18
    • Reinecke K., Lucius R., Reinecke A., Rickert U., Herdegen T., Unger T. Angiotensin II accelerates functional recovery in the rat sciatic nerve in vivo: role of the AT2 receptor and the transcription factor NF-kappaB. FASEB J 2003, 17(14):2094-2096. Epub 2003 Sep 18.
    • (2003) FASEB J , vol.17 , Issue.14 , pp. 2094-2096
    • Reinecke, K.1    Lucius, R.2    Reinecke, A.3    Rickert, U.4    Herdegen, T.5    Unger, T.6
  • 52
    • 84904735782 scopus 로고    scopus 로고
    • AT2 receptor activation induces natriuresis and lowers blood pressure
    • Jun 5. pii: CIRC RESAHA.114.304110. [Epub ahead of print]
    • Kemp B.A., Howell N.L., Gildea J.J., Keller S.R., Padia S.H., Carey R.M. AT2 receptor activation induces natriuresis and lowers blood pressure. Circ Res 2014, 115(3):388-399. Jun 5. pii: CIRC RESAHA.114.304110. [Epub ahead of print].
    • (2014) Circ Res , vol.115 , Issue.3 , pp. 388-399
    • Kemp, B.A.1    Howell, N.L.2    Gildea, J.J.3    Keller, S.R.4    Padia, S.H.5    Carey, R.M.6
  • 53
    • 0030031398 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor mediates programmed cell death
    • Yamada T., Horiuchi M., Dzau V.J. Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci U S A 1996, 93:156-160.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 156-160
    • Yamada, T.1    Horiuchi, M.2    Dzau, V.J.3
  • 54
    • 0030789196 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis
    • Horiuchi M., Hayashida W., Kambe T., Yamada T., Dzau V.J. Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J Biol Chem 1997, 272:19022-19026.
    • (1997) J Biol Chem , vol.272 , pp. 19022-19026
    • Horiuchi, M.1    Hayashida, W.2    Kambe, T.3    Yamada, T.4    Dzau, V.J.5
  • 55
    • 0030924217 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis
    • Horiuchi M., Yamada T., Hayashida W., Dzau V.J. Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis. J Biol Chem 1997, 272(18):11952-11958.
    • (1997) J Biol Chem , vol.272 , Issue.18 , pp. 11952-11958
    • Horiuchi, M.1    Yamada, T.2    Hayashida, W.3    Dzau, V.J.4
  • 56
    • 0032476160 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor mediates vascular muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: an in vitro gene transfer study
    • Yamada T., Akishita M., Pollman M., Gibbons G.H., Dzau V.J., Horiuchi M. Angiotensin II type 2 receptor mediates vascular muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: an in vitro gene transfer study. Life Sci 1998, 63(19):289-295.
    • (1998) Life Sci , vol.63 , Issue.19 , pp. 289-295
    • Yamada, T.1    Akishita, M.2    Pollman, M.3    Gibbons, G.H.4    Dzau, V.J.5    Horiuchi, M.6
  • 57
    • 0033546423 scopus 로고    scopus 로고
    • Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis
    • Lehtonen J.Y., Horiuchi M., Daviet L., Akishita M., Dzau V.J. Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis. J Biol Chem 1999, 274(24):16901-16906.
    • (1999) J Biol Chem , vol.274 , Issue.24 , pp. 16901-16906
    • Lehtonen, J.Y.1    Horiuchi, M.2    Daviet, L.3    Akishita, M.4    Dzau, V.J.5
  • 58
    • 0032589730 scopus 로고    scopus 로고
    • AT2 receptor stimulation induces generation of ceramides in PC12W cells
    • Gallinat S., Busche S., Schütze S., Krönke M., Unger T. AT2 receptor stimulation induces generation of ceramides in PC12W cells. FEBS Lett 1999, 443(1):75-79.
    • (1999) FEBS Lett , vol.443 , Issue.1 , pp. 75-79
    • Gallinat, S.1    Busche, S.2    Schütze, S.3    Krönke, M.4    Unger, T.5
  • 59
    • 0032077159 scopus 로고    scopus 로고
    • Neuronal ion channel signalling pathways: modulation by angiotensin II
    • Sumners C., Gelband C.H. Neuronal ion channel signalling pathways: modulation by angiotensin II. Cell Signal 1998, 10:303-311.
    • (1998) Cell Signal , vol.10 , pp. 303-311
    • Sumners, C.1    Gelband, C.H.2
  • 60
    • 18244407290 scopus 로고    scopus 로고
    • Cardiovascular and renal regulation by the angiotensin type 2 receptor: the AT2 receptor comes of age
    • Carey R.M. Cardiovascular and renal regulation by the angiotensin type 2 receptor: the AT2 receptor comes of age. Hypertension 2005, 45:840-844.
    • (2005) Hypertension , vol.45 , pp. 840-844
    • Carey, R.M.1
  • 63
    • 31944442876 scopus 로고    scopus 로고
    • The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy
    • D'Amore A., Black M.J., Thomas W.G. The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy. Hypertension 2005, 46:1347-1354.
    • (2005) Hypertension , vol.46 , pp. 1347-1354
    • D'Amore, A.1    Black, M.J.2    Thomas, W.G.3
  • 64
    • 0030035596 scopus 로고    scopus 로고
    • Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure
    • Levy B.I., Benessiano J., Henrion D., Caputo L., Heymes C., Duriez M., et al. Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure. J Clin Invest 1996, 98:418-425.
    • (1996) J Clin Invest , vol.98 , pp. 418-425
    • Levy, B.I.1    Benessiano, J.2    Henrion, D.3    Caputo, L.4    Heymes, C.5    Duriez, M.6
  • 65
    • 0033837996 scopus 로고    scopus 로고
    • Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload
    • Senbonmatsu T., Ichihara S., Price E., Gaffney F.A., Inagami T. Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload. J Clin Invest 2000, 106:R25-R29.
    • (2000) J Clin Invest , vol.106 , pp. R25-R29
    • Senbonmatsu, T.1    Ichihara, S.2    Price, E.3    Gaffney, F.A.4    Inagami, T.5
  • 66
    • 0033679159 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptors stimulate collagen synthesis in cultured vascular smooth muscle cells
    • Mifune M., Sasamura H., Shimizu-Hirota R., Miyazaki H., Saruta T. Angiotensin II type 2 receptors stimulate collagen synthesis in cultured vascular smooth muscle cells. Hypertension 2000, 36:845-850.
    • (2000) Hypertension , vol.36 , pp. 845-850
    • Mifune, M.1    Sasamura, H.2    Shimizu-Hirota, R.3    Miyazaki, H.4    Saruta, T.5
  • 67
    • 0035902572 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension
    • Ichihara S., Senbonmatsu T., Price E., Ichiki T., Gaffney F.A., Inagami T. Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation 2001, 104:346-351.
    • (2001) Circulation , vol.104 , pp. 346-351
    • Ichihara, S.1    Senbonmatsu, T.2    Price, E.3    Ichiki, T.4    Gaffney, F.A.5    Inagami, T.6
  • 68
    • 0032004934 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects
    • Masaki H., Kurihara T., Yamaki A., Norio I., Nozawa Y., Mori Y., et al. Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest 1998, 101(3):527-535.
    • (1998) J Clin Invest , vol.101 , Issue.3 , pp. 527-535
    • Masaki, H.1    Kurihara, T.2    Yamaki, A.3    Norio, I.4    Nozawa, Y.5    Mori, Y.6
  • 69
    • 77957263791 scopus 로고    scopus 로고
    • The angiotensin AT2 receptor in left ventricular hypertrophy
    • Steckelings U.M., Widdop R.E., Paulis L., Unger T. The angiotensin AT2 receptor in left ventricular hypertrophy. J Hypertens 2010, 28:S50-S55.
    • (2010) J Hypertens , vol.28 , pp. S50-S55
    • Steckelings, U.M.1    Widdop, R.E.2    Paulis, L.3    Unger, T.4
  • 70
    • 0032918581 scopus 로고    scopus 로고
    • Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth
    • Akishita M., Ito M., Lehtonen J.Y., Daviet L., Dzau V.J., Horiuchi M. Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. J Clin Invest 1999, 103(1):63-71.
    • (1999) J Clin Invest , vol.103 , Issue.1 , pp. 63-71
    • Akishita, M.1    Ito, M.2    Lehtonen, J.Y.3    Daviet, L.4    Dzau, V.J.5    Horiuchi, M.6
  • 71
    • 0032102353 scopus 로고    scopus 로고
    • Sciatic nerve transection evokes lasting up-regulation of angiotensin AT2 and AT1 receptor mRNA in adult rat dorsal root ganglia and sciatic nerves
    • Gallinat S., Yu M., Dorst A., Unger T., Herdegen T. Sciatic nerve transection evokes lasting up-regulation of angiotensin AT2 and AT1 receptor mRNA in adult rat dorsal root ganglia and sciatic nerves. Brain Res Mol Brain Res 1998, 57:111-122.
    • (1998) Brain Res Mol Brain Res , vol.57 , pp. 111-122
    • Gallinat, S.1    Yu, M.2    Dorst, A.3    Unger, T.4    Herdegen, T.5
  • 73
    • 33644874726 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution
    • Sales V.L., Sukhova G.K., Lopez-Ilasaca M.A., Libby P., Dzau V.J., Pratt R.E. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation 2005, 112:3328-3336.
    • (2005) Circulation , vol.112 , pp. 3328-3336
    • Sales, V.L.1    Sukhova, G.K.2    Lopez-Ilasaca, M.A.3    Libby, P.4    Dzau, V.J.5    Pratt, R.E.6
  • 74
    • 0028237958 scopus 로고
    • Molecular biology of angiotensin receptors: target for drug research?
    • Dzau V.J., Mukoyama M., Pratt R.E. Molecular biology of angiotensin receptors: target for drug research?. J Hypertens 1994, 12(2):S1-S5.
    • (1994) J Hypertens , vol.12 , Issue.2 , pp. S1-S5
    • Dzau, V.J.1    Mukoyama, M.2    Pratt, R.E.3
  • 75
    • 0031611616 scopus 로고    scopus 로고
    • AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism
    • Gohlke P., Pees C., Unger T. AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension 1998, 31:349-355.
    • (1998) Hypertension , vol.31 , pp. 349-355
    • Gohlke, P.1    Pees, C.2    Unger, T.3
  • 76
    • 0141834774 scopus 로고    scopus 로고
    • Effect of angiotensin AT2 receptor stimulation on vascular cyclic GMP production in normotensive Wistar Kyoto rats
    • Pees C., Unger T., Gohlke P. Effect of angiotensin AT2 receptor stimulation on vascular cyclic GMP production in normotensive Wistar Kyoto rats. Int J Biochem Cell Biol 2003, 35:963-972.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 963-972
    • Pees, C.1    Unger, T.2    Gohlke, P.3
  • 77
    • 0345167173 scopus 로고    scopus 로고
    • Angiotensin subtype 1 receptor (AT1) blockade improves vasorelaxation in heart failure by up-regulation of endothelial nitric-oxide synthase via activation of the AT2 receptor
    • Thai H., Wollmuth J., Goldman S., Gaballa M. Angiotensin subtype 1 receptor (AT1) blockade improves vasorelaxation in heart failure by up-regulation of endothelial nitric-oxide synthase via activation of the AT2 receptor. J Pharmacol Exp Ther 2003, 307:1171-1178.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 1171-1178
    • Thai, H.1    Wollmuth, J.2    Goldman, S.3    Gaballa, M.4
  • 78
    • 33750228279 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade
    • Barker T.A., Massett M.P., Korshunov V.A., Mohan A.M., Kennedy A.J., Berk B.C. Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade. Hypertension 2006, 48:942-949.
    • (2006) Hypertension , vol.48 , pp. 942-949
    • Barker, T.A.1    Massett, M.P.2    Korshunov, V.A.3    Mohan, A.M.4    Kennedy, A.J.5    Berk, B.C.6
  • 80
  • 81
    • 0029010357 scopus 로고
    • Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors
    • Linz W., Wiemer G., Gohlke P., Unger T., Schölkens B.A. Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors. Pharmacol Rev 1995, 47:25-49.
    • (1995) Pharmacol Rev , vol.47 , pp. 25-49
    • Linz, W.1    Wiemer, G.2    Gohlke, P.3    Unger, T.4    Schölkens, B.A.5
  • 82
    • 37549028011 scopus 로고    scopus 로고
    • Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide
    • Yayama K., Okamoto H. Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide. Int Immunopharmacol 2008, 8:312-318.
    • (2008) Int Immunopharmacol , vol.8 , pp. 312-318
    • Yayama, K.1    Okamoto, H.2
  • 83
    • 0038334979 scopus 로고    scopus 로고
    • Contribution of bradykinin and nitric oxide to AT2 receptor-mediated differentiation in PC12 W cells
    • Zhao Y., Biermann T., Luther C., Unger T., Culman J., Gohlke P. Contribution of bradykinin and nitric oxide to AT2 receptor-mediated differentiation in PC12 W cells. J Neurochem 2003, 85:759-767.
    • (2003) J Neurochem , vol.85 , pp. 759-767
    • Zhao, Y.1    Biermann, T.2    Luther, C.3    Unger, T.4    Culman, J.5    Gohlke, P.6
  • 85
    • 84874446135 scopus 로고    scopus 로고
    • How does angiotensin AT(2) receptor activation help neuronal differentiation and improve neuronal pathological situations?
    • Guimond M.-O., Gallo-Payet N. How does angiotensin AT(2) receptor activation help neuronal differentiation and improve neuronal pathological situations?. Front Endocrinol 2012, 3:164.
    • (2012) Front Endocrinol , vol.3 , pp. 164
    • Guimond, M.-O.1    Gallo-Payet, N.2
  • 88
    • 0029809061 scopus 로고    scopus 로고
    • Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptors
    • Laflamme L., Gasparo M., Gallo J.M., Payet M.D., Gallo-Payet N. Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptors. J Biol Chem 1996, 271:22729-22735.
    • (1996) J Biol Chem , vol.271 , pp. 22729-22735
    • Laflamme, L.1    Gasparo, M.2    Gallo, J.M.3    Payet, M.D.4    Gallo-Payet, N.5
  • 89
    • 0028954586 scopus 로고
    • A G protein is involved in the angiotensin AT2 receptor inhibition of the T-type calcium current in non-differentiated NG108-15 cells
    • Buisson B., Laflamme L., Bottari S.P., de Gasparo M., Gallo-Payet N., Payet M.D. A G protein is involved in the angiotensin AT2 receptor inhibition of the T-type calcium current in non-differentiated NG108-15 cells. J Biol Chem 1995, 270:1670-1674.
    • (1995) J Biol Chem , vol.270 , pp. 1670-1674
    • Buisson, B.1    Laflamme, L.2    Bottari, S.P.3    de Gasparo, M.4    Gallo-Payet, N.5    Payet, M.D.6
  • 90
    • 0030606680 scopus 로고    scopus 로고
    • The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells
    • Meffert S., Stoll M., Steckelings U.M., Bottari S.P., Unger T. The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol Cell Endocrinol 1996, 122:59-67.
    • (1996) Mol Cell Endocrinol , vol.122 , pp. 59-67
    • Meffert, S.1    Stoll, M.2    Steckelings, U.M.3    Bottari, S.P.4    Unger, T.5
  • 91
    • 0025912598 scopus 로고
    • Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain
    • Tsutsumi K., Saavedra J.M. Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain. Am J Physiol 1991, 261:R209-R216.
    • (1991) Am J Physiol , vol.261 , pp. R209-R216
    • Tsutsumi, K.1    Saavedra, J.M.2
  • 92
    • 0028985621 scopus 로고
    • Angiotensin AT1 receptor-mediated vasopressin release and drinking are potentiated by an AT2 receptor antagonist
    • Höhle S., Spitznagel H., Rascher W., Culman J., Unger T. Angiotensin AT1 receptor-mediated vasopressin release and drinking are potentiated by an AT2 receptor antagonist. Eur J Pharmacol 1995, 275:277-282.
    • (1995) Eur J Pharmacol , vol.275 , pp. 277-282
    • Höhle, S.1    Spitznagel, H.2    Rascher, W.3    Culman, J.4    Unger, T.5
  • 93
    • 79954420898 scopus 로고    scopus 로고
    • AT2 receptor signaling and sympathetic regulation
    • Gao L., Zucker I.H. AT2 receptor signaling and sympathetic regulation. Curr Opin Pharmacol 2011, 11:124-130.
    • (2011) Curr Opin Pharmacol , vol.11 , pp. 124-130
    • Gao, L.1    Zucker, I.H.2
  • 94
    • 0036009738 scopus 로고    scopus 로고
    • Angiotensin AT2 receptor ligands: do they have potential as future treatments for neurological disease?
    • Rosenstiel P., Gallinat S., Arlt A., Unger T., Sievers J., Lucius R. Angiotensin AT2 receptor ligands: do they have potential as future treatments for neurological disease?. CNS Drugs 2002, 16:145-153.
    • (2002) CNS Drugs , vol.16 , pp. 145-153
    • Rosenstiel, P.1    Gallinat, S.2    Arlt, A.3    Unger, T.4    Sievers, J.5    Lucius, R.6
  • 96
    • 8644281991 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist
    • Wan Y., Wallinder C., Plouffe B., Beaudry H., Mahalingam A.K., Wu X., et al. Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist. J Med Chem 2004, 47:5995-6008.
    • (2004) J Med Chem , vol.47 , pp. 5995-6008
    • Wan, Y.1    Wallinder, C.2    Plouffe, B.3    Beaudry, H.4    Mahalingam, A.K.5    Wu, X.6
  • 98
    • 84869137622 scopus 로고    scopus 로고
    • Direct angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPARγ activation
    • Ohshima K., Mogi M., Jing F., Iwanami J., Tsukuda K., Min L.-J., et al. Direct angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPARγ activation. PLoS One 2012, 7:e48387.
    • (2012) PLoS One , vol.7 , pp. e48387
    • Ohshima, K.1    Mogi, M.2    Jing, F.3    Iwanami, J.4    Tsukuda, K.5    Min, L.-J.6
  • 99
    • 84899486119 scopus 로고    scopus 로고
    • As drug target reemerges, the question is to block or stimulate it
    • Willyard C. As drug target reemerges, the question is to block or stimulate it. Nat Med 2014, 20:222.
    • (2014) Nat Med , vol.20 , pp. 222
    • Willyard, C.1


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