Recent progress in angiotensin II type 2 receptor research in the cardiovascular system

Hypertension

Volumn 33, Issue 2, 1999, Pages 613-621

  Horiuchi, Masatsugu ^a,b   Akishita, Masahiro ^a   Dzau, Victor J ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiotensin II; Apoptosis; Blood vessels; Cell growth; Heart; Receptors; Signaling

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR;

APOPTOSIS; BLOOD PRESSURE REGULATION; CARDIOVASCULAR AUTOREGULATION; CELL GROWTH; HUMAN; HYPERTENSION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 0033031543     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.33.2.613     Document Type: Short Survey

References (91)

1. Dzau VJ. Cardiac renin-angiotensin system: molecular and functional aspects. Am J Med. 1988;84(suppl 3A):22-27.
2. Dzau VJ, Gibbons GH, Pratt RE. Molecular mechanism of vascular renin-angiotensin system in myointimal hyperplasia. Hypertension. 1991; 18(suppl II):II-100-II-105.
3. Whitebread S, Mele M, Kamber B, de Gasparo M. Preliminary bio-chemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun. 1989;163:284-291.
4. Chiu AT, Herblin WF, McCall DE, Ardecky RJ, Carini DJ, Duncia JV, Pease LJ, Wong PC, Wexler RR, Johnson AL, Timmermans P. Identification of angiotensin II receptor subtypes. Biochem Biophys Res Commun. 1989;165:196-203.
5. Sasaki K, Yamano Y, Bardhan S, Iwai N, Murray JJ, Hasegawa M, Matsuda Y, Inagami T. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature. 1991; 351:230-233.
6. Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE. Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature. 1991;351:233-236.
7. Mukoyama M, Nakajima M, Horiuchi M, Sasamura H, Pratt RE, Dzau VJ. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. J Biol Chem. 1993;268: 24539-24542.
8. Kambayashi Y, Bardhan S, Takahashi K, Tsuzuki S, Inui H, Hamakubo T, Inagami T. Molecular cloning of novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J Biol Chem. 1993; 268:24543-24546.
9. Nakajima M, Hutchinson H, Fujinaga M, Hayashida W, Morishita R, Zhang L, Horiuchi M, Pratt RE, Dzau VJ. The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the ATI receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci U S A. 1995;92: 10663-10667
10. Yamada H, Horiuchi M, Akishita M, Dzau VJ. Regulation of vascular development and differentiation by angiotensin II type 2 receptor. Hypertension. 1997;30:470. Abstract.
11. Shanmugam S, Corvol P, Gasc J-M. Angiotensin II type 2 receptor mRNA expression in the developing cardiopulmonary system of the rat. Hypertension. 1996;28:91-97.
12. Hein L, Barsh GS, Pratt RE, Dzau VJ, Kobilka BK. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature. 1995;377:744-747.
13. Meffert S, Stoll M, Steckelings UM, Bottari SP, Unger T. The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol Cell Endocrinol. 1996;122:59-67.
14. Laflamme L, Gasparo M, Gallo JM, Payet MD, Gallo-Payet N. Angiotensin II induction of neunte outgrowth by AT2 receptors in NG108-15 cells: effect counteracted by the ATI receptors. J Biol Chem. 1996;271: 22729-22735.
15. Akishita M, Horiuchi M, Yamada H, Zhang L, Dzau VJ. Accentuated vascular proliferation and altered remodeling after injury in mice lacking angiotensin II type 2 receptor. Circulation. 1997;96(suppl I):I-547. Abstract.
16. Yamada T, Akishita M, Pollman M, Gibbons GH, Dzau VJ, Horiuchi M. Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin type 1 receptor action: an in vitro gene transfer study. Life Sci. 1998;63:PL289-PL295.
17. Stoll M, Steckelings M, Paul M, Bottari SP, Metzger R, Unger T. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest. 1995;95:651-657.
18. Goto M, Mukoyama M, Suga S, Matsumoto T, Nakagawa M, Ishibashi R, Kasahara M, Sugawara A, Tanaka I, Nakao K. Growth-dependent induction of angiotensin II type 2 receptor in rat mesangial cells. Hypertension. 1997;30:358-362.
19. Tsuzuki S, Eguchi S, Inagami T. Inhibition of cell proliferation and activation of protein tyrosine phosphatase mediated by angiotensin II type 2 (AT2) receptor in R3T3 cells. Biochem Biophys Res Commun. 1996; 228:825-830.
20. Tsuzuki S, Matoba T, Eguchi S, Inagami T. Angiotensin II type 2 receptor inhibits cell proliferation and activates tyrosine phosphatase. Hypertension. 1996;28:916-918.
21. Otsuka S, Sugano M, Makino N, Sawada S, Hata T, Niho Y. Interaction of mRNAs for angiotensin II type 1 and type 2 receptors to vascular remodeling in spontaneously hypertensive rats. Hypertension. 1998;32: 467-472.
22. Levy BI, Benessiano J, Henrion D, Caputo L, Heymes C, Duriez M, Poitevin P, Samuel JL. Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure. J Clin Invest. 1996;98:418-425.
23. Pollman M, Yamada M, Horiuchi M, Gibbons GH. Vasoactive substances regulate vascular smooth muscle cell apoptosis: countervailing influences of nitric oxide and angiotensin II. Circ Res. 1996;79:748-756.
24. Yamada T, Horiuchi M, Dzau VJ. Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci U S A. 1996;93:156-160.
25. Hayashida W, Horiuchi M, Grandchamp J, Dzau VJ. Antagonistic action of angiotensin II type-1 and type-2 receptors on apoptosis in cultured neonatal rat ventricular myocytes. Hypertension. 1996;28:535. Abstract.
26. Horiuchi M, Yamada T, Hayashida W, Dzau VJ. Interferon regulatory factor-1 upregulates angiotensin type 2 receptor and induces apoptosis. J Biol Chem. 1997;272:11952-11958.
27. Horiuchi M, Hayashida W, Kambe T, Yamada T, Dzau VJ. Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen activated protein kinase phosphatase-1 and induces apoptosis. J Biol Chem. 1997; 272:19022-19026.
28. Dimmeler S, Rippmann V, Weiland U, Haendeler J, Zeiher AM. Angiotensin II induces apoptosis of human endothelial cells: protective effect of nitric oxide. Circ Res. 1997;81:970-976.
29. Li W, Ye Y, Fu B, Wang J, Yu L, Ichiki T, Inagami T, Ichikawa I, Chen X. Genetic deletion of AT2 receptor antagonizes angiotensin II-induced apoptosis in fibroblasts of the mouse embryo. Biochem Biophys Res Commun. 1998;250:72-76.
30. Ichiki T, Labosky PA, Shiota C, Okuyama S, Imagawa Y, Fugo A, Niimura F, Ichikawa I, Hogan BL, Inagami T. Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type-2 receptor. Nature. 1995;377:748-750.
31. Munzenmaier DH, Greene AS. Opposing actions of angiotensin II on microvascular growth and arterial blood pressure. Hypertension. 1996; 27:760-765.
32. Arima S, Endo Y, Yaoita H, Omata K, Ogawa S, Tsunoda K, Abe M, Takeuchi K, Abe K. Ito S. Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole. J Clin Invest. 1997; 100:2816-2823.
33. Lo M, Liu KL, Lantelme P, Sassard J. Subtype 2 of angiotensin II receptors controls pressure-natriuresis in rats. J Clin Invest. 1995;95: 1394-1397.
34. Siragy HM, Carey RM. The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3′, 5′-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats. J Clin Invest. 1996;97:1978-1982.
35. Siragy HM, Carey RM. The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J Clin Invest. 1997;100:264-269.
36. Seyedi N, Xu X, Nasjletti A, Hintze TH. Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation. Hypertension. 1995;26:164-170.
37. 2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension. 1998;31:349-355.
38. Madrid MI, Garcia-Salom M, Tornel J, De Gasparo M, Fenoy FJ. Effect of interactions between nitric oxide and angiotensin II on pressure diuresis and natriuresis. Am J Physiol. 1997;273:R1676-R1682.
39. Jin XH, Wang ZQ, Siragy HM, Guerrant RL, Carey RM. Regulation of jejunal sodium and water absorption by angiotensin subtype receptors. Am J Physiol. 1998;275:R515-R523.
40. Ozono R, Wang ZQ, Moore AF, Inagami T, Siragy HM, Carey RM. Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney. Hypertension. 1997;30:1238-1246.
41. Booz GW, Baker KM. Role of type 1 and type 2 angiotensin receptors in angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy. Hypertension. 1996;28:635-640.
42. van Kesteren CA, van Heugten HA, Lamers JM, Saxena PR, Schalekamp MA, Danser AH. Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts. J Mol Cell Cardiol. 1997;29:2147-2157.
43. Kajstura J, Cigola E, Malhotra A, Li P, Cheng W, Meggs LG, Anversa P. Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. J Mol Cell Cardiol. 1997;29:859-870.
44. Pierzchalski P, Reiss K, Cheng W, Cirielli C, Kajstura J, Nitahara JA, Rizk M, Capogrossi MC, Anversa P. p53 induces myocyte apoptosis via the activation of the renin-angiotensin system. Exp Cell Res. 1997;234: 57-65.
45. Leri A, Claudio PP, Li Q, Wang X, Reiss K, Wang S, Malhotra A, Kajstura J, Anversa P. Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. J Clin Invest. 1998;101:1326-1342.
46. Nio Y, Matsubara H, Murasawa S, Kanasaki M, Inada M. Regulation of gene transcription of angiotensin n receptor subtypes in myocardial infarction. J Clin Invest. 1995;95:46-54.
47. Lopez J, Lorell BH, Ingelfinger JR, Weinberg EO, Schunkert H, Diamant D, Tang S-H. Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. Am J Physiol. 1994; 36:H844-H852.
48. Ohkubo N, Matsubara H, Nozawa Y, Mori Y, Murasawa S, Kijima K, Maruyama K, Masaki H, Tsutumi Y, Shibazaki Y, Iwasaka T, Inada M. Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism. Circulation. 1997;96:3954-3962.
49. Dzau VJ, Horiuchi M. Differential expression of angiotensin receptor subtypes in the myocardium: a hypothesis. Eur Heart J. 1996;17: 978-980.
50. Haywood GA, Gullestad L, Katsuya T, Hutchinson HG, Pratt RE, Horiuchi M, Fowler MB. AT1 and AT2 receptor gene expression in human heart failure. Circulation. 1997;95:1201-1206.
51. Wharton J, Morgan K, Rutherford RA, Calravas JD, Chester A, Whitehead BF, De Leval MR, Yacoub MH, Polak JM. Differential distribution of angiotensin AT2 receptors in the normal and failing human heart. J Pharmacol Exp Ther. 1998;284:323-336.
52. Liu Y-H, Yang X-P, Sharov VG, Nass O, Sabbah HN, Peterson E, Carretero OA. Effect of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. J Clin Invest. 1997;99:1926-1935.
53. Masaki H, Kurihara T, Yamaki A, Inomata N, Nozawa Y, Mori Y, Murasawa S, Kizima K, Maruyama K, Horiuchi M, Dzau VJ, Takahashi H, Iwasaka T, Inada M, Matsubara H. Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest. 1998;101: 527-535.
54. Bottari SP, King IN, Reichlin S, Dahlstroem I, Lydon N, de Gasparo M. The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase. Biochem Biophys Res Commun. 1992;183:206-211.
55. Buisson B, Laflamme L, Bottari SP, de Gasparo M, Gallo-Payet N, Payet MD. A G protein is involved in the angiotensin AT2 receptor inhibition of the T-type calcium current in non-differentiated NG108-15 cells. J Biol Chem. 1995;270:1670-1674.
56. Hayashida W, Horiuchi M, Dzau VJ. Intracellular third loop domain of angiotensin II type 2 receptor: role in the cellular signal transduction and functional expression. J Biol Chem. 1996;271:21985-21992.
57. Bedecs K, Elbaz N, Sutren M, Masson M, Susini C, Strosberg AD, Nahmias C. Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase. Biochem J. 1997;325:449-454.
58. Huang XC, Richards EM, Sumners C. Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptors. J Biol Chem. 1996;271:15635-15641.
59. Sun H, Charles CH, Lau LF, Tonks NK. MKP-1 (3CH134), an immediate early gene product, is dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell. 1993;75:487-493.
60. Lai K, Wang H, Lee WS, Jain MK, Lee ME, Haber E. Mitogen-activated protein kinase phosphatase-1 in rat arterial smooth muscle cell proliferation. J Clin Invest. 1996;98:1560-1567.
61. Xu Q, Fawcett TW, Gorospe M, Guyton KZ, Liu Y, Holbrook NJ. Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension. Hypertension. 1997;30:106-111.
62. May WS, Tyler PG, Ito T, Armstromg DK, Qatsha KA, Davidson NE. Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2α in association with suppression of apoptosis. J Biol Chem. 1994;269: 26865-26870.
63. Halder S, Jena N, Croce CM. Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci U S A. 1995;92:4507-4511.
64. Ras in Ras-induced apoptosis. J Biol Chem. 1996;271: 2376-2379.
65. L. Cell. 1996;87:619-628.
66. Horiuchi M, Akishita M, Dzau VJ. Molecular and cellular mechanism of angiotensin II-mediated apoptosis. Endocrine Res. In press.
67. Lehtonen JA, Horiuchi M, Dzau VJ. Ceramide as a second messenger for angiotensin II type 2 receptor mediated apoptosis. Circulation. 1997;96: I-554. Abstract.
68. Zhang J, Pratt RE. The AT2 receptor selectively associates with Giα2 and Giα3 in the rat fetus. J Biol Chem. 1996;271:15026-15033.
69. Kang J, Richards EM, Posner P, Sumners C. Modulation of the delayed rectifier K+ current in neurons by an angiotensin II type 2 receptor fragment. Am J Physiol. 1995;268:C278-C282.
70. Horiuchi M, Koike G, Yamada T, Mukoyama M, Nakajima M, Dzau VJ. The growth dependent angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2. J Biol Chem. 1995;270:20225-20230.
71. Dudley DT, Hubbell SE, Summerfelt RM. Characterization of angiotensin II (AT2) binding sites in R3T3 cells. Mol Pharmacol. 1991;40: 360-367.
72. Dudley DT, Summerfelt RM. Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells. Regul Pept. 1993;44:199-206.
73. Kamijo R, Harada H, Matsuyama T, Bosland M, Gerecitano J, Shapiro D, Le J, Koh SI, Kimura T, Green SJ, Mak TW, Taniguchi T, Vilcek J. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages. Science. 1994;263:1612-1615.
74. Tamura T, Ishihara M, Lamphier MS, Tanaka N, Oishi I, Aizawa S, Matsuyama T, Mak TW, Taki S, Taniguchi T. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature. 1995;376:596-599.
75. Horiuchi M, Yamada H, Akishita M, Ito M, Tamura K, Dzau VJ. Interferon regulatory factors regulate interleukin-1β-converting enzyme expression and apoptosis in vascular smooth muscle cells. Hypertension. 1999;33:162-166.
76. Ichiki T, Kambayashi Y, Inagami T. Multiple growth factors modulate mRNA expression of angiotensin II type-2 receptor in R3T3 cells. Circ Res. 1995;77:1070-1076.
77. Csikos T, Balmforth AJ, Grojec M, Gohlke P, Culman J, Unger T. Angiotensin AT2 receptor degradation is prevented by ligand occupation. Biochem Biophys Res Commun. 1998;243:142-147.
78. Kambayashi Y, Nagata K, Ichiki T, Inagami T. Insulin and insulin-like growth factors induce expression of angiotensin type-2 receptor in vascular-smooth-muscle cells. Eur J Biochem. 1996;239:558-565.
79. Ichiki T, Kambayashi Y, Inagami T. Differential inducibility of angiotensin II AT2 receptor between SHR and WKY vascular smooth muscle cells. Kidney Int. 1996;55:S14-S17.
80. Kijima K, Matsubara H, Murasawa S, Maruyama K, Ohkubo N, Mori Y, Inada M. Regulation of angiotensin II type 2 receptor gene by the protein kinase C-calcium pathway. Hypertension. 1996;27:529-534.
81. The CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med. 1987; 316:1429-1435.
82. The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med. 1992;327:685-691.
83. Acute Infarction Ramipril Efficacy (AIRE) Study Investigators. Effect of ramipril on mortality and morbility of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet. 1993;342: 821-828.
84. Csikos T, Chung O, Unger T. Receptors and their classification: focus on angiotensin II and the AT2 receptor. J Hum Hypertens. 1998;12: 311-318.
85. Campbell DJ, Kladis A, Valentijn AJ. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol. 1995;26:233-240.
86. Abassi ZA, Kelly G, Golomb E, Klein H, Keiser HR. Losartan improves the natriuretic response to ANF in rats with high-output heart failure. J Pharmacol Exp Ther. 1994;268:224-230.
87. Dickstein K, Gottlieb S, Fleck E, Kostis J, Levine B, DeKock M, LeJemtel T. Hemodynamic and neurohumoral effects of the angiotensin II antagonist losartan in patients with heart failure. J Hypertens. 1994; 12(suppl):S31-S35.
88. Dickstein K, Chang P, Willenheimer R, Haunso S, Remes J, Hall C, Kjekshus J. Comparison of the effects of losartan and enalapril on clinical status and exercise performance in patients with moderate or severe chronic heart failure. J Am Coll Cardiol. 1995;26:438-445.
89. Gottlieb SS, Dickstein K, Fleck E, Kostis J, Levine TB, LeJemtel T, DeKock M. Hemodynamic and neurohormonal effects of the angiotensin II antagonist losartan in patients with congestive heart failure. Circulation. 1993;88:1602-1609.
90. Gavras I, Manolis A, Gavras H. Effects of ACE inhibition on the heart. J Hum Hypertens. 1995;9:455-458.
91. Gavras H, Gavras I. Cardioprotective potential of angiotensin converting enzyme inhibitors. J Hypertens. 1991;9:385-392.