Angiotensin II Type 2 receptors stimulate collagen synthesis in cultured vascular smooth muscle cells

Hypertension

Volumn 36, Issue 5, 2000, Pages 845-850

  Mifune, Mizuo ^a   Sasamura, Hiroyuki ^a   Shimizu Hirota, Ryoko ^a   Miyazaki, Hitoshi ^b   Saruta, Takao ^a  

^a KEIO UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Angiotensin II; Collagen; Fibroblasts; Muscle; Receptor, angiotensin II; Smooth, vascular

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTISENSE OLIGONUCLEOTIDE; COLLAGEN; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINOYLTYROSYL(N BENZYLOXYCARBONYLARGINYL)LYSYLHISTIDYLPROLYLISOLEUCINE; PERTUSSIS TOXIN; PROTEIN P42; PROTEIN P44; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD PRESSURE REGULATION; CELL CULTURE; CELL TYPE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE TRANSFER; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0033679159     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.36.5.845     Document Type: Article

References (22)

1. Molecular biology and signaling of angiotensin receptors: An overview
2. Heterogeneity of angiotensin synthetic pathways and receptor subtypes: Physiological and pharmacologic implications
3. 2 receptors and cellular localization of subtype mRNAs in adult human renal cortex, in situ hybridization
4. Role of angiotensin receptor subtypes in mesenteric vascular proliferation and hypertrophy
5. 2 receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries
6. 1 receptor antagonist in hypertensive rats
7. Angiotensin II stimulates collagen synthesis in cultured vascular smooth muscle cells
8. Mechanism of angiotensin II-mediated regulation of fibronectin gene in rat vascular smooth muscle cells
9. 2 receptor antagonists in angiotensin II-infused rats
10. 2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure
11. Regulation of vascular type 1 angiotensin receptors by cytokines
12. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors
13. Effects of ACTH on adrenal angiotensin II receptor subtype expression in vivo
14. Vascular endothelial growth factor activates MAP kinase and enhances collagen synthesis in human mesangial cells
15. Antisense oligodeoxynucleotides to Gs protein alpha-subunit sequence accelerate differentiation of fibroblasts to adipocytes
16. The angiotensin II type 2 receptor primarily inhibits cell growth via pertussis toxin-sensitive G proteins
17. Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: An in vitro gene transfer study
18. 2) angiotensin receptor
19. + currents involves an inhibitory GTP binding protein
20. 2+ channel currents via activation of a G protein, Gi
21. Angiotensin II-induced transactivation of epidermal growth factor receptor regulates fibronectin and transforming growth factor-β synthesis via transcriptional and posttranscriptional mechanisms
22. Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism