Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension

Circulation

Volumn 104, Issue 3, 2001, Pages 346-351

  Ichihara, Sahoko ^a   Senbonmatsu, Takaaki ^a   Price Jr , Edward ^a   Ichiki, Toshihiro ^a   Gaffney, F Andrew ^a   Inagami, Tadashi ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiotensin; Collagen; Heart failure; Hypertrophy

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; COLLAGEN;

ANIMAL MODEL; ARTICLE; HEART FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HYPERTENSION; HYPOTHESIS; LONG TERM CARE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE;

EID: 0035902572     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.104.3.346     Document Type: Article

References (30)

1. Pathological hypertrophy and cardiac interstitium: Fibrosis and renin-angiotensin-aldosterone system
2. Impaired diastolic function and coronary reserve in genetic hypertension: Role of interstitial fibrosis and medial thickening of intramyocardial coronary arteries
3. Angiotensin II induces smooth muscle proliferation in the normal and injured rat arterial wall
4. Cardiac action of angiotensin II: Role of an intracardiac renin-angiotensin system
5. Identification of functional angiotensin II receptors on rat cardiac fibroblasts
6. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro
7. Extracellular matrix remodeling in heart failure: A role for de novo angiotensin II generation
8. Angiotensin II receptors and angiotensin II receptor antagonists
9. 1 receptor
10. 2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure
11. Angiotensin II type 2 receptors stimulate collagen synthesis in cultured vascular smooth muscle cells
12. Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in vivo pressure overload
13. Effect on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
14. Echocardiographic and cardiac Doppler assessment of mice
15. Transthoracic echocardiography in models of cardiac disease in the mouse
16. Wall stress and patterns of hypertrophy in the human left ventricle
17. Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle
18. Geometric changes allow normal ejection fraction despite depressed myocardial shortening in hypertensive left ventricular hypertrophy
19. Left ventricular adaptation to chronic pressure overload induced by inhibition of nitric oxide synthase in rats
20. G-Nitro-L-arginine methyl ester-induced hypertension: Novel molecular adaptation to systolic load in absence of hypertrophy
21. 2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism
22. 2 receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries
23. 2) angiotensin receptor
24. Collagen metabolism in cultured adult rat cardiac fibroblast: Response to angiotensin II and aldosterone
25. Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure: Role of kinins and angiotensin II type 2 receptors
26. Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodeling after aortic banding in mice
27. Enhanced expression of angiotensin II type 2 receptor, inositol 1,4,5-trisphosphate receptor, and protein kinase Cε during cardioprotection induced by angiotensin II type 2 receptor blockade
28. Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression
29. Remodeling of the rat right and left ventricles in experimental hypertension
30. Differential effects of angiotensin II on cardiac cell proliferation and intramyocardial perivascular fibrosis in vivo