Synthetic 1,2,3-triazole-linked glycoconjugates bind with high affinity to human galectin-3

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 13, 2015, Pages 3414-3425

  Marchiori, Marcelo Fiori ^a   Pires Souto, Dênio Emanuel ^b   Oliveira Bortot, Leandro ^a   Francisco Pereira, João ^a   Kubota, Lauro Tatsuo ^b   Cummings, Richard D ^c   Dias Baruffi, Marcelo ^a   Carvalho, Ivone ^a   Campo, Vanessa Leiria ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

'Click chemistry'; Galectin 3; Glycoconjugates; Molecular modeling; Surface plasmon resonance; Triazole

Indexed keywords

GALECTIN 3; METHYL 3 O METHYL [(6 AMINO HEXAN 2 OIC) 1H 1,2,3 TRIAZOL 4 YL] ALPHA DEXTRO GALACTOPYRANOSIDE; METHYL 3 O METHYL [[(3 CARBOXYL) PROPAN 1 OIC] 1H 1,2,3 TRIAZOL 4 YL] ALPHA DEXTRO GALACTOPYRANOSIDE; METHYL 3 O METHYL [[(3 HYDROXY) 2 BUTAN 1 OIC] 1H 1,2,3 TRIAZOL 4 YL] ALPHA DEXTRO GALACTOPYRANOSIDE; METHYL 3 O METHYL [[(3 INDOL 3 YL) PROPAN 1 OIC] 1H 1,2,3 TRIAZOL 4 YL] ALPHA DEXTRO GALACTOPYRANOSIDE; METHYL 3 O METHYL [[(3 PHENYL) 2 PROPAN 1 OIC] 1H 1,2,3 TRIAZOL 4 YL] ALPHA DEXTRO GALACTOPYRANOSIDE; METHYL 3 O METHYL [[(3,4 HYDROXYPHENYL) 2 PROPAN 1OIC] 1H 1,2,3 TRIAZOL 4 YL] ALPHA DEXTROGALACTOPYRANOSIDE; METHYL [1 (1H 1,2,3 TRIAZOL 4 YL) 2 [2 (2 ETHOXY)ETHOXY]ETHYL 4 O (BETA DEXTRO GALACTOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSIDE] 4 O (BETA DEXTRO GALACTOPYRANOSYL) BETA DEXTRO GLUCOPYRANOSIDE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; ALKYNE; AMINO ACID; AZIDE; GALACTOSIDE; GALECTIN-3, HUMAN; GLYCOCONJUGATE; LACTOSE; LIGAND; PROTEIN BINDING; TRIAZOLE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CLICK CHEMISTRY; CONTROLLED STUDY; CROSS LINKING; CYCLOADDITION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; SURFACE PLASMON RESONANCE; CHEMISTRY; HUMAN; MOLECULAR DOCKING; MOLECULAR DYNAMICS; SYNTHESIS;

ALKYNES; AMINO ACIDS; AZIDES; CLICK CHEMISTRY; CYCLOADDITION REACTION; GALACTOSIDES; GALECTIN 3; GLYCOCONJUGATES; HUMANS; LACTOSE; LIGANDS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; TRIAZOLES;

EID: 84937394819     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.04.044     Document Type: Article

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