Structural and thermodynamic studies on cation-II interactions in lectin-ligand complexes: High-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction

Journal of the American Chemical Society

Volumn 127, Issue 6, 2005, Pages 1737-1743

  Sörme, Pernilla ^a   Arnoux, Pascal ^b,c   Kahl Knutsson, Barbro ^a   Leffler, Hakon ^a   Rini, James M ^b   Nilsson, Ulf J ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF TORONTO   (Canada)

^c IRFM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATES; CARBOXYLIC ACIDS; CRYSTAL STRUCTURE; ENZYME INHIBITION; FLUORESCENCE; ORGANIC COMPOUNDS; POLARIZATION; POSITIVE IONS; THERMODYNAMIC PROPERTIES; X RAY ANALYSIS;

AROMATIC AMIDES; BINDING; ISOTHERMAL TITRATION; REORIENTATIONS;

PROTEINS;

4 METHOXY 2,3,5,6 TETRAFLUOROBENZAMIDO; ARGININE; BENZAMIDINE DERIVATIVE; CARBOHYDRATE; CATION; GALECTIN 3; GLUCOPYRANOSIDE; LECTIN; LIGAND; N ACETYLLACTOSAMINE SYNTHASE; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBOHYDRATE ANALYSIS; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; ENTHALPY; FLUORESCENCE POLARIZATION IMMUNOASSAY; ISOTHERMAL TITRATION CALORIMETRY; LECTIN BINDING; LIGAND BINDING; MOLECULAR RECOGNITION; SCINTISCANNING; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

AMINO SUGARS; ARGININE; CATIONS; CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE POLARIZATION; GALACTOSE; GALECTIN 3; HUMANS; KINETICS; MODELS, MOLECULAR; THERMODYNAMICS;

EID: 13644272606     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja043475p     Document Type: Article

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