Design and synthesis of novel N-acetylgalactosamine-terminated glycolipids for targeting of lipoproteins to the hepatic asialoglycoprotein receptor

Journal of Medicinal Chemistry

Volumn 47, Issue 23, 2004, Pages 5798-5808

  Rensen, Patrick C N ^a,b   Van Leeuwen, Steven H ^a   Sliedregt, Leo A J M ^a   Van Berkel, Theo J C ^a   Biessen, Erik A L ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ASIALOGLYCOPROTEIN RECEPTOR; ASIALOOROSOMUCOID; BILE ACID; GLYCOLIPID; HIGH DENSITY LIPOPROTEIN; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN; N ACETYLGALACTOSAMINE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; DOSE RESPONSE; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; LIVER CELL; LIVER PARENCHYMA; MALE; MOUSE; NONHUMAN; PROTEIN TARGETING; PROTEIN TRANSPORT; RECEPTOR BINDING; WILD TYPE;

ACETYLGALACTOSAMINE; ANIMALS; ANTICHOLESTEREMIC AGENTS; ASIALOGLYCOPROTEIN RECEPTOR; BLOOD PROTEINS; DRUG DESIGN; GLYCOLIPIDS; HUMANS; HYPERLIPIDEMIAS; IODINE RADIOISOTOPES; ISOTOPE LABELING; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN BINDING; RECEPTORS, LDL;

EID: 7444229247     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049481d     Document Type: Article

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