'Click chemistry' synthesis of a library of 1,2,3-triazole-substituted galactose derivatives and their evaluation against Trypanosoma cruzi and its cell surface trans-sialidase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 7, 2010, Pages 2412-2427

  Carvalho, Ivone ^a   Andrade, Peterson ^a   Campo, Vanessa L ^a   Guedes, Paulo M M ^a   Sesti Costa, Renata ^a   Silva, João S ^a   Schenkman, Sergio ^b   Dedola, Simone ^c   Hill, Lionel ^c   Rejzek, Martin ^c   Nepogodiev, Sergey A ^c   Field, Robert A ^c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c JOHN INNES CENTRE   (United Kingdom)

Author keywords

'Click chemistry'; Galactose; Trans sialidase; Triazole; Trypanosoma cruzi

Indexed keywords

ALKYNE DERIVATIVE; ANTITRYPANOSOMAL AGENT; AZIDE; BENZNIDAZOLE; CARBOHYDRATE DERIVATIVE; COPPER; GALACTOSE; METHYL [1 (METHYL 6 DEOXY BETA DEXTRO GALACTOPYRANOSID 6 YL) 1H 1,2,3 TRIAZOL 4 YL]CARBOXYLATE; N ACETYLNEURAMINIC ACID; N BENZYL N METHYL 1 [1 (METHYL 6 DEOXY BETA DEXTRO GALACTOPYRANOSID 6 YL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINE; SIALIDASE; TRIAZOLE DERIVATIVE; UMBELLIFERONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CATALYSIS; CELL INVASION; CELL SURFACE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLOADDITION; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HOST CELL; HYDROLYSIS; IN VITRO STUDY; MOUSE; NONHUMAN; QUANTUM YIELD; SPLEEN CELL; STEREOCHEMISTRY; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; AZIDES; CELL LINE; CELL SURVIVAL; CHROMATOGRAPHY, THIN LAYER; FLUOROMETRY; GALACTOSE; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 77950061698     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.053     Document Type: Article

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