C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: Efficient lectin inhibition through double arginine-arene interactions

Angewandte Chemie - International Edition

Volumn 44, Issue 32, 2005, Pages 5110-5112

  Cumpstey, Ian ^a   Sundin, Anders ^a   Leffler, Hakon ^a   Nilsson, Ulf J ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Arenes; Drug design; Inhibitors; Proteins; Stacking interactions

Indexed keywords

AROMATIC COMPOUNDS; DERIVATIVES; PROTEINS; SYNTHESIS (CHEMICAL);

ARENES; DRUG DESIGN; INHIBITORS; STACKING INTERACTIONS;

AMINO ACIDS;

ARGININE; BENZAMIDE DERIVATIVE; GALECTIN 3; THIOGLYCOSIDE;

ARTICLE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; STRUCTURE ACTIVITY RELATION;

ARGININE; BENZAMIDES; COMPUTER SIMULATION; GALECTIN 3; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOGALACTOSIDES;

EID: 23944500772     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200500627     Document Type: Article

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