A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α

Journal of Biological Chemistry

Volumn 289, Issue 52, 2014, Pages 36284-36302

  Chen, Shu Jen ^a   Hoffman, Nicholas E ^b   Shanmughapriy, Santhanam ^a,b   Bao, Lei ^a   Keefer, Kerry ^a   Conrad, Kathleen ^a   Merali, Salim ^b   Takahashi, Yoshinori ^a   Abraham, Thomas ^a   Hirschler Laszkiewicz, Iwona ^a   Wang, JuFang ^b   Zhang, Xue Qian ^b   Song, Jianliang ^b   Barrero, Carlos ^b   Shi, Yuguang ^a   Kawasawa, Yuka Imamura ^a   Bayerl, Michael ^a   Sun, Tianyu ^a   Barbour, Mustafa ^a   Wang, Hong Gang ^a   Madesh, Muniswamy ^b   Cheung, Joseph Y ^b   Miller, Barbara A ^a,c   more..

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYTOLOGY; ELECTRON TRANSPORT PROPERTIES; ENZYMES; OXIDATIVE STRESS; OXYGEN; TUMORS;

CYTOCHROME OXIDASE; HYPOXIA-INDUCIBLE FACTORS; MITOCHONDRIAL ELECTRON TRANSPORT CHAIN; MITOCHONDRIAL FUNCTION; NEUROBLASTOMA CELLS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE 2; TRANSCRIPTION FACTOR-3;

CELLS;

ADENOSINE TRIPHOSPHATE; CLOTRIMAZOLE; CYTOCHROME C OXIDASE; CYTOCHROME OXIDASE 4.1; CYTOCHROME OXIDASE 4.2; DOXORUBICIN; ENOLASE; ENOLASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE A; MESSENGER RNA; NDUFA4L2 PROTEIN; PROTEIN BNIP3; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; TRANSCRIPTION FACTOR FKHRL1; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; UNCLASSIFIED DRUG; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN; ANTINEOPLASTIC ANTIBIOTIC; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HIF1A PROTEIN, HUMAN; ISOPROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, HUMAN;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CALCIUM TRANSPORT; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG SENSITIVITY; FEMALE; GLYCOLYSIS; HUMAN; HUMAN TISSUE; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOPHAGY; MOUSE; NEUROBLASTOMA; NEUROBLASTOMA CELL LINE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; CELL PROLIFERATION; DOWN REGULATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MEMBRANE POTENTIAL; METABOLISM; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; PROTEIN TRANSPORT; TUMOR CELL LINE; TUMOR VOLUME;

ADRENAL GLANDS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AUTOPHAGY; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; DOXORUBICIN; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE POTENTIALS; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEUROBLASTOMA; PROTEIN ISOFORMS; PROTEIN TRANSPORT; TRPM CATION CHANNELS; TUMOR BURDEN;

EID: 84937242801     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.620922     Document Type: Article

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