메뉴 건너뛰기




Volumn 112, Issue 28, 2015, Pages E3738-E3747

Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice

Author keywords

Anemia; HIF 2 ; Iron homeostasis; Lactation; Pregnancy

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 2ALPHA; IRON; IRON DEXTRAN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CATION TRANSPORT PROTEIN; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2;

EID: 84937158390     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1504891112     Document Type: Article
Times cited : (20)

References (62)
  • 1
    • 0033599057 scopus 로고    scopus 로고
    • Disorders of iron metabolism
    • Andrews NC (1999) Disorders of iron metabolism. N Engl J Med 341(26):1986-1995.
    • (1999) N Engl J Med , vol.341 , Issue.26 , pp. 1986-1995
    • Andrews, N.C.1
  • 2
    • 84886902763 scopus 로고    scopus 로고
    • The gut in iron homeostasis: Role of HIF-2 under normal and pathological conditions
    • Mastrogiannaki M, Matak P, Peyssonnaux C (2013) The gut in iron homeostasis: Role of HIF-2 under normal and pathological conditions. Blood 122(6):885-892.
    • (2013) Blood , vol.122 , Issue.6 , pp. 885-892
    • Mastrogiannaki, M.1    Matak, P.2    Peyssonnaux, C.3
  • 3
    • 84894387582 scopus 로고    scopus 로고
    • Hypoxia-inducible factors link iron homeostasis and erythropoiesis
    • Shah YM, Xie L (2014) Hypoxia-inducible factors link iron homeostasis and erythropoiesis. Gastroenterology 146(3):630-642.
    • (2014) Gastroenterology , vol.146 , Issue.3 , pp. 630-642
    • Shah, Y.M.1    Xie, L.2
  • 4
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306(5704):2090-2093.
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1
  • 5
    • 33750133047 scopus 로고    scopus 로고
    • Regulation of iron metabolism by hepcidin
    • Nemeth E, Ganz T (2006) Regulation of iron metabolism by hepcidin. Annu Rev Nutr 26:323-342.
    • (2006) Annu Rev Nutr , vol.26 , pp. 323-342
    • Nemeth, E.1    Ganz, T.2
  • 6
    • 84905718869 scopus 로고    scopus 로고
    • Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload
    • Altamura S, et al. (2014) Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload. Cell Metab 20(2):359-367.
    • (2014) Cell Metab , vol.20 , Issue.2 , pp. 359-367
    • Altamura, S.1
  • 7
    • 20444416123 scopus 로고    scopus 로고
    • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
    • Donovan A, et al. (2005) The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1(3):191-200.
    • (2005) Cell Metab , vol.1 , Issue.3 , pp. 191-200
    • Donovan, A.1
  • 8
    • 33745752870 scopus 로고    scopus 로고
    • Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis
    • Lesbordes-Brion JC, et al. (2006) Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood 108(4):1402-1405.
    • (2006) Blood , vol.108 , Issue.4 , pp. 1402-1405
    • Lesbordes-Brion, J.C.1
  • 9
    • 0032478409 scopus 로고    scopus 로고
    • Recommendations to prevent and control iron deficiency in the United States
    • Anonymous Centers for Disease Control, Atlanta
    • Anonymous (1998) Recommendations to prevent and control iron deficiency in the United States. Recommendations and Reports: Morbidity and Mortality Weekly Report (Centers for Disease Control, Atlanta), 47(RR-3):1-29.
    • (1998) Recommendations and Reports: Morbidity and Mortality Weekly Report , vol.47 , Issue.RR-3 , pp. 1-29
  • 10
    • 84871909567 scopus 로고    scopus 로고
    • Pregnancy and iron homeostasis: An update
    • Cao C, O'Brien KO (2013) Pregnancy and iron homeostasis: An update. Nutr Rev 71(1):35-51.
    • (2013) Nutr Rev , vol.71 , Issue.1 , pp. 35-51
    • Cao, C.1    O'Brien, K.O.2
  • 11
    • 84866245750 scopus 로고    scopus 로고
    • Oral iron prophylaxis in pregnancy: Not too little and not too much!
    • Milman N (2012) Oral iron prophylaxis in pregnancy: Not too little and not too much! J Pregnancy 2012:514345.
    • (2012) J Pregnancy , vol.2012
    • Milman, N.1
  • 12
    • 0028282990 scopus 로고
    • Absorption of non-haem iron from food during normal pregnancy
    • Barrett JF, Whittaker PG, Williams JG, Lind T (1994) Absorption of non-haem iron from food during normal pregnancy. BMJ 309(6947):79-82.
    • (1994) BMJ , vol.309 , Issue.6947 , pp. 79-82
    • Barrett, J.F.1    Whittaker, P.G.2    Williams, J.G.3    Lind, T.4
  • 13
    • 77956976980 scopus 로고    scopus 로고
    • Maternal serum hepcidin is low at term and independent of cord blood iron status
    • Rehu M, et al. (2010) Maternal serum hepcidin is low at term and independent of cord blood iron status. Eur J Haematol 85(4):345-352.
    • (2010) Eur J Haematol , vol.85 , Issue.4 , pp. 345-352
    • Rehu, M.1
  • 15
    • 84857377135 scopus 로고    scopus 로고
    • Serum maternal hepcidin levels 3 days after delivery are higher compared to those measured at parturition
    • Gyarmati B, et al. (2011) Serum maternal hepcidin levels 3 days after delivery are higher compared to those measured at parturition. J Obstet Gynaecol Res 37(11):1620-1624.
    • (2011) J Obstet Gynaecol Res , vol.37 , Issue.11 , pp. 1620-1624
    • Gyarmati, B.1
  • 16
    • 2342425296 scopus 로고    scopus 로고
    • Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat
    • Millard KN, Frazer DM, Wilkins SJ, Anderson GJ (2004) Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat. Gut 53(5):655-660.
    • (2004) Gut , vol.53 , Issue.5 , pp. 655-660
    • Millard, K.N.1    Frazer, D.M.2    Wilkins, S.J.3    Anderson, G.J.4
  • 17
    • 58749094789 scopus 로고    scopus 로고
    • Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency
    • Shah YM, Matsubara T, Ito S, Yim SH, Gonzalez FJ (2009) Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency. Cell Metab 9(2):152-164.
    • (2009) Cell Metab , vol.9 , Issue.2 , pp. 152-164
    • Shah, Y.M.1    Matsubara, T.2    Ito, S.3    Yim, S.H.4    Gonzalez, F.J.5
  • 18
    • 66449124596 scopus 로고    scopus 로고
    • HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice
    • Mastrogiannaki M, et al. (2009) HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice. J Clin Invest 119(5):1159-1166.
    • (2009) J Clin Invest , vol.119 , Issue.5 , pp. 1159-1166
    • Mastrogiannaki, M.1
  • 19
    • 79957616004 scopus 로고    scopus 로고
    • Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis
    • Anderson ER, Xue X, Shah YM (2011) Intestinal hypoxia-inducible factor-2alpha (HIF-2alpha) is critical for efficient erythropoiesis. J Biol Chem 286(22):19533-19540.
    • (2011) J Biol Chem , vol.286 , Issue.22 , pp. 19533-19540
    • Anderson, E.R.1    Xue, X.2    Shah, Y.M.3
  • 20
    • 79958146087 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice
    • Taylor M, et al. (2011) Hypoxia-inducible factor-2α mediates the adaptive increase of intestinal ferroportin during iron deficiency in mice. Gastroenterology 140(7):2044-2055.
    • (2011) Gastroenterology , vol.140 , Issue.7 , pp. 2044-2055
    • Taylor, M.1
  • 21
    • 84890288632 scopus 로고    scopus 로고
    • Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia
    • Anderson ER, et al. (2013) Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia. Proc Natl Acad Sci USA 110(50):E4922-E4930.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.50 , pp. E4922-E4930
    • Anderson, E.R.1
  • 22
    • 0034070941 scopus 로고    scopus 로고
    • Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload
    • Trinder D, Oates PS, Thomas C, Sadleir J, Morgan EH (2000) Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Gut 46(2):270-276.
    • (2000) Gut , vol.46 , Issue.2 , pp. 270-276
    • Trinder, D.1    Oates, P.S.2    Thomas, C.3    Sadleir, J.4    Morgan, E.H.5
  • 23
    • 0019845275 scopus 로고
    • Effects of maternal iron nutrition during lactation on milk iron and rat neonatal iron status
    • Anaokar SG, Garry PJ (1981) Effects of maternal iron nutrition during lactation on milk iron and rat neonatal iron status. Am J Clin Nutr 34(8):1505-1512.
    • (1981) Am J Clin Nutr , vol.34 , Issue.8 , pp. 1505-1512
    • Anaokar, S.G.1    Garry, P.J.2
  • 24
    • 33745502924 scopus 로고    scopus 로고
    • Long-lasting neural and behavioral effects of iron deficiency in infancy
    • discussion S72-S91
    • Lozoff B, et al. (2006) Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 64(5 Pt 2):S34-43; discussion S72-S91.
    • (2006) Nutr Rev , vol.64 , Issue.5 , pp. S34-S43
    • Lozoff, B.1
  • 25
    • 33846287556 scopus 로고    scopus 로고
    • Iron in fetal and neonatal nutrition
    • Rao R, Georgieff MK (2007) Iron in fetal and neonatal nutrition. Semin Fetal Neonatal Med 12(1):54-63.
    • (2007) Semin Fetal Neonatal Med , vol.12 , Issue.1 , pp. 54-63
    • Rao, R.1    Georgieff, M.K.2
  • 26
    • 0014533301 scopus 로고
    • The effect of pregnancy on peripheral blood in the mouse
    • Rugh R, Somogyi C (1969) The effect of pregnancy on peripheral blood in the mouse. Biol Bull 136(3):454-460.
    • (1969) Biol Bull , vol.136 , Issue.3 , pp. 454-460
    • Rugh, R.1    Somogyi, C.2
  • 27
    • 84877850023 scopus 로고    scopus 로고
    • Effect of dietary iron on fetal growth in pregnant mice
    • Hubbard AC, et al. (2013) Effect of dietary iron on fetal growth in pregnant mice. Comp Med 63(2):127-135.
    • (2013) Comp Med , vol.63 , Issue.2 , pp. 127-135
    • Hubbard, A.C.1
  • 28
    • 0035146908 scopus 로고    scopus 로고
    • An analysis of anemia and pregnancy-related maternal mortality
    • discussion 614S-615S
    • Brabin BJ, Hakimi M, Pelletier D (2001) An analysis of anemia and pregnancy-related maternal mortality. J Nutr 131(2S-2):604S-614S; discussion 614S-615S.
    • (2001) J Nutr , vol.131 , Issue.2 , pp. 604S-614S
    • Brabin, B.J.1    Hakimi, M.2    Pelletier, D.3
  • 29
    • 44449177930 scopus 로고    scopus 로고
    • The serine protease TMPRSS6 is required to sense iron deficiency
    • Du X, et al. (2008) The serine protease TMPRSS6 is required to sense iron deficiency. Science 320(5879):1088-1092.
    • (2008) Science , vol.320 , Issue.5879 , pp. 1088-1092
    • Du, X.1
  • 30
    • 57349171358 scopus 로고    scopus 로고
    • Setting the stage for child health and development: Prevention of iron deficiency in early infancy
    • Chaparro CM (2008) Setting the stage for child health and development: Prevention of iron deficiency in early infancy. J Nutr 138(12):2529-2533.
    • (2008) J Nutr , vol.138 , Issue.12 , pp. 2529-2533
    • Chaparro, C.M.1
  • 31
    • 0019191276 scopus 로고
    • Iron deficiency in infancy and childhood
    • Dallman PR, Siimes MA, Stekel A (1980) Iron deficiency in infancy and childhood. Am J Clin Nutr 33(1):86-118.
    • (1980) Am J Clin Nutr , vol.33 , Issue.1 , pp. 86-118
    • Dallman, P.R.1    Siimes, M.A.2    Stekel, A.3
  • 32
    • 34547618810 scopus 로고    scopus 로고
    • Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk
    • Wan Y, et al. (2007) Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. Genes Dev 21(15):1895-1908.
    • (2007) Genes Dev , vol.21 , Issue.15 , pp. 1895-1908
    • Wan, Y.1
  • 33
    • 18244399587 scopus 로고    scopus 로고
    • Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver
    • Gunshin H, et al. (2005) Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest 115(5):1258-1266.
    • (2005) J Clin Invest , vol.115 , Issue.5 , pp. 1258-1266
    • Gunshin, H.1
  • 34
    • 77955494166 scopus 로고    scopus 로고
    • Iron deficiency anemia and cognitive function in infancy
    • Carter RC, et al. (2010) Iron deficiency anemia and cognitive function in infancy. Pediatrics 126(2):e427-e434.
    • (2010) Pediatrics , vol.126 , Issue.2 , pp. e427-e434
    • Carter, R.C.1
  • 35
    • 84861527511 scopus 로고    scopus 로고
    • Iron deficiency in infancy is associated with altered neural correlates of recognition memory at 10 years
    • Congdon EL, et al. (2012) Iron deficiency in infancy is associated with altered neural correlates of recognition memory at 10 years. J Pediatr 160(6):1027-1033.
    • (2012) J Pediatr , vol.160 , Issue.6 , pp. 1027-1033
    • Congdon, E.L.1
  • 36
    • 84864746948 scopus 로고    scopus 로고
    • Changing iron content of the mouse brain during development
    • Holmes-Hampton GP, et al. (2012) Changing iron content of the mouse brain during development. Metallomics 4(8):761-770.
    • (2012) Metallomics , vol.4 , Issue.8 , pp. 761-770
    • Holmes-Hampton, G.P.1
  • 37
    • 84920517373 scopus 로고    scopus 로고
    • Kinetics of iron import into developing mouse organs determined by a pup-swapping method
    • Chakrabarti M, Barlas MN, McCormick SP, Lindahl LS, Lindahl PA (2015) Kinetics of iron import into developing mouse organs determined by a pup-swapping method. J Biol Chem 290(1):520-528.
    • (2015) J Biol Chem , vol.290 , Issue.1 , pp. 520-528
    • Chakrabarti, M.1    Barlas, M.N.2    McCormick, S.P.3    Lindahl, L.S.4    Lindahl, P.A.5
  • 38
    • 33746596589 scopus 로고    scopus 로고
    • CREB antisense oligodeoxynucleotide administration into the dorsal hippocampal CA3 region impairs long- but not short-term spatial memory in mice
    • Florian C, Mons N, Roullet P (2006) CREB antisense oligodeoxynucleotide administration into the dorsal hippocampal CA3 region impairs long- but not short-term spatial memory in mice. Learn Mem 13(4):465-472.
    • (2006) Learn Mem , vol.13 , Issue.4 , pp. 465-472
    • Florian, C.1    Mons, N.2    Roullet, P.3
  • 39
    • 33747605325 scopus 로고    scopus 로고
    • Neocortical neurogenesis in humans is restricted to development
    • Bhardwaj RD, et al. (2006) Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci USA 103(33):12564-12568.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.33 , pp. 12564-12568
    • Bhardwaj, R.D.1
  • 40
    • 0028071507 scopus 로고
    • Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
    • Bourtchuladze R, et al. (1994) Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79(1):59-68.
    • (1994) Cell , vol.79 , Issue.1 , pp. 59-68
    • Bourtchuladze, R.1
  • 42
    • 84877978900 scopus 로고    scopus 로고
    • ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: Implications for tissue iron uptake in iron-related disorders
    • Nam H, et al. (2013) ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: Implications for tissue iron uptake in iron-related disorders. Haematologica 98(7):1049-1057.
    • (2013) Haematologica , vol.98 , Issue.7 , pp. 1049-1057
    • Nam, H.1
  • 43
    • 84870248829 scopus 로고    scopus 로고
    • Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis
    • Beuck S, Scha¨nzer W, Thevis M (2012) Hypoxia-inducible factor stabilizers and other small-molecule erythropoiesis-stimulating agents in current and preventive doping analysis. Drug Test Anal 4(11):830-845.
    • (2012) Drug Test Anal , vol.4 , Issue.11 , pp. 830-845
    • Beuck, S.1    Scha¨nzer, W.2    Thevis, M.3
  • 44
    • 0017352380 scopus 로고
    • Role of the placenta in intestinal absorption of iron in pregnant rats
    • Batey RG, Gallagher ND (1977) Role of the placenta in intestinal absorption of iron in pregnant rats. Gastroenterology 72(2):255-259.
    • (1977) Gastroenterology , vol.72 , Issue.2 , pp. 255-259
    • Batey, R.G.1    Gallagher, N.D.2
  • 45
    • 84904635716 scopus 로고    scopus 로고
    • Molecular mediators governing iron-copper interactions
    • Gulec S, Collins JF (2014) Molecular mediators governing iron-copper interactions. Annu Rev Nutr 34:95-116.
    • (2014) Annu Rev Nutr , vol.34 , pp. 95-116
    • Gulec, S.1    Collins, J.F.2
  • 46
    • 0642307063 scopus 로고    scopus 로고
    • Iron supplementation during infancy - Effects on expression of iron transporters, iron absorption, and iron utilization in rat pups
    • Leong WI, Bowlus CL, Tallkvist J, Lönnerdal B (2003) Iron supplementation during infancy - effects on expression of iron transporters, iron absorption, and iron utilization in rat pups. Am J Clin Nutr 78(6):1203-1211.
    • (2003) Am J Clin Nutr , vol.78 , Issue.6 , pp. 1203-1211
    • Leong, W.I.1    Bowlus, C.L.2    Tallkvist, J.3    Lönnerdal, B.4
  • 47
    • 34247628002 scopus 로고    scopus 로고
    • Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency
    • Sanchez M, Galy B, Muckenthaler MU, Hentze MW (2007) Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol 14(5):420-426.
    • (2007) Nat Struct Mol Biol , vol.14 , Issue.5 , pp. 420-426
    • Sanchez, M.1    Galy, B.2    Muckenthaler, M.U.3    Hentze, M.W.4
  • 48
    • 84873361483 scopus 로고    scopus 로고
    • The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption
    • Anderson SA, et al. (2013) The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Cell Metab 17(2):282-290.
    • (2013) Cell Metab , vol.17 , Issue.2 , pp. 282-290
    • Anderson, S.A.1
  • 49
    • 84873338684 scopus 로고    scopus 로고
    • Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α
    • Ghosh MC, et al. (2013) Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α. Cell Metab 17(2):271-281.
    • (2013) Cell Metab , vol.17 , Issue.2 , pp. 271-281
    • Ghosh, M.C.1
  • 50
    • 0034971747 scopus 로고    scopus 로고
    • Prevalence of iron deficiency in 12-mo-old infants from 11 European areas and influence of dietary factors on iron status (Euro-Growth study)
    • Male C, et al.; Euro-Growth Iron Study Group (2001) Prevalence of iron deficiency in 12-mo-old infants from 11 European areas and influence of dietary factors on iron status (Euro-Growth study). Acta Paediatr 90(5):492-498.
    • (2001) Acta Paediatr , vol.90 , Issue.5 , pp. 492-498
    • Male, C.1
  • 51
    • 84929131984 scopus 로고    scopus 로고
    • Cognitive and neurodevelopmental benefits of extended formula-feeding in infants: Re: Deoni et al. 2013
    • Anderson A, Burggren A (2014) Cognitive and neurodevelopmental benefits of extended formula-feeding in infants: Re: Deoni et al. 2013. Neuroimage 100:706-709.
    • (2014) Neuroimage , vol.100 , pp. 706-709
    • Anderson, A.1    Burggren, A.2
  • 52
    • 0017897733 scopus 로고
    • Inhibition of lactation and inhibition of prolactin release after mechanical breast stimulation in puerperal women given tamoxifen or placebo
    • Masala A, et al. (1978) Inhibition of lactation and inhibition of prolactin release after mechanical breast stimulation in puerperal women given tamoxifen or placebo. Br J Obstet Gynaecol 85(2):134-137.
    • (1978) Br J Obstet Gynaecol , vol.85 , Issue.2 , pp. 134-137
    • Masala, A.1
  • 54
    • 0034548853 scopus 로고    scopus 로고
    • The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border
    • Canonne-Hergaux F, et al. (2000) The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood 96(12):3964-3970.
    • (2000) Blood , vol.96 , Issue.12 , pp. 3964-3970
    • Canonne-Hergaux, F.1
  • 55
    • 0030763856 scopus 로고    scopus 로고
    • Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
    • Fleming MD, et al. (1997) Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16(4):383-386.
    • (1997) Nat Genet , vol.16 , Issue.4 , pp. 383-386
    • Fleming, M.D.1
  • 56
    • 0030001813 scopus 로고    scopus 로고
    • Brain iron and behavior of rats are not normalized by treatment of iron deficiency anemia during early development
    • Felt BT, Lozoff B (1996) Brain iron and behavior of rats are not normalized by treatment of iron deficiency anemia during early development. J Nutr 126(3):693-701.
    • (1996) J Nutr , vol.126 , Issue.3 , pp. 693-701
    • Felt, B.T.1    Lozoff, B.2
  • 57
    • 84867993283 scopus 로고    scopus 로고
    • Quantitative proteomic analyses of cerebrospinal fluid using iTRAQ in a primate model of iron deficiency anemia
    • Patton SM, Coe CL, Lubach GR, Connor JR (2012) Quantitative proteomic analyses of cerebrospinal fluid using iTRAQ in a primate model of iron deficiency anemia. Dev Neurosci 34(4):354-365.
    • (2012) Dev Neurosci , vol.34 , Issue.4 , pp. 354-365
    • Patton, S.M.1    Coe, C.L.2    Lubach, G.R.3    Connor, J.R.4
  • 58
    • 59149091750 scopus 로고    scopus 로고
    • The role of iron in neurodevelopment: Fetal iron deficiency and the developing hippocampus
    • Georgieff MK (2008) The role of iron in neurodevelopment: Fetal iron deficiency and the developing hippocampus. Biochem Soc Trans 36(Pt 6):1267-1271.
    • (2008) Biochem Soc Trans , vol.36 , Issue.6 , pp. 1267-1271
    • Georgieff, M.K.1
  • 59
    • 84961966153 scopus 로고    scopus 로고
    • Iron-mediated redox modulation in neural plasticity
    • Muñoz P (2012) Iron-mediated redox modulation in neural plasticity. Commun Integr Biol 5(2):166-168.
    • (2012) Commun Integr Biol , vol.5 , Issue.2 , pp. 166-168
    • Muñoz, P.1
  • 60
    • 84872110776 scopus 로고    scopus 로고
    • Overweight impairs efficacy of iron supplementation in iron-deficient South African children: A randomized controlled intervention
    • Baumgartner J, et al. (2013) Overweight impairs efficacy of iron supplementation in iron-deficient South African children: A randomized controlled intervention. Int J Obes (Lond) 37(1):24-30.
    • (2013) Int J Obes (Lond) , vol.37 , Issue.1 , pp. 24-30
    • Baumgartner, J.1
  • 61
    • 77954145632 scopus 로고    scopus 로고
    • Elevated systemic hepcidin and iron depletion in obese premenopausal females
    • Tussing-Humphreys LM, et al. (2010) Elevated systemic hepcidin and iron depletion in obese premenopausal females. Obesity (Silver Spring) 18(7):1449-1456.
    • (2010) Obesity (Silver Spring) , vol.18 , Issue.7 , pp. 1449-1456
    • Tussing-Humphreys, L.M.1
  • 62


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.