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Volumn 103, Issue 10, 2015, Pages 3166-3178

Elastin-like recombinamers with acquired functionalities for gene-delivery applications

Author keywords

cationic polymers; elastin like recombinamers; ELR; gene therapy; polyplex

Indexed keywords

BIOCOMPATIBILITY; CELL CULTURE; ELASTIN; GENE TRANSFER; GENES; GLYCOPROTEINS; MOLECULAR BIOLOGY; PARTICLE SIZE; POLYMERS;

EID: 84937050923     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.35455     Document Type: Article
Times cited : (20)

References (63)
  • 2
    • 84865567760 scopus 로고    scopus 로고
    • Regulated protein expression for in vivo gene therapy for neurological disorders: Progress, strategies, and issues
    • Manfredsson FP, Bloom DC, Mandel RJ,. Regulated protein expression for in vivo gene therapy for neurological disorders: Progress, strategies, and issues. Neurobiol Dis 2012; 48: 212-221.
    • (2012) Neurobiol Dis , vol.48 , pp. 212-221
    • Manfredsson, F.P.1    Bloom, D.C.2    Mandel, R.J.3
  • 3
    • 79955581945 scopus 로고    scopus 로고
    • Spermine grafted galactosylated chitosan for improved nanoparticle mediated gene delivery
    • Alex SM, Rekha MR, Sharma CP,. Spermine grafted galactosylated chitosan for improved nanoparticle mediated gene delivery. Int J Pharm 2011; 410:125-137.
    • (2011) Int J Pharm , vol.410 , pp. 125-137
    • Alex, S.M.1    Rekha, M.R.2    Sharma, C.P.3
  • 4
    • 84879883811 scopus 로고    scopus 로고
    • Cardiovascular gene therapy with vascular endothelial growth factors
    • Yla-Herttuala S,. Cardiovascular gene therapy with vascular endothelial growth factors. Gene 2013; 525: 217-219.
    • (2013) Gene , vol.525 , pp. 217-219
    • Yla-Herttuala, S.1
  • 8
    • 70350101102 scopus 로고    scopus 로고
    • Adeno-associated virus capsid structure drives CD4-dependent cd8+ T cell response to vector encoded proteins
    • Mays LE, Vandenberghe LH, Xiao R, Bell P, Nam HJ, Agbandje-McKenna M, Wilson JM,. Adeno-associated virus capsid structure drives CD4-dependent cd8+ T cell response to vector encoded proteins. J Immunol 2009; 182: 6051-6060.
    • (2009) J Immunol , vol.182 , pp. 6051-6060
    • Mays, L.E.1    Vandenberghe, L.H.2    Xiao, R.3    Bell, P.4    Nam, H.J.5    Agbandje-McKenna, M.6    Wilson, J.M.7
  • 9
    • 0032580348 scopus 로고    scopus 로고
    • Human gene therapy
    • Anderson WF,. Human gene therapy. Nature 1998; 392(6679 Suppl): 25-30.
    • (1998) Nature , vol.392 , Issue.6679 , pp. 25-30
    • Anderson, W.F.1
  • 10
    • 68549130637 scopus 로고    scopus 로고
    • Chemical vectors for gene delivery: A current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
    • Midoux P, Pichon C, Yaouanc JJ, Jaffres PA,. Chemical vectors for gene delivery: A current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers. Br J Pharmacol 2009; 157: 166-178.
    • (2009) Br J Pharmacol , vol.157 , pp. 166-178
    • Midoux, P.1    Pichon, C.2    Yaouanc, J.J.3    Jaffres, P.A.4
  • 11
    • 64549134676 scopus 로고    scopus 로고
    • Nonviral vectors for gene delivery
    • Mintzer MA, Simanek EE,. Nonviral vectors for gene delivery. Chem Rev 2009; 109: 259-302.
    • (2009) Chem Rev , vol.109 , pp. 259-302
    • Mintzer, M.A.1    Simanek, E.E.2
  • 14
    • 41149156893 scopus 로고    scopus 로고
    • Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans
    • Kosuge M, Takeuchi T, Nakase I, Jones AT, Futaki S,. Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans. Bioconjug Chem 2008; 19: 656-664.
    • (2008) Bioconjug Chem , vol.19 , pp. 656-664
    • Kosuge, M.1    Takeuchi, T.2    Nakase, I.3    Jones, A.T.4    Futaki, S.5
  • 16
    • 0037133097 scopus 로고    scopus 로고
    • PEG grafted polylysine with fusogenic peptide for gene delivery: High transfection efficiency with low cytotoxicity
    • Lee H, Jeong JH, Park TG,. PEG grafted polylysine with fusogenic peptide for gene delivery: High transfection efficiency with low cytotoxicity. J Control Release 2002; 79: 283-291.
    • (2002) J Control Release , vol.79 , pp. 283-291
    • Lee, H.1    Jeong, J.H.2    Park, T.G.3
  • 17
    • 84855441518 scopus 로고    scopus 로고
    • Unraveling the intracellular efficacy of dextran-histidine polycation as an efficient nonviral gene delivery system
    • Thomas JJ, Rekha MR, Sharma CP,. Unraveling the intracellular efficacy of dextran-histidine polycation as an efficient nonviral gene delivery system. Mol Pharm 2012; 9: 121-134.
    • (2012) Mol Pharm , vol.9 , pp. 121-134
    • Thomas, J.J.1    Rekha, M.R.2    Sharma, C.P.3
  • 18
    • 78049431662 scopus 로고    scopus 로고
    • Hemocompatible pullulan-polyethyleneimine conjugates for liver cell gene delivery: In vitro evaluation of cellular uptake, intracellular trafficking and transfection efficiency
    • Rekha MR, Sharma CP,. Hemocompatible pullulan-polyethyleneimine conjugates for liver cell gene delivery: In vitro evaluation of cellular uptake, intracellular trafficking and transfection efficiency. Acta Biomater 2011; 7: 370-379.
    • (2011) Acta Biomater , vol.7 , pp. 370-379
    • Rekha, M.R.1    Sharma, C.P.2
  • 19
    • 33751404700 scopus 로고    scopus 로고
    • Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity
    • Hunter AC,. Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity. Adv Drug Deliv Rev 2006; 58: 1523-1531.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1523-1531
    • Hunter, A.C.1
  • 20
    • 77951916908 scopus 로고    scopus 로고
    • Balancing protection and release of DNA: Tools to address a bottleneck of nonviral gene delivery
    • Grigsby CL, Leong KW,. Balancing protection and release of DNA: Tools to address a bottleneck of nonviral gene delivery. J R Soc Interface 2010; 7(Suppl 1): S67-S82.
    • (2010) J R Soc Interface , vol.71 , pp. S67-S82
    • Grigsby, C.L.1    Leong, K.W.2
  • 21
    • 72949094624 scopus 로고    scopus 로고
    • Nonviral gene delivery: Principle, limitations, and recent progress
    • Al-Dosari MS, Gao X,. Nonviral gene delivery: Principle, limitations, and recent progress. AAPS J 2009; 11: 671-681.
    • (2009) AAPS J , vol.11 , pp. 671-681
    • Al-Dosari, M.S.1    Gao, X.2
  • 23
    • 84878820102 scopus 로고    scopus 로고
    • Efficient cell and cell-sheet harvesting based on smart surfaces coated with a multifunctional and self-organizing elastin-like recombinamer
    • Pierna M, Santos M, Arias FJ, Alonso M, Rodriguez-Cabello JC,. Efficient cell and cell-sheet harvesting based on smart surfaces coated with a multifunctional and self-organizing elastin-like recombinamer. Biomacromolecules 2013; 14: 1893-1903.
    • (2013) Biomacromolecules , vol.14 , pp. 1893-1903
    • Pierna, M.1    Santos, M.2    Arias, F.J.3    Alonso, M.4    Rodriguez-Cabello, J.C.5
  • 24
    • 84897103762 scopus 로고    scopus 로고
    • Genetically engineered nanocarriers for drug delivery
    • Shi P, Gustafson JA, MacKay JA,. Genetically engineered nanocarriers for drug delivery. Int J Nanomed 2014; 9: 1617-1626.
    • (2014) Int J Nanomed , vol.9 , pp. 1617-1626
    • Shi, P.1    Gustafson, J.A.2    MacKay, J.A.3
  • 27
  • 28
    • 84865714324 scopus 로고    scopus 로고
    • Cell penetrating peptides fused to a thermally targeted biopolymer drug carrier improve the delivery and antitumor efficacy of an acid-sensitive doxorubicin derivative
    • Walker L, Perkins E, Kratz F, Raucher D,. Cell penetrating peptides fused to a thermally targeted biopolymer drug carrier improve the delivery and antitumor efficacy of an acid-sensitive doxorubicin derivative. Int. J. Pharm. 2012; 436:825-832.
    • (2012) Int. J. Pharm , vol.436 , pp. 825-832
    • Walker, L.1    Perkins, E.2    Kratz, F.3    Raucher, D.4
  • 29
    • 78649846843 scopus 로고    scopus 로고
    • Cell penetrating elastin-like polypeptides for therapeutic peptide delivery
    • Bidwell GL, 3, Raucher D,. Cell penetrating elastin-like polypeptides for therapeutic peptide delivery. Adv Drug Deliv Rev 2010; 62: 1486-1496.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 1486-1496
    • Bidwell, G.L.1    Raucher, D.2
  • 30
    • 82355193783 scopus 로고    scopus 로고
    • Synthesis of genetically engineered protein polymers (recombinamers) as an example of advanced self-assembled smart materials
    • Rodriguez-Cabello JC, Girotti A, Ribeiro A, Arias FJ,. Synthesis of genetically engineered protein polymers (recombinamers) as an example of advanced self-assembled smart materials. Methods Mol Biol 2012; 811: 17-38.
    • (2012) Methods Mol Biol , vol.811 , pp. 17-38
    • Rodriguez-Cabello, J.C.1    Girotti, A.2    Ribeiro, A.3    Arias, F.J.4
  • 31
    • 2442645420 scopus 로고    scopus 로고
    • Influence of the molecular weight on the inverse temperature transition of a model genetically engineered Elastin-like pH-responsive polymer
    • Girotti A, Reguera J, Arias FJ, Alonso M, Testera AM, Rodríguez-Cabello JC,. Influence of the molecular weight on the inverse temperature transition of a model genetically engineered Elastin-like pH-responsive polymer. Macromolecules 2004; 37: 3396-3400.
    • (2004) Macromolecules , vol.37 , pp. 3396-3400
    • Girotti, A.1    Reguera, J.2    Arias, F.J.3    Alonso, M.4    Testera, A.M.5    Rodríguez-Cabello, J.C.6
  • 32
    • 77955761867 scopus 로고    scopus 로고
    • Overexpression of cd133 promotes drug resistance in c6 glioma cells
    • Angelastro JM, Lame MW,. Overexpression of cd133 promotes drug resistance in c6 glioma cells. Mol Cancer Res 2010; 8: 1105-1115.
    • (2010) Mol Cancer Res , vol.8 , pp. 1105-1115
    • Angelastro, J.M.1    Lame, M.W.2
  • 34
    • 67649625287 scopus 로고    scopus 로고
    • Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells
    • Li G, Li W, Angelastro JM, Greene LA, Liu DX,. Identification of a novel DNA binding site and a transcriptional target for activating transcription factor 5 in c6 glioma and mcf-7 breast cancer cells. Mol Cancer Res 2009; 7: 933-943.
    • (2009) Mol Cancer Res , vol.7 , pp. 933-943
    • Li, G.1    Li, W.2    Angelastro, J.M.3    Greene, L.A.4    Liu, D.X.5
  • 35
    • 33947572267 scopus 로고    scopus 로고
    • Effects of trehalose click polymer length on pDNA complex stability and delivery efficacy
    • Srinivasachari S, Liu Y, Prevette LE, Reineke TM,. Effects of trehalose click polymer length on pDNA complex stability and delivery efficacy. Biomaterials 2007; 28: 2885-2898.
    • (2007) Biomaterials , vol.28 , pp. 2885-2898
    • Srinivasachari, S.1    Liu, Y.2    Prevette, L.E.3    Reineke, T.M.4
  • 37
    • 84878782419 scopus 로고    scopus 로고
    • Cell-penetrating peptides: 20 years later, where do we stand?
    • Bechara C, Sagan S,. Cell-penetrating peptides: 20 years later, where do we stand? FEBS Lett 2013; 587: 1693-1702.
    • (2013) FEBS Lett , vol.587 , pp. 1693-1702
    • Bechara, C.1    Sagan, S.2
  • 38
    • 0031587941 scopus 로고    scopus 로고
    • The enhancing effect of anionic alpha-helical peptide on cationic peptide-mediating transfection systems
    • Ohmori N, Niidome T, Wada A, Hirayama T, Hatakeyama T, Aoyagi H,. The enhancing effect of anionic alpha-helical peptide on cationic peptide-mediating transfection systems. Biochem Biophys Res Commun 1997; 235: 726-729.
    • (1997) Biochem Biophys Res Commun , vol.235 , pp. 726-729
    • Ohmori, N.1    Niidome, T.2    Wada, A.3    Hirayama, T.4    Hatakeyama, T.5    Aoyagi, H.6
  • 39
    • 19744372388 scopus 로고    scopus 로고
    • Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis
    • Akinc A, Thomas M, Klibanov AM, Langer R,. Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis. J Gene Med 2005; 7: 657-663.
    • (2005) J Gene Med , vol.7 , pp. 657-663
    • Akinc, A.1    Thomas, M.2    Klibanov, A.M.3    Langer, R.4
  • 41
    • 84899555747 scopus 로고    scopus 로고
    • Cellular uptake of multilayered capsules produced with natural and genetically engineered biomimetic macromolecules
    • Costa RR, Girotti A, Santos M, Arias FJ, Mano JF, Rodriguez-Cabello JC,. Cellular uptake of multilayered capsules produced with natural and genetically engineered biomimetic macromolecules. Acta Biomater 2014; 10: 2653-2662.
    • (2014) Acta Biomater , vol.10 , pp. 2653-2662
    • Costa, R.R.1    Girotti, A.2    Santos, M.3    Arias, F.J.4    Mano, J.F.5    Rodriguez-Cabello, J.C.6
  • 44
    • 79958242998 scopus 로고    scopus 로고
    • Tunable elastin-like polypeptide hollow sphere as a high payload and controlled delivery gene depot
    • Dash BC, Mahor S, Carroll O, Mathew A, Wang W, Woodhouse KA, Pandit A,. Tunable elastin-like polypeptide hollow sphere as a high payload and controlled delivery gene depot. J Control Release 2011; 152: 382-392.
    • (2011) J Control Release , vol.152 , pp. 382-392
    • Dash, B.C.1    Mahor, S.2    Carroll, O.3    Mathew, A.4    Wang, W.5    Woodhouse, K.A.6    Pandit, A.7
  • 45
    • 84857726912 scopus 로고    scopus 로고
    • A comparative study of cell behavior on different energetic and bioactive polymeric surfaces made from elastin-like recombinamers
    • Garcia-Arevalo C, Pierna M, Girotti A, Arias FJ, Rodriguez-Cabello JC,. A comparative study of cell behavior on different energetic and bioactive polymeric surfaces made from elastin-like recombinamers. Soft Matter 2012; 8: 3239-3249.
    • (2012) Soft Matter , vol.8 , pp. 3239-3249
    • Garcia-Arevalo, C.1    Pierna, M.2    Girotti, A.3    Arias, F.J.4    Rodriguez-Cabello, J.C.5
  • 46
    • 84909948145 scopus 로고    scopus 로고
    • Enhanced intracellular uptake and endocytic pathway selection mediated by hemocompatible ornithine grafted chitosan polycation for gene delivery
    • Alex SM, Sharma CP,. Enhanced intracellular uptake and endocytic pathway selection mediated by hemocompatible ornithine grafted chitosan polycation for gene delivery. Colloids Surf B Biointerfaces 2014; 122: 792-800.
    • (2014) Colloids Surf B Biointerfaces , vol.122 , pp. 792-800
    • Alex, S.M.1    Sharma, C.P.2
  • 47
    • 70349820287 scopus 로고    scopus 로고
    • Revisit the complexation of PEI and DNA - How to make low cytotoxic and highly efficient PEI gene transfection nonviral vectors with a controllable chain length and structure?
    • Deng R, Yue Y, Jin F, Chen Y, Kung HF, Lin MC, Wu C,. Revisit the complexation of PEI and DNA-How to make low cytotoxic and highly efficient PEI gene transfection nonviral vectors with a controllable chain length and structure? J Control Release 2009; 140: 40-46.
    • (2009) J Control Release , vol.140 , pp. 40-46
    • Deng, R.1    Yue, Y.2    Jin, F.3    Chen, Y.4    Kung, H.F.5    Lin, M.C.6    Wu, C.7
  • 48
    • 77956167428 scopus 로고    scopus 로고
    • Comparative studies on the genotoxicity and cytotoxicity of polymeric gene carriers polyethylenimine (PEI) and polyamidoamine (PAMAM) dendrimer in jurkat T-cells
    • Choi YJ, Kang SJ, Kim YJ, Lim YB, Chung HW,. Comparative studies on the genotoxicity and cytotoxicity of polymeric gene carriers polyethylenimine (PEI) and polyamidoamine (PAMAM) dendrimer in jurkat T-cells. Drug Chem Toxicol 2010; 33: 357-366.
    • (2010) Drug Chem Toxicol , vol.33 , pp. 357-366
    • Choi, Y.J.1    Kang, S.J.2    Kim, Y.J.3    Lim, Y.B.4    Chung, H.W.5
  • 49
    • 33751404700 scopus 로고    scopus 로고
    • Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity
    • Hunter AC,. Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity. Adv Drug Deliv Rev 2006; 58: 1523-1531.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1523-1531
    • Hunter, A.C.1
  • 50
    • 0346634895 scopus 로고    scopus 로고
    • In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis
    • Fischer D, Li Y, Ahlemeyer B, Krieglstein J, Kissel T,. In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis. Biomaterials 2003; 24: 1121-1131.
    • (2003) Biomaterials , vol.24 , pp. 1121-1131
    • Fischer, D.1    Li, Y.2    Ahlemeyer, B.3    Krieglstein, J.4    Kissel, T.5
  • 51
    • 19444372923 scopus 로고    scopus 로고
    • A two-stage poly(ethylenimine)-mediated cytotoxicity: Implications for gene transfer/therapy
    • Moghimi SM, Symonds P, Murray JC, Hunter AC, Debska G, Szewczyk A,. A two-stage poly(ethylenimine)-mediated cytotoxicity: Implications for gene transfer/therapy. Mol Ther 2005; 11: 990-995.
    • (2005) Mol Ther , vol.11 , pp. 990-995
    • Moghimi, S.M.1    Symonds, P.2    Murray, J.C.3    Hunter, A.C.4    Debska, G.5    Szewczyk, A.6
  • 52
    • 77649339137 scopus 로고    scopus 로고
    • Nonviral polyplexes: Scaffold mediated delivery for gene therapy
    • O'Rorke S, Keeney M, Pandit A,. Nonviral polyplexes: Scaffold mediated delivery for gene therapy. Prog Polym Sci 2010; 35: 441-458.
    • (2010) Prog Polym Sci , vol.35 , pp. 441-458
    • O'Rorke, S.1    Keeney, M.2    Pandit, A.3
  • 53
    • 13444263549 scopus 로고    scopus 로고
    • Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling
    • Le Roy C, Wrana JL,. Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol 2005; 6: 112-126.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 112-126
    • Le Roy, C.1    Wrana, J.L.2
  • 54
    • 0343938838 scopus 로고    scopus 로고
    • DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers
    • Oupicky D, Konak C, Ulbrich K, Wolfert MA, Seymour LW,. DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers. J Control Release 2000; 65: 149-171.
    • (2000) J Control Release , vol.65 , pp. 149-171
    • Oupicky, D.1    Konak, C.2    Ulbrich, K.3    Wolfert, M.A.4    Seymour, L.W.5
  • 56
    • 68549110328 scopus 로고    scopus 로고
    • Twenty years of cell-penetrating peptides: From molecular mechanisms to therapeutics
    • Heitz F, Morris MC, Divita G,. Twenty years of cell-penetrating peptides: From molecular mechanisms to therapeutics. Br J Pharmacol 2009; 157: 195-206.
    • (2009) Br J Pharmacol , vol.157 , pp. 195-206
    • Heitz, F.1    Morris, M.C.2    Divita, G.3
  • 57
    • 13844298046 scopus 로고    scopus 로고
    • Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides
    • Gupta B, Levchenko TS, Torchilin VP,. Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides. Adv Drug Deliv Rev 2005; 57: 637-651.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 637-651
    • Gupta, B.1    Levchenko, T.S.2    Torchilin, V.P.3
  • 58
    • 77952956320 scopus 로고    scopus 로고
    • Cellular uptake mechanisms and intracellular distributions of polysorbate 80-modified poly (D,L-lactide-co-glycolide) nanospheres for gene delivery
    • Tahara K, Yamamoto H, Kawashima Y,. Cellular uptake mechanisms and intracellular distributions of polysorbate 80-modified poly (D,L-lactide-co-glycolide) nanospheres for gene delivery. Eur J Pharm Biopharm 2010; 75: 218-224.
    • (2010) Eur J Pharm Biopharm , vol.75 , pp. 218-224
    • Tahara, K.1    Yamamoto, H.2    Kawashima, Y.3
  • 60
    • 40549142439 scopus 로고    scopus 로고
    • Intelligent biosynthetic nanobiomaterials (IBNs) for hyperthermic gene delivery
    • Chen T-H, Bae Y, Furgeson D,. Intelligent biosynthetic nanobiomaterials (IBNs) for hyperthermic gene delivery. Pharm Res 2008; 25: 683-691.
    • (2008) Pharm Res , vol.25 , pp. 683-691
    • Chen, T.-H.1    Bae, Y.2    Furgeson, D.3
  • 61
    • 84858747563 scopus 로고    scopus 로고
    • Biodegradable hybrid recombinant block copolymers for nonviral gene transfection
    • Chen TH, Bae Y, Furgeson DY, Kwon GS,. Biodegradable hybrid recombinant block copolymers for nonviral gene transfection. Int J Pharm 2012; 427: 105-112.
    • (2012) Int J Pharm , vol.427 , pp. 105-112
    • Chen, T.H.1    Bae, Y.2    Furgeson, D.Y.3    Kwon, G.S.4
  • 63
    • 0042412569 scopus 로고    scopus 로고
    • A comparison of linear and branched polyethylenimine (PEI) with DCChol//DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo
    • Wiseman JW, Goddard CA, McLelland D, Colledge WH,. A comparison of linear and branched polyethylenimine (PEI) with DCChol//DOPE liposomes for gene delivery to epithelial cells in vitro and in vivo. Gene Ther 2003; 10: 1654-1662.
    • (2003) Gene Ther , vol.10 , pp. 1654-1662
    • Wiseman, J.W.1    Goddard, C.A.2    McLelland, D.3    Colledge, W.H.4


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