Cell penetrating peptides fused to a thermally targeted biopolymer drug carrier improve the delivery and antitumor efficacy of an acid-sensitive doxorubicin derivative

International Journal of Pharmaceutics

Volumn 436, Issue 1-2, 2012, Pages 825-832

  Walker, Leslie ^a   Perkins, Eddie ^a   Kratz, Felix ^b   Raucher, Drazen ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b TUMOR BIOLOGY CENTER   (Germany)

Author keywords

6 (Maleimidocaproyl)hydrazone derivative of doxorubicin (DOXO EMCH, INNO 206); Acid sensitive prodrugs; Cell penetrating peptide (CPP); Doxorubicin; Elastin like polypeptide (ELP); Hyperthermia

Indexed keywords

BIOPOLYMER; CELL PENETRATING PEPTIDE; DOXORUBICIN; DRUG CARRIER; ELASTIN; SYNB1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CARCINOMA CELL; CELL NUCLEUS; CELL PROLIFERATION; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HYPERTHERMIA; IC 50; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELL-PENETRATING PEPTIDES; DOXORUBICIN; DRUG CARRIERS; ELASTIN; FEMALE; HUMANS; HYDRAZONES; HYDROGEN-ION CONCENTRATION; MCF-7 CELLS; MICE; MICE, INBRED C57BL; PEPTIDES; TUMOR BURDEN;

EID: 84865714324     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.07.043     Document Type: Article

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