Recent contributions of elastin-like recombinamers to biomedicine and nanotechnology

Current Topics in Medicinal Chemistry

Volumn 14, Issue 6, 2014, Pages 819-836

  Javier Arias, F ^a   Santos, Mercedes ^a   Fernández Colino, Alicia ^a   Pinedo, Guillermo ^a   Girotti, Alessandra ^a  

^a UNIVERSITY OF VALLADOLID   (Spain)

Author keywords

Drug delivery; Elastin like recombinamers; Nanotechnology; Self assembly; Stimuli responsive; Surface modification; Tissue engineering

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; BIOMATERIAL; ELASTIN LIKE RECOMBINAMER; GOLD NANOPARTICLE; MOLECULAR SCAFFOLD; QUANTUM DOT; UNCLASSIFIED DRUG;

ARTICLE; BIOCOMPATIBILITY; CHEMICAL MODIFICATION; DISCIPLINES RELATING TO BIOMEDICINE; DRUG DELIVERY SYSTEM; EXTRACELLULAR MATRIX; INTRACELLULAR SIGNALING; MOLECULAR INTERACTION; NANODEVICE; NANOTECHNOLOGY; PHYSICAL CHEMISTRY; SELF ASSEMBLY; SURFACE MODIFICATION; TISSUE ENGINEERING; TRANSMISSION ELECTRON MICROSCOPY;

BIOMEDICAL RESEARCH; BIOMIMETIC MATERIALS; ELASTIN; NANOTECHNOLOGY;

EID: 84896355506     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/1568026614666140118223412     Document Type: Article

References (159)

1. Hu, X.; Cebe, P.; Weiss, A.S.; Omenetto, F.; Kaplan, D. L. Proteinbased composite materials. Mater. Today, 2012, 15, 208-215.
2. Girotti, A.; Fernández-Colino, A.; López, I.M.; Rodríguez-Cabello, J.C.; Arias, F. J.Elastin-like recombinamers: Biosynthetic strategies and biotechnological applications. Biotechnol. J., 2011, 6, 1174-1186.
3. Rodríguez-Cabello, J.; Girotti, A.; Ribeiro, A.; Arias, F., Synthesis of Genetically Engineered Protein Polymers (Recombinamers) as an Example of Advanced Self-Assembled Smart Materials. Methods Mol. Biol., 2012, 811,17-38.
4. MacEwan, S.R.; Chilkoti, A. Elastin-like polypeptides: Biomedical applications of tunable biopolymers. Pept. Sci., 2011, 94, 60-77.
5. Rodríguez-Cabello, J.C.; Martín, L.; Alonso, M.; Arias, F.J.; Testera, A. M."Recombinamers" as advanced materials for the post-oil age. Polymer, 2009, 50, 5159-5169.
6. Miao, M.; Bellingham, C.M.; Stahl, R.J.; Sitarz, E.E.; Lane, C.J.; Keeley, F. W.Sequence and structure determinants for the selfaggregation of recombinant polypeptides modeled after human elastin. J. Biol. Chem., 2003, 278, 48553-48562.
7. Urry, D.W.; Hugel, T.; Seitz, M.; Gaub, H.E.; Sheiba, L.; Dea, J.; Xu, J.; Parker, T.Elastin: a representative ideal protein elastomer. Philos. Trans. R. Soc. Lond. B, 2002, 357, 169-184.
8. Di Zio, K.; Tirrell, D. A.Mechanical properties of artificial protein matrices engineered for control of cell and tissue behavior. Macromolecules, 2003, 36, 1553-1558.
9. Rodríguez-Cabello, J.C.; Reguera, J.; Girotti, A.; Arias, F.J.; Alonso, M. Genetic Engineering of Protein-Based Polymers: The Example of Elastin like Polymers. Adv. Polym. Sci., 2006, 200, 119-167.
10. Urry, D. W., What sustains life? Consilient mechanisms for protein-based machines and materials. Springer-Verlag: New York, 2006.
11. San Biagio, P.L.; Madonia, F.; Trapane, T.L.; Urry, D. W.The Overlap of Elastomeric Polypeptide Coils in Solution Required for Single-Phase Initiation of Elastogenesis. Chem. Phys. Lett., 1988, 145, 571-574.
12. Ribeiro, A.; Arias, F.J.; Reguera, J.; Alonso, M.; Rodriguez-Cabello, J. C.Influence of the amino-acid sequence on the inverse temperature transition of elastin-like polymers. Biophys. J., 2009, 97, 312-320.
13. Alvarez-Rodriguez, R.; Arias, F.J.; Santos, M.; Testera, A.M.; Rodriguez-Cabello, J. C. Gold Tailored Photosensitive Elastin-like Polymer: Synthesis of Temperature, pH and UV-vis Sensitive Probes. Macromol. Rapid Commun., 2010, 31, 568-573.
14. Reguera, J.; Urry, D.W.; Parker, T.M.; McPherson, D.T.; Rodriguez-Cabello, J. C. Effect of NaCl on the Exothermic and Endothermic Components of the Inverse Temperature Transition of a Model Elastin-like Polymer. Biomacromolecules, 2007, 8, 354-358.
15. Bochicchio, B.; Aït-Ali, A.; Tamburro, A.M.; Alix, A. J. P. Spectroscopic evidence revealing polyproline II structure in hydrophobic, putatively elastomeric sequences encoded by specific exons of human tropoelastin. Biopolymers, 2004, 73, 484-493.
16. Tamburro, A.M.; Guantieri, V.; Pandolfo, L.; Scopa, A. Synthetic fragments and analogues of elastin. II. Conformational studies. Biopolymers, 1990, 29, 855-870.
17. Debelle, L.; Alix, A. J. P. Optical spectroscopic determination of bovine tropoelastin molecular model. J. Mol. Struct., 1995, 348, 321-324.
18. MacEwan, S.R.; Chilkoti, A.Elastin-like polypeptides: biomedical applications of tunable biopolymers. Biopolymers, 2010, 94, 60-77.
19. Macewan, S.R.; Chilkoti, A. Elastin-like polypeptides: Biomedical applications of tunable biopolymers. Biopolymers, 94, 60-77.
20. Nettles, D.L.; Chilkoti, A.; Setton, L. A. Applications of elastin-like polypeptides in tissue engineering. Adv. Drug Deliv. Rev., 2010, 62, 1479-1485.
21. McDaniel, J.R.; Callahan, D.J.; Chilkoti, A. Drug delivery to solid tumors by elastin-like polypeptides. Adv. Drug Deliv. Rev., 2010, 62, 1456-1467.
22. Huang, L.; McMillan, R.A.; Apkarian, R.P.; Pourdeyhimi, B.; Conticello, V.P.; Chaikof, E. L. Generation of Synthetic Elastin-Mimetic Small Diameter Fibers and Fiber Networks. Macromolecules, 2000, 33, 2989-2997.
23. Lee, T. A.T.; Cooper, A.; Apkarian, R.P.; Conticello, V. P. Thermoreversible self-assembly of nanoparticles derived from elastinmimetic polypeptides. Adv. Mater., 2000, 12, 1105-1110.
24. Rodríguez-Cabello, J.C.; Prieto, S.; Arias, F.J.; Reguera, J.; Ribeiro, A. Nanobiotechnological approach to engineered biomaterial design: the example of elastin-like polymers. Nanomedicine (London, U. K.) 2006, 1, 267-280.
25. Kim, T.G.; Shin, H.; Lim, D. W. Biomimetic Scaffolds for Tissue Engineering. Adv. Funct. Mater., 2012, 22, 2446-2468.
26. Luan, C.-H.; Urry, D. W., Elastic, Plastic, and Hydrogel Proteinbased Polymers. In Polymer Data Handbook, Mark, J. E., Ed. Oxford University Press: New York, 1999; pp 78-89.
27. Martin, L.; Alonso, M.; Moller, M.; Rodriguez-Cabello, J.C.; Mela, P. 3D microstructuring of smart bioactive hydrogels based on recombinant elastin-like polymers. Soft Matter, 2009, 5, 1591-1593.
28. Martin, L.; Javier Arias, F.; Alonso, M.; Garcia-Arevalo, C.; Rodriguez-Cabello, J. C.Rapid micropatterning by temperaturetriggered reversible gelation of a recombinant smart elastin-like tetrablock-copolymer. Soft Matter, 2010, 6, 1121-1124.
29. McDaniel, J.R.; Radford, D.C.; Chilkoti, A. A Unified Model for De Novo Design of Elastin-like Polypeptides with Tunable Inverse Transition Temperatures. Biomacromolecules, 2013, 14, 2866-2872.
30. Sbrana, F.; Fotia, C.; Bracalello, A.; Baldini, N.; Marletta, G.; Ciapetti, G.; Bochicchio, B.; Vassalli, M. Multiscale characterization of a chimeric biomimetic polypeptide for stem cell culture. Bioinspiration Biomimetics, 2012, 7, 1-9.
31. Nicol A. G. D., Parker TM, Urry DW Cell adhesive properties of bioelastic materials containing cell attachment sequences. Plenum Press.: New York, 1994.
32. Nagaoka, M.; Jiang, H.-L.; Hoshiba, T.; Akaike, T.; Cho, C.-S. Application of Recombinant Fusion Proteins for Tissue Engineering. Ann. Biomed. Eng., 2010, 38, 683-693.
33. Nagapudi, K.; Brinkman, W.T.; Thomas, B.S.; Park, J.O.; Srinivasarao, M.; Wright, E.; Conticello, V.P.; Chaikof, E. L. Viscoelastic and mechanical behavior of recombinant protein elastomers. Biomaterials, 2005, 26, 4695-4706.
34. Sallach, R.E.; Cui, W.; Wen, J.; Martinez, A.; Conticello, V.P.; Chaikof, E. L. Elastin-mimetic protein polymers capable of physical and chemical crosslinking. Biomaterials, 2009, 30, 409-422.
35. Lim, D.W.; Nettles, D.L.; Setton, L.A.; Chilkoti, A. In situ crosslinkinig of elastin-like polypeptide block copolymers for tissue repair. Biomacromolecules, 2008, 9, 222-230.
36. Betre, H.; Ong, S.R.; Guilak, F.; Chilkoti, A.; Fermor, B.; Setton, L. A.Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide. Biomaterials, 2006, 27, 91-99.
37. Sallach, R.E.; Cui, W.; Balderrama, F.; Martinez, A.W.; Wen, J.; Haller, C.A.; Taylor, J.V.; Wright, E.R.; Long, R. C., Jr.; Chaikof, E. L. Long-term biostability of self-assembling protein polymers in the absence of covalent crosslinking. Biomaterials, 2010, 31, 779-791.
38. Ravi, S.; Caves, J.M.; Martinez, A.W.; Haller, C.A.; Chaikof, E. L. Incorporation of fibronectin to enhance cytocompatibility in multilayer elastin-like protein scaffolds for tissue engineering. J. Biomed. Mater. Res. A, 2013, 101A, 1915-1924.
39. Stevens, M.M.; George, J. H. Exploring and engineering the cell surface interface. Science, 2005, 310, 1135-1138.
40. Bae, J.; Goto, S.; Mie, M.; Kobatake, E. Construction of a thermostable cell adhesion protein for reverse transfection. J. Biotechnol., 2010, 150, 447-451.
41. Assal, Y.; Mie, M.; Kobatake, E. The promotion of angiogenesis by growth factors integrated with ECM proteins through coiled-coil structures. Biomaterials, 2013, 34, 3315-3323.
42. Nakamura, M.; Mie, M.; Nakamura, M.; Kobatake, E. Construction of multi-functional extracellular matrix proteins that inhibits migration and tube formation of endothelial cells. Biotechnol. Lett., 2012, 34, 1571-1577.
43. Prieto, S.; Shkilnyy, A.; Rumplasch, C.; Ribeiro, A.; Arias, F.J.; Carlos Rodriguez-Cabello, J.; Taubert, A. Biomimetic Calcium Phosphate Mineralization with Multifunctional Elastin-Like Recombinamers. Biomacromolecules, 2011, 12, 1480-1486.
44. Yannas, I. V. Emerging rules for inducing organ regeneration. Biomaterials, 2013, 34, 321-330.
45. Garcia-Arevalo, C.; Pierna, M.; Girotti, A.; Arias, F.J.; Rodriguez-Cabello, J. C. A comparative study of cell behavior on different energetic and bioactive polymeric surfaces made from elastin-like recombinamers. Soft Matter, 2012, 8, 3239-3249.
46. Straley, K.S.; Heilshorn, S. C. Design and adsorption of modular engineered proteins to prepare customized, neuron-compatible coatings. Front Neuroeng., 2009, 2, 9.
47. Liu, J.; Tirrell, D. Cell response to RGD density in cross-linked artificial extracellular matrix protein films. Biomacromolecules, 2008, 9, 2984-2988.
48. Ozturk, N.; Girotti, A.; Kose, G.T.; Rodriguez-Cabello, J.C.; Hasirci, V. Dynamic cell culturing and its application to micropatterned, elastin-like protein-modified poly(N-isopropylacrylamide) scaffolds. Biomaterials, 2009, 30, 5417-5426.
49. Chung, C.; Anderson, E.; Pera, R.R.; Pruitt, B.L.; Heilshorn, S. C. Hydrogel crosslinking density regulates temporal contractility of human embryonic stem cell-derived cardiomyocytes in 3D cultures. Soft Matter, 2012, 8, 10141-10148.
50. Punet, X.; Mauchauffe, R.; Giannotti, M.I.; Rodriguez-Cabello, J.C.; Sanz, F.; Engel, E.; Mateos-Timoneda, M.A.; Planell, J. A. Enhanced Cell-Material Interactions through the Biofunctionalization of Polymeric Surfaces with Engineered Peptides. Biomacromolecules, 2013, 14, 2690-2702.
51. Choi, S.K.; Park, J.K.; Lee, K.M.; Lee, S.K.; Jeon, W. B. Improved neural progenitor cell proliferation and differentiation on poly(lactide-co-glycolide) scaffolds coated with elastin-like polypeptide. J. Biomed. Mater. Res. B Appl. Biomater., 2013, 101B, 1329-1339.
52. Lampe, K.J.; Antaris, A.L.; Heilshorn, S. C. Design of threedimensional engineered protein hydrogels for tailored control of neurite growth. Acta Biomater., 2013, 9, 5590-5599.
53. Lee, K.-M.; Jung, G.-S.; Park, J.-K.; Choi, S.-K.; Jeon, W. B. Effects of Arg-Gly-Asp-modified elastin-like polypeptide on pseudoislet formation via up-regulation of cell adhesion molecules and extracellular matrix proteins. Acta Biomater., 2013, 9, 5600-5608.
54. Tejeda-Montes, E.; Smith, K.H.; Rebollo, E.; Gomez, R.; Alonso, M.; Rodriguez-Cabello, J.C.; Engel, E.; Mata, A. Bioactive membranes for bone regeneration applications: effect of physical and biomolecular signals on mesenchymal stem cell behaviour. Acta Biomater., 2013, 10, 134-141.
55. Ciofani, G.; Genchi, G.G.; Liakos, I.; Athanassiou, A.; Mattoli, V.; Bandiera, A. Human recombinant elastin-like protein coatings for muscle cell proliferation and differentiation. Acta Biomater., 2013, 9, 5111-5121.
56. Kinikoglu, B.; Carlos Rodriguez-Cabello, J.; Damour, O.; Hasirci, V. A smart bilayer scaffold of elastin-like recombinamer and collagen for soft tissue engineering. J. Mater. Sci: Mater. Med., 2011, 22, 1541-1554.
57. Kinikoglu, B.; Carlos Rodriguez-Cabello, J.; Damour, O.; Hasirci, V. The influence of elastin-like recombinant polymer on the selfrenewing potential of a 3D tissue equivalent derived from human lamina propria fibroblasts and oral epithelial cells. Biomaterials, 2011, 32, 5756-5764.
58. Srivastava, G.K.; Martin, L.; Singh, A.K.; Fernandez-Bueno, I.; Gayoso, M.J.; Garcia-Gutierrez, M.T.; Girotti, A.; Alonso, M.; Rodriguez-Cabello, J.C.; Pastor, J. C.Elastin-like recombinamers as substrates for retinal pigment epithelial cell growth. J. Biomed. Mater. Res. A, 2011, 97A, 243-250.
59. Singh, A.K.; Srivastava, G.K.; Martín, L.; Alonso, M.; Pastor, J. C. Bioactive substrates for human retinal pigment epithelial cell growth from elastin-like recombinamers. J. Biomed. Mater. Res. A, 2013, DOI: 10.1002/jbm.a.34726
60. Heilshorn, S.C.; Liu, J.C.; Tirrell, D. A. Cell-binding domain context affects cell behavior on engineered proteins. Biomacromolecules, 2005, 6, 318-323.
61. Liu, J.C.; Heilshorn, S.C.; Tirrell, D. A. Comparative cell response to artificial extracellular matrix proteins containing the RGD and CS5 cell-binding domains. Biomacromolecules, 2004, 5, 497-504.
62. Plouffe, B.D.; Njoka, D.N.; Harris, J.; Liao, J.; Horick, N.K.; Radisic, M.; Murthy, S. K. Peptide-mediated selective adhesion of smooth muscle and endothelial cells in microfluidic shear flow. Langmuir, 2007, 23, 5050-5055.
63. Garcia, Y.; Hemantkumar, N.; Collighan, R.; Griffin, M.; Rodriguez-Cabello, J.C.; Pandit, A. In vitro characterization of a collagen scaffold enzymatically cross-linked with a tailored elastin-like polymer. Tissue Eng. Part A, 2009, 15, 887-899.
64. Spector, M. An interview with I V Yannas. Tracing one of the deepest roots of biomaterials in tissue engineering/regenerative medicine. Biomed. Mater., 2013, 8, 040401.
65. Girotti, A.; Reguera, J.; Rodríguez-Cabello, J.C.; Arias, F.J.; Alonso, M.; Testera, A. M. Design and bioproduction of a recombinant multi(bio)functional elastin-like protein polymer containing cell adhesion sequences for tissue engineering purposes. J. Mater. Sci: Mater. Med., 2004, 15, 479-484.
66. Straley, K.S.; Heilshorn, S. C. Independent tuning of multiple biomaterial properties using protein engineering. Soft Matter, 2009, 5, 114-124.
67. Martin, L.; Alonso, M.; Girotti, A.; Javier Arias, F.; Carlos Rodriguez-Cabello, J. Synthesis and Characterization of Macroporous Thermosensitive Hydrogels from Recombinant Elastin-Like Polymers. Biomacromolecules, 2009, 10, 3015-3022.
68. Ravi, S.; Haller, C.A.; Sallach, R.E.; Chaikof, E. L. Cell behavior on a CCN1 functionalized elastin-mimetic protein polymer. Biomaterials, 2012, 33, 2431-2438.
69. Minato, A.; Ise, H.; Goto, M.; Akaike, T. Cardiac differentiation of embryonic stem cells by substrate immobilization of insulin-like growth factor binding protein 4 with elastin-like polypeptides. Biomaterials, 2012, 33, 515-523.
70. Tirrell, M.; Kokkoli, E.; Biesalski, M. The role of surface science in bioengineered materials. Surf. Sci., 2002, 500, 61-83.
71. Mitragotri, S.; Lahann, J. Physical approaches to biomaterial design. Nat. Mater., 2009, 8, 15-23.
72. Raghavan, S.; Chen, C. S. Micropatterned Environments in Cell Biology. Adv. Mater., 2004, 16, 1303-1313.
73. Bandiera, A. Human Elastin derived Biomimetic Coating Surface to Support Cell Growth. World Acad. Sci. Engg. Technol., 2010, 61, 30-34.
74. Schulte, V.A.; Díez, M.; Möller, M.; Lensen, M. C. Surface Topography Induces Fibroblast Adhesion on Intrinsically Nonadhesive Poly(ethylene glycol) Substrates. Biomacromolecules, 2009, 10, 2795-2801.
75. Tejeda-Montes, E.; Smith, K.H.; Poch, M.; López-Bosque, M.J.; Martín, L.; Alonso, M.; Engel, E.; Mata, A. Engineering membrane scaffolds with both physical and biomolecular signaling. Acta Biomat., 2012, 8, 998-1009.
76. Srokowski, E.; Woodhouse, K. Surface and adsorption characteristics of three elastin-like polypeptide coatings with varying sequence lengths. J. Mater. Sci: Mater. Med., 2013, 24, 71-84.
77. Srokowski, E.M.; Blit, P.H.; McClung, W.G.; Brash, J.L.; Santerre, J.P.; Woodhouse, K. A. Platelet Adhesion and Fibrinogen Accretion on a Family of Elastin-Like Polypeptides. J Biomater Sci, Polym Ed., 2011, 22, 41-57.
78. Janorkar, A.V.; Rajagopalan, P.; Yarmush, M.L.; Megeed, Z.The use of elastin-like polypeptide-polyelectrolyte complexes to control hepatocyte morphology and function in vitro. Biomaterials, 2008, 29, 625-632.
79. Barbosa, J.S.; Ribeiro, A.; Testera, A.M.; Alonso, M.; Arias, F.J.; Rodríguez-Cabello, J.C.; Mano, J. F. Development of Biomimetic Chitosan-Based Hydrogels Using an Elastin-Like Polymer. Adv. Eng. Mater, 2010, 12, B37-B44.
80. Costa, R.R.; Custódio, C.A.; Testera, A.M.; Arias, F.J.; Rodríguez-Cabello, J.C.; Alves, N.M.; Mano, J. F. Stimuli-Responsive Thin Coatings Using Elastin-Like Polymers for Biomedical Applications. Adv. Eng. Mater., 2009, 19, 3210-3218.
81. González, M.; Salvagni, E.; Rodríguez-Cabello, J.C.; Rupérez, E.; Gil, F.J.; Peña, J.; Manero, J. M. A low elastic modulus Ti-Nb-Hf alloy bioactivated with an elastin-like protein-based polymer enhances osteoblast cell adhesion and spreading. J. Biomed. Mater. Res. A, 2012, 101, 819-826.
82. Decher, G. Fuzzy Nanoassemblies: Toward Layered Polymeric Multicomposites. Science, 1997, 277, 1232-1237.
83. Costa, R.R.; Custodio, C.A.; Arias, F.J.; Rodriguez-Cabello, J.C.; Mano, J. F.Layer-by-Layer Assembly of Chitosan and Recombinant Biopolymers into Biomimetic Coatings with Multiple Stimuli-Responsive Properties. Small, 2011, 7, 2640-2649.
84. Golonka, M.; Bulwan, M.; Nowakowska, M.; Testera, A.M.; Rodriguez-Cabello, J.C.; Zapotoczny, S. Thermoresponsive multilayer films based on ionic elastin-like recombinamers. Soft Matter, 2011, 7, 9402-9409.
85. Swierczewska, M.; Hajicharalambous, C.S.; Janorkar, A.V.; Megeed, Z.; Yarmush, M.L.; Rajagopalan, P. Cellular response to nanoscale elastin-like polypeptide polyelectrolyte multilayers. Acta Biomater., 2008, 4, 827-837.
86. Costa, R.R.; Custódio, C.A.; Arias, F.J.; Rodríguez-Cabello, J.C.; Mano, J. F.Nanostructured and thermoresponsive recombinant biopolymer-based microcapsules for the delivery of active molecules. Nanomed.-Nanotechnol. Biol. Med., 2013, 9, 895-902.
87. Kumar, A.; Srivastava, A.; Galaev, I.Y.; Mattiasson, B. Smart polymers: Physical forms and bioengineering applications. Prog. Polym. Sci. 2007, 32, 1205-1237.
88. Kikuchi, A.; Okano, T. Intelligent thermoresponsive polymeric stationary phases for aqueous chromatography of biological compounds. Prog. Polym. Sci., 2002, 27, 1165-1193.
89. Nath, N.; Chilkoti, A. Creating "Smart" Surfaces Using Stimuli Responsive Polymers. Adv. Mater., 2002, 14, 1243-1247.
90. Nath, N.; Hyun, J.; Ma, H.; Chilkoti, A. Surface engineering strategies for control of protein and cell interactions. Surf. Sci., 2004, 570, 98-110.
91. Fu, Q.; Rao, G. V.R.; Ista, L.K.; Wu, Y.; Andrzejewski, B.P.; Sklar, L.A.; Ward, T.L.; López, G. P. Control of molecular transport through stimuli-responsive ordered mesoporous materials. Adv. Mater., 2003, 15, 1262-1266.
92. Lee, J.; Jung, J.; Na, K.; Heo, P.; Hyun, J. Polypeptide-Mediated Switchable Microarray of Bacteria. ACS Appl. Mater. Interfaces, 2009, 1, 1359-1363.
93. Nakagami, H.; Morishita, R.; Maeda, K.; Kikuchi, Y.; Ogihara, T.; Kaneda, Y. Adipose Tissue-Derived Stromal Cells as a Novel Option for Regenerative Cell Therapy. J. Atheroscler. Thromb., 2006, 13, 77-81.
94. Okano, T.; Yamada, N.; Okuhara, M.; Sakai, H.; Sakurai, Y. Mechanism of cell detachment from temperature-modulated, hydrophilic-hydrophobic polymer surfaces. Biomaterials, 1995, 16, 297-303.
95. Hannachi, I.E.; Yamato, M.; Okano, T. Cell sheet technology and cell patterning for biofabrication. Biofabrication, 2009, 1, 022002.
96. Mie, M.; Mizushima, Y.; Kobatake, E. Novel extracellular matrix for cell sheet recovery using genetically engineered elastin-like protein. J. Biomed. Mater. Res. B, 2008, 86B, 283-290.
97. Pierna, M.; Santos, M.; Arias, F.J.; Alonso, M.; Rodríguez-Cabello, J. C. Efficient Cell and Cell-Sheet Harvesting Based on Smart Surfaces Coated with a Multifunctional and Self-Organizing Elastin-Like Recombinamer. Biomacromolecules, 2013, 14, 1893-1903.
98. Uhrich, K.E.; Cannizzaro, S.M.; Langer, R.S.; Shakesheff, K. M. Polymeric systems for controlled drug release. Chem. Rev., 1999, 99, 3181-3198.
99. Altunbas, A.; Pochan, D. J. Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering. Top. Curr. Chem., 2012, 310, 135-167.
100. Lee, M.K.; Kim, S.; Ahn, C.H.; Lee, J. Hydrophilic and hydrophobic amino acid copolymers for nano-comminution of poorly soluble drugs. Int. J. Pharm., 2010, 384, 173-180.
101. Urry, D.W.; Gowda, D.C.; Harris, C.M.; Harris, R. D., Bioelastic materials and the _Tt-Mechanism in drug delivery. In Polymeric Drugs and Drug Administration, Ottenbrite, R. M., Ed. ACS: Washintong DC, 1994; p 15.
102. Rodriguez-Cabello, J.C.; Gonzalez de Torre, I.; Pinedo, G., CHAPTER 19 Elastin-like Hydrogels and Self-assembled Nanostructures for Drug Delivery. In Smart Materials for Drug Delivery: Volume 2, The Royal Society of Chemistry: 2013; 2, pp 180-198.
103. Li, Y.; Rodrigues, J.; Tomas, H. Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications. Chem. Soc. Rev., 2012, 41, 2193-2221.
104. Hart, D.S.; Gehrke, S. H. Thermally associating polypeptides designed for drug delivery produced by genetically engineered cells. J. Pharm. Sci., 2007, 96, 484-516.
105. Asai, D.; Xu, D.; Liu, W.; Garcia Quiroz, F.; Callahan, D.J.; Zalutsky, M.R.; Craig, S.L.; Chilkoti, A. Protein polymer hydrogels by in situ, rapid and reversible self-gelation. Biomaterials, 2012, 33, 5451-5458.
106. McHale, M.K.; Setton, L.A.; Chilkoti, A. Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair. Tissue Eng., 2005, 11, 1768-1779.
107. Lim, D.W.; Nettles, D.L.; Setton, L.A.; Chilkoti, A. Rapid crosslinking of elastin-like polypeptides with (hydroxymethyl) phosphines in aqueous solution. Biomacromolecules, 2007, 8, 1463-1470.
108. Nagapudi, K.; Brinkman, W.T.; Leisen, J.E.; Huang, L.; McMillan, R.A.; Apkarian, R.P.; Conticello, V.P.; Chaikof, E. L. Photomediated Solid-State Cross-Linking of an Elastin_Mimetic Recombinant Protein Polymer. Macromolecules, 2002, 35, 1730-1737.
109. Betre, H.; Liu, W.; Zalutsky, M.R.; Chilkoti, A.; Kraus, V.B.; Setton, L. A. A thermally responsive biopolymer for intra-articular drug delivery. J. Control. Release, 2006, 115, 175-182.
110. Liu, W.; MacKay, J.A.; Dreher, M.R.; Chen, M.; McDaniel, J.R.; Simnick, A.J.; Callahan, D.J.; Zalutsky, M.R.; Chilkoti, A. Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model. J. Control. Release, 2010, 144, 2-9.
111. Betre, H.; Setton, L.A.; Meyer, D.E.; Chilkoti, A. Characterization of a genetically engineered elastin-like polypeptide for cartilaginous tissue repair. Biomacromolecules, 2002, 3, 910-916.
112. Nagarsekar, A.; Crissman, J.; Crissman, M.; Ferrari, F.; Cappello, J.; Ghandehari, H. Genetic synthesis and characterization of pHand temperature-sensitive silk-elastinlike protein block copolymers. J. Biomed. Mater. Res. 2002, 62, 195-203.
113. Takahashi, Y.; Gehoh, M.; Yuzuriha, K. Structure refinement and diffuse streak scattering of silk (Bombyx mori). Int. J. Biol. Macromol., 1999, 24, 127-138.
114. Cappello, J.; Crissman, J.W.; Crissman, M.; Ferrari, F.A.; Textor, G.; Wallis, O.; Whitledge, J.R.; Zhou, X.; Burman, D.; Aukerman, L.; Stedronsky, E. R. In-situ self-assembling protein polymer gel systems for administration, delivery, and release of drugs. J. Control. Release, 1998, 53, 105-117.
115. Megeed, Z.; Cappello, J.; Ghandehari, H. Genetically engineered silk-elastinlike protein polymers for controlled drug delivery. Adv. Drug Deliv. Rev., 2002, 54, 1075-1091.
116. Gustafson, J.A.; Price, R.A.; Greish, K.; Cappello, J.; Ghandehari, H. Silk-elastin-like hydrogel improves the safety of adenovirusmediated gene-directed enzyme-prodrug therapy. Mol. Pharm., 2010, 7, 1050-1056.
117. Greish, K.; Frandsen, J.; Scharff, S.; Gustafson, J.; Cappello, J.; Li, D.; O'Malley, B. W., Jr.; Ghandehari, H. Silk-elastinlike protein polymers improve the efficacy of adenovirus thymidine kinase enzyme prodrug therapy of head and neck tumors. J. Gene Med., 2010, 12, 572-579.
118. Herrero-Vanrell, R.; Rincon, A.C.; Alonso, M.; Reboto, V.; Molina-Martinez, I.T.; Rodriguez-Cabello, J. C. Self-assembled particles of an elastin-like polymer as vehicles for controlled drug release. J. Control. Release, 2005, 102, 113-122.
119. Rincon, A.C.; Molina-Martinez, I.T.; de Las Heras, B.; Alonso, M.; Bailez, C.; Rodriguez-Cabello, J.C.; Herrero-Vanrell, R. Biocompatibility of elastin-like polymer poly(VPAVG) microparticles: in vitro and in vivo studies. J. Biomed. Mater. Res. A, 2006, 78, 343-351.
120. Bessa, P.C.; Machado, R.; Nurnberger, S.; Dopler, D.; Banerjee, A.; Cunha, A.M.; Rodriguez-Cabello, J.C.; Redl, H.; van Griensven, M.; Reis, R.L.; Casal, M. Thermoresponsive self-assembled elastin-based nanoparticles for delivery of BMPs. J. Control. Release, 2010, 142, 312-318.
121. MacKay, J.A.; Chen, M.; McDaniel, J.R.; Liu, W.; Simnick, A.J.; Chilkoti, A. Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection. Nat. Mater., 2009, 8, 993-999.
122. Sallach, R.E.; Wei, M.; Biswas, N.; Conticello, V.P.; Lecommandoux, S.; Dluhy, R.A.; Chaikof, E. L. Micelle density regulated by a reversible switch of protein secondary structure. J. Am. Chem. Soc., 2006, 128, 12014-12019.
123. Dreher, M.R.; Simnick, A.J.; Fischer, K.; Smith, R.J.; Patel, A.; Schmidt, M.; Chilkoti, A. Temperature triggered self-assembly of polypeptides into multivalent spherical micelles. J. Am. Chem. Soc., 2008, 130, 687-694.
124. García-Arévalo, C.; Bermejo-Martín, J.F.; Rico, L.; Iglesias, V.; Martín, L.; Rodríguez-Cabello, J.C.; Arias, F. J. Immunomodulatory Nanoparticles from Elastin-Like Recombinamers: Single-Molecules for Tuberculosis Vaccine Development. Mol. Pharm., 2013, 10, 586-597.
125. Kaldis, A.; Ahmad, A.; Reid, A.; McGarvey, B.; Brandle, J.; Ma, S.; Jevnikar A.; Kohalmi, S.E.; Menassa R. High-level production of human interleukin-10 fusions in tobacco cell suspension cultures. Plant Biotechnol. Jnl., 2013, 11, 535-545.
126. Shamji, M.F.; Whitlatch, L.; Friedman, A.H.; Richardson, W.J.; Chilkoti, A.; Setton, L. A. An injectable and in situ-gelling biopolymer for sustained drug release following perineural administration. Spine (Phila Pa 1976), 2008, 33, 748-754.
127. Conrad, U.; Plagmann, I.; Malchow, S.; Sack, M.; Floss, D.M.; Kruglov, A.A.; Nedospasov, S.A.; Rose-John, S.; Scheller, J. ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock. Plant Biotechnol. Jnl., 2011, 9, 22-31.
128. Greish, K. Enhanced permeability and retention of macromolecular drugs in solid tumors: a royal gate for targeted anticancer nanomedicines. J. Drug Target. 2007, 15, 457-464.
129. Dreher, M.R.; Liu, W.; Michelich, C.R.; Dewhirst, M.W.; Chilkoti, A. Thermal cycling enhances the accumulation of a temperaturesensitive biopolymer in solid tumors. Cancer Res., 2007, 67, 4418-4424.
130. McDaniel, J.R.; Macewan, S.R.; Dewhirst, M.; Chilkoti, A. Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia. J. Control. Release, 2012, 159, 362-367.
131. Bidwell, G. L., 3rd; Raucher, D. Cell penetrating elastin-like polypeptides for therapeutic peptide delivery. Adv. Drug Deliv. Rev., 2010, 62, 1486-1496.
132. Bidwell, G. L., 3rd; Davis, A.N.; Fokt, I.; Priebe, W.; Raucher, D. A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance. Invest. New Drugs, 2007, 25, 313-326.
133. Bidwell, G. L., 3rd; Fokt, I.; Priebe, W.; Raucher, D. Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin. Biochem. Pharmacol., 2007, 73, 620-631.
134. Massodi, I.; Thomas, E.; Raucher, D. Application of Thermally Responsive Elastin-like Polypeptide Fused to a Lactoferrin-derived Peptide for Treatment of Pancreatic Cancer. Molecules, 2009, 14, 1999-2015.
135. Macewan, S.R.; Chilkoti, A. Digital switching of local arginine density in a genetically encoded self-assembled polypeptide nanoparticle controls cellular uptake. Nano Lett., 2012, 12, 3322-3328.
136. Rodriguez-Cabello, J.C.; Martin, L.; Girotti, A.; Garcia-Arevalo, C.; Arias, F.J.; Alonso, M. Emerging applications of multifunctional elastin-like recombinamers. Nanomedicine (London, U. K.), 2011, 6, 111-122.
137. Kreibig, U.; Volmer, M., Optical properties of metal clusters. Springer: 1995, 20, p. 535.
138. Shipway, A.N.; Katz, E.; Willner, I. Nanoparticle Arrays on Surfaces for Electronic, Optical, and Sensor Applications. Chemphyschem., 2000, 1, 18-52.
139. Baraton, M.-I., Synthesis, functionalization and surface treatment of nanoparticles. American Scientific Publishers: Stevenson Ranch, Calif., 2003.
140. Norman, T.J.; Grant, C.D.; Magana, D.; Zhang, J.Z.; Liu, J.; Cao, D.; Bridges, F.; Van Buuren, A. Near Infrared Optical Absorption of Gold Nanoparticle Aggregates. J. Phys. Chem. B, 2002, 106, 7005-7012.
141. Brown, S.D.; Nativo, P.; Smith, J.-A.; Stirling, D.; Edwards, P.R.; Venugopal, B.; Flint, D.J.; Plumb, J.A.; Graham, D.; Wheate, N. J. Gold Nanoparticles for the Improved Anticancer Drug Delivery of the Active Component of Oxaliplatin. J. Am. Chem. Soc., 2010, 132, 4678-4684.
142. Stuchinskaya, T.; Moreno, M.; Cook, M.J.; Edwards, D.R.; Russell, D. A. Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates. Photochem. Photobiol. Sci., 2011, 10, 822-831.
143. Alvarez-Rodriguez, R.; Alonso, M.; Girotti, A.; Reboto, V.; Rodriguez-Cabello, J. C. One-pot synthesis of pH and temperature sensitive gold clusters mediated by a recombinant elastin-like polymer. Eur. Polym. J., 2010, 46, 643-650.
144. Lemieux, V.; Adams, P.H.; van Hest, J. C. Elastin-based stimuliresponsive gold nanoparticles. Chem. Commun., 2010, 46, 3071-3073.
145. Nath, N.; Chilkoti, A. Interfacial phase transition of an environmentally responsive elastin biopolymer adsorbed on functionalized gold nanoparticles studied by colloidal surface plasmon resonance. J. Am. Chem. Soc., 2001, 123, 8197-8202.
146. Anh, T.T.; Xing, M.; Le, D.H.; Sugawara-Narutaki, A.; Fong, E. Elastin-based silver-binding proteins with antibacterial capabilities. Nanomedicine (London, U. K.) 2013, 8, 567-575.
147. Klostranec, J.M.; Chan, W. C. W. Quantum Dots in Biological and Biomedical Research: Recent Progress and Present Challenges. Adv. Mater., 2006, 18, 1953-1964.
148. Lao, U.L.; Mulchandani, A.; Chen, W. Simple Conjugation and Purification of Quantum Dot_Antibody Complexes Using a Thermally Responsive Elastin-Protein L Scaffold As Immunofluorescent Agents. J. Am. Chem. Soc., 2006, 128, 14756-14757.
149. Fahmi, A.; Pietsch, T.; Bryszewska, M.; Rodríguez-Cabello, J.C.; Koceva-Chyla, A.; Arias, F.J.; Rodrigo, M.A.; Gindy, N. Fabrication of CdSe-Nanofibers with Potential for Biomedical Applications. Adv. Funct. Mater., 2010, 20, 1011-1018.
150. Yang, K.; Zhang, S.; Zhang, G.; Sun, X.; Lee, S.-T.; Liu, Z. Graphene in Mice: Ultrahigh In Vivo Tumor Uptake and Efficient Photothermal Therapy. Nano Lett., 2010, 10, 3318-3323.
151. Sun, X.; Liu, Z.; Welsher, K.; Robinson, J.; Goodwin, A.; Zaric, S.; Dai, H. Nano-graphene oxide for cellular imaging and drug delivery. Nano Res., 2008, 1, 203-212.
152. Hong, H.; Yang, K.; Zhang, Y.; Engle, J.W.; Feng, L.; Yang, Y.; Nayak, T.R.; Goel, S.; Bean, J.; Theuer, C.P.; Barnhart, T.E.; Liu, Z.; Cai, W. In Vivo Targeting and Imaging of Tumor Vasculature with Radiolabeled, Antibody-Conjugated Nanographene. ACS Nano., 2012, 6, 2361-2370.
153. Chen, G.Y.; Pang, D. W.P.; Hwang, S.M.; Tuan, H.Y.; Hu, Y. C. A graphene-based platform for induced pluripotent stem cells culture and differentiation. Biomaterials, 2012, 33, 418-427.
154. Wang, E.; Desai, M.S.; Lee, S.-W. Light-Controlled Graphene-Elastin Composite Hydrogel Actuators. Nano Lett., 2013, 13, 2826-2830.
155. Ribeiro, A.; Arias, F.J.; Reguera, J.; Alonso, M.; Rodriguez-Cabello, J. C. Influence of the amino-acid sequence on the inverse temperature transition of elastin-like polymers. Biophys. J., 2009, 97, 312-320.
156. Martín, L.; Castro, E.; Ribeiro, A.; Alonso, M.; Rodríguez-Cabello, J. C. Temperature-Triggered Self-Assembly of Elastin-Like Block Co-Recombinamers: The Controlled Formation of Micelles and Vesicles in an Aqueous Medium. Biomacromolecules, 2012, 13, 293-298.
157. Kim, W.; Thévenot, J.; Ibarboure, E.; Lecommandoux, S.; Chaikof, E. L. Self-Assembly of Thermally Responsive Amphiphilic Diblock Copolypeptides into Spherical Micellar Nanoparticles. Angew. Chem., Int. Ed. Engl., 2010, 49, 4257-4260.
158. Dash, B.C.; Mahor, S.; Carroll, O.; Mathew, A.; Wang, W.; Woodhouse, K.A.; Pandit, A. Tunable elastin-like polypeptide hollow sphere as a high payload and controlled delivery gene depot. J. Control. Release, 2011, 152, 382-392.
159. Wu, Y.; MacKay, J.A.; McDaniel, J.R.; Chilkoti, A.; Clark, R. L. Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying. Biomacromolecules, 2009, 10, 19-24.