Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p

Nature Communications

Volumn 6, Issue , 2015, Pages

  Madsen, Christian T ^a,c   Sylvestersen, Kathrine B ^a   Young, Clifford ^a   Larsen, Sara C ^a   Poulsen, Jon W ^a   Andersen, Marianne A ^b   Palmqvist, Eva A ^c   Hey Mogensen, Martin ^c   Jensen, Per B ^c   Treebak, Jonas T ^b   Lisby, Michael ^d   Nielsen, Michael L ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Capital Region   (Denmark)

^c NOVO NORDISK A S   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; BIOTIN; HST4P PROTEIN; MITOCHONDRIAL PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN 3; UNCLASSIFIED DRUG; HISTONE DEACETYLASE; HST4 PROTEIN, S CEREVISIAE; NICOTINAMIDE; SACCHAROMYCES CEREVISIAE PROTEIN;

ABNORMALITY; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENE EXPRESSION; HOMEOSTASIS; METABOLISM; MITOCHONDRION; PROTEIN; STARVATION; VITAMIN; YEAST;

ARTICLE; BIOTINYLATION; CELL ENERGY; CELL RESPIRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EUKARYOTIC CELL; GENE ONTOLOGY; GENE SILENCING; HOMEOSTASIS; IMMUNOFLUORESCENCE MICROSCOPY; INTRACELLULAR SPACE; METABOLIC DISORDER; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; PROTEIN ACETYLATION; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYPERACETYLATION; PROTEOMICS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ACETYLATION; DEFICIENCY; ENERGY METABOLISM; FLUORESCENCE MICROSCOPY; GENETICS; MASS SPECTROMETRY; METABOLISM; MITOCHONDRION; STARVATION; TRANSGENIC ORGANISM;

EUKARYOTA;

ACETYL COENZYME A; ACETYLATION; BIOTIN; CELL RESPIRATION; ENERGY METABOLISM; HISTONE DEACETYLASES; HOMEOSTASIS; MASS SPECTROMETRY; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NAD; NIACINAMIDE; ORGANISMS, GENETICALLY MODIFIED; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STARVATION;

EID: 84936992221     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8726     Document Type: Article

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