New approach to develop ultra-high inhibitory drug using the power function of the stoichiometry of the targeted nanomachine or biocomplex

Nanomedicine

Volumn 10, Issue 12, 2015, Pages 1881-1897

  Shu, Dan ^a   Pi, Fengmei ^a   Wang, Chi ^b   Zhang, Peng ^c   Guo, Peixuan ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

binomial distribution; bionanotechnology; drug target; hexameric ATPase; nanobiotechnology; nanomotor; phi29 viral assembly

Indexed keywords

ARTICLE; BACILLUS PHAGE PHI29; BINOMIAL DISTRIBUTION; COPY NUMBER VARIATION; DNA PACKAGING; DRUG INHIBITION; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; STOICHIOMETRY; VIRION; VIRUS INHIBITION; VIRUS REPLICATION; ALGORITHM; ANTAGONISTS AND INHIBITORS; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DRUG DESIGN; PROTEIN TERTIARY STRUCTURE; VIRUS ASSEMBLY;

ADENOSINE TRIPHOSPHATASE; MOLECULAR MOTOR; NANOPARTICLE; PROTEIN BINDING; VIRUS DNA;

ADENOSINE TRIPHOSPHATASES; ALGORITHMS; COMPUTER SIMULATION; DNA PACKAGING; DNA, VIRAL; DRUG DESIGN; MODELS, CHEMICAL; MOLECULAR MOTOR PROTEINS; NANOPARTICLES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; VIRUS ASSEMBLY;

EID: 84936972846     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.15.37     Document Type: Article

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